Meteorin is a Chemokinetic Factor in Neuroblast Migration and Promotes Stroke-Induced Striatal Neurogenesis

Journal of Cerebral Blood Flow and Metabolism - Tập 32 Số 2 - Trang 387-398 - 2012
Zhaolu Wang1, Nuno Andrade1, Malene Torp2, Somsak Wattananit3, Åke Arvidsson1, Zaal Kokaia3,4, Jesper Roland Jørgensen2, Olle Lindvall1,4
1Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, Lund, Sweden
2NsGene A/S, Ballerup, Denmark
3Laboratory of Neural Stem Cell Biology and Therapy, Lund, Sweden
4Lund Stem Cell Center, University Hospital, Lund, Sweden

Tóm tắt

Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-d-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of endogenous METRN in cells with neuronal phenotype in striatum. Recombinant METRN infused into the stroke-damaged brain stimulates cell proliferation in SVZ, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum. Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke.

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Thông tin xuất bản

Journal of Cerebral Blood Flow and Metabolism

Tập 32 Số 2

387-398

Thông tin tác giả