High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

Cell - Tập 72 - Trang 835-846 - 1993
Birgit Millauer1, Susanne Wizigmann-Voos2, Harald Schnürch2, Ricardo Martinez3, Niels Peter H. Møller1, Werner Risau2, Axel Ullrich1
1Department of Molecular Biology Max Planck Institute for Biochemistry, Am Klopferspitz 18A 8033 Martinsried Federal Republic of Germany
2Department of Neurochemistry Max Planck Institute for Psychiatry Am Klopferspitz 18A 8033 Martinsried Federal Republic of Germany
3Department of Molecular Biology SUGEN Incorporated 515 Galveston Drive Redwood City, California 94063, USA

Tài liệu tham khảo

Aroian, 1990, The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily, Nature, 348, 693, 10.1038/348693a0 Aviv, 1972, Purification of biologically active globin messenger RNA by chromatography on oligothymidilic acid cellulose, 69, 1408 Bär, 1980, The vascular system of the cerebral cortex, Adv. Anat. Embryol. Cell. Biol., 59, 1, 10.1007/978-3-642-67432-7_1 Barbacid, 1991, The trk family of tyrosine protein kinase receptors, Biochim. Biophys. Acta, 1072, 115 Basler, 1988, Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain, Cell, 54, 299, 10.1016/0092-8674(88)90193-6 Breier, 1992, Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation, Development, 114, 521, 10.1242/dev.114.2.521 Chabot, 1988, The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W-locus, Nature, 335, 88, 10.1038/335088a0 Chen, 1987, High-efficiency transformation of mammalian cells by plasmid DNA, Mol. Cell. Biol., 7, 2745 Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 Claesson-Welsh, 1989, cDNA cloning and expression of the human A-type plateletderived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor, 86, 4917 Clauss, 1990, Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte proagulant activity, and promotes monocyte migration, J. Exp. Mad., 172, 1535, 10.1084/jem.172.6.1535 Conn, 1990, Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line, 87, 1323 Czech, 1989, Signal transmission by the insulin-like growth factors, Cell, 59, 235, 10.1016/0092-8674(89)90281-X De Vries, 1992, The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor, Science, 255, 989, 10.1126/science.1312256 Dionne, 1990, Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors, EMBO J., 9, 2685, 10.1002/j.1460-2075.1990.tb07454.x Dumont, 1992, Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors, Oncogene, 7, 1471 Engermann, 1967, Cell turnover of capillaries, Lab. Invest., 17, 738 Fahmer, 1987, Transcription of H-2 and Qa genes in embryonic and adult mice, EMBO J., 6, 1497 Feinberg, 1983, A technique for radiolabeling DNA restriction and endonuclease fragments to high specific activity, Anal. Biochem., 132, 6, 10.1016/0003-2697(83)90418-9 Fendly, 1990, Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product, Cancer Res., 50, 1550 Ferrara, 1989, Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells, Biochem. Biophys. Res. Commun., 161, 851, 10.1016/0006-291X(89)92678-8 Geissler, 1988, The dominant-white spotting (W) locus of the mouse encodes the c-kit protooncogene, Cell, 55, 185, 10.1016/0092-8674(88)90020-7 Ginsburg, 1985, Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization, Science, 228, 1401, 10.1126/science.3874428 Gorman, 1989, The human cytomegalovirus major immediate early promoter can be transactivated by adenovirus early proteins, Virology, 171, 377, 10.1016/0042-6822(89)90605-3 Gospodarowicz, 1989, Isolation and characterization of a vascular endothelial mitogen produced by pituitary-derived folliculo stellate cells, 86, 7311 Greene, 1976, Establishment of a noradrenergic clonal line of ratadrenal pheochromocytoma cells which respond to nerve growth factor, 7, 2424 Hanks, 1988, The protein kinase family: conserved proteins and deduced phylogeny of the catalytic domains, Science, 241, 42, 10.1126/science.3291115 Heuer, 1990, Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system, Neuron, 5, 283, 10.1016/0896-6273(90)90165-C Hogan, 1986 Hunter, 1962, Preparation of iodine-131 labelled human growth hormone of high specific activity, Nature, 194, 495, 10.1038/194495a0 Kaplan, 1991, The trk proto-oncogene product: a signal transducing receptor for nerve growth factor, Science, 252, 554, 10.1126/science.1850549 Klagsbrun, 1989, The fibroblast growth factor family: structural and biological properties, Prog. Growth Factor Res., 1, 207, 10.1016/0955-2235(89)90012-4 Klein, 1991, The trk proto-oncogene encodes a receptor for nerve growth factor, Cell, 65, 189, 10.1016/0092-8674(91)90419-Y Kris, 1985, Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein, Cell, 40, 619, 10.1016/0092-8674(85)90210-7 Kuroda, 1989, Differentiation of germ cells in semniferous tubules transplanted to tests of germ cell-deficient mice of W/WV and S1/S1d genotypes, J. Cell. Physiol., 139, 329, 10.1002/jcp.1041390215 Leppink, 1989, Inducible expression of an endothelial cell antigen on murine myocardial vasculature in association with interstitial cellular infiltration, Transplantation, 48, 874, 10.1097/00007890-198911000-00032 Levy, 1989, An endothelial cell growth factor from the mouse neuroblastoma cell line NB 41, Growth Factors, 2, 9, 10.3109/08977198909069077 Maglione, 1991, Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor, 88, 9267 Maher, 1988, Tyrosine phosphorylated proteins in different tissues during chick embryo development, J. Cell Biol., 106, 1747, 10.1083/jcb.106.5.1747 Matthews, 1991, A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit, 88, 9026 Montesano, 1991, Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor, Cell, 67, 901, 10.1016/0092-8674(91)90363-4 Munson, 1980, Ligand, a versatile computerized approach for the characterization of ligand binding systems, Anal. Biochem., 107, 220, 10.1016/0003-2697(80)90515-1 Nocka, 1990, Molecular basis of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37 Wv, W41 and W, EMBO J., 9, 1805, 10.1002/j.1460-2075.1990.tb08305.x Okayama, 1983, A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells, Mol. Cell. Biol., 3, 280 Peters, 1992, Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse, Development, 114, 233, 10.1242/dev.114.1.233 Reith, 1990, W mutant mice with mild or severe developmental defects contain distinc t point mutations in the kinase domain of the c-kit receptor, Genes Dev., 4, 390, 10.1101/gad.4.3.390 Risau, 1991, Vasculogenesis, angiogenesis and endothelial cell differentiation during embryonic development, 58 Risau, 1988, Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis, Dev. Biol., 125, 441, 10.1016/0012-1606(88)90225-4 Risau, 1990, Immune function of the blood-brain barrier: incomplete presentation of protein (auto-) antigens by rat brain microvascular endothelium in vitro, J. Cell Biol., 110, 1757, 10.1083/jcb.110.5.1757 Robertson, 1985, Angiogenesis in developing rat brain: an in vivo and in vitro study, Dev. Brain Res., 23, 219, 10.1016/0165-3806(85)90044-6 Robinson, 1991, Multiple receptors found for the growing FGF-family, Trends Pharmacol. Sci., 12, 123, 10.1016/0165-6147(91)90525-W Russell, 1979, Hereditary anemias of the mouse: a review for geneticists, Adv. Genet., 20, 257 Saiki, 1985, Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia, Science, 230, 1350, 10.1126/science.2999980 Sambrook, 1989 Sarzani, 1992, A novel endothelial tyrosine kinase cDNA homologous to platelet-derived growth factor receptor cDNA, Biochem. Biophys. Res. Commun., 186, 706, 10.1016/0006-291X(92)90804-T Schnürch, 1991, Differentiating and adult neurons express the acidic fibroblast growth factor gene during chick neural development, Development, 111, 1143, 10.1242/dev.111.4.1143 Schumacher, 1991, Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors, J. Biol. Chem., 266, 19288, 10.1016/S0021-9258(18)54996-6 Shibuya, 1990, Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family, Oncogene, 5, 519 Smith, 1988, Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene, 67, 31, 10.1016/0378-1119(88)90005-4 Tan, 1990, The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase, Science, 247, 209, 10.1126/science.1688471 Terman, 1991, Identification of a new endothelial cell growth factor receptor tyrosine kinase, Oncogene, 6, 1677 Ullrich, 1990, Signal transduction by receptors with tyrosine kinase activity, Cell, 61, 203, 10.1016/0092-8674(90)90801-K Ullrich, 1985, Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes, Nature, 313, 756, 10.1038/313756a0 Wanaka, 1991, Expression of FGF receptor gene in rat development, Development, 111, 455, 10.1242/dev.111.2.455 Wilks, 1989, Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction, 86, 1603 Yeh, 1989, Functional and morphologic expressions of trophoblast, Lab. Invest., 61, 1