Metabolic load and heterologous gene expression

Austin, 1988, Plasmid partition, Plasmid, 20, 1, 10.1016/0147-619X(88)90001-7 Barth, 1981, Development of broad-host-range plasmid vectors, 439 Bailey, 1991, Toward a science of metabolic engineering, Science, 230, 144 Bentley, 1990, Plasmid-encoded protein: The principal factor in the “metabolic burden” associated with recombinant bacteria, Biotechnol. Bioeng., 35, 668, 10.1002/bit.260350704 Birnbaum, 1991, Plasmid presence changes the relative levels of many host cell proteins and ribosome components in recombinant Escherichia coli, Biotechnol. Bioeng., 37, 736, 10.1002/bit.260370808 Brownlie, 1990, Effect of growth rate on plasmid maintenance by Escherichia coli HB101 (pAT153), J. Gen. Microbiol., 136, 2471, 10.1099/00221287-136-12-2471 Buckholz, 1991, Yeast systems for the commercial production of heterologous proteins, Bio/Technology, 9, 1067, 10.1038/nbt1191-1067 Carrier, 1983, High expression of cloned genes in E. coli and its consequences, Trends Biotechnol., 1, 109, 10.1016/0167-7799(83)90033-1 Cheah, 1987, Effects of recombinant plasmid size on cellular processes in Escherichia coli, Plasmid, 18, 127, 10.1016/0147-619X(87)90040-0 Chen, 1991, Molecular design of expression systems: Comparison of different repressor control configurations using molecular mechanism models, Biotechnol. Bioeng., 38, 679, 10.1002/bit.260380702 Chou, 1994, Effect of modified glucose uptake using genetic engineering techniques on high-level recombinant protein production in Escherichia coli dense cultures, Biotechnol. Bioeng., 44, 952, 10.1002/bit.260440811 Diaz-Ricci, 1992, Influence of expression of the pet operon on intracellular metabolic fluxes of Escherichia coli., Biotechnol. Bioeng., 39, 59, 10.1002/bit.260390110 Ernst, 1988, Codon usage and gene expression, Trends Biotechnol., 6, 196, 10.1016/0167-7799(88)90046-7 Fu, 1993, Continuous, high level production and excretion of a plasmid-encoded protein by Escherichia coli in a two-stage chemostat, Biotechnol. Bioeng., 41, 937, 10.1002/bit.260411004 Georgiou, 1988, Release of periplasmic enzymes and other physiological effects of β-lactamase overproduction in Escherichia coli, Biotechnol. Bioeng., 32, 741, 10.1002/bit.260320603 Glick, 1985, Transformation of Azotobacter vinelandii with plasmid DNA, J. Bacteriol., 162, 276, 10.1128/JB.162.1.276-279.1985 Glick, 1986, Environmental implications of recombination DNA technology, Biotechnol. Adv., 4, 261, 10.1016/0734-9750(86)90312-5 Glick, 1986, Physiological effects of plasmid DNA transformation on Azotobacter vinelandii, Can. J. Microbiol., 32, 145, 10.1139/m86-028 Glick, 1987, Factors affecting the expression of foreign proteins in Escherichia coli, J. Ind. Microbiol., 1, 277, 10.1007/BF01569305 Glick, 1989, Effect of transformation of Azotobacter vinelandii with the low copy number plasmid pRK290, Curr. Microbiol., 19, 143, 10.1007/BF01568932 Glick, 1994 Harcum, 1993, Response dynamics of 26-, 34-, 39-, 54-, and 80-kDa proteases in induced cultures of recombinant Escherichia coli, Biotechnol. Bioeng., 42, 675, 10.1002/bit.260420602 Harrington, 1986, Molecular cloning of the phosphoenolpyruvate carboxylase gene of Anabaena variabilis, Gene, 45, 113, 10.1016/0378-1119(86)90139-3 Hopkins, 1987, Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401, Biotechnol. Bioeng., 29, 85, 10.1002/bit.260290113 Hong, 1991, Biological consequences of plasmid transformation of the plant growth promoting rhizobacterium Pseudomonas putida GR12-2, Can. J. Microbiol., 37, 796, 10.1139/m91-137 Hong, 1991, Plant-microbial interaction under gnotobiotic conditions: A scanning electron microscope study, Curr. Microbiol., 23, 111, 10.1007/BF02092259 Hong, 1995, Transformation of the plant growth promoting rhizobacterium Pseudomonas putida GR12-2 with an exogenous β-glucosidase gene, Can. J. Microbiol., 10.1139/m95-083 Kaprálek, 1992, The structural stability of an expression plasmid bearing a heterologous cloned gene depends on whether this gene is expressed or not, Biotechnol. Lett., 14, 251, 10.1007/BF01022319 Katayama, 1990, Inhibition of cell growth and stable DNA replication by overexpression of the bla gene of plasmid pBR322 in Escherichia coli, Molec. Gen. Genet., 223, 353, 10.1007/BF00264440 Khosravi, 1990, Variation of oxygen requirement with plasmid size in recombinant Escherichia coli, Plasmid, 23, 138, 10.1016/0147-619X(90)90032-8 Kim, 1991, The effects of plasmid content, transcription efficiency, and translation efficiency on the productivity of a cloned gene in Escherichia coli, Biotechnol. Bioeng., 38, 1271, 10.1002/bit.260381103 Kumar, 1991, Strategies for improving plasmid stability in genetically modified bacteria in bacteria, Trends Biotechnol., 9, 279, 10.1016/0167-7799(91)90090-5 Kyslik, 1993, Plasmid burden in chemostat culture of Escherichia coli.: Its effect on the selection for overproducers of host enzymes, Biotechnol. Bioeng., 41, 325, 10.1002/bit.260410306 Lee, 1985, Expression of tetracycline resistance in pBR322 derivatives reduces the reproductive fitness of plasmid-containing Escherichia coli, Gene, 39, 173, 10.1016/0378-1119(85)90311-7 Lucknow, 1988, Trends in the development of baculovirus expression vectors, Bio/Technology, 6, 47, 10.1038/nbt0188-47 Lutzer, 1994, Two-stage process for increasing cell disruption of E. coli for intracellular products recovery, 909 Martin, 1989, Expression of proteins encoded by foreign genes in Saccharomyces cerevisiae, Biotechnol. Adv., 7, 155, 10.1016/0734-9750(89)90357-1 Miki, 1993, Procedures for introducing foreign DNA into plants, 67 Neidhardt, 1987, Heat shock response, vol. 2, 1334 Park, 1991, Two-stage fermentation with bacteriophage λ as an expression vector in Escherichia coli, Biotechnol. Bioeng., 37, 297, 10.1002/bit.260370402 Renaud, 1989, Integration of exogenous DNA into the genome of Azotobacter vinelandii, Arch. Microbiol., 152, 437, 10.1007/BF00446925 Ryan, 1989, Expression of β-lactamase by recombinant Escherichia coli strains containing plasmids of different sizes - Effects of pH, phosphate, and dissolved oxygen, Biotechnol. Bioeng., 34, 309, 10.1002/bit.260340306 Sano, 1990, Expression of a cloned streptavidin gene in Escherichia coli, 87, 142 Sauer, 1989, Disruption of native and recombinant Escherichia coli in a high-pressure homogenizer, Biotechnol. Bioeng., 33, 1330, 10.1002/bit.260331016 Scorer, 1991, Amino acid misincorporation during high-level expression of mouse epidermal growth factor in Escherichia coli, Nucl. Acids Res., 19, 3511, 10.1093/nar/19.13.3511 Seidler, 1992, Evaluation of methods for detecting ecological effects from genetically engineered microorganisms and microbial pest control agents in terrestrial systems, Biotechnol. Adv., 10, 149, 10.1016/0734-9750(92)90001-P Seigel, 1985, Kinetic study of instability of recombinant plasmid pPLc23trpAI in E. coli using two-stage continuous culture system, Biotechnol. Bioeng., 27, 28, 10.1002/bit.260270105 Seo, 1985, Effects of recombinant plasmid content on growth properties and cloned gene product formation in Escherichia coli, Biotechnol. Bioeng., 27, 1668, 10.1002/bit.260271207 Seressiotis, 1987, Optimal gene expression and amplification strategies for batch and continuous recombinant cultures, Biotechnol. Bioeng., 29, 392, 10.1002/bit.260290317 Skare, 1989, A mutation in the amino terminus of a hybrid TrpC-TonB protein relieves overproduction lethality and results in cytoplasmic accumulation, J. Bacteriol., 171, 4442, 10.1128/jb.171.8.4442-4447.1989 Sommerville, 1994, Bacterial aspects associated with the expression of a single-chain antibody fragment in Escherichia coli, Appl. Microbiol. Biotechnol., 42, 595, 10.1007/BF00173926 Summers, 1991, The kinetics of plasmid loss, Trends Biotechnol., 9, 273, 10.1016/0167-7799(91)90089-Z Tang, 1994, Stimulation of canola root growth by Pseudomonas putida GR12-2 and its genetically engineered derivatives, Plant Physiol. (Life Sci. Adv.), 13, 89 Tang, 1995, Persistence in soil of the plant growth-promoting rhizobacterium Pseudomonas putida GR12-2 and genetically manipulated derived strains, Can. J. Microbiol., 10.1139/m95-060 Tempest, 1992, Physiological and energetic aspects of bacterial metabolite overproduction, FEMS Microbiol. Lett., 100, 169, 10.1111/j.1574-6968.1992.tb14036.x Togna, 1993, Effects of plasmid copy number and runaway plasmid replication on overproduction and excretion of β-lactamase from Escherichia coli, Biotechnol. Prog., 9, 31, 10.1021/bp00019a005 Tolbert, 1990, Manufacture of biopharmaceutical proteins by mammalian cell culture systems, Biotechnol. Adv., 8, 729, 10.1016/0734-9750(90)91994-R Valera, 1994, Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism, Human Gene Ther., 5, 449, 10.1089/hum.1994.5.4-449 Van Voris, 1985, Terrestrial microcosms: applications, validation, and cost-benefit analysis, 117 White, 1994, Bacterial yeast and fungal cultures: The effect of microorganism type and culture characteristics on bioreactor design and operation, 1 Whitney, 1989, Induction of T4 DNA ligase in a recombinant strain of Escherichia coli, Biotechnol. Bioeng., 33, 991, 10.1002/bit.260330808 Wilcox, 1988, Expression of foreign proteins in microorganisms, Biotechnol. Appl. Biochem., 10, 500 Wood, 1988, Harvesting of E. coli cells using cross-flow membrane filtration Wood, 1991, Effect of chemically-induced cloned-gene expression on protein synthesis in E. coli, Biotechnol. Bioeng., 38, 397, 10.1002/bit.260380410