Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability

Small - Tập 15 Số 22 - 2019
Yiming Xiang1, Congyang Mao1, Xiangmei Liu1, Zhenduo Cui2, Doudou Jing3, Xianjin Yang2, Yanqin Liang2, Zhaoyang Li2, Shengli Zhu2, Yufeng Zheng4, Kwk Yeung5, Dong Zheng3, Xianbao Wang1, Shuilin Wu1,2
1Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Ministry of Education, Wuhan, 430062 China
2School of Materials Science & Engineering, Key Laboratory of Advanced Ceramics and Machining Technology, Tianjin University, Ministry of Education, Tianjin, 300072 China
3Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
4State Key Laboratory for Turbulence and Complex System, and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
5Department of Orthopaedics & Traumatology, Li KaShing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China

Tóm tắt

AbstractOne of the most difficult challenges in the biomedical field is bacterial infection, which causes tremendous harm to human health. In this work, an injectable hydrogel is synthesized through rapid assembly of dopamine (DA) and folic acid (FA) cross‐linked by transition metal ions (TMIs, i.e., Zn2+), which was named as DFT‐hydrogel. Both the two carboxyl groups in the FA molecule and catechol in polydopamine (PDA) easily chelates Zn2+ to form metal–ligand coordination, thereby allowing this injectable hydrogel to match the shapes of wounds. In addition, PDA in the hydrogel coated around carbon quantum dot‐decorated ZnO (C/ZnO) nanoparticles (NPs) to rapidly generate reactive oxygen species (ROS) and heat under illumination with 660 and 808 nm light, endows this hybrid hydrogel with great antibacterial efficacy against Staphylococcus aureus (S. aureus, typical Gram‐positive bacteria) and Escherichia coli (E. coli, typical Gram‐negative bacteria). The antibacterial efficacy of the prepared DFT‐C/ZnO‐hydrogel against S. aureus and E. coli under dual‐light irradiation is 99.9%. Importantly, the hydrogels release zinc ions over 12 days, resulting in a sustained antimicrobial effect and promoted fibroblast growth. Thus, this hybrid hydrogel exhibits great potential for the reconstruction of bacteria‐infected tissues, especially exposed wounds.

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Small

Tập 15 Số 22

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