Gene therapy - the challenge for the future

Brenner, 1993, Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients, Lancet, 342, 1134, 10.1016/0140-6736(93)92122-A Dunbar, 1995, Retrovirally marked CD34 enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation, Blood, 85, 3048, 10.1182/blood.V85.11.3048.bloodjournal85113048 Bordignon, 1995, Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients, Science, 270, 470, 10.1126/science.270.5235.470 Chalitta, 1994, Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo, Proc Natl Acad Sci USA, 91, 2567, 10.1073/pnas.91.7.2567 Gorman, 1985, Negative regulation of viral enhancers in undifferentiated embryonic stem cells, Cell, 42, 519, 10.1016/0092-8674(85)90109-6 Pawliuk, 1994, Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer, Blood, 84, 2868, 10.1182/blood.V84.9.2868.2868 Ward, 1994, Transfer and expression of the human multiple drug resistance gene in human CD34+ cells, Blood, 84, 1408, 10.1182/blood.V84.5.1408.1408 Brega, 1992, Human peripheral blood hematopoietic progenitors are optimal targets of retroviral mediated gene transfer, Blood, 80, 1418, 10.1182/blood.V80.6.1418.1418 Bauer, 1995, Improved transfer of the leukocyte integrin CD18 subunit into hematopoietic cell lines by using retroviral vectors having a gibbon ape leukemia virus envelope, Blood, 86, 2379, 10.1182/blood.V86.6.2379.bloodjournal8662379 Sorrentino, 1992, Selection of drugresistant bone marrow cells in vivo after retroviral transfer of human MDRI, Science, 257, 99, 10.1126/science.1352414 Richardson, 1995, Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene, Blood, 86, 2579, 10.1182/blood.V86.7.2579.2579 Li, 1994, Development of a retroviral construct containing a human mutated dihydrofolate reductase CDNA for hematopoietic stem cell transduction, Blood, 83, 3403, 10.1182/blood.V83.11.3403.3403 Flasshove, 1995, Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase CDNA via retroviral gene transfer, Blood, 85, 566, 10.1182/blood.V85.2.566.566 May, 1995, Protection of mice from lethal doses of methotrexate by transplantation with transgenic marrow expressing drug-resistant dihydrofolate reductase activity, Blood, 86, 2440, 10.1182/blood.V86.6.2439.bloodjournal8662439 Flasshove, 1995, Increased resistance to methotrexate in human hematopoietic cells after gene transfer of the Ser31 DHFR mutant, Leukemia, 9, S34 Markowitz, 1988, Construction and use of a safe and efficient amphotropic packaging cell line, Virology, 167, 400, 10.1016/S0042-6822(88)90101-8 Higuchi, 1989, Rapid, efficient DNA extraction for PCR from cells or blood, Amplifications, 2, 1 Moore, 1994, Ex vivo expansion of cord blood-derived stem cells and progenitors, Blood Cells, 20, 468 Moore, 1995, Hematopoietic reconstruction: New approaches, Clin Cancer Res, 1, 3 Ponchio, 1995, Quantitation of the quiescent fraction of long-term culture-initiating cells in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro, Blood, 86, 3314, 10.1182/blood.V86.9.3314.bloodjournal8693314 Shah, 1995, FLT3 ligand (FL) is a potent inducer of proliferation of highly quiescent human bone marrow CD34+ CD38- cells, Blood, 86, 423 Dao, 1995, FLT3 ligand preserves viability of human hematopoietic stem cells during in vitro transduction, Blood, 86, 423