The metallobiology of Alzheimer's disease

Atwood, 1999, Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease, Met. Ions Biol. Syst., 36, 309 Cuajungco, 2000, Metal chelation as a potential therapy for Alzheimer's disease, Ann. New York Acad. Sci., 920, 292, 10.1111/j.1749-6632.2000.tb06938.x Schenk, 1999, Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse, Nature, 400, 173, 10.1038/22124 Callahan, 2001, Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice, Am. J. Pathol., 158, 1173, 10.1016/S0002-9440(10)64064-3 Vaughan, 1981, The structure of neuritic plaques in the cerebral cortex of aged rats, J. Neuropathol. Exp. Neurol., 40, 472, 10.1097/00005072-198107000-00009 McLean, 1999, Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's Disease, Ann. Neurol., 46, 860, 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M Cherny, 1999, Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion, J. Biol. Chem., 274, 23223, 10.1074/jbc.274.33.23223 Bush, 1994, Modulation of Aβ adhesiveness and secretase site cleavage by zinc, J. Biol. Chem., 269, 12152, 10.1016/S0021-9258(17)32694-7 Bush, 1994, Rapid induction of Alzheimer Aβ amyloid formation by zinc, Science, 265, 1464, 10.1126/science.8073293 Miura, 2000, Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes, Biochemistry, 39, 7024, 10.1021/bi0002479 Atwood, 1998, Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis, J. Biol. Chem., 273, 12817, 10.1074/jbc.273.21.12817 Hartter, 1988, Brain tissue accumulates 67copper by two ligand-dependent saturable processes, J. Biol. Chem., 263, 799, 10.1016/S0021-9258(19)35425-0 Hartter, 1988, Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper, Synapse, 2, 412, 10.1002/syn.890020408 Assaf, 1984, Release of endogenous Zn2+ from brain tissue during activity, Nature, 308, 734, 10.1038/308734a0 Howell, 1984, Stimulation-induced uptake and release of zinc in hippocampal slices, Nature, 308, 736, 10.1038/308736a0 Lovell, 1998, Copper, iron and zinc in Alzheimer's disease senile plaques, J. Neurol. Sci., 158, 47, 10.1016/S0022-510X(98)00092-6 Suh, 2000, Histological evidence implicating zinc in Alzheimer's disease, Brain Res., 852, 274, 10.1016/S0006-8993(99)02096-X Opazo, 2002, Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol and biological reducing agents to neurotoxic H2O2, J. Biol. Chem., 277, 40302, 10.1074/jbc.M206428200 Liu, 1999, Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the Aβ peptide of Alzheimer's disease, Biochemistry, 38, 9373, 10.1021/bi990205o Curtain, 2001, Alzheimer's disease amyloid binds Cu and Zn to generate an allosterically-ordered membrane-penetrating structure containing SOD-like subunits, J. Biol. Chem., 276, 20466, 10.1074/jbc.M100175200 Morgan, 2002, Metal switch for amyloid formation: insight into the structure of the nucleus, J. Am. Chem. Soc., 124, 12644, 10.1021/ja0273086 Duff, 1996, Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1, Nature, 383, 710, 10.1038/383710a0 Cole, 1999, Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene, Proc. Natl. Acad. Sci. U. S. A., 96, 1716, 10.1073/pnas.96.4.1716 Lee, 2002, Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice, Proc. Natl. Acad. Sci. U. S. A., 99, 7705, 10.1073/pnas.092034699 Palmiter, 1996, ZnT-3, a putative transporter of zinc into synaptic vesicles, Proc. Natl. Acad. Sci. U. S. A., 93, 14934, 10.1073/pnas.93.25.14934 Frederickson, 2001, Synaptically released zinc: physiological functions and pathological effects, Biometals, 14, 353, 10.1023/A:1012934207456 Bush, 2000, Metals and neuroscience, Curr. Opin. Chem. Biol., 4, 184, 10.1016/S1367-5931(99)00073-3 Atwood, 2000, Characterization of copper interactions with Alzheimer Aβ peptides - identification of an attomolar affinity copper binding site on Aβ1-42, J. Neurochem., 75, 1219, 10.1046/j.1471-4159.2000.0751219.x Grundke-Iqbal, 1990, Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia, Acta Neuropathol., 81, 105, 10.1007/BF00334497 Huang, 1999, The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction, Biochemistry, 38, 7609, 10.1021/bi990438f Huang, 1999, Cu(II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction, J. Biol. Chem., 274, 37111, 10.1074/jbc.274.52.37111 Rottkamp, 2001, Redox-active iron mediates amyloid-β toxicity, Free Radic. Biol. Med., 30, 447, 10.1016/S0891-5849(00)00494-9 Smith, 1996, Oxidative damage in Alzheimer's, Nature, 382, 120, 10.1038/382120b0 Sayre, 1997, 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease, J. Neurochem., 68, 2092, 10.1046/j.1471-4159.1997.68052092.x Nunomura, 1999, RNA oxidation is a prominent Feature of vulnerable neurons in Alzheimer's disease, J. Neurosci., 19, 1959, 10.1523/JNEUROSCI.19-06-01959.1999 Nunomura, 2000, Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome, J. Neuropathol. Exp. Neurol., 59, 1011, 10.1093/jnen/59.11.1011 Nunomura, 2001, Oxidative damage is the earliest event in Alzheimer disease, J. Neuropathol. Exp. Neurol., 60, 759, 10.1093/jnen/60.8.759 Lovell, 1999, Protection against amyloid β peptide toxicity by zinc, Brain Res., 823, 88, 10.1016/S0006-8993(99)01114-2 Cuajungco, 2000, Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc, J. Biol. Chem., 275, 19439, 10.1074/jbc.C000165200 Sayre, 2000, In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals, J. Neurochem., 74, 270, 10.1046/j.1471-4159.2000.0740270.x Lue, 1999, Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease, Am. J. Pathol., 155, 853, 10.1016/S0002-9440(10)65184-X Wang, 1999, The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging, Exp. Neurol., 158, 328, 10.1006/exnr.1999.7085 Atwood, 2000, Copper catalyzed oxidation of Alzheimer Aβ, Cell. Mol. Biol., 46, 777 Kuo, 1996, Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains, J. Biol. Chem., 271, 4077, 10.1074/jbc.271.8.4077 Walsh, 2002, Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, 535, 10.1038/416535a Stadtman, 1991, Metal-catalyzed oxidation of proteins. Physiological consequences, J. Biol. Chem., 266, 2005, 10.1016/S0021-9258(18)52199-2 Curtain, 2003, Metal ions, pH and cholesterol regulate the interactions of Alzheimer's disease amyloid-β peptide with membrane lipid, J. Biol. Chem., 278, 2977, 10.1074/jbc.M205455200 Maynard, 2002, Overexpression of Alzheimer's disease β-amyloid opposes the age-dependent elevations of brain copper and iron levels, J. Biol. Chem., 277, 44670, 10.1074/jbc.M204379200 Frederikse, 1996, Oxidative stress increases production of β-amyloid precursor protein and β-amyloid (A-β) in mammalian lenses, and A-β has toxic effects on lens epithelial cells, J. Biol. Chem., 271, 10169, 10.1074/jbc.271.17.10169 Pullen, 1990, 65zinc uptake from blood into brain and other tissues in the rat, Neurochem. Res., 15, 1003, 10.1007/BF00965746 Pullen, 1991, 65Zn uptake from blood into brain in the rat, J. Neurochem., 56, 485, 10.1111/j.1471-4159.1991.tb08176.x Kalaria, 1989, Reduced glucose transporter at the blood–brain barrier, J. Neurochem., 53, 1083, 10.1111/j.1471-4159.1989.tb07399.x Kalaria, 1995, Differential degeneration of the cerebral microvasculature in Alzheimer's disease, NeuroReport, 6, 477, 10.1097/00001756-199502000-00018 Bush, 1993, A novel zinc(II) binding site modulates the function of the βA4 amyloid protein precursor of Alzheimer's disease, J. Biol. Chem., 268, 16109, 10.1016/S0021-9258(19)85394-2 Van Nostrand, 1995, Zinc(II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid -β-protein precursor, Thromb. Res., 78, 43, 10.1016/0049-3848(95)00033-X Simons, 2002, Evidence for a copper-binding superfamily of the amyloid precursor protein, Biochemistry, 41, 9310, 10.1021/bi0258647 White, 1999, Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice, Brain Res., 842, 439, 10.1016/S0006-8993(99)01861-2 Rogers, 2002, An iron-responsive element type II in the 5′ untranslated region of the Alzheimer's amyloid precursor protein transcript, J. Biol. Chem., 277, 45518, 10.1074/jbc.M207435200 Kontush, 2001, Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasma, Free Radic. Biol. Med., 30, 119, 10.1016/S0891-5849(00)00458-5 Kontush, 2001, Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-β content, Free Radic. Res., 35, 507, 10.1080/10715760100301521 Zou, 2002, A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage, J. Neurosci., 22, 4833, 10.1523/JNEUROSCI.22-12-04833.2002 Squitti, 2002, Elevation of serum copper levels in Alzheimer's disease, Neurology, 59, 1153, 10.1212/WNL.59.8.1153 Rao, 1980, Effects of 2,2′-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function, Biochim. Biophys. Acta, 628, 468, 10.1016/0304-4165(80)90395-5 Rao, 1983, Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin, Arteriosclerosis, 3, 383, 10.1161/01.ATV.3.4.383 Cherny, 2001, Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice, Neuron, 30, 665, 10.1016/S0896-6273(01)00317-8 Regland, 2001, Treatment of Alzheimer's disease with clioquinol, Dement. Geriatr. Cogn. Disord., 12, 408, 10.1159/000051288 Huang, 1997, Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors, J. Biol. Chem., 272, 26464, 10.1074/jbc.272.42.26464 Wu, 1997, The binding of receptor-recognized α2-macroglobulin to the low density lipoprotein receptor-related protein and the α2M signaling receptor is decoupled by oxidation, J. Biol. Chem., 272, 20627, 10.1074/jbc.272.33.20627 DeMattos, 2001, Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. U. S. A., 98, 8850, 10.1073/pnas.151261398 Yassin, 2000, Changes in uptake of vitamin B12 and trace metals in brains of mice treated with clioquinol, J. Neurol. Sci., 173, 40, 10.1016/S0022-510X(99)00297-X Crapper-McLachlan, 1991, Intramuscular desferrioxamine in patients with Alzheimer's disease, Lancet, 337, 1304, 10.1016/0140-6736(91)92978-B May, 1983, The present status of chelating agents in medicine, Prog. Med. Chem., 20, 225, 10.1016/S0079-6468(08)70220-0 McKenzie, 1998, Reversibility of scrapie inactivation is enhanced by copper, J. Biol. Chem., 273, 25545, 10.1074/jbc.273.40.25545 Estevez, 1999, Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase, Science, 286, 2498, 10.1126/science.286.5449.2498 Goldstein, 2000, 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote α-crystallin cross-linking by metal ion reduction, Biochemistry, 39, 7266, 10.1021/bi992997s Paik, 1999, Copper(II)-induced self-oligomerization of α-synuclein, Biochem. J., 340, 821, 10.1042/0264-6021:3400821 Head, 2001, Oxidation of Aβ and plaque biogenesis in Alzheimer's disease and Down syndrome, Neurobiol. Dis., 8, 792, 10.1006/nbdi.2001.0431 Giulian, 1998, The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease, J. Biol. Chem., 273, 29719, 10.1074/jbc.273.45.29719