The effect of bariatric surgery on bone Health: From mechanism to management

Al-Mutawa, 2018, Nutritional status of bariatric surgery candidates, Nutrients, 10, 10.3390/nu10010067 Aleksandrova, 2016, Obesity and liver cancer. Recent results in cancer research. Fortschritte der Krebsforschung, Progres dans les recherches sur le cancer, 208, 177 Angrisani, 2015, Bariatric surgery worldwide 2013, Obes. Surg., 25, 1822, 10.1007/s11695-015-1657-z Angrisani, 2017, Bariatric surgery and endoluminal procedures: IFSO worldwide survey 2014, Obes. Surg., 27, 2279, 10.1007/s11695-017-2666-x Axelsson, 2018, Fracture risk after gastric bypass surgery: a retrospective cohort study, J. Bone Miner. Res. : Off. J. Am. Soc. Bone Miner. Res., 33, 2122, 10.1002/jbmr.3553 Bi, 2019, Relationships between adiponectin and bone: sex difference, Nutrition, 70 Biagioni, 2017, Bariatric roux-en-Y gastric bypass surgery: adipocyte proteins involved in increased bone remodeling in humans, Obes. Surg., 27, 1789, 10.1007/s11695-017-2546-4 Bihuniak, 2015, The effects of dietary protein and amino acids on skeletal metabolism, Mol. Cell. Endocrinol., 410, 78, 10.1016/j.mce.2015.03.024 Blom-Hogestol, 2019, Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass, Bone, 127, 436, 10.1016/j.bone.2019.07.014 Bojsen-Moller, 2015, Accelerated protein digestion and amino acid absorption after Roux-en-Y gastric bypass, Am. J. Clin. Nutr., 102, 600, 10.3945/ajcn.115.109298 Briganti, 2018, Irisin as a regulator of bone and glucose metabolism, Minerva Endocrinol., 43, 489, 10.23736/S0391-1977.17.02779-1 Busetto, 2017, Practical recommendations of the obesity management task force of the European association for the study of obesity for the post-bariatric surgery medical management, Obes. Facts., 10, 597, 10.1159/000481825 Campanha-Versiani, 2017, The effect of a muscle weight-bearing and aerobic exercise program on the body composition, muscular strength, biochemical markers, and bone mass of obese patients who have undergone gastric bypass surgery, Obes. Surg., 27, 2129, 10.1007/s11695-017-2618-5 Carrasco, 2018, Calcium absorption may be affected after either sleeve gastrectomy or Roux-en-Y gastric bypass in premenopausal women: a 2-y prospective study, Am. J. Clin. Nutr., 108, 24, 10.1093/ajcn/nqy071 Cashman, 2007, Diet, nutrition, and bone health, J. Nutr., 137, 2507s, 10.1093/jn/137.11.2507S Chakhtoura, 2016, Hypovitaminosis D in bariatric surgery: a systematic review of observational studies, Metabol. Clin. Exp., 65, 574, 10.1016/j.metabol.2015.12.004 Chen, 2015, Roles of leptin in bone metabolism and bone diseases, J. Bone Miner. Metabol., 33, 474, 10.1007/s00774-014-0569-7 Chen, 2018, Effects of bariatric surgery on change of Brown adipocyte tissue and energy metabolism in obese mice, Obes. Surg., 28, 820, 10.1007/s11695-017-2899-8 Cheng, 2019, Glucagon-like peptide-1 receptor agonists and risk of bone fracture in patients with type 2 diabetes: a meta-analysis of randomized controlled trials, Diabetes. Metabol. Res. Rev., 35, e3168, 10.1002/dmrr.3168 Chin, 2018, Vitamin C and bone health: evidence from cell, animal and human studies, Curr. Drug Targets, 19, 439, 10.2174/1389450116666150907100838 Chooi, 2019, The epidemiology of obesity, Metabol. Clin. Exp., 92, 6, 10.1016/j.metabol.2018.09.005 Chou, 2017, Dietary intake and weight changes 5 Years after laparoscopic sleeve gastrectomy, Obes. Surg., 27, 3240, 10.1007/s11695-017-2765-8 Christensen, 2018, Glucose-dependent insulinotropic polypeptide (GIP) inhibits bone resorption independently of insulin and glycemia, J. Clin. Endocrinol. Metabol., 103, 288, 10.1210/jc.2017-01949 Coates, 2004, Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass, J. Clin. Endocrinol. Metabol., 89, 1061, 10.1210/jc.2003-031756 Colaianni, 2019, Irisin and bone: from preclinical studies to the evaluation of its circulating levels in different populations of human subjects, Cells, 8, 10.3390/cells8050451 Crawford, 2018, Increased bone turnover IN type 2 diabetes patients randomized to bariatric surgery versus medical therapy at 5 years, Endocr. Pract. : Off. J. Am. Coll. Endricol. Am. Assoc. Clin. Endocrinologists, 24, 256, 10.4158/EP-2017-0072 Dantas, 2018, Reversal of improved endothelial function after bariatric surgery is mitigated by exercise training, J. Am. Coll. Cardiol., 72, 2278, 10.1016/j.jacc.2018.07.094 Ding, 2018, Amino acids as signaling molecules modulating bone turnover, Bone, 115, 15, 10.1016/j.bone.2018.02.028 Elefteriou, 2005, Leptin regulation of bone resorption by the sympathetic nervous system and CART, Nature, 434, 514, 10.1038/nature03398 Engin-Ustun, 2016, Postmenopausal osteoporosis is associated with serum chemerin and irisin but not with apolipoprotein M levels, J. Menopausal. Med., 22, 76, 10.6118/jmm.2016.22.2.76 Fashandi, 2018, Bariatric surgery increases risk of bone fracture, Surg. Endosc., 32, 2650, 10.1007/s00464-017-5628-4 Fortner, 2016, Obesity and breast cancer. Recent results in cancer research. Fortschritte der Krebsforschung, Progres dans les recherches sur le cancer, 208, 43 Frederiksen, 2016, Bone structural changes and estimated strength after gastric bypass surgery evaluated by HR-pQCT, Calcif. Tissue Int., 98, 253, 10.1007/s00223-015-0091-5 Frost, 1987, Bone "mass" and the "mechanostat": a proposal, Anat. Rec., 219, 1, 10.1002/ar.1092190104 Gagnon, 2018, Bone health after bariatric surgery, JBMR plus, 2, 121, 10.1002/jbm4.10048 Gluck, 2019, Serum irisin, adropin, and preptin in obese patients 6 Months after bariatric surgery, Obes. Surg., 29, 3334, 10.1007/s11695-019-03998-y Gregory, 2017, The effects of bariatric surgery on bone metabolism, Endocrinol Metab. Clin. N. Am., 46, 105, 10.1016/j.ecl.2016.09.011 Hansen, 2020, Towards optimized care after bariatric surgery by physical activity and exercise intervention: a review, Obes. Surg., 10.1007/s11695-020-04390-x Hewitt, 2018, Relationships of serum 25-hydroxyvitamin D, ionized calcium and parathyroid hormone after obesity surgery, Clin. Endocrinol., 88, 372, 10.1111/cen.13531 Hey, 1982, Delayed fracture healing following jejunoileal bypass surgery for obesity, Calcif. Tissue Int., 34, 13, 10.1007/BF02411201 Higgins, 2018, Multiple vertebral fractures sustained 5 months after Roux-en-Y gastric bypass: a case report, Arch. Osteoporos., 13, 51, 10.1007/s11657-018-0471-3 Javanainen, 2018, Two-year nutrition data in terms of vitamin D, vitamin B12, and albumin after bariatric surgery and long-term fracture data compared with conservatively treated obese patients: a retrospective cohort study, Obes. Surg., 28, 2968, 10.1007/s11695-018-3336-3 Jiang, 2019, Central adiponectin induces trabecular bone mass partly through epigenetic downregulation of cannabinoid receptor CB1, J. Cell. Physiol., 234, 7062, 10.1002/jcp.27460 Katsareli, 2014, Biomarkers in the field of obesity and its related comorbidities, Expert Opin. Ther. Targets, 18, 385, 10.1517/14728222.2014.882321 Kim, 2018, Irisin mediates effects on bone and fat via alphaV integrin receptors, Cell, 175, 1756, 10.1016/j.cell.2018.10.025 Kolhe, 2018, Modulation of miRNAs by vitamin C in human bone marrow stromal cells, Nutrients, 10, 10.3390/nu10020186 Lakkis, 2018, Obesity and kidney disease, Prog. Cardiovasc. Dis., 61, 157, 10.1016/j.pcad.2018.07.005 Lecka-Czernik, 2008, Local and systemic functions of bone fat and its contribution to the energy metabolism--the effect of diabetes and obesity on bone, J. Musculoskelet. Neuronal Interact., 8, 346 Lee, 2019, Association of circulating irisin concentrations with weight loss after roux-en-Y gastric bypass surgery, Int. J. Environ. Res. Publ. Health, 16 Li, 2019, Obesity and leptin influence vitamin D metabolism and action in human marrow stromal cells, J. Steroid Biochem. Mol. Biol., 198 Liu, 2016, Changes in bone metabolism in morbidly obese patients after bariatric surgery: a meta-analysis, Obes. Surg., 26, 91, 10.1007/s11695-015-1724-5 Lu, 2015, Fracture risk after bariatric surgery: a 12-year nationwide cohort study, Medicine, 94, 10.1097/MD.0000000000002087 Lu, 2019, Variations in irisin, bone mineral density, bone mineral content, and body composition after laparoscopic bariatric procedures in obese adults, J. Clin. Densitom. : Offc. J. Int. soc. Clin. Densitom. Majorczyk, 2019, The influence of bariatric surgery on serum levels of irisin and nesfatin-1, Acta Chir. Belg., 119, 363, 10.1080/00015458.2018.1534393 Mantzoros, 2011, Leptin in human physiology and pathophysiology, Am. J. Physiol. Endocrinol. Metab., 301, E567, 10.1152/ajpendo.00315.2011 Mechanick, 2019, Endocr. Pract. : Off. J. Am. Coll. Endricol. Am. Assoc. Clin. Endocrinologists Melo, 2017, Bone turnover after bariatric surgery, Arch. Endricol. Metabol., 61, 332, 10.1590/2359-3997000000279 Moize, 2003, Obese patients have inadequate protein intake related to protein intolerance up to 1 year following Roux-en-Y gastric bypass, Obes. Surg., 13, 23, 10.1381/096089203321136548 Murai, 2019, Exercise mitigates bone loss in women with severe obesity after roux-en-Y gastric bypass: a randomized controlled trial, J. Clin. Endocrinol. Metabol., 104, 4639, 10.1210/jc.2019-00074 Muschitz, 2015, Sclerostin levels and changes in bone metabolism after bariatric surgery, J. Clin. Endocrinol. Metabol., 100, 891, 10.1210/jc.2014-3367 Nakamura, 2014, Fracture risk following bariatric surgery: a population-based study, Osteoporos. Int. : J. Established. Res. Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA., 25, 151, 10.1007/s00198-013-2463-x Netto, 2012, vol.27, 114 Nguyen, 2017, Bariatric surgery for obesity and metabolic disorders: state of the art, Nat. Rev. Gastroenterol. Hepatol., 14, 160, 10.1038/nrgastro.2016.170 Nicoletti, 2013, Protein and amino acid status before and after bariatric surgery: a 12-month follow-up study, Surg. Obes. Relat. Dis. : Off. J. Am. Soc. Bariatrics. Surg., 9, 1008, 10.1016/j.soard.2013.07.004 Osland, 2016, Postoperative early major and minor complications in laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic roux-en-Y gastric bypass (LRYGB) procedures: a meta-analysis and systematic review, Obes. Surg., 26, 2273, 10.1007/s11695-016-2101-8 Parrott, 2017, American society for metabolic and bariatric surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 update: micronutrients. Surgery for obesity and related diseases, Off. J. Am. Soc. Bariatrics. Surg., 13, 727 Pournaras, 2010, Ghrelin and metabolic surgery, Int. J. Pept., 10.1155/2010/217267 Rosen, 2003, Severe hypocalcemia after intravenous bisphosphonate therapy in occult vitamin D deficiency, N. Engl. J. Med., 348, 1503, 10.1056/NEJM200304103481521 Rousseau, 2016, Change in fracture risk and fracture pattern after bariatric surgery: nested case-control study, Br. Med. J., 354, i3794, 10.1136/bmj.i3794 Saad, 2019, Bone health following bariatric surgery: an update, J. Clin. Densitom. : Offc. J. Int. soc. Clin. Densitom. Salazar, 2019, Variable thresholds of vitamin D plasma levels to suppress PTH: the effect of weight and bariatric surgery, Obes. Surg. Schafer, 2015, Intestinal calcium absorption decreases dramatically after gastric bypass surgery despite optimization of vitamin D status, J. Bone Miner. Res. : Off. J. Am. Soc. Bone Miner. Res., 30, 1377, 10.1002/jbmr.2467 Schafer, 2018, Effects of gastric bypass surgery on bone mass and microarchitecture occur early and particularly impact postmenopausal women, J. Bone Miner. Res. : Off. J. Am. Soc. Bone Miner. Res., 33, 975, 10.1002/jbmr.3371 Schiellerup, 2019, Gut hormones and their effect on bone metabolism. Potential drug therapies in future osteoporosis treatment, Front. Endocrinol., 10, 75, 10.3389/fendo.2019.00075 Scott, 2019, Multiple vertebral compression fractures after sleeve gastrectomy and a subsequent pregnancy: a case report, Osteoporos. Int. : J. Established. Res. Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA., 30, 2151, 10.1007/s00198-019-05073-9 Shanbhogue, 2017, Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study, Eur. J. Endocrinol., 176, 685, 10.1530/EJE-17-0014 Skov-Jeppesen, 2019, GLP-2 and GIP exert separate effects on bone turnover: a randomized, placebo-controlled, crossover study in healthy young men, Bone, 125, 178, 10.1016/j.bone.2019.05.014 Wang, 2019, Unacylated ghrelin is correlated with the decline of bone mineral density after Roux-en-Y gastric bypass in obese Chinese with type 2 diabetes. Surgery for obesity and related diseases, Off. J. Am. Soc. Bariatrics. Surg., 15, 1473 Wei, 2018, High incidence of secondary hyperparathyroidism in bariatric patients: comparing different procedures, Obes. Surg., 28, 798, 10.1007/s11695-017-2932-y Weivoda, 2020, Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism, Nat. Commun., 11, 87, 10.1038/s41467-019-14003-6 Wilson, 2016, Obesity and kidney cancer. Recent results in cancer research. Fortschritte der Krebsforschung, Progres dans les recherches sur le cancer, 208, 81 Wongdee, 2019, Factors inhibiting intestinal calcium absorption: hormones and luminal factors that prevent excessive calcium uptake, J. Physiol. Sci. : JPS, 69, 683, 10.1007/s12576-019-00688-3 Xanthakos, 2009, Nutritional deficiencies in obesity and after bariatric surgery, Pediatr. Clin., 56, 1105 Yan, 2018, Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women, Joint Bone Spine : revue du rhumatisme, 85, 353, 10.1016/j.jbspin.2017.03.011 Yang, 2019, Adiponectin deficiency triggers bone loss by up-regulation of osteoclastogenesis and down-regulation of osteoblastogenesis, Front. Endocrinol., 10, 815, 10.3389/fendo.2019.00815 Ye, 2019, The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization, Int. J. Biol. Macromol. Yu, 2018, Bariatric surgery: weighing in on bone loss, J. Bone Miner. Res. : Off. J. Am. Soc. Bone Miner. Res., 33, 973, 10.1002/jbmr.3432 Yu, 2016, Effects of gastric bypass and gastric banding on bone remodeling in obese patients with type 2 diabetes, J. Clin. Endocrinol. Metabol., 101, 714, 10.1210/jc.2015-3437 Yu, 2017, Fracture risk after bariatric surgery: roux-en-Y gastric bypass versus adjustable gastric banding, J. Bone Miner. Res. : Off. J. Am. Soc. Bone Miner. Res., 32, 1229, 10.1002/jbmr.3101 Zhang, 2018, The bone anabolic effects of irisin are through preferential stimulation of aerobic glycolysis, Bone, 114, 150, 10.1016/j.bone.2018.05.013 Zhang, 2018, A meta-analysis of the effects of bariatric surgery on fracture risk, Obes. Rev. Offc. J. Int. Assoc. Stud. Obes., 19, 728, 10.1111/obr.12665 Zhang, 2019, Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway, J. Transl. Med., 17, 64, 10.1186/s12967-019-1805-7