Human Aging and Longevity Are Characterized by High Levels of Mitokines

Maria Conte1,2, Rita Ostan1,2, Cristina Fabbri1, Aurelia Santoro1,2, Giulia Guidarelli1, Giovanni Vitale3,4, Daniela Mari5, Federica Sevini1, Miriam Capri1,2, Marco Sandri6,7, Daniela Monti8, Claudio Franceschi9, Stefano Salvioli1,2
1Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Cusano Milanino
2Interdepartmental Centre “L. Galvani” (CIG), University of Bologna, Cusano Milanino
3Department of Clinical Sciences and Community Health, University of Milan, Cusano Milanino
4Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Cusano Milanino
5Geriatric Unit, Fondazione Ca’ Granda, IRCCS Ospedale Maggiore Policlinico, Milan
6Department of Biomedical Science, University of Padova, Padova
7Venetian Institute of Molecular Medicine, Padova
8Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Bologna, Italy
9IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy

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Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J Gerontol, 11, 298, 10.1093/geronj/11.3.298

Sun, 2016, The mitochondrial basis of aging, Mol Cell, 61, 654, 10.1016/j.molcel.2016.01.028

Pérez, 2009, Is the oxidative stress theory of aging dead, Biochim Biophys Acta, 1790, 1005, 10.1016/j.bbagen.2009.06.003

Edrey, 2014, Revisiting an age-old question regarding oxidative stress, Free Radic Biol Med, 71, 368, 10.1016/j.freeradbiomed.2014.03.038

Rea, 2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans, PLoS Biol, 5, e259, 10.1371/journal.pbio.0050259

Schiavi, 2015, Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C.elegans, Curr Biol, 25, 1810, 10.1016/j.cub.2015.05.059

Durieux, 2011, The cell-non-autonomous nature of electron transport chain-mediated longevity, Cell, 144, 79, 10.1016/j.cell.2010.12.016

Copeland, 2009, Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain, Curr Biol, 19, 1591, 10.1016/j.cub.2009.08.016

Owusu-Ansah, 2013, Muscle mitohormesis promotes longevity via systemic repression of insulin signaling, Cell, 155, 699, 10.1016/j.cell.2013.09.021

Kim, 2013, Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation, Biochem Biophys Res Commun, 440, 76, 10.1016/j.bbrc.2013.09.026

Kim, 2013, Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine, Nat Med, 19, 83, 10.1038/nm.3014

Dillin, 2002, Rates of behavior and aging specified by mitochondrial function during development, Science, 298, 2398, 10.1126/science.1077780

Lee, 2003, A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity, Nat Genet, 33, 40, 10.1038/ng1056

Hansen, 2008, A role for autophagy in the extension of lifespan by dietary restriction in C. elegans, PLoS Genet, 4, e24, 10.1371/journal.pgen.0040024

Fujita, 2015, GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases, Mitochondrion, 20, 34, 10.1016/j.mito.2014.10.006

Salminen, 2017, Regulation of longevity by FGF21: interaction between energy metabolism and stress responses, Ageing Res Rev, 37, 79, 10.1016/j.arr.2017.05.004

Xie, 2017, Fibroblast growth factor 21: a regulator of metabolic disease and health span, Am J Physiol Endocrinol Metab, 313, E292, 10.1152/ajpendo.00101.2017

Liu, 2015, The role of fibroblast growth factor 21 in diabetes and its complications: a review from clinical perspective, Diabetes Res Clin Pract, 108, 382, 10.1016/j.diabres.2015.02.032

Hanks, 2015, Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals, J Clin Transl Endocrinol, 2, 77

Tezze, 2017, Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence, Cell Metab, 25, 1374, 10.1016/j.cmet.2017.04.021

Yatsuga, 2015, Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders, Ann Neurol, 78, 814, 10.1002/ana.24506

Fujita, 2016, Secreted growth differentiation factor15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders, Geriatr Gerontol Int, 16, 17, 10.1111/ggi.12724

Wang, 2014, hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling, Aging (Albany NY), 6, 690, 10.18632/aging.100687

Adela, 2015, GDF-15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective, J Diabetes Res, 2015, 490842, 10.1155/2015/490842

Corre, 2013, Concise review: growth differentiation factor 15 in pathology: a clinical role, Stem Cells Transl Med, 2, 946, 10.5966/sctm.2013-0055

Hashimoto, 2001, A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta, Proc Natl Acad Sci U S A, 98, 6336, 10.1073/pnas.101133498

Guo, 2003, Humanin peptide suppresses apoptosis by interfering with Bax activation, Nature, 423, 456, 10.1038/nature01627

Zarse, 2015, A mitochondrially encoded hormone ameliorates obesity and insulin resistance, Cell Metab, 21, 355, 10.1016/j.cmet.2015.02.013

Cobb, 2016, Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers, Aging (Albany NY), 8, 796, 10.18632/aging.100943

Ijiri, 2005, Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality, Ann Rheum Dis, 64, 816, 10.1136/ard.2004.025445

Lenaz, 1998, Oxidative stress, antioxidant defences and aging, Biofactors, 8, 195, 10.1002/biof.5520080305

Short, 2005, Decline in skeletal muscle mitochondrial function with aging in humans, Proc Natl Acad Sci U S A, 102, 5618, 10.1073/pnas.0501559102

Bratic, 2013, The role of mitochondria in aging, J Clin Invest, 123, 951, 10.1172/JCI64125

Sgarbi, 2014, Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians, Aging (Albany NY), 6, 296, 10.18632/aging.100654

Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883

Vitale, 2012, Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians’ offspring, Aging (Albany NY), 4, 580, 10.18632/aging.100484

Muzumdar, 2009, Humanin: a novel central regulator of peripheral insulin action, PLoS One, 4, e6334, 10.1371/journal.pone.0006334

Lee, 2014, IGF-I regulates the age-dependent signaling peptide humanin, Aging Cell, 13, 958, 10.1111/acel.12243

Lee, 2013, Humanin: a harbinger of mitochondrial-derived peptides, Trends Endocrinol Metab, 24, 222, 10.1016/j.tem.2013.01.005

Rose, 2017, Mitochondria and mitochondria-induced signalling molecules as longevity determinants, Mech Ageing Dev, 165, 115, 10.1016/j.mad.2016.12.002

Arai, 2001, Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein, J Gerontol A Biol Sci Med Sci, 56, M79, 10.1093/gerona/56.2.M79

Cong, 2013, Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury, Can J Physiol Pharmacol, 91, 973, 10.1139/cjpp-2012-0441

Fisher, 2016, Understanding the physiology of FGF21, Annu Rev Physiol, 78, 223, 10.1146/annurev-physiol-021115-105339

Youm, 2016, Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution, Proc Natl Acad Sci U S A, 113, 1026, 10.1073/pnas.1514511113

Gong, 2014, Humanin and age-related diseases: a new link, Front Endocrinol (Lausanne), 5, 210, 10.3389/fendo.2014.00210

Ost, 2016, Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action, Mol Metab, 5, 79, 10.1016/j.molmet.2015.11.002

Calabrese, 2011, Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity, Mol Aspects Med, 32, 279, 10.1016/j.mam.2011.10.007

Horvath, 2015, Accelerated epigenetic aging in Down syndrome, Aging Cell, 14, 491, 10.1111/acel.12325

Borelli, 2015, Plasma N-glycome signature of down syndrome, J Proteome Res, 14, 4232, 10.1021/acs.jproteome.5b00356

Barma, 2017, Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension, Aging Clin Exp Res, 29, 1055, 10.1007/s40520-016-0636-0