Calculating measures of biological interaction

European Journal of Epidemiology - Tập 20 - Trang 575-579 - 2005
Tomas Andersson1, Lars Alfredsson1,2, Henrik Källberg2, Slobodan Zdravkovic2, Anders Ahlbom1,2
1Stockholm Centre for Public Health, Sweden
2Institute of Environmental Medicine, Stockholm, Sweden

Tóm tắt

An editorial in this issue explains that the degree of biological interaction between risk factors is measured as the deviation from additivity by the corresponding disease rates and not for example as deviation from multiplicativity. It is the purpose of this article to describe how a logistic regression model, or a Cox regression model, can be defined in order to produce the output that is needed for assessment of biological interaction. We will also demonstrate how common software can be programmed to deliver this output. Finally, we show how this output can be used as input in an Excel sheet that is set up to calculate the measures of biological interaction to be used for the assessment.

Tài liệu tham khảo

Ahlbom A, Alfredsson L. Interaction: Word with two meanings creates confusion. Eur J Epidemiol, in press KJ Rothman (2002) Epidemiology. An Introduction Oxford University Press New York M Lundberg P Fredlund J Hallqvist F Diderichsen (1996) ArticleTitleA SAS program calculating three measures of interaction with confidence intervals Epidemiology 7 655–656 Occurrence Handle8899400 DW Hosmer S Lemeshow (1992) ArticleTitleConfidence interval estimation of interaction Epidemiology 3 452–456 Occurrence Handle1391139 J Hallqvist A Ahlbom F Diderichsen C Reuterwall (1996) ArticleTitleHow to evaluate interaction between causes: A review of practices in cardiovascular epidemiology J Intern Med 239 377–382 Occurrence Handle10.1046/j.1365-2796.1996.431782000.x Occurrence Handle8642229 SF Assmann DW Hosmer S Lemeshow KA Mundt (1996) ArticleTitleConfidence intervals for measures of interaction Epidemiology 7 286–290 Occurrence Handle8728443 L Padyukov C Silva P Stolt L Alfredsson L Klareskog (2004) ArticleTitleA gene–environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis Arthritis Rheum 50 3085–3092 Occurrence Handle10.1002/art.20553 Occurrence Handle15476204