Replacing nebulizers by MDI-spacers for bronchodilator and inhaled corticosteroid administration: Impact on the utilization of hospital resources

Wildhaber, 1999, Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? in vivo comparison of lung deposition in children, J Pediatr, 135, 28, 10.1016/S0022-3476(99)70323-9 Schuh, 1999, Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma, J Pediatr, 135, 22, 10.1016/S0022-3476(99)70322-7 Lin, 1995, Metered dose inhaler and nebuliser in acute asthma, Arch Dis Child, 72, 214, 10.1136/adc.72.3.214 Parkin, 1995, Randomized trial spacer v nebuliser for acute asthma, Arch Dis Child, 72, 239, 10.1136/adc.72.3.239 Gunawardena, 1986, A comparison of metered dose inhalers with nebulizers from the delivery of ipratropium bromide in domiciliary practice, Br J Dis Chest, 80, 170, 10.1016/0007-0971(86)90038-0 Kwok, 2014, Delivery of inhalation drugs to children for asthma and other respiratory diseases, Adv Drug Deliv Rev, 73, 83, 10.1016/j.addr.2013.11.007 Walsh, 2011, European paediatric formulation initiative (EuPFI), delivery devices for the administration of paediatric formulations: overview of current practice, challenges and recent developments, Int J Pharm, 415, 221, 10.1016/j.ijpharm.2011.05.048 Lee, 2003, A major outbreak of severe acute respiratory syndrome in Hong Kong, N Engl J Med, 348, 1986, 10.1056/NEJMoa030685 Al-Moamary, 2012, The Saudi initiative for asthma – 2012 update: guidelines for the diagnosis and management of asthma in adults and children, Ann Thorac Med, 7, 175, 10.4103/1817-1737.102166 Pedersen, 2011, Global strategy for the diagnosis and management of asthma in children 5 years and younger, Pediatr Pulmonol, 46, 1, 10.1002/ppul.21321 Delgado, 2003, Nebulizers vs metered-dose inhalers with spacers for bronchodilator therapy to treat wheezing in children aged 2 to 24 months in a pediatric emergency department, Arch Pediatr Adolesc Med, 157, 76, 10.1001/archpedi.157.1.76 Leversha, 2000, Costs and effectiveness of spacer versus nebulizer in young children with moderate and severe acute asthma, J Pediatr, 136, 497, 10.1016/S0022-3476(00)90013-1 Bowton, 1992, Substitution of metered dose inhalers for hand-held nebulizers: success and cost savings in a large, acute care hospital, Chest, 101, 305, 10.1378/chest.101.2.305 Jasper, 1987, Cost-benefit comparison of aerosol bronchodilator delivery methods in hospitalized patients, Chest, 91, 614, 10.1378/chest.91.4.614 Tenholder, 1992, A model for conversion from small volume nebulizer to metered dose inhaler aerosol therapy, Chest, 101, 634, 10.1378/chest.101.3.634 Summer, 1989, Aerosol bron- chodilator delivery methods. Relative impact on pulmonary function and cost of respiratory care, Arch Intern Med, 149, 618, 10.1001/archinte.1989.00390030092018 Castro-Rodriguez, 2004, Beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or asthma in children under 5 years of age: a systematic review with meta-analysis, J Pediatr, 145, 172, 10.1016/j.jpeds.2004.04.007 Osmond, 2007, PERC spacer study group, barriers to metered-dose inhaler/spacer use in Canadian pediatric emergency departments: a national survey, Acad Emerg Med, 14, 1106, 10.1197/j.aem.2007.05.009 Salyer, 2008, The conversion to metered-dose inhaler with valved holding chamber to administer inhaled albuterol: a pediatric hospital experience, Respir Care, 53, 338 Cotterell, 2002, Child and parent satisfaction with the use of spacer devices in acute asthma, J Paediatr Child Health, 38, 604, 10.1046/j.1440-1754.2002.00063.x