Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

Trivella, 2020, Novel targeted therapies for the management of liver fibrosis, Expert Opin Emerg Drugs, 25, 59, 10.1080/14728214.2020.1735350 Ezhilarasan, 2018, Oxidative stress is bane in chronic liver diseases: clinical and experimental perspective, Arab J Gastroenterol, 19, 56, 10.1016/j.ajg.2018.03.002 Dhar, 2020, Mechanisms of liver fibrosis and its role in liver cancer, Exp Biol Med (Maywood), 245, 96, 10.1177/1535370219898141 Llovet, 2016, Hepatocellular carcinoma, Nat Rev Dis Primers, 2, 16018, 10.1038/nrdp.2016.18 Devaraj, 2020, Nanomedicine for hepatic fibrosis Wang, 2020, Hepatic fibrosis: a convergent response to liver injury that is reversible, J Hepatol, 73, 210, 10.1016/j.jhep.2020.03.011 Ezhilarasan, 2018, Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets, Hepatobiliary Pancreat Dis Int, 17, 192, 10.1016/j.hbpd.2018.04.003 Shang, 2018, Human hepatic stellate cell isolation and characterization, J Gastroenterol, 53, 6, 10.1007/s00535-017-1404-4 Ezhilarasan, 2019, Lead compounds with the potentials for the treatment of chronic liver diseases Li, 2019, Roles of hepatic stellate cells in acute liver failure: from the perspective of inflammation and fibrosis, World J Hepatol, 11, 412, 10.4254/wjh.v11.i5.412 Sherman, 2018, Stellate cells in tissue repair, inflammation, and cancer, Annu Rev Cell Dev Biol, 34, 333, 10.1146/annurev-cellbio-100617-062855 Haaker, 2020, Retinoids in health and disease: a role for hepatic stellate cells in affecting retinoid levels, Biochim Biophys Acta Mol Cell Biol Lipids, 1865 Gandhi, 2017, Hepatic stellate cell activation and pro-fibrogenic signals, J Hepatol, 67, 1104, 10.1016/j.jhep.2017.06.001 Tsuchida, 2017, Mechanisms of hepatic stellate cell activation, Nat Rev Gastroenterol Hepatol, 14, 397, 10.1038/nrgastro.2017.38 Higashi, 2017, Hepatic stellate cells as key target in liver fibrosis, Adv Drug Deliv Rev, 121, 27, 10.1016/j.addr.2017.05.007 Degli Esposti, 2012, Mitochondrial roles and cytoprotection in chronic liver injury, Biochem Res Int, 2012, 10.1155/2012/387626 Higgs, 2010, Reduced mitochondrial dysfunction delays liver fibrosis, Nat Rev Gastroenterol Hepatol, 7, 6 Mansouri, 2018, Mitochondrial dysfunction and signaling in chronic liver diseases, Gastroenterology, 155, 629, 10.1053/j.gastro.2018.06.083 Simões, 2018, Mitochondria in non-alcoholic fatty liver disease, Int J Biochem Cell Biol, 95, 93, 10.1016/j.biocel.2017.12.019 Vakifahmetoglu-Norberg, 2017, The role of mitochondria in metabolism and cell death, Biochem Biophys Res Commun, 482, 426, 10.1016/j.bbrc.2016.11.088 Ai, 2018, Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell, Biochim Biophys Acta Mol Basis Dis, 1864, 3780, 10.1016/j.bbadis.2018.09.011 Bae, 2019, Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells, J Nutr Biochem, 71, 82, 10.1016/j.jnutbio.2019.06.001 Gajendiran, 2018, Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin, J Cell Mol Med, 22, 2210, 10.1111/jcmm.13501 Hur, 2019, Serine protease HtrA2/Omi deficiency impairs mitochondrial homeostasis and promotes hepatic fibrogenesis via activation of hepatic stellate cells, Cells, 8, 1119, 10.3390/cells8101119 Bates, 2020, Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation, J Hepatol, 73, 896, 10.1016/j.jhep.2020.04.037 Du, 2018, Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells, Gastroenterology, 154, 1465, 10.1053/j.gastro.2017.12.022 Demine, 2019, Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases, Cells, 8, 795, 10.3390/cells8080795 Fujisawa, 2009, TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis, Biochem Biophys Res Commun, 379, 43, 10.1016/j.bbrc.2008.11.141 Guimarães, 2012, Mitochondrial uncouplers inhibit hepatic stellate cell activation, BMC Gastroenterol, 12, 68, 10.1186/1471-230X-12-68 Rohas, 2007, A fundamental system of cellular energy homeostasis regulated by PGC-1alpha, Proc Natl Acad Sci USA, 104, 7933, 10.1073/pnas.0702683104 Chen, 2012, Hedgehog controls hepatic stellate cell fate by regulating metabolism, Gastroenterology, 143, 1319, 10.1053/j.gastro.2012.07.115 Lian, 2016, Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase, IUBMB Life, 68, 589, 10.1002/iub.1518 Hou, 2018, Role of metabolism in hepatic stellate cell activation and fibrogenesis, Front Cell Dev Biol, 6, 150, 10.3389/fcell.2018.00150 Kim, 2017, Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling, Sci Rep, 7, 3815, 10.1038/s41598-017-03782-x Gao, 2018, Role of canonical Hedgehog signaling pathway in liver, Int J Biol Sci, 14, 1636, 10.7150/ijbs.28089 Novo, 2012, The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells, J Pathol, 226, 588, 10.1002/path.3005 Bobowski-Gerard, 2018, Retinoids issued from hepatic stellate cell lipid droplet loss as potential signaling molecules orchestrating a multicellular liver injury response, Cells, 7, 137, 10.3390/cells7090137 Watford, 2015, Glutamine and glutamate: nonessential or essential amino acids?, Anim Nutr, 1, 119, 10.1016/j.aninu.2015.08.008 Yu, 2019, Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells, Cell Metab, 29, 966, 10.1016/j.cmet.2019.01.016 Li, 2017, Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism, PLoS One, 12 Manmadhan, 2019, Hippo signaling in the liver - a long and ever-expanding story, Front Cell Dev Biol, 7, 33, 10.3389/fcell.2019.00033 Chen, 2019, ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury, FASEB J, 33, 9602, 10.1096/fj.201900213R Wu, 2020, Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs, Future Med Chem, 12, 533, 10.4155/fmc-2019-0312 Yang, 2016, Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury, Toxicol Lett, 262, 80, 10.1016/j.toxlet.2016.09.014 Liang, 2017, AMPK: a novel target for treating hepatic fibrosis, Oncotarget, 8, 62780, 10.18632/oncotarget.19376 Caligiuri, 2008, Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells, Hepatology, 47, 668, 10.1002/hep.21995 Roehlen, 2020, Liver fibrosis: mechanistic concepts and therapeutic perspectives, Cells, 9, 875, 10.3390/cells9040875 Liu, 2009, Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258, Lab Invest, 89, 1152, 10.1038/labinvest.2009.77 Brunati, 2010, Thiol redox systems and protein kinases in hepatic stellate cell regulatory processes, Free Radic Res, 44, 363, 10.3109/10715760903555836 Gandhi, 2012, Oxidative stress and hepatic stellate cells: a PARADOXICAL relationship, Trends Cell Mol Biol, 7, 1 Kojima-Yuasa, 2005, Role of reactive oxygen species in zinc deficiency-induced hepatic stellate cell activation, Free Radic Biol Med, 39, 631, 10.1016/j.freeradbiomed.2005.04.015 Siegmund, 2007, The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species, FASEB J, 21, 2798, 10.1096/fj.06-7717com Ezhilarasan, 2016, Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats, Chin J Nat Med, 14, 40 Ghatak, 2011, Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice, Toxicol Appl Pharmacol, 251, 59, 10.1016/j.taap.2010.11.016 Ezhilarasan, 2012, Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats, Environ Toxicol Pharmacol, 34, 1004, 10.1016/j.etap.2012.07.004 Das, 2017, Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice, J Pineal Res, 62, 10.1111/jpi.12404 Zhao, 2019, p66Shc contributes to liver fibrosis through the regulation of mitochondrial reactive oxygen species, Theranostics, 9, 1510, 10.7150/thno.29620 Tian, 2018, Role of mitophagy regulation by ROS in hepatic stellate cells during acute liver failure, Am J Physiol Gastrointest Liver Physiol, 315, G374, 10.1152/ajpgi.00032.2018 Li, 2018, Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase, World J Gastroenterol, 24, 819, 10.3748/wjg.v24.i7.819 Ban, 2019, Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2, Cell Mol Biol Lett, 24, 52, 10.1186/s11658-019-0179-4