One-pot three-component Mannich reaction catalyzed by iodine under solvent-free conditions

Kinetics and Catalysis - Tập 52 - Trang 397-400 - 2011
Li Gang1, Long Ruiling2, Yang Jiangli1
1College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, China
2Department of Life Science and Technology, Xinxiang Medical University, Xinxiang, China

Tóm tắt

One-pot three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines are effectively catalyzed by molecular iodine at room temperature under solvent-free conditions to afford the corresponding β-amino carbonyl compounds with moderate to excellent yields. The method has the following advantages: no use of solvent, mild condition, high reaction speed and small quantity of catalyst.

Tài liệu tham khảo

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