Prenatal and early postnatal fatty acid status and neurodevelopmental outcome

Journal of Perinatal Medicine - Tập 35 Số s1 - Trang S28-S34 - 2007
Mijna Hadders‐Algra1, Hylco Bouwstra2, Saskia A. van Goor3, D.A. Janneke Dijck‐Brouwer4, Frits A.J. Muskiet5
11. Department of Neurology – Developmental Neurology, University Medical Center Groningen, Groningen, The Netherlands
22. Department of Neurology – Developmental Neurology, University Medical Center Groningen, Groningen, The Netherlands
33. Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
44. Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
55. Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands

Tóm tắt

AbstractThe present review addresses the effect of pre- and postnatal supplementation of nutrition with long-chain polyunsaturated fatty acids (LCPUFA) on neurodevelopmental outcome. The few studies which addressed the effect of prenatal LCPUFA status or prenatal LCPUFA supplementation suggest that a better prenatal arachidonic acid (AA) and doxosahexaenoic acid (DHA) status might be related to a better neurodevelopmental outcome until at least 18 months of age. A review of the few randomized controlled trials on formula supplementation with LCPUFA in preterm infants did not provide evidence for a significant beneficial effect of LCPUFA on developmental outcome. A review of the trials on formula supplementation with LCPUFA in term infants revealed that supplementation with LCPUFA, in particularly supplementation with ≥0.30% DHA, has a beneficial effect on neurodevelopmental outcome until 4 months. The studies could not demonstrate a consistent positive effect beyond that age. It was concluded that the relatively subtle effects of LCPUFA supplementation on neurodevelopmental outcome do not only depend on dosage but also on the gestational period during which the nutritional components are supplied: supplementation prior to term seems to have more effect than that after term.

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Thông tin xuất bản

Journal of Perinatal Medicine

Tập 35 Số s1

S28-S34

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