Inflammatory Response to Cardiopulmonary Bypass

Kirklin, 1990, Cardiopulmonary bypass for cardiac surgery, 1107 Elgebaly, 1994, Evidence of cardiac inflammation after open heart operations, Ann Thorac Surg, 57, 391, 10.1016/0003-4975(94)91003-0 Cremer, 1996, Systemic inflammatory response syndrome after cardiac operations, Ann Thorac Surg, 61, 1714, 10.1016/0003-4975(96)00055-0 Utley, 1990, Pathophysiology of cardiopulmonary bypass: current issues, J Card Surg, 5, 177, 10.1111/j.1540-8191.1990.tb01036.x Chenoweth, 1981, Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins, N Engl J Med, 304, 497, 10.1056/NEJM198102263040901 Cavarocchi, 1985, Evidence for complement activation by protamine-heparin interaction after cardiopulmonary bypass, Surgery, 98, 525 Kirklin, 1986, Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state, Ann Thorac Surg, 41, 193, 10.1016/S0003-4975(10)62668-9 Moore, 1988, The effects of complement activation during cardiopulmonary bypass: attenuation by hypothermia, heparin, and hemodilution, Ann Surg, 208, 95, 10.1097/00000658-198807000-00014 Jansen, 1992, Endotoxin release and tumor necrosis factor formation during cardiopulmonary bypass, Ann Thorac Surg, 54, 744, 10.1016/0003-4975(92)91021-Z Fosse, 1987, Complement activation during major operations with or without cardiopulmonary bypass, J Thorac Cardiovasc Surg, 93, 860, 10.1016/S0022-5223(19)37046-1 Hammerschmidt, 1981, Complement activation and neutropenia occurring during cardiopulmonary bypass, J Thorac Cardiovasc Surg, 81, 370, 10.1016/S0022-5223(19)37600-7 Cavarocchi, 1986, Oxygen free radical generation during cardiopulmonary bypass: correlation with complement activation, Circulation, 74, III-130 Kirklin, 1983, Complement and the damaging effects of cardiopulmonary bypass, J Thorac Cardiovasc Surg, 86, 845, 10.1016/S0022-5223(19)39061-0 Westfall, 1991, Complement activation during prolonged extracorporeal membrane oxygenation, Surgery, 110, 887 Steinberg, 1993, Cytokine and complement levels in patients undergoing cardiopulmonary bypass, J Thorac Cardiovasc Surg, 106, 1008, 10.1016/S0022-5223(19)33971-6 Tennenberg, 1990, Complement activation and lung permeability during cardiopulmonary bypass, Ann Thorac Surg, 50, 597, 10.1016/0003-4975(90)90196-D Bando, 1990, Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass, J Thorac Cardiovasc Surg, 99, 873, 10.1016/S0022-5223(19)36903-X Wakefield, 1991, Absence of complement-mediated events after protamine reversal of heparin anticoagulation, J Surg Res, 51, 72, 10.1016/0022-4804(91)90072-T Seghaye, 1993, Complement activation during cardiopulmonary bypass in infants and children: relation to postoperative multiple system organ failure, J Thorac Cardiovasc Surg, 106, 978, 10.1016/S0022-5223(19)33968-6 Seghaye, 1994, Complement, leukocytes, and leukocyte elastase in full-term neonates undergoing cardiac operation, J Thorac Cardiovasc Surg, 108, 29, 10.1016/S0022-5223(94)70214-4 Dreyer, 1995, Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass, Cardiovasc Res, 29, 775, 10.1016/0008-6363(96)88612-3 Dreyer, 1995, Neutrophil sequestration and pulmonary dysfunction in a canine model of open heart surgery with cardiopulmonary bypass: evidence for a CD18-dependent mechanism, Circulation, 92, 2276, 10.1161/01.CIR.92.8.2276 Gu, 1992, Leukocyte activation with increased expression of CR3 receptors during cardiopulmonary bypass, Ann Thorac Surg, 53, 839, 10.1016/0003-4975(92)91447-H Gillinov, 1993, Neutrophil adhesion molecule expression during cardiopulmonary bypass with bubble and membrane oxygenators, Ann Thorac Surg, 56, 847, 10.1016/0003-4975(93)90342-F Rinder, 1992, Cardiopulmonary bypass induces leukocyte adhesion, Blood, 79, 1201, 10.1182/blood.V79.5.1201.1201 Gillinov, 1994, Inhibition of neutrophil adhesion during cardiopulmonary bypass, Ann Thorac Surg, 57, 126, 10.1016/0003-4975(94)90380-8 Gillinov, 1994, Complement and neutrophil activation during cardiopulmonary bypass: a study in the complement-deficient dog, Ann Thorac Surg, 57, 345, 10.1016/0003-4975(94)90995-4 Youker, 1994, Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart, Circulation, 89, 2736, 10.1161/01.CIR.89.6.2736 Horgan, 1990, Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury, Am J Physiol, 259, L315 Byrne, 1992, Complete prevention of myocardial stunning, contracture, low-reflow, and edema after heart transplantation by blocking neutrophil adhesion molecules during reperfusion, J Thorac Cardiovasc Surg, 104, 1589, 10.1016/S0022-5223(19)33888-7 Boldt, 1995, Circulating adhesion molecules in cardiac operations: influence of high-dose aprotinin, Ann Thorac Surg, 59, 100, 10.1016/0003-4975(94)00851-W McCord, 1985, Oxygen-derived free radicals in postischemic tissue injury, N Engl J Med, 312, 159, 10.1056/NEJM198501173120305 Prasad, 1990, Polymorphonuclear leukocyte activation and cardiac function at organ and cellular level, Am Heart J, 119, 538, 10.1016/S0002-8703(05)80276-5 Ferreira, 1988, Assessment of myocardial oxidative stress in patients after myocardial revascularization, Am Heart J, 115, 307, 10.1016/0002-8703(88)90475-9 Weisel, 1989, Myocardial free-radical injury after cardioplegia, Circulation, 80, III-14 Davies, 1990, Systemic pattern of free radical generation during coronary bypass surgery, Br Heart J, 64, 236, 10.1136/hrt.64.4.236 Prasad, 1992, Increased oxygen free radical activity in patients on cardiopulmonary bypass undergoing aortocoronary bypass surgery, Am Heart J, 123, 37, 10.1016/0002-8703(92)90744-G Davies, 1993, Time-course of free radical activity during coronary artery operations with cardiopulmonary bypass, J Thorac Cardiovasc Surg, 105, 979, 10.1016/S0022-5223(19)33769-9 Toivonen, 1994, Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting, J Thorac Cardiovasc Surg, 108, 140, 10.1016/S0022-5223(94)70230-6 Pesonen, 1995, Regional generation of free oxygen radicals during cardiopulmonary bypass in children, J Thorac Cardiovasc Surg, 110, 768, 10.1016/S0022-5223(95)70110-9 Seccombe, 1994, Oxygen radical-mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries, J Thorac Cardiovasc Surg, 107, 505, 10.1016/S0022-5223(94)70096-6 Pearson, 1992, Global myocardial ischemia and reperfusion impair endothelium-dependent relaxations to aggregating platelets in the canine coronary artery: a possible cause of vasospasm after cardiopulmonary bypass, J Thorac Cardiovasc Surg, 103, 1147, 10.1016/S0022-5223(19)34880-9 Haniuda, 1995, Free radical-mediated vascular injury in lungs preserved at moderate hypothermia, Ann Thorac Surg, 60, 1376, 10.1016/0003-4975(95)00620-Z Menasche, 1994, Does normothermia during cardiopulmonary bypass increase neutrophil-endothelium interactions?, Circulation, 90, II-275 Menasche, 1995, Influence of temperature on neutrophil trafficking during clinical cardiopulmonary bypass, Circulation, 92, II-334, 10.1161/01.CIR.92.9.334 Le Deist, 1995, Hypothermia during cardiopulmonary bypass delays but does not prevent neutrophil-endothelial cell adhesion: a clinical study., Circulation, 92, II-354, 10.1161/01.CIR.92.9.354 Downing, 1992, Release of vasoactive substances during cardiopulmonary bypass, Ann Thorac Surg, 54, 1236, 10.1016/0003-4975(92)90113-I Singh, 1995, Prostacyclin and thromboxane levels in pleural space fluid during cardiopulmonary bypass, Ann Thorac Surg, 59, 647, 10.1016/0003-4975(94)01007-2 Hashimoto, 1992, Evidence of organ damage after cardiopulmonary bypass: the role of elastase and vasoactive mediators, J Thorac Cardiovasc Surg, 104, 666, 10.1016/S0022-5223(19)34734-8 Byrne, 1993, Cardiac-derived thromboxane A2: an initiating mediator of reperfusion injury?, J Thorac Cardiovasc Surg, 105, 689, 10.1016/S0022-5223(19)34195-9 Cave, 1993, Thromboxane A2 mediates pulmonary hypertension after cardiopulmonary bypass in the rabbit, J Thorac Cardiovasc Surg, 106, 959, 10.1016/S0022-5223(19)33966-2 Mendeloff, 1994, Thromboxane A2 receptor-specific antagonism in hypothermic cardiopulmonary bypass, Ann Thorac Surg, 57, 999, 10.1016/0003-4975(94)90223-2 Smith, 1994, Prevention of complement-induced pulmonary hypertension and improvement of right ventricular function by selective thromboxane receptor antagonism, J Thorac Cardiovasc Surg, 107, 800, 10.1016/S0022-5223(94)70335-3 Friedman, 1995, Pulmonary injury after total or partial cardiopulmonary bypass with thromboxane synthesis inhibition, Ann Thorac Surg, 59, 598, 10.1016/0003-4975(94)00919-8 Faichney, 1982, Prostacyclin in cardiopulmonary bypass operations, J Thorac Cardiovasc Surg, 84, 601, 10.1016/S0022-5223(19)38990-1 Feng, 1996, Prostaglandin E1 (PGE1) reduces cardiac-derived TXA2 release in ischaemic arrest in isolated working rat heart, Int J Cardiol, 55, 265, 10.1016/0167-5273(96)02715-5 Vincent, 1992, Prostaglandin E1 infusion for right ventricular failure after cardiac transplantation, J Thorac Cardiovasc Surg, 103, 33, 10.1016/S0022-5223(19)35062-7 Gadaleta, 1994, Neutrophil leukotriene generation increases after cardiopulmonary bypass, J Thorac Cardiovasc Surg, 108, 642, 10.1016/S0022-5223(94)70288-8 Utoh, 1989, Perioperative alteration of neutrophil functions after open heart and other major surgeries, J Cardiovasc Surg, 30, 692 Gadaleta, 1994, Pulmonary failure and the production of leukotrienes, J Am Coll Surg, 178, 309 Andersen, 1987, Presence of circulating endotoxins during cardiac operations, J Thorac Cardiovasc Surg, 93, 115, 10.1016/S0022-5223(19)36483-9 Rocke, 1987, Endotoxemia associated with cardiopulmonary bypass, J Thorac Cardiovasc Surg, 93, 832, 10.1016/S0022-5223(19)37043-6 Kharazmi, 1989, Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass, J Thorac Cardiovasc Surg, 98, 381, 10.1016/S0022-5223(19)34384-3 Nilsson, 1990, Endotoxins in cardiopulmonary bypass, J Thorac Cardiovasc Surg, 100, 777, 10.1016/S0022-5223(19)35477-7 Baue, 1993, The role of the gut in the development of multiple organ dysfunction in cardiothoracic patients, Ann Thorac Surg, 55, 822, 10.1016/0003-4975(93)90098-3 Ohri, 1993, Cardiopulmonary bypass impairs small intestinal transport and increases gut permeability, Ann Thorac Surg, 55, 1080, 10.1016/0003-4975(93)90011-6 Andersen, 1993, Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor-α concentrations in patients undergoing cardiopulmonary bypass, Crit Care Med, 21, 210, 10.1097/00003246-199302000-00011 Sinclair, 1995, The effect of cardiopulmonary bypass on intestinal and pulmonary endothelial permeability, Chest, 108, 718, 10.1378/chest.108.3.718 Riddington, 1996, Intestinal permeability, gastric intramucosal pH, and systemic endotoxemia in patients undergoing cardiopulmonary bypass, JAMA, 275, 1007, 10.1001/jama.1996.03530370045029 Tao, 1995, Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand, J Thorac Cardiovasc Surg, 110, 819, 10.1016/S0022-5223(95)70116-8 Jansen, 1994, Perfusion-related factors of endotoxin release during cardiopulmonary bypass, Eur J Cardiothorac Surg, 8, 125, 10.1016/1010-7940(94)90167-8 te Velthuis, 1995, Myocardial performance in elderly patients after cardiopulmonary bypass is suppressed by tumor necrosis factor, J Thorac Cardiovasc Surg, 110, 1663, 10.1016/S0022-5223(95)70028-5 Oudemans-van Straaten, 1996, Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia, Intensive Care Med, 22, 294, 10.1007/BF01700449 Watarida, 1994, A clinical study on the effects of pulsatile cardiopulmonary bypass on the blood endotoxin levels, J Thorac Cardiovasc Surg, 108, 620, 10.1016/S0022-5223(94)70285-3 Taggart, 1994, Endotoxemia, complement, and white blood cell activation in cardiac surgery: a randomized trial of laxatives and pulsatile perfusion, Ann Thorac Surg, 57, 376, 10.1016/0003-4975(94)91000-6 Wan, 1997, Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation, Ann Thorac Surg, 63, 269, 10.1016/S0003-4975(96)00931-9 Wan, 1996, Human cytokine responses to cardiac transplantation and coronary artery bypass grafting, J Thorac Cardiovasc Surg, 111, 469, 10.1016/S0022-5223(96)70458-0 Ohkawa, 1995, Effects of inflammatory cytokines on vascular tone, Cardiovasc Res, 30, 711, 10.1016/0008-6363(95)00101-8 Menasche, 1994, A potential mechanism of vasodilation after warm heart surgery: the temperature-dependent release of cytokines, J Thorac Cardiovasc Surg, 107, 293, 10.1016/S0022-5223(94)70484-8 Deng, 1996, Impact of left ventricular dysfunction on cytokines, hemodynamics, and outcome in bypass grafting, Ann Thorac Surg, 62, 184, 10.1016/0003-4975(96)00230-5 Hennein, 1994, Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization, J Thorac Cardiovasc Surg, 108, 626, 10.1016/S0022-5223(94)70286-1 Preiser, 1991, Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog, Cytokine, 3, 1, 10.1016/1043-4666(91)90002-U Partrick, 1996, The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure, Am J Surg, 172, 425, 10.1016/S0002-9610(96)00252-8 Eppinger, 1996, Regulatory effects of interleukin-10 on lung ischemia-reperfusion injury, J Thorac Cardiovasc Surg, 112, 1301, 10.1016/S0022-5223(96)70144-7 Wan, 1996, Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass, J Thorac Cardiovasc Surg, 112, 806, 10.1016/S0022-5223(96)70068-5 Wan, 1997, Hepatic release of interleukin-10 during cardiopulmonary bypass in steroidpretreated patients, Am Heart J, 133, 335, 10.1016/S0002-8703(97)70229-1 Ko, 1991, Myocardial reperfusion injury: platelet-activating factor stimulates polymorphonuclear leukocyte hydrogen peroxide production during myocardial reperfusion, J Thorac Cardiovasc Surg, 102, 297, 10.1016/S0022-5223(19)36563-8 Kubes, 1990, Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence, Am J Physiol, 259, G300 Raschke, 1995, Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia, Cardiovasc Res, 29, 569, 10.1016/0008-6363(96)88536-1 Siren, 1989, Effects of platelet activating factor and BN52021 on cardiac functions and regional blood flow in conscious rats, Am J Physiol, 257, H25 Sawa, 1994, Platelet-activating factor plays an important role in reperfusion injury in myocardium: efficacy of platelet-activating factor receptor antagonist (CV3988) as compared with leukocyte-depleted reperfusion, J Thorac Cardiovasc Surg, 108, 953, 10.1016/S0022-5223(94)70196-2 Zehr, 1995, Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass, Ann Thorac Surg, 59, 328, 10.1016/0003-4975(94)00725-M Mehta, 1995, Endothelium, coronary vasodilation, and organic nitrates, Am Heart J, 129, 382, 10.1016/0002-8703(95)90021-7 Rodeberg, 1995, Nitric oxide: an overview, Am J Surg, 170, 292, 10.1016/S0002-9610(05)80017-0 Ruvolo, 1994, Nitric oxide formation during cardiopulmonary bypass, Ann Thorac Surg, 57, 1055, 10.1016/0003-4975(94)90249-6 Li, 1996, Heparin and protamine stimulate the production of nitric oxide, J Cardiovasc Surg, 37, 445 Tsujino, 1994, Induction of nitric oxide synthase gene by interleukin-lp in cultured rat cardiocytes, Circulation, 90, 375, 10.1161/01.CIR.90.1.375 Ungureanu-Longrois, 1995, Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to β-adrenergic agonists, Circ Res, 77, 494, 10.1161/01.RES.77.3.494 Shindo, 1995, Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines, Cardiovasc Res, 29, 813, 10.1016/0008-6363(96)88617-2 Delgado, 1995, Ca2+-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass, Thorax, 50, 403, 10.1136/thx.50.4.403 Hill, 1995, Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass, Am J Respir Crit Care Med, 152, 1791, 10.1164/ajrccm.152.6.8520738 Evora, 1994, Impaired endothelium-dependent relaxation after coronary reperfusion injury: evidence for G-protein dysfunction, Ann Thorac Surg, 57, 1550, 10.1016/0003-4975(94)90121-X Lin, 1994, Acute endothelial reperfusion injury after coronary artery bypass grafting, Ann Thorac Surg, 58, 782, 10.1016/0003-4975(94)90749-8 Lefer, 1993, Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs, Circulation, 88, 2337, 10.1161/01.CIR.88.5.2337 Ma, 1993, Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium, Circ Res, 72, 403, 10.1161/01.RES.72.2.403 Hiramatsu, 1995, Effects of L-arginine and L-nitro-arginine methyl ester on recovery of neonatal lamb hearts after cold ischemia: evidence for an important role of endothelial production of nitric oxide, J Thorac Cardiovasc Surg, 109, 81, 10.1016/S0022-5223(95)70423-X Engelman, 1995, L-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion, Ann Thorac Surg, 60, 1275, 10.1016/0003-4975(95)00614-Q Vinten-Johansen, 1995, Reduction in surgical ischemic-reperfusion injury with adenosine and nitric oxide therapy, Ann Thorac Surg, 60, 852, 10.1016/0003-4975(95)00571-2 Villarreal, 1995, Nitric oxide donors improve gut function after prolonged hypothermic ischemia, Transplantation, 59, 685, 10.1097/00007890-199503150-00007 Giaid, 1995, Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension, N Engl J Med, 333, 214, 10.1056/NEJM199507273330403 Adatia, 1994, Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation, Ann Thorac Surg, 57, 1311, 10.1016/0003-4975(94)91382-X Van Camp, 1994, Regulation of pulmonary vascular resistance by endogenous and exogenous nitric oxide, Ann Thorac Surg, 58, 1025, 10.1016/0003-4975(94)90448-0 Miller, 1994, Very-low-dose inhaled nitric oxide: a selective pulmonary vasodilator after operations for congenital heart disease, J Thorac Cardiovasc Surg, 108, 487, 10.1016/S0022-5223(12)70258-1 Tonz, 1994, Treatment of acute pulmonary hypertension with inhaled nitric oxide, Ann Thorac Surg, 58, 1031, 10.1016/0003-4975(94)90449-9 Michael, 1996, Endothelins and the lung, Am J Respir Crit Care Med, 154, 555, 10.1164/ajrccm.154.3.8810589 Chang, 1993, Plasma endothelin levels and surgically correctable pulmonary hypertension, Ann Thorac Surg, 55, 450, 10.1016/0003-4975(93)91018-I Zhu, 1994, The dynamic change of plasma endothelin-1 during the perioperative period in patients with rheumatic valvular disease and secondary pulmonary hypertension, J Thorac Cardiovasc Surg, 108, 960, 10.1016/S0022-5223(94)70197-0 Ishikawa, 1995, Elevated levels of plasma endothelin-1 in young patients with pulmonary hypertension caused by congenital heart disease are decreased after successful surgical repair, J Thorac Cardiovasc Surg, 110, 271, 10.1016/S0022-5223(05)80036-4 Matheis, 1995, Circulating endothelin in patients undergoing coronary bypass grafting, Eur J Cardiothorac Surg, 9, 269, 10.1016/S1010-7940(05)80161-7 Hasdai, 1996, Is the heart a source for elevated circulating endothelin levels during aorta-coronary artery bypass grafting surgery in human beings?, J Thorac Cardiovasc Surg, 112, 531, 10.1016/S0022-5223(96)70282-9 te Velthuis, 1996, Circulating endothelin in cardiac operations: influence of blood pressure and endotoxin, Ann Thorac Surg, 61, 904, 10.1016/0003-4975(95)01187-0 Dupuis, 1996, Human pulmonary circulation is an important site for both clearance and production of endothelin-1, Circulation, 94, 1578, 10.1161/01.CIR.94.7.1578 McGowan, 1995, Coronary vasoconstriction mediated by endothelin-1 in neonates: reversal by nitroglycerin, J Thorac Cardiovasc Surg, 109, 88, 10.1016/S0022-5223(95)70424-8 Hiramatsu, 1996, Effects of endothelin-1 and L-arginine after cold ischemia in lamb hearts, Ann Thorac Surg, 61, 36, 10.1016/0003-4975(95)00982-5 Zaugg, 1996, Endothelin-1-induced release of thromboxane A2 increases the vasoconstrictor effect of endothelin-1 in postischemic reperfused rat hearts, Circulation, 94, 742, 10.1161/01.CIR.94.4.742 Berkenboom, 1995, Plasma endothelin and early coronary endothelial dysfunction in recipients of a cardiac transplant, Am Heart J, 129, 1178, 10.1016/0002-8703(95)90401-8 Schersten, 1996, Increased levels of endothelin-1 in bronchoalveolar lavage fluid of patients with lung allografts, J Thorac Cardiovasc Surg, 111, 253, 10.1016/S0022-5223(96)70423-3 Aharinejad, 1995, Endothelin-1 focally constricts pulmonary veins in rats, J Thorac Cardiovasc Surg, 110, 148, 10.1016/S0022-5223(05)80020-0 Replogle, 1966, Use of corticosteroids during cardiopulmonary bypass: possible lysosome stabilization, Circulation, 33, I Dietzman, 1969, Low output syndrome: recognition and treatment, J Thorac Cardiovasc Surg, 57, 138, 10.1016/S0022-5223(19)42770-0 Dietzman, 1975, The use of methylprednisolone during cardiopulmonary bypass: a review of 427 cases, J Thorac Cardiovasc Surg, 69, 870, 10.1016/S0022-5223(19)40411-X Niazi, 1979, Effects of glucocorticosteroids in patients undergoing coronary artery bypass surgeiy, Chest, 76, 262, 10.1378/chest.76.3.262 Engelman, 1989, Steroidinduced myocardial preservation with decreased cell membrane microviscosity, Circulation, 80, III-36 Goldman, 1978, Failure of methylprednisolone to protect myocardial function or prevent myocardial edema following ischemic cardiac arrest, J Surg Res, 24, 477, 10.1016/0022-4804(78)90045-8 Morton, 1976, Effect of methylprednisolone on myocardial preservation during coronary artery surgery, Am J Surg, 131, 419, 10.1016/0002-9610(76)90150-1 Codd, 1977, Steroids and myocardial preservation, J Thorac Cardiovasc Surg, 74, 418, 10.1016/S0022-5223(19)41356-1 Tennenberg, 1986, The effects of methylprednisolone on complement-mediated neutrophil activation during cardiopulmonary bypass, Surgery, 100, 134 Andersen, 1989, Effect of methylprednisolone on endotoxemia and complement activation during cardiac surgery, J Cardiothorac Anesth, 3, 544, 10.1016/0888-6296(89)90150-6 Jansen, 1991, Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass, J Thorac Cardiovasc Surg, 102, 515, 10.1016/S0022-5223(20)31421-5 Jansen, 1991, The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass, Eur J Cardiothorac Surg, 5, 211, 10.1016/1010-7940(91)90032-F Tabardel, 1996, Corticosteroids increase blood interleukin 10 levels during cardiopulmonary bypass in men, Surgery, 119, 76, 10.1016/S0039-6060(96)80217-0 Teoh, 1995, Steroid inhibition of cytokine-mediated vasodilation after warm heart surgery, Circulation, 92, II-347, 10.1161/01.CIR.92.9.347 Engelman, 1995, Influence of steroids on complement and cytokine generation after cardiopulmonary bypass, Ann Thorac Surg, 60, 801, 10.1016/0003-4975(95)00211-3 Kawamura, 1995, Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery, Can J Anaesth, 42, 399, 10.1007/BF03015485 Jorens, 1993, Interleukin-8 production in patients undergoing cardiopulmonary bypass: the influence of pretreatment with methylprednisolone, Am Rev Respir Dis, 148, 890, 10.1164/ajrccm/148.4_Pt_1.890 Wan, 1996, Steroid administration in heart and heart-lung transplantation: is the timing adequate?, Ann Thorac Surg, 61, 674, 10.1016/0003-4975(95)01059-9 Cronstein, 1992, A mechanism for the anti-inflammatory effects of corticosteroids: the glucocorticoids receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1, Proc Natl Acad Sci USA, 89, 9991, 10.1073/pnas.89.21.9991 Engelman, 1994, Fast-track recovery of the coronary bypass patient, Ann Thorac Surg, 58, 1742, 10.1016/0003-4975(94)91674-8 Westaby, 1993, Aprotinin in perspective, Ann Thorac Surg, 55, 1033, 10.1016/0003-4975(93)90149-C Gurevitch, 1994, Aprotinin improves myocardial recovery after ischemia and reperfusion: effects of the drug on isolated rat hearts, J Thorac Cardiovasc Surg, 108, 109, 10.1016/S0022-5223(94)70226-8 Bukhari, 1995, Does aprotinin increase the myocardial damage in the setting of ischemia and preconditioning?, Ann Thorac Surg, 60, 307, 10.1016/0003-4975(95)00398-5 Wendel, 1995, Lower cardiac troponin T levels in patients undergoing cardiopulmonary bypass and receiving high-dose aprotinin therapy indicate reduction of perioperative myocardial damage, J Thorac Cardiovasc Surg, 109, 1164, 10.1016/S0022-5223(95)70200-8 Hill, 1995, Aprotinin and methylprednisolone equally blunt cardiopulmonary bypassinduced inflammation in humans, J Thorac Cardiovasc Surg, 110, 1658, 10.1016/S0022-5223(95)70027-7 Seghaye, 1996, Influence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children, Ann Thorac Surg, 61, 1205, 10.1016/0003-4975(96)00013-6 van Oeveren, 1990, Aprotinin protects platelets against the initial effect of cardiopulmonary bypass, J Thorac Cardiovasc Surg, 99, 788, 10.1016/S0022-5223(19)36893-X Wachtfogel, 1993, Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracoiporeal perfusion, J Thorac Cardiovasc Surg, 106, 1, 10.1016/S0022-5223(19)33735-3 Shinfeld, 1995, Aprotinin improves hemostasis after cardiopulmonary bypass better than singledonor platelet concentrate, Ann Thorac Surg, 59, 872, 10.1016/0003-4975(95)00009-A Primack, 1996, Aprotinin modulation of platelet activation in patients undergoing cardiopulmonary bypass operations, Ann Thorac Surg, 61, 1188, 10.1016/0003-4975(96)00016-1 Jansen, 1996, Heparin-coated circuits and aprotinin prime for coronary artery bypass grafting, Ann Thorac Surg, 61, 1363, 10.1016/0003-4975(96)00056-2 Prendergast, 1996, Defining the role of aprotinin in heart transplantation, Ann Thorac Surg, 62, 670, 10.1016/S0003-4975(96)00436-5 Julia, 1991, Studies of controlled reperfusion after ischemia: XXI. Reperfusate composition: superiority of blood cardioplegia over crystalloid cardioplegia in limiting reperfusion damage—importance of endogenous oxygen free radical scavengers in red blood cells, J Thorac Cardiovasc Surg, 101, 303, 10.1016/S0022-5223(19)36766-2 Pyles, 1995, Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease, J Thorac Cardiovasc Surg, 110, 165, 10.1016/S0022-5223(05)80022-4 Sun, 1992, Improved recovery of heart transplants by combined use of oxygen-derived free radical scavengers and energy enhancement, J Thorac Cardiovasc Surg, 104, 830, 10.1016/S0022-5223(19)34757-9 Yau, 1994, Vitamin E for coronary bypass operations: a prospective, double-blind, randomized trial, J Thorac Cardiovasc Surg, 108, 302, 10.1016/S0022-5223(94)70012-5 Ballmer, 1994, Depletion of plasma vitamin C but not of vitamin E in response to cardiac operations, J Thorac Cardiovasc Surg, 108, 311, 10.1016/S0022-5223(94)70013-3 Sisto, 1995, Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting, Ann Thorac Surg, 59, 1519, 10.1016/0003-4975(95)00197-S Drossos, 1995, Deferoxamine cardioplegia reduces superoxide radical production in human myocardium, Ann Thorac Surg, 59, 169, 10.1016/0003-4975(94)00726-N Yokoyama, 1996, Coenzyme Q10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect, Surgery, 120, 189, 10.1016/S0039-6060(96)80287-X Ren, 1994, Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10, J Thorac Cardiovasc Surg, 108, 126, 10.1016/S0022-5223(94)70228-4 Gott, 1963, Heparin bonding on colloidal graphite surfaces, Science, 142, 1297, 10.1126/science.142.3597.1297 von Segesser, 1989, Cardiopulmonary bypass without systemic heparinization: performance of heparin-coated oxygenators in comparison with classic membrane and bubble oxygenators, J Thorac Cardiovasc Surg, 98, 386, 10.1016/S0022-5223(19)34385-5 Dowling, 1993, Clinical cardiopulmonary bypass without systemic anticoagulation, Ann Thorac Surg, 56, 1176, 10.1016/0003-4975(95)90044-6 von Segesser, 1991, Clinical application of heparin-coated perfusion equipment with special emphasis on patients refusing homologous transfusions, Perfusion, 6, 227, 10.1177/026765919100600312 von Segesser, 1992, Reduction and elimination of systemic heparinization during cardiopulmonary bypass, J Thorac Cardiovasc Surg, 103, 790, 10.1016/S0022-5223(19)34964-5 Mollnes, 1991, Formation of C5a during cardiopulmonary bypass: inhibition by precoating with heparin, Ann Thorac Surg, 52, 92, 10.1016/0003-4975(91)91426-V Videm, 1992, Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations, J Thorac Cardiovasc Surg, 103, 806, 10.1016/S0022-5223(19)34966-9 Jones, 1994, Safe use of heparin-coated bypass circuits incorporating a pump-oxygenator, Ann Thorac Surg, 57, 815, 10.1016/0003-4975(94)90181-3 von Segesser, 1994, Risk and benefit of low systemic heparinization during open heart operations, Ann Thorac Surg, 58, 391, 10.1016/0003-4975(94)92213-6 Pekna, 1994, Complement activation during cardiopulmonary bypass: effects of immobilized heparin, Ann Thorac Surg, 58, 421, 10.1016/0003-4975(94)92219-5 Fosse, 1994, Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass, Ann Thorac Surg, 58, 472, 10.1016/0003-4975(94)92231-4 Ovrum, 1995, High and low heparin dose with heparin-coated cardiopulmonary bypass: activation of complement and granulocytes, Ann Thorac Surg, 60, 1755, 10.1016/0003-4975(95)00763-6 Borowiec, 1992, Heparin-coated circuits reduce activation of granulocytes during cardiopulmonary bypass: a clinical study, J Thorac Cardiovasc Surg, 104, 642, 10.1016/S0022-5223(19)34730-0 Ovrum, 1995, Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass, Circulation, 92, 2579, 10.1161/01.CIR.92.9.2579 Ovrum, 1995, Completely heparinized cardiopulmonary bypass and reduced systemic heparin: clinical and hemostatic effects, Ann Thorac Surg, 60, 365, 10.1016/0003-4975(95)00366-S Aldea, 1996, Heparin-bonded circuits with a reduced anticoagulation protocol in primary CABG: a prospective, randomized study, Ann Thorac Surg, 62, 410, 10.1016/0003-4975(96)00249-4 El Habbal, 1995, Effect of heparin anticoagulation on neutrophil adhesion molecules and release of IL8: C3 is not essential, Cardiovasc Res, 30, 676, 10.1016/S0008-6363(95)00069-0 Korn, 1996, The effects of Carmeda bioactive surface on human blood components during simulated extracorporeal circulation, J Thorac Cardiovasc Surg, 111, 1073, 10.1016/S0022-5223(96)70384-7 Plötz, 1992, A heparin-coated circuit reduces complement activation and the release of leukocyte inflammatory mediators during extracorporeal circulation in a rabbit, Artif Organs, 16, 366, 10.1111/j.1525-1594.1992.tb00533.x te Velthuis, 1996, Specific complement inhibition with heparin-coated extracorporeal circuits, Ann Thorac Surg, 61, 1153, 10.1016/0003-4975(95)01199-4 Hatori, 1994, Biocompatibility of heparin-coated membrane oxygenator during cardiopulmonary bypass, Artif Organs, 18, 904, 10.1111/j.1525-1594.1994.tb03342.x Gu, 1993, Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass, Ann Thorac Surg, 55, 917, 10.1016/0003-4975(93)90117-Z Weerwind, 1995, Influence of Duraflo II heparin-treated extracorporeal circuits on the systemic inflammatory response in patients having coronary bypass, J Thorac Cardiovasc Surg, 110, 1633, 10.1016/S0022-5223(95)70024-2 Steinberg, 1995, Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass, Ann Thorac Surg, 60, 525, 10.1016/0003-4975(95)00482-Z Redmond, 1993, Heparin-coated bypass circuits reduce pulmonary injury, Ann Thorac Surg, 56, 474, 10.1016/0003-4975(93)90882-I Ranucci, 1996, Beneficial effects of Duraflo II heparin-coated circuits on postperfusion lung dysfunction, Ann Thorac Surg, 61, 76, 10.1016/0003-4975(95)00820-9 Pradhan, 1991, Clinical experience with heparin-coated cardiopulmonary bypass circuits, Perfusion, 6, 235, 10.1177/026765919100600313 Shigemitsu, 1994, Biocompatibility of a heparin-bonded membrane oxygenator (Carmeda Maxima) during the first 90 minutes of cardiopulmonary bypass: clinical comparison with the conventional system, Artif Organs, 18, 936 Boonstra, 1994, Heparin coating of an extracorporeal circuit partly improves hemostasis after cardiopulmonary bypass, J Thorac Cardiovasc Surg, 107, 289, 10.1016/S0022-5223(94)70483-X O'Donnell, 1995, (1) Is oxygen consumption or lactate production altered by heparin-coated circuits during bypass? (2) Do heparin-coated bypass circuits improve haemodynamic performance following bypass? [abstracts], Br J Surg, 82, 21 Jansen, 1995, Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits, J Thorac Cardiovasc Surg, 110, 829, 10.1016/S0022-5223(95)70117-6 Muehrcke, 1996, Biocompatibility of heparin-coated extracorporeal bypass circuits: a randomized, masked clinical trial, J Thorac Cardiovasc Surg, 112, 472, 10.1016/S0022-5223(96)70275-1 Moen, 1995, Disparity in blood activation by two different heparin-coated bypass systems, Ann Thorac Surg, 60, 1317, 10.1016/0003-4975(95)00777-I Ovrum, 1995, Complement and granulocyte activation in two different types of heparinized extracorporeal circuits, J Thorac Cardiovasc Surg, 110, 1623, 10.1016/S0022-5223(95)70023-4 Weissmann, 1980, Release of inflammatory mediators from stimulated neutrophils, N Engl J Med, 303, 27, 10.1056/NEJM198007033030109 Sawa, 1994, Myocardial protective effect and its mechanism of leukocyte-depleted reperfusion in neonatal rabbit hearts, Ann Thorac Surg, 58, 1386, 10.1016/0003-4975(94)91919-4 Wilson, 1993, Temporary leukocyte depletion reduces ventricular dysfunction during prolonged postischemic reperfusion, J Thorac Cardiovasc Surg, 106, 805, 10.1016/S0022-5223(19)34033-4 Lazar, 1995, Role of leukocyte depletion during cardiopulmonary bypass and cardioplegic arrest, Ann Thorac Surg, 60, 1745, 10.1016/0003-4975(95)00737-7 Wilson, 1993, Leukocyte depletion in a neonatal model of cardiac surgery, Ann Thorac Surg, 55, 12, 10.1016/0003-4975(93)90467-V Pillai, 1990, Leukocyte depletion results in excellent heart-lung function after 12 hours of storage, Ann Thorac Surg, 50, 211, 10.1016/0003-4975(90)90736-P Steimle, 1992, Neutrophils are not necessary for ischemia-reperfusion lung injury, Ann Thorac Surg, 53, 64, 10.1016/0003-4975(92)90758-V Eppinger, 1995, Pattern of injury and the role of neutrophils in reperfusion injury of rat lung, J Surg Res, 58, 713, 10.1006/jsre.1995.1112 Kofsky, 1991, Studies of controlled reperfusion after ischemia: XXII. Reperfusate composition: effects of leukocyte depletion of blood and blood cardioplegic reperfusates after acute coronary occlusion, J Thorac Cardiovasc Surg, 101, 350, 10.1016/S0022-5223(19)36771-6 Coleman, 1994, Leukocyte depletion reduces postoperative oxygen requirements, Ann Thorac Surg, 58, 1567, 10.1016/0003-4975(94)91982-8 Englander, 1995, Efficacy of leukocyte filters in the bypass circuit for infants undergoing cardiac operations, Ann Thorac Surg, 60, S533, 10.1016/0003-4975(95)00772-5 Mihaljevic, 1995, The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function: a clinical study, J Thorac Cardiovasc Surg, 109, 1138, 10.1016/S0022-5223(95)70197-4 Sawa, 1994, Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency artery bypass grafting, J Thorac Cardiovasc Surg, 108, 1125, 10.1016/S0022-5223(94)70156-3 Morioka, 1996, Leukocyte and platelet depletion with a blood cell separator: effects on lung injury after cardiac surgery with cardiopulmonary bypass, J Thorac Cardiovasc Surg, 111, 45, 10.1016/S0022-5223(96)70400-2 Gu, 1996, Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery, J Thorac Cardiovasc Surg, 112, 450, 10.1016/S0022-5223(96)70277-5 Naik, 1991, A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery, Circulation, 84, III-422 Journois, 1994, Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery: effects on hemostasis, cytokines, and complement components, Anesthesiology, 81, 1181, 10.1097/00000542-199411000-00011 Journois, 1996, High-volume, zero-balanced hemofiltration to reduced delayed inflammatory response to cardiopulmonary bypass in children, Anesthesiology, 85, 965, 10.1097/00000542-199611000-00003 Millar, 1993, Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass, Ann Thorac Surg, 56, 1499, 10.1016/0003-4975(93)90740-9 Wang, 1996, Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations, Ann Thorac Surg, 61, 651, 10.1016/0003-4975(95)00974-4 Saatvedt, 1996, Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement, Cardiovasc Res, 31, 596, 10.1016/0008-6363(95)00237-5 Yellon, 1993, Preconditioning the human myocardium, Lancet, 342, 276, 10.1016/0140-6736(93)91819-8 Perrault, 1996, Ischemic preconditioning in cardiac surgery: a word of caution, J Thorac Cardiovasc Surg, 112, 1378, 10.1016/S0022-5223(96)70155-1 Burns, 1995, Does cardiopulmonary bypass alone elicit myoprotective preconditioning?, Circulation, 92, II-447, 10.1161/01.CIR.92.9.447 Menasche, 1995, Preconditioning with potassium channel openers: a new concept for enhancing cardioplegic protection?, J Thorac Cardiovasc Surg, 110, 1606, 10.1016/S0022-5223(95)70020-X Currie, 1988, Heat-shock response is associated with enhanced postischemic ventricular recovery, Circ Res, 63, 543, 10.1161/01.RES.63.3.543 Liu, 1992, Heat shock: a new approach for myocardial preservation in cardiac surgery, Circulation, 86, II-358 Maulik, 1993, Interleukin-la preconditioning reduces myocardial ischemia reperfusion injury, Circulation, 88, 387 Maulik, 1995, Drug-induced heat-shock preconditioning improves postischemic ventricular recovery after cardiopulmonary bypass, Circulation, 92, II-381, 10.1161/01.CIR.92.9.381 Robinson, 1995, Accelerated recovery of postischemic stunned myocardium after induced expression of myocardial heat-shock protein (HSP70), J Thorac Cardiovasc Surg, 109, 753, 10.1016/S0022-5223(95)70358-6 Gorman, 1996, Surface-bound heparin fails to reduce thrombin formation during clinical cardiopulmonary bypass, J Thorac Cardiovasc Surg, 111, 1, 10.1016/S0022-5223(96)70395-1 Videm, 1991, Biocompatibility of extracorporeal circulation: in vitro comparison of heparin-coated and uncoated oxygenator circuits, J Thorac Cardiovasc Surg, 101, 654, 10.1016/S0022-5223(19)36696-6