Methoxyflurane: Effects upon cardiac contractility, rhythmicity, and blood pressure in dogs
Tóm tắt
Methoxyflurane was administered to unpremedicated dogs in increasing and decreasing cpncentrations while normal pulmonary ventilation was rigidly maintained. Myocardial contractility, blood pressure, pulse rate, electrocardiogram, and electroencephalogram were recorded continuously. A progressive decrease in contractile force of the heart muscle resulted as the inhaled concentration of methoxyflurane increased. A parallel decrease in systolic, diastolic, and pulse pressure occurred. Sinus bradycardia and an alteration in repolarization of cardiac muscle accompanied the dynamic changes. A lag occurred in recovery of all cardiovascular functions and the EEG following withdrawal of the agent. Burst suppression appeared when hypotension below 90 mm. Hg occurred. A comparison of the results of this study with those previously reported is presented.
Tài liệu tham khảo
Artusio, J. F. Jr. &Van Poznak, A. Clinical Evaluation of Methoxyflurane in Man. Fed. Proc.19: 273 (1960).
Artusio, J. F. Jr.;Van Poznak, A.;Hunt, R. E.;Tiers, F. M.; &Alexander, M. A. Clinical Evaluation of Methoxyflurane in Man. Anesthesiology21: 512 (1960).
Van Poznak, A. &Artusio, J. F. Jr. Series of Fluorinated Ethers. Fed. Proc.19: 273 (1960).
North, C.;Knox, P. R.;Vartanian, V.; &Stephen, C. R. Respiratory, Circulatory and Hepatic Effects of Methoxyflurane in Dogs. Anesthesioldgy22: 139 (1961).
Siebecker, K. L.;Jumes, M.;Bamforth, B. J.; &OrtH, O. S. The Respiratory Effect of Methoxyflurane on Dog and Man. Anesthesiology22: 143 (1961).
Andersen, N. &Andersen, E. W. Methoxyflurane, a New Volatile Anaesthetic Agent. Acta Anaesth. Scand.5: 179 (1961).
Price, H. L.;Linde, H. W.;Jones, R. E.;Black, G. W.; &Price, M. L. Sympathoadrenal Responses to General Anesthesia in Man and Their Relation to Hemodynamics. Anesthesiology20: 563 (1959).
Boniface, K. J.;Brodee, O. J.;Walton, R. P. Resistance Strain Gauge Arches for Direct Measurement of Heart Contractile Force in Animals. Proc. Soc. Exper. Biol. & Med.84: 263 (1953).
Lannek, N. A Clinical and Experimental Study of the EKG in Pogs. Med. Clin. Roy. Vet. Coll. Stockholm (1949).
Thomasqn, R.;Light, G.; &Holaday, D. A. Methoxyflurane Anesthesia: A Clinical Appraisal. Anesth. & Analg.41: 225 (1962).
Bagwell, E. E.;Woods, E. F.; &Gadsden, R. H. Blood Levels arid Cardiovascular Dynamics during Methoxyflurane Inhalation in Dogs. Anesthesiology23: 243 (1962).
Wyant, G. M.;Chang, C. A.; &Rapicavoli, E. Methoxyflurane (Penthrane): A Laboratory and Clinical Study. Canad. Anaesth. Soc. J.8: 477 (1961).
DobkIn, A. B. &Fedoruk, S. Comparison of the Cardiovascular, Respiratory and Metabolic Effects of Methoxyflurane and Halothane in Dogs. Anesthesiology22: 355 (1961).
Campbell, M. W.;Hvolboll, A. P.; &Brechner, V. L. Penthrane, a Clinical Evaluation in 50 Cases. Anesth. & Analg.41: 134 (1962).
Knox, P. R.;North, W. C.; &Stephen, C. R. Methoxyflurane—A Clinical Evaluation. Anesthesiology23: 238 (1962).