Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study

Lancet Respiratory Medicine,The - Tập 1 Số 6 - Trang 453-461 - 2013
Daniel W. Belsky1,2, Malcolm R. Sears3, Robert J. Hancox4, HonaLee Harrington5,6,2, Renate Houts5,6,2, Terrie E. Moffitt5,6,2,7, Karen Sugden6,2,7, Benjamin Williams6,2,7, Richie Poulton4, Avshalom Caspi5,6,2,7
1Center for the Study of Aging and Human Development Duke University Medical Center, Durham, NC USA
2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
3Division of Respirology, Department of Medicine, DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
4Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin, New Zealand
5Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
6Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
7Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK

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Sears, 1997, Descriptive epidemiology of asthma, Lancet, 350, S1, 10.1016/S0140-6736(97)90028-3

Wenzel, 2012, Asthma phenotypes: the evolution from clinical to molecular approaches, Nat Med, 18, 716, 10.1038/nm.2678

Zhang, 2012, Genetic and genomic approaches to asthma: new insights for the origins, Curr Opin Pulm Med, 18, 6, 10.1097/MCP.0b013e32834dc532

Ober, 2011, The genetics of asthma and allergic disease: a 21st century perspective, Immunol Rev, 242, 10, 10.1111/j.1600-065X.2011.01029.x

Bonfield, 2012, Asthma heterogeneity and therapeutic options from the clinic to the bench, Curr Opin Allergy Clin Immunol, 12, 60, 10.1097/ACI.0b013e32834edb5b

Agache, 2012, Untangling asthma phenotypes and endotypes, Allergy, 67, 835, 10.1111/j.1398-9995.2012.02832.x

Pearson, 2008, How to interpret a genome-wide association study, JAMA, 299, 1335, 10.1001/jama.299.11.1335

Belsky DW, Moffitt TE, Caspi A. Genetics in population health science: strategies and opportunities. Am J Public Health (in press).

Moffatt, 2010, A large-scale, consortium-based genomewide association study of asthma, N Engl J Med, 363, 1211, 10.1056/NEJMoa0906312

Sears, 2003, A longitudinal, population-based, cohort study of childhood asthma followed to adulthood, N Engl J Med, 349, 1414, 10.1056/NEJMoa022363

Moffitt, 2001

Chipps, 2004, Determinants of asthma and its clinical course, Ann Allergy Asthma Immunol, 93, 309, 10.1016/S1081-1206(10)61388-9

Cowan, 2012, Pediatric asthma phenotypes, Curr Opin Pediatr, 24, 344, 10.1097/MOP.0b013e32835357ab

Joos, 2003, Indirect airway challenges, Eur Respir J, 21, 1050, 10.1183/09031936.03.00008403

Anderson, 2010, Indirect challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance, Chest, 138, 25S, 10.1378/chest.10-0116

Brightling, 2012, Lung damage and airway remodelling in severe asthma, Clin Exp Allergy, 42, 638, 10.1111/j.1365-2222.2011.03917.x

Valdez, 2010, Family history in public health practice: a genomic tool for disease prevention and health promotion, Annu Rev Public Health, 31, 69, 10.1146/annurev.publhealth.012809.103621

Sullivan, 2007, Spurious genetic associations, Biol Psychiatry, 61, 1121, 10.1016/j.biopsych.2006.11.010

Spycher, 2012, Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort, J Allergy Clin Immunol, 130, 503, 10.1016/j.jaci.2012.06.002

Joubert, 2011, Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population, BMC Med Genet, 12, 25, 10.1186/1471-2350-12-25

Plomin, 2009, Common disorders are quantitative traits, Nat Rev Genet, 10, 872, 10.1038/nrg2670

Milne, 2008, How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study, Psychol Med, 38, 1793, 10.1017/S0033291708003115

Jones, 1987, Childhood asthma in New-Zealand, Br J Dis Chest, 81, 332, 10.1016/0007-0971(87)90181-1

Taylor, 2005, Asthma in remission—can relapse in early adulthood be predicted at 18 years of age?, Chest, 127, 845, 10.1378/chest.127.3.845

Sutherland, 2009, Leptin, adiponectin, and asthma: findings from a population-based cohort study, Ann Allergy Asthma Immunol, 103, 101, 10.1016/S1081-1206(10)60161-5

Sears, 1989, The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma, Clin Exp Allergy, 19, 419, 10.1111/j.1365-2222.1989.tb02408.x

Sears, 1993, Atopy in childhood. I. Gender and allergen related risks for development of hay fever and asthma, Clin Exp Allergy, 23, 9410

Hancox, 2005, Sex differences in the relation between body mass index and asthma and atopy in a birth cohort, Am J Respir Crit Care Med, 171, 440, 10.1164/rccm.200405-623OC

Sears, 1991, Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children, N Engl J Med, 325, 1067, 10.1056/NEJM199110103251504

Sears, 1986, Prevalence of bronchial reactivity to inhaled methacholine in New Zealand children, Thorax, 41, 283, 10.1136/thx.41.4.283

Sears, 1993, Atopy in childhood. II. Relationship to airway responsiveness, hay fever and asthma, Clin Exp Allergy, 23, 949, 10.1111/j.1365-2222.1993.tb00280.x

Rasmussen, 2002, Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood, Am J Respir Crit Care Med, 165, 1480, 10.1164/rccm.2108009

1993, Standardized lung function testing, Eur Respir J, 16, 1

Zeger, 1988, Models for longitudinal data: a generalized estimating equation approach, Biometrics, 44, 104, 10.2307/2531734

Decramer, 2012, Chronic obstructive pulmonary disease, Lancet, 379, 1341, 10.1016/S0140-6736(11)60968-9

Belsky, 2013, Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study, JAMA Psychiatry, 70, 534, 10.1001/jamapsychiatry.2013.736

Forno, 2012, Genome-wide association study of the age of onset of childhood asthma, J Allergy Clin Immunol, 130, 83, 10.1016/j.jaci.2012.03.020

Bouzigon, 2008, Effect of 17q21 variants and smoking exposure in early-onset asthma, N Engl J Med, 359, 1985, 10.1056/NEJMoa0806604

Halapi, 2010, A sequence variant on 17q21 is associated with age at onset and severity of asthma, Eur J Hum Genet, 18, 902, 10.1038/ejhg.2010.38

Ferreira, 2011, Identification of IL6R and chromosome 11q13.5 as risk loci for asthma, Lancet, 378, 1006, 10.1016/S0140-6736(11)60874-X

Heald, 2012, Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers, Eur J Hum Genet, 20, 547, 10.1038/ejhg.2011.224

Do, 2012, Comparison of family history and SNPs for predicting risk of complex disease, PLoS Genet, 8, e1002973, 10.1371/journal.pgen.1002973

Belsky, 2012, Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study, Arch Pediatr Adolesc Med, 166, 515, 10.1001/archpediatrics.2012.131

Meigs, 2008, Genotype score in addition to common risk factors for prediction of type 2 diabetes, N Engl J Med, 359, 2208, 10.1056/NEJMoa0804742

So, 2011, Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening, Am J Hum Genet, 88, 548, 10.1016/j.ajhg.2011.04.001

Purcell, 2009, Common polygenic variation contributes to risk of schizophrenia and bipolar disorder, Nature, 460, 748, 10.1038/nature08185

Gibson, 2011, Rare and common variants: twenty arguments, Nat Rev Genet, 13, 135, 10.1038/nrg3118

von Mutius, 2009, Gene-environment interactions in asthma, J Allergy Clin Immunol, 123, 3, 10.1016/j.jaci.2008.10.046

Guerra, 2008, Asthma genetics: from linear to multifactorial approaches, Annu Rev Med, 59, 327, 10.1146/annurev.med.59.060406.213232

Khoury, 2012, Beyond base pairs to bedside: a population perspective on how genomics can improve health, Am J Public Health, 102, 34, 10.2105/AJPH.2011.300299

Wjst, 2013, Genome-wide association studies in asthma: what they really told us about pathogenesis, Curr Opin Allergy Clin Immunol, 13, 112, 10.1097/ACI.0b013e32835c1674

Wray, 2007, Prediction of individual genetic risk to disease from genome-wide association studies, Genome Res, 17, 1520, 10.1101/gr.6665407