Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations

International Journal of Pharmaceutics - Tập 453 - Trang 253-284 - 2013
Amrit Paudel1, Zelalem Ayenew Worku1, Joke Meeus1, Sandra Guns1, Guy Van den Mooter1
1Laboratory of Pharmacotechnology and Biopharmacy, KU Leuven, Leuven, Belgium

Tài liệu tham khảo

Adhikari, 2003, Surface stickiness of drops of carbohydrate and organic acid solutions during convective drying: experiments and modeling, Dry. Technol., 21, 839, 10.1081/DRT-120021689 Aınaoui, 1998, Modelling the plasma drug level with oral controlled release dosage forms with lipidic Gelucire, Int. J. Pharm., 169, 155, 10.1016/S0378-5173(98)00105-7 Al-Obaidi, 2009, Anomalous properties of spray dried solid dispersions, J. Pharm. Sci., 98, 4724, 10.1002/jps.21782 Al-Obaidi, 2009, Evaluation of griseofulvin binary and ternary solid dispersions with HPMCAS, AAPS PharmSciTech., 10, 1172, 10.1208/s12249-009-9319-x Al-Obaidi, 2011, Characterization and stability of ternary solid dispersions with PVP and PHPMA, Int. J. Pharm., 419, 20, 10.1016/j.ijpharm.2011.06.052 Albers, 2011, Evaluation of predictive models for stable solid solution formation, J. Pharm. Sci., 100, 667, 10.1002/jps.22313 Alexander, 1985, Factors governing surface morphology of spray-dried amorphous substances, Dry. Technol., 3, 321, 10.1080/07373938508916275 Alhalaweh, 2010, Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying, Cryst. Growth Des., 10, 3302, 10.1021/cg100451q Alonzo, 2011, Dissolution and precipitation behavior of amorphous solid dispersions, J. Pharm. Sci., 100, 3316, 10.1002/jps.22579 Alves, 2004, Phospholipid dry powders produced by spray drying processing: structural, thermodynamic and physical properties, Powder Technol., 145, 139, 10.1016/j.powtec.2004.06.008 Ambike, 2004, Stability study of amorphous valdecoxib, Int. J. Pharm., 282, 151, 10.1016/j.ijpharm.2004.06.009 Ambike, 2005, Spray-dried amorphous solid dispersions of simvastatin, a low Tg drug: In Vitro and in Vivo evaluations, Pharm. Res., 22, 990, 10.1007/s11095-005-4594-z Ambühl, M., Haeberlin, B., Lückel, B., Meinzer, A., Lambert, O., Marchal, L., 2010. Pharmaceutical composition. United States Patent and Trademark Office, US 2010/0215734 A1. Ansari, 2008, Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone, Arch. Pharm. Res., 31, 390, 10.1007/s12272-001-1169-6 Araújo, 2010, The preparation of ternary solid dispersions of an herbal drug via spray drying of liquid feed, Dry. Technol., 28, 412, 10.1080/07373931003648540 Arnum, 2010, Green drug delivery: spray-dried solid amorphous dispersions with a cellulosic exicpient, Pharm. Technol. Ayenew, 2012, Can compression induce demixing in amorphous solid dispersions? A case study of naproxen – PVP K25, Eur. J. Pharm. Biopharm., 81, 207, 10.1016/j.ejpb.2012.01.007 Baek, 2011, Enhanced solubility and bioavailability of flurbiprofen by cycloamylose, Arch. Pharm. Res., 34, 391, 10.1007/s12272-011-0306-x Bain, 1999, Solvent influence on spray-dried biodegradable microspheres, J. Microencapsul., 16, 453, 10.1080/026520499288915 Baird, 2012, Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state, Pharm. Res., 1, 271, 10.1007/s11095-011-0540-4 Balakrishnan, 2009, Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS), Eur. J. Pharm. Biopharm., 72, 539, 10.1016/j.ejpb.2009.03.001 Baldinger, 2011, Quality by design approach in the optimization of the spray-drying process, Pharm. Dev. Technol. Bee, 2010, Using polymer technology to enhance bioavailability, Pharm. Technol. Benmore, 2011, Amorphization of molecular liquids of pharmaceutical drugs by acoustic levitation, Phys. Rev. X, 1, 110041, 10.1103/PhysRevX.1.011004 Bercea, 2009, Islands of immiscibility for solutions of compatible polymers in a common solvent: experiment and theory, Macromolecules, 42, 3620, 10.1021/ma9002769 Bercea, 2009, Vapor pressures of polymer solutions and the modeling of their composition dependence, Ind. Eng. Chem. Res., 48, 4603, 10.1021/ie801965h Beyerinck, R.A., Diebele, H.L.M., Dobry, D.E., Ray, R.J., Settell, D.M., Spence, K.R., 2005. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus. United States Patent & Trademark Office, US20110277339. Beyerinck, R.A., Diebele, H.L.M., Dobry, D.E., Ray, R.J., Settell, D.M., Spence, K.R., 2005. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus. United States Patent & Trademark Office, US6973741B2. Beyerinck, R.A., Dobry, D.E., Friesen, D.T., Settell, D.M., Ray, R.J., 2005. Spray drying processes for forming solid amorphous dispersions of drugs and polymers. WO Patent WO/2005,011,636. Beyerinck, R.A., Ray, R.J., Dobry, D.E.,Settell, D.M., 2010. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles. United States Patent & Trademark Office, US7780988. Bhende, 2012, Moringa coagulant as a stabilizer for amorphous solids: Part I, AAPS PharmSciTech., 1 Bikiaris, 2011, Solid dispersions Part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs, Expert Opin. Drug Deliv., 8, 1501, 10.1517/17425247.2011.618181 Biradar, 2006, A comparative study of approaches used to improve solubility of roxithromycin, Powder Technol., 169, 22, 10.1016/j.powtec.2006.07.016 Bittorf, K.J., Katstra, J.P., Gaspar, F., 2009. Fluidized spray drying. United States Patent and Treademark Office, US20100011610. Bittorf, K.J., Katstra, J.P., Gaspar, F., 2009. Pharmaceutical compositions. United States Patent and Trademark Office, US20090247468. Bodmeier, 1988, Solvent selection in the preparation of poly (dl-lactide) microspheres prepared by the solvent evaporation method, Int. J. Pharm., 43, 179, 10.1016/0378-5173(88)90073-7 Boghra, 2011, Solubility, dissolution rate and bioavailability enhancement of irbesartan by solid dispersion technique, Chem. Pharm. Bull., 59, 438, 10.1248/cpb.59.438 Bohr, 2011, Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying, Int. J. Pharm., 412, 59, 10.1016/j.ijpharm.2011.04.005 Bohr, 2012, Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug, J. R. Soc. Interface, 10.1098/rsif.2012.0166 Bothiraja, 2009, Evaluation of molecular pharmaceutical and in vivo properties of spray-dried isolated andrographolide—PVP, J. Pharm. Pharmacol., 61, 1465, 10.1211/jpp.61.11.0005 Bothiraja, 2009, Evaluation of molecular pharmaceutical and in vivo properties of spray-dried isolated andrographolide-PVP, J. Pharm. Pharmacol., 61, 1465, 10.1211/jpp.61.11.0005 Buhler, 2005, Soluble polyvinylpyrrolidone (povidone) Cal, 2010, Spray drying technique. I. Hardware and process parameters, J. Pharm. Sci., 99, 575, 10.1002/jps.21886 Caron, 2011, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Mol. Pharm., 8, 532, 10.1021/mp1003674 Celik, 2007, Spray drying and pharmaceutical applications, 129 Chauhan, 2005, Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique, AAPS PharmSciTech, 6, E405, 10.1208/pt060350 Chiou, 1971, Pharmaceutical application of solid dispersion system, J. Pharm. Sci., 60, 1281, 10.1002/jps.2600600902 Chen, 2008, Preparation of functional composite particles of salbutamol sulfate using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 56, 254, 10.1248/cpb.56.254 Chen, 2004, Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 52, 1066, 10.1248/cpb.52.1066 Chen, 2006, Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 54, 1486, 10.1248/cpb.54.1486 Chiou, 2007, Partial crystallization behavior during spray drying: simulations and experiments, Dry. Technol., 26, 27, 10.1080/07373930701781181 Chow, L.C., Sun, L., 2010. Nanostructured bioactive materials prepared by dual nozzle spray drying techniques. United States Patent & Trademark Office, US7670579B2. Cilurzo, 2008, Characterization and physical stability of fast-dissolving microparticles containing nifedipine, Eur. J. Pharm. Biopharm., 68, 579, 10.1016/j.ejpb.2007.06.012 Cilurzo, 2007, Binary polymeric blends to microencapsulate nitroflurbiprofen: physicochemical and in silico studies, Eur. J. Pharm. Sci., 31, 202, 10.1016/j.ejps.2007.03.010 Corrigan, 2003, The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials, Int. J. Pharm., 262, 125, 10.1016/S0378-5173(03)00338-7 Corrigan, 2004, T Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems, Int. J. Pharm., 273, 171, 10.1016/j.ijpharm.2004.01.005 Corrigan, 1995, Thermal analysis of spray dried products, Thermochim. Acta, 248, 245, 10.1016/0040-6031(94)01891-J Corrigan, 2002, Comparative physicochemical properties of hydrocortisone–PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying, Int. J. Pharm., 245, 75, 10.1016/S0378-5173(02)00326-5 Corrigan, 1983, Physicochemical properties of spray dried drugs: phenobarbitone and hydroflumethiazide, Ind. Pharm., 9, 1, 10.3109/03639048309048541 Corrigan, 1984, Amorphous spray-dried hydroflumethiazide-polyvinylpyrrolidone systems: physicochemical properties, J. Pharm. Pharmacol., 36, 217, 10.1111/j.2042-7158.1984.tb04353.x Corrigan, 1985, Mechanisms of dissolution of fast release solid dispersions, Drug Dev. Ind. Pharm., 11, 697, 10.3109/03639048509056896 Craig, 2002, The mechanisms of drug release from solid dispersions in water-soluble polymers, Int. J. Pharm., 231, 131, 10.1016/S0378-5173(01)00891-2 Cui, Y., Murphy, M., Dinehart, K., Hurter, P., Connelly, P., 2006. Pharmaceutical compositions. US Patent Application, 20,060,089,385. Curatolo, 2009, Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu, Pharm. Res., 26, 1419, 10.1007/s11095-009-9852-z Dahlberg, C., 2010. Doctoral Thesis. Drugs and polymers in dissolving solid dispersions: NMR imaging and spectroscopy. Royal Institute of Technology, Stockholm. Dahlberg, 2008, Surface composition and contact angle relationships for differently prepared solid dispersions, Eur. J. Pharm. Biopharm., 70, 478, 10.1016/j.ejpb.2008.05.026 Dahlberg, 2010, Relationships between solid dispersion preparation process, particle size and drug release–an NMR and NMR microimaging study, Eur. J. Pharm. Biopharm., 76, 311, 10.1016/j.ejpb.2010.06.006 Dahlberg, 2010, Polymer–drug interactions and wetting of solid dispersions, Eur. J. Pharm. Sci., 39, 125, 10.1016/j.ejps.2009.11.005 Dhumal, 2009, Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability, J. Pharm. Pharmacol., 61, 743, 10.1211/jpp.61.06.0006 Dhumal, 2007, Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers, Acta Pharm., 57, 287, 10.2478/v10007-007-0023-7 Dobry, D., 2011. Spray-dried dispersion background and science of scale. AAPS Annual Meeting & Exposition. Dobry, 2009, A model-based methodology for spray-drying process development, J. Pharm. Innov., 4, 133, 10.1007/s12247-009-9064-4 Dontireddy, 2011, A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions, Drug Dev. Ind. Pharm., 37, 1, 10.3109/03639045.2011.562213 Duret, 2012, Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties, Int. J. Pharm., 428, 103, 10.1016/j.ijpharm.2012.03.002 El-Badry, 2010, Improvement of the in vitro release of omeprazole from suppository bases using Kollicoat IR, J. Drug Del. Sci. Tech., 20, 391, 10.1016/S1773-2247(10)50064-9 E.L-Badry, 2010, Effects of Kollicoat IR® and hydroxypropyl-β-cyclodextrin on the dissolution rate of omeprazole from its microparticles and enteric-coated capsules, Pharm. Dev. Technol., 15, 500, 10.3109/10837450903300171 Elversson, 2005, Particle size and density in spray drying—effects of carbohydrate properties, J. Pharm. Sci., 94, 2049, 10.1002/jps.20418 Engers, 2010, A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion, J. Pharm. Sci., 99, 3901, 10.1002/jps.22233 Fogler, 1938, Spray drying, Ind. Eng. Chem. Res., 30, 1372, 10.1021/ie50348a007 Fouad, 2011, The use of spray-drying to enhance celecoxib solubility, Drug Dev. Ind. Pharm., 37, 1463, 10.3109/03639045.2011.587428 Friesen, 2008, Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions. An overview, Mol. Pharm., 5, 1003, 10.1021/mp8000793 Gad, 2012, Preparation and characterisation of novel spray-dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, J. Pharm. Pharmacol., 10.1201/b12007 Ghebremeskel, 2007, Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer–surfactant combinations using solubility parameters and testing the processability, Int. J. Pharm., 328, 119, 10.1016/j.ijpharm.2006.08.010 Goddeeris, 2008, Formulation of fast disintegrating tablets of ternary solid dispersions consisting of TPGS 1000 and HPMC 2910 or PVPVA 64 to improve the dissolution of the anti-HIV drug UC 781, Eur. J. Pharm. Sci., 34, 293, 10.1016/j.ejps.2008.05.005 Gonnissen, 2007, Development of directly compressible powders via co-spray drying, Eur. J. Pharm. Biopharm., 67, 220, 10.1016/j.ejpb.2006.12.021 Gonnissen, 2008, Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs, Eur. J. Pharm. Biopharm., 69, 320, 10.1016/j.ejpb.2007.11.009 Greenhalgh, 1999, Solubility parameters as predictors of miscibility in solid dispersions, J. Pharm. Sci., 88, 1182, 10.1021/js9900856 Grisedale, 2012, An investigation into water interactions with amorphous and milled salbutamol sulphate: the development of predictive models for uptake and recrystallization, Int. J. Pharm., 422, 220, 10.1016/j.ijpharm.2011.10.055 Guns, 2011, Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol, Pharm. Res., 28, 673, 10.1007/s11095-010-0324-2 Guns, 2010, Characterization of the copolymer poly (ethyleneglycol-g-vinylalcohol) as a potential carrier in the formulation of solid dispersions, Eur. J. Pharm. Biopharm., 74, 239, 10.1016/j.ejpb.2009.09.009 Gupta, 2005, Spray drying for generation of a ternary amorphous system of celecoxib, PVP, and meglumine, Pharm. Dev. Technol., 10, 273, 10.1081/PDT-54460 Hasegawa, 1985, Physical properties of solid dispersions of poorly water-soluble drugs with enteric coating agents, Chem. Pharm. Bull. (Tokyo), 33, 3429, 10.1248/cpb.33.3429 Heng, 2011, The nano spray dryer B-90, Expert Opin. Drug Deliv., 8, 965, 10.1517/17425247.2011.588206 Huang, 2011, Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers, Int. J. Pharm., 420, 59, 10.1016/j.ijpharm.2011.08.021 ICHQ3(R5), 2011. Impurities guideline for residual solvents, International Conference on Harmonisation, Geneva. ICHQ8(R2), 2009. Pharmaceutical Development, International Conference on Harmonisation, Geneva. Imamura, 2011, Influence of compression on water sorption, glass transition, and enthalpy relaxation behavior of freeze-dried amorphous sugar matrices, Int. J. Pharm., 408, 76, 10.1016/j.ijpharm.2011.01.052 Islam, 2010, The effect of different atomizing gases and drying media on the crystallization behavior of spray-dried powders, Dry. Technol., 28, 1035, 10.1080/07373937.2010.505513 Islam, 2010, An investigation into lactose crystallization under high temperature conditions during spray drying, Food Res. Int., 43, 46, 10.1016/j.foodres.2009.08.010 Ivanov, 2009, Effect of chirality on PVP/drug interaction within binary physical mixtures of ibuprofen, ketoprofen, and naproxen. A DSC study, Chirality, 21, 719, 10.1002/chir.20671 Jachowicz, 2008, Preparation and evaluation of piroxicam-HPMCAS solid dispersions for ocular use, Pharm. Dev. Technol., 13, 495, 10.1080/10837450802282462 Jachowicz, 1997, Enhanced release of oxazepam from tablets containing solid dispersions, Int. J. Pharm., 159, 149, 10.1016/S0378-5173(97)00279-2 Jachowicz, 1993, Solid dispersions of oxazepam, Int. J. Pharm., 99, 321, 10.1016/0378-5173(93)90375-P Janssens, 2009, Spray drying from complex solvent systems broadens the applicability of Kollicoat IR as a carrier in the formulation of solid dispersions, Eur. J. Pharm. Sci., 37, 241, 10.1016/j.ejps.2009.02.020 Janssens, 2007, The use of a new hydrophilic polymer, Kollicoat IR, in the formulation of solid dispersions of Itraconazole, Eur. J. Pharm. Sci., 30, 288, 10.1016/j.ejps.2006.11.015 Janssens, 2008, Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5, J. Pharm. Sci., 97, 2110, 10.1002/jps.21128 Janssens, 2010, Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and eudragit E100, Pharm. Res., 27, 775, 10.1007/s11095-010-0069-y Janssens, 2008, Influence of polyethylene glycol chain length on compatibility and release characteristics of ternary solid dispersions of itraconazole in polyethylene glycol/hydroxypropylmethylcellulose 2910 E5 blends, Eur. J. Pharm. Sci., 35, 203, 10.1016/j.ejps.2008.06.014 Janssens, 2008, Evaluation of the formulation of solid dispersions by co-spray drying itraconazole with Inutec SP1, a polymeric surfactant, in combination with PVPVA 64, Eur. J. Pharm. Biopharm., 70, 500, 10.1016/j.ejpb.2008.05.025 Janssens, 2008, Formulation and characterization of ternary solid dispersions made up of itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study, Eur. J. Pharm. Biopharm., 69, 158, 10.1016/j.ejpb.2007.11.004 Jung, 1999, Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique, Int. J. Pharm., 187, 209, 10.1016/S0378-5173(99)00191-X Kai, 1996, Oral absorption improvement of poorly soluble drug using solid dispersion technique, Chem. Pharm. Bull. (Tokyo), 44, 568, 10.1248/cpb.44.568 Kamlet, 1983, Linear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, .pi.*, .alpha., and .beta., and some methods for simplifying the generalized solvatochromic equation, J. Org. Chem., 48, 2877, 10.1021/jo00165a018 Kang, 2011, Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS), Eur. J. Pharm. Biopharm., 80, 289, 10.1016/j.ejpb.2011.11.005 Karavas, 2007, Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug–polymer interactions, Eur. J. Pharm. Biopharm., 66, 334, 10.1016/j.ejpb.2006.11.020 Kawashima, 1975, Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique, J. Pharm. Pharmcol., 27, 1, 10.1111/j.2042-7158.1975.tb09369.x Ke, 2012, Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions, Int. J. Pharm., 422, 170, 10.1016/j.ijpharm.2011.10.047 Kennedy, 2008, Enhanced bioavailability of a poorly soluble VR1 antagonist using an amorphous solid dispersion approach. A case study, Mol. Pharm., 5, 981, 10.1021/mp800061r Kiil, 2011, Mathematical modelling of simultaneous solvent evaporation and chemical curing in thermoset coatings. A parameter study, Prog. Org. Coat., 70, 192, 10.1016/j.porgcoat.2010.08.013 Kim, 2003, On the mechanisms of surface formation and the surface compositions of industrial milk powders, Dry. Technol., 21, 265, 10.1081/DRT-120017747 Kim, 2008, Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process, Int. J. Pharm., 359, 211, 10.1016/j.ijpharm.2008.04.006 Kim, 2011, New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs, Int. J. Pharm., 415, 129, 10.1016/j.ijpharm.2011.05.059 Konno, 2006, Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine, J. Pharm. Sci., 95, 2692, 10.1002/jps.20697 Kudra, 2008, Pulse-combustion drying: status and potentials, Dry. Technol., 26, 1409, 10.1080/07373930802458812 Langrish, 2007, New engineered particles from spray dryers. Research needs in spray drying, Dry. Technol., 25, 971, 10.1080/07373930701396766 Langrish, 2008, Assessing the rate of solid-phase crystallization for lactose: the effect of the difference between material and glass-transition temperatures, Food Res. Int., 41, 630, 10.1016/j.foodres.2008.04.010 Law, 2001, Physicochemical considerations in the preparation of amorphous ritonavir–poly (ethylene glycol) 8000 solid dispersions, J. Pharm. Sci., 90, 1015, 10.1002/jps.1054 Leane, 2012, Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant, Pharm. Dev. Technol., Early Online, 1 Lebrun, 2012, Design space approach in the optimization of the spray-drying process, Eur. J. Pharm. Biopharm., 80, 226, 10.1016/j.ejpb.2011.09.014 Lee, 2001, Bioavailability of cyclosporin A dispersed in sodium lauryl sulfate–dextrin based solid microspheres, Int. J. Pharm., 218, 125, 10.1016/S0378-5173(01)00621-4 Lee, 2010, Interaction between physical aging, deformation, and segmental mobility in poly (methyl methacrylate) glasses, J. Chem. Phys., 133, 014901, 10.1063/1.3450318 Lee, 2009, Deformation-induced mobility in polymer glasses during multistep creep experiments and simulations, Macromolecules, 42, 4328, 10.1021/ma900394n Lee, 2011, Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy, Int. J. Pharm., 403, 192, 10.1016/j.ijpharm.2010.10.012 Lee, T., 2003. Chemical screening method. United States Patent & Trademark Office, US20030129753. Lee, 2003, Drug-carrier screening on a chip, Pharma. Technol,, 27, 40 Leiterer, 2008, Structure analysis using acoustically levitated droplets, Anal. Bioanal. Chem., 391, 1221, 10.1007/s00216-008-2011-2 Leuner, 2000, Improving drug solubility for oral delivery using solid dispersions, Eur. J. Pharm. Biopharm., 50, 47, 10.1016/S0939-6411(00)00076-X Li, 2011, Formation of bicalutamide nanodispersion for dissolution rate enhancement, Int. J. Pharm., 404, 257, 10.1016/j.ijpharm.2010.11.015 Li, 2010, Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium, Biol. Pharm. Bull., 33, 279, 10.1248/bpb.33.279 Li, 2010, Nanoparticles by spray drying using innovative new technology: the Buchi Nano Spray Dryer B-90, J. Controlled Release, 147, 304, 10.1016/j.jconrel.2010.07.113 Lim, 2010, Development of novel sibutramine base-loaded solid dispersion with gelatin and HPMC: physicochemical characterization and pharmacokinetics in beagle dogs, Int. J. Pharm., 397, 225, 10.1016/j.ijpharm.2010.07.013 Lindfors, 2008, Nucleation and crystal growth in supersaturated solutions of a model drug, J. Colloid Interface Sci., 325, 404, 10.1016/j.jcis.2008.05.034 Littringer, 2012, Spray drying of mannitol as a drug carrier—the impact of process parameters on product properties, Dry. Technol., 30, 114, 10.1080/07373937.2011.620726 Loebmann, 2011, Co-amorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen, Mol. Pharm., 8, 1919, 10.1021/mp2002973 Lubach, 2007, Investigation of the effects of pharmaceutical processing upon solid-state NMR relaxation times and implications to solid-state formulation stability, J. Pharm. Sci., 96, 777, 10.1002/jps.20684 Maas, 2011, The impact of spray drying outlet temperature on the particle morphology of mannitol, Powder Technol., 213, 27, 10.1016/j.powtec.2011.06.024 Mahlin, 2011, Toward in silico prediction of glass-forming ability from molecular structure alone. A screening tool in early drug development, Mol. Pharm., 8, 498, 10.1021/mp100339c Malavolta, 2002, Solvation of polymers as model for solvent effect investigation: proposition of a novel polarity scale, Tetrahedron, 58, 4383, 10.1016/S0040-4020(02)00417-9 Mansky, 2007, Screening method to identify preclinical liquid and semi-solid formulations for low solubility compounds: miniaturization and automation of solvent casting and dissolution testing, J. Pharm. Sci., 96, 1548, 10.1002/jps.20799 Marin, 2011, Order-to-disorder transition in ring-shaped colloidal stains, Phys. Rev. Lett., 107, 855021, 10.1103/PhysRevLett.107.085502 Mitchnick, 2011, Solumer™ technology: a viable oral dosage form option for BCS class II molecules, ONdrugDelivery, 1, 861 Marsac, 2009, Estimation of drug–polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters, Pharm. Res., 26, 139, 10.1007/s11095-008-9721-1 Martins, 2012, Microstructured ternary solid dispersions to improve carbamazepine solubility, Powder Technol., 215-216, 156, 10.1016/j.powtec.2011.09.041 Matsuda, 1992, Amorphism and physicochemical stability of spray-dried frusemide, J. Pharm. Pharmacol., 44, 627, 10.1111/j.2042-7158.1992.tb05483.x Maury, 2005, Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer, Eur. J. Pharm. Biopharm., 59, 565, 10.1016/j.ejpb.2004.10.002 Miller, 2012, Spray-drying technology, vol. 3, 363 Millqvist-Fureby, 1999, Spray-drying of trypsin—surface characterisation and activity preservation, Int. J. Pharm., 188, 243, 10.1016/S0378-5173(99)00226-4 Miyazaki, 2011, Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP, Int. J. Pharm., 407, 111, 10.1016/j.ijpharm.2011.01.035 Mizoe, 2007, One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier, J. Controlled Release, 120, 205, 10.1016/j.jconrel.2007.05.002 Mizoe, 2008, Application of a four-fluid nozzle spray drier to prepare inhalable rifampicin-containing mannitol microparticles, AAPS PharmSciTech., 9, 755, 10.1208/s12249-008-9109-x Mizuno, 2005, Inhibition of a solid phase reaction among excipients that accelerates drug release from a solid dispersion with aging, Int. J. Pharm., 305, 37, 10.1016/j.ijpharm.2005.08.021 Molyneux, 1961, The interaction of polyvinylpyrrolidone with aromatic compounds in aqueous solution. Part 1I.l The effect of the interaction on the molecular size of the polymer2, J. Am. Chem. Soc., 83, 3175, 10.1021/ja01476a002 Mosén, 2006, The apparent plasticizing effect of polyethylene glycol (PEG) on the crystallinity of spray dried lactose/PEG composites, Eur. J. Pharm. Biopharm., 64, 206, 10.1016/j.ejpb.2006.05.015 Murtomaa, 2004, Static electrification of powders during spray drying, J. Electrost., 62, 63, 10.1016/j.elstat.2004.05.001 Nagy, 2009, Process parameter analysis and process understanding—some industrial examples, Powder Technol., 189, 343, 10.1016/j.powtec.2008.04.032 Nair, 2001, Influence of various drugs on the glass transition temperature of poly (vinylpyrrolidone): a thermodynamic and spectroscopic investigation, Int. J. Pharm., 225, 83, 10.1016/S0378-5173(01)00767-0 Nandiyanto, 2011, Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges, Adv. Powder Technol., 22, 1, 10.1016/j.apt.2010.09.011 Newman, 2012, Assessing the performance of amorphous solid dispersions, J. Pharm. Sci., 101, 1355, 10.1002/jps.23031 Nollenberger, 2009, Using polymers to enhance solubility of poorly soluble drugs, Pharma. Technol. Oakley, 2004, Spray dryer modeling in theory and practice, Dry. Technol., 22, 1371, 10.1081/DRT-120038734 Oh, 2011, Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change, Drug Deliv., 18, 46, 10.3109/10717544.2010.509365 Ohashi, 2009, One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis, J. Controlled Release, 135, 19, 10.1016/j.jconrel.2008.11.027 Ohta, 2005, A study of the differences between two amorphous spray-dried samples of cefditoren pivoxil which exhibited different physical stabilities, Int. J. Pharm., 289, 31, 10.1016/j.ijpharm.2004.09.029 Orienti, 2002, Polyvinylalcohol substituted with triethyleneglycolmonoethylether as a new material for preparation of solid dispersions of hydrophobic drugs, Eur. J. Pharm. Biopharm., 54, 229, 10.1016/S0939-6411(02)00055-3 Otsuka, 1993, Hygroscopic stability and dissolution properties of spray-dried solid dispersions of furosemide with eudragit, J. Pharm. Sci., 82, 32, 10.1002/jps.2600820108 Ozer, R.W., Lockwood Jr, H., Kimball, G.J., Pikus, I., 1993. Pulse combustion drying system. United States Patent & Trademark Office, US5252061. Palmieri, 2002, Lonidamine solid dispersions: in vitro and in vivo evaluation, Drug Dev. Ind. Pharm., 28, 1241, 10.1081/DDC-120015357 Paradkar, 2004, Characterization of curcumin–PVP solid dispersion obtained by spray drying, Int. J. Pharm., 271, 281, 10.1016/j.ijpharm.2003.11.014 Paramita, 2010, Effect of additives on the morphology of spray-dried powder, Dry. Technol., 28, 323, 10.1080/07373931003627098 Paramita, 2010, Effect of feed liquid temperature on the structural morphologies of d-limonene microencapsulated powder and its preservation, J. Food Sci., 75, E39, 10.1111/j.1750-3841.2009.01406.x Park, 2009, Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution, Arch. Pharm. Res., 32, 767, 10.1007/s12272-009-1516-3 Park, 2009, Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate, Arch. Pharm. Res., 32, 893, 10.1007/s12272-009-1611-5 Park, 2010, Development of novel itraconazole-loaded solid dispersion without crystalline change with improved bioavailability, Arch. Pharm. Res., 33, 1217, 10.1007/s12272-010-0812-2 Patel, 2012, Preparation and structural characterization of amorphous spray-dried dispersions of tenoxicam with enhanced dissolution, J. Pharm. Sci., 101, 641, 10.1002/jps.22800 Patel, 2005, Prediction of spray-dried product quality using two simple drying kinetics models, J. Food Process Eng., 28, 567, 10.1111/j.1745-4530.2005.00039.x Patterson, 2007, Preparation of glass solutions of three poorly water soluble drugs by spray drying melt extrusion and ball milling, Int. J. Pharm., 336, 22, 10.1016/j.ijpharm.2006.11.030 Patterson, 2008, Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers, Drug Dev. Ind. Pharm., 34, 95, 10.1080/03639040701484627 Paudel, 2012, Influence of solvent composition on the miscibility and physical stability of naproxen/PVP K 25 solid dispersions prepared by cosolvent spray-drying, Pharm. Res., 29, 1, 10.1007/s11095-011-0539-x Paudel, 2010, Theoretical and experimental investigation on the solid solubility and miscibility of naproxen in poly(vinylpyrrolidone), Mol. Pharm., 7, 1133, 10.1021/mp100013p Peltonen, 2010, Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles, Expert Opin. Drug Deliv., 7, 705, 10.1517/17425241003716802 Percy, S.R., 1872. Improvement in drying and concentrating liquid substances by atomizing. United States Patent & Trademark Office, US125,406. Pokharkar, 2006, Development, characterization and stabilization of amorphous form of a low Tg drug, Powder Technol., 167, 20, 10.1016/j.powtec.2006.05.012 Puri, 2011, Investigation of atypical dissolution behavior of an encapsulated amorphous solid dispersion, J. Pharm. Sci., 100, 2460, 10.1002/jps.22462 Puri, 2012, Barrier coated drug layered particles for enhanced performance of amorphous solid dispersion dosage form, J. Pharm. Sci., 101, 342, 10.1002/jps.22743 Puri, 2010, Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug, Eur. J. Pharm. Sci., 40, 84, 10.1016/j.ejps.2010.03.003 Pyo, 2007, Preparation and dissolution profiles of the amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel, Dry. Technol., 25, 1759, 10.1080/07373930701593180 Qian, 2010, Drug–polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development, J. Pharm. Sci., 99, 2941, 10.1002/jps.22074 Qian, 2007, Mechanistic investigation of Pluronic® based nano-crystalline drug-polymer solid dispersions, Pharm. Res., 24, 1551, 10.1007/s11095-007-9275-7 Radnik, 2011, Levitated droplets as model system for spray drying of complex oxides. A simultaneous in situ X-ray diffraction/Raman study, Chem. Mater., 23, 5425, 10.1021/cm202674f Raith, 2002, Characterization of povidone products by means of 13C-NMR, MALDI-TOF, and electrospray mass spectrometry, Pharm. Res., 19, 556, 10.1023/A:1015172402248 Rane, 2007, Investigations on factors affecting chitosan for dissolution enhancement of oxcarbazepine by spray dried microcrystal formulation with an experimental design approach, Drug Dev. Ind. Pharm., 33, 1008, 10.1080/03639040601179749 Ré, 2006, Formulating drug delivery systems by spray drying, Dry. Technol., 24, 433, 10.1080/07373930600611877 Rizi, 2011, Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties, J. Pharm. Sci., 100, 566, 10.1002/jps.22291 Rumondor, 2009, Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture, Mol. Pharm., 7, 477, 10.1021/mp9002283 Sahoo, 2009, Solubility enhancement of a poorly water-soluble anti-malarial drug: experimental design and use of a modified multifluid nozzle pilot spray drier, J. Pharm. Sci., 98, 281, 10.1002/jps.21399 Sahoo, 2010, Fabrication of composite microparticles of artemisinin for dissolution enhancement, Powder Technol., 203, 277, 10.1016/j.powtec.2010.05.019 Sahoo, 2011, Dissolution enhancement of a poorly water-soluble antimalarial drug by means of a modified multi-fluid nozzle pilot spray drier, Mater. Sci. Eng. C, 31, 391, 10.1016/j.msec.2010.10.018 Sajewicz, 2010, Spontaneous oscillatory in vitro chiral conversion of simple carboxylic acids and its possible mechanism, J. Phys. Org. Chem., 23, 1066, 10.1002/poc.1739 Schmolka, 1991, A comparison of block copolymer surfactant gels, J. Am. Oil Chem. Soc., 68, 206, 10.1007/BF02657771 Shah, N., Sandhu, H., Choi, D. S., Kalb, O., Page, S., Wyttenbach, N., 2012. Structured development approach for amorphous systems. In: Williams III, R.O., Watts, A.B., Miller, D.A., Gil, M. (Eds.), Vol. 3, Formulating Poorly Water Soluble Drugs. pp. 267–310. Shanbhag, 2008, Method for screening of solid dispersion formulations of low-solubility compounds—miniaturization and automation of solvent casting and dissolution testing, Int. J. Pharm., 351, 209, 10.1016/j.ijpharm.2007.09.042 Shi, 2012, A novel spray-drying technology to improve the bioavailability of biopharmaceutical classification system class II molecules, Drug Dev. Deliv., 12, 26 Shimpi, 2007, Application of polyglycolized glycerides in protection of amorphous form of etoricoxib during compression, Chem. Pharm. Bull. (Tokyo), 55, 1448, 10.1248/cpb.55.1448 Shimpi, 2009, Study on mechanism for amorphous drug stabilization using gelucire 50/13, Chem. Pharm. Bull., 57, 937, 10.1248/cpb.57.937 Singh, 2011, Oral formulation strategies to improve solubility of poorly water-soluble drugs, Expert Opin. Drug Deliv., 8, 1361, 10.1517/17425247.2011.606808 Sollohub, 2010, Spray drying technique: II. Current applications in pharmaceutical technology, J. Pharm. Sci., 99, 587, 10.1002/jps.21963 Sonje, 2011, Effect of counterions on the properties of amorphous atorvastatin salts, Eur. J. Pharm. Sci., 44, 462, 10.1016/j.ejps.2011.08.023 Srinarong, 2011, Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations, Expert Opin. Drug Deliv., 8, 1, 10.1517/17425247.2011.598147 Sun, 2010, Solubilities of crystalline drugs in polymers: an improved analytical method and comparison of solubilities of indomethacin and nifedipine in PVP, PVP/VA, and PVAc, J. Pharm. Sci., 99, 4023, 10.1002/jps.22251 Takeuchi, 1987, Enhancement of the dissolution rate of a poorly water-soluble drug (tolbutamide) by a spray-drying solvent deposition method and disintegrants, J. Pharm. Pharmacol., 39, 769, 10.1111/j.2042-7158.1987.tb05117.x Thiele, 2011, Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer, Lab Chip, 11, 2362, 10.1039/c1lc20298g Thybo, 2008, Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion, Pharm. Res., 25, 1610, 10.1007/s11095-008-9565-8 Thybo, 2007, Characterization and physical stability of tolfenamic acid-PVP K30 solid dispersions, Pharm. Dev. Technol., 12, 43, 10.1080/10837450601166577 Thybo, 2008, Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30, Pharm. Dev. Technol., 13, 375, 10.1080/10837450802244843 Tobyn, 2009, Amorphous drug–PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state, J. Pharm. Sci., 98, 3456, 10.1002/jps.21738 Tomasko, 1999, Tailoring of specific interactions to modify the morphology of naproxen, J. Cryst. Growth, 205, 233, 10.1016/S0022-0248(99)00237-7 Tung, 2011, Formulation of solid dispersion of rebamipide evaluated in a rat model for improved bioavailability and efficacy, J. Pharm. Pharmacol., 63, 1539, 10.1111/j.2042-7158.2011.01360.x Uchiyama, 2011, Fluorescence investigation of a specific structure formed by aggregation of transglycosylated stevias: solubilizing effect of poorly water-soluble drugs, Eur. J. Pharm. Sci., 43, 71, 10.1016/j.ejps.2011.03.014 Uchiyama, 2010, Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with a-glucosyl hesperidin, Int. J. Pharm., 392, 101, 10.1016/j.ijpharm.2010.03.037 Uchiyama, 2010, Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability, Eur. J. Pharm. Biopharm., 76, 238, 10.1016/j.ejpb.2010.07.006 Ueno, 1998, Pharmaceutics: characterization of amorphous ursodeoxycholic acid prepared by spray-drying, J. Pharm. Pharmacol., 50, 1213, 10.1111/j.2042-7158.1998.tb03336.x Van den Mooter, G., 2011. The use of amorphous solid dispersions: a formulation strategy to overcome poor solubility and dissolution rate. Drug Discov. Today: Technol., in press, http://dx.doi.org/10.1016/j.ddtec.2011.10.002. Van den Mooter, 2006, Evaluation of Inutec SP1 as a new carrier in the formulation of solid dispersions for poorly soluble drugs, Int. J. Pharm., 316, 1, 10.1016/j.ijpharm.2006.02.025 van Drooge, 2004, Solid dispersions based on inulin for the stabilisation and formulation of (9-tetrahydrocannabinol, Eur. J. Pharm. Sci., 21, 511, 10.1016/j.ejps.2003.11.014 Van Eerdenbrugh, 2011, An ab initio polymer selection methodology to prevent crystallization in amorphous solid dispersions by application of crystal engineering principles, CrystEngComm, 13, 6171, 10.1039/c1ce05183k Vandecruys, 2007, Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design, Int. J. Pharm., 342, 168, 10.1016/j.ijpharm.2007.05.006 Vehring, 2008, Pharmaceutical particle engineering via spray drying, Pharm. Res., 25, 999, 10.1007/s11095-007-9475-1 Vehring, 2007, Particle formation in spray drying, J. Aerosol Sci., 38, 728, 10.1016/j.jaerosci.2007.04.005 Vogt, 2008, Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations, Eur. J. Pharm. Biopharm., 68, 283, 10.1016/j.ejpb.2007.05.010 Wang, 2009, Effect of process parameters on the performance of spray dried hydroxyapatite microspheres, Powder Technol., 191, 1, 10.1016/j.powtec.2008.10.020 Wang, 2007, Improvement of the dissolution rate of nitrendipine using a new pulse combustion drying method, Chem. Pharm. Bull. (Tokyo), 55, 1119, 10.1248/cpb.55.1119 Wang, 2009, A review of process simulations and the use of additives in spray drying, Food Res. Int., 42, 13, 10.1016/j.foodres.2008.09.006 Weber, 2012, Acoustic levitation: recent developments and emerging opportunities in biomaterials research, Eur. Biophys. J., 41, 397, 10.1007/s00249-011-0767-3 Weuts, 2004, Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64, Eur. J. Pharm. Sci., 22, 375, 10.1016/j.ejps.2004.04.002 Weuts, 2005, Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64, Eur. J. Pharm. Sci., 25, 313, 10.1016/j.ejps.2005.03.012 Weuts, 2005, Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying, Eur. J. Pharm. Biopharm., 59, 119, 10.1016/j.ejpb.2004.05.011 Weuts, 2005, Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage, Eur. J. Pharm. Sci., 25, 387, 10.1016/j.ejps.2005.04.011 Weuts, 2011, Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: Etravirine, J. Pharm. Sci., 100, 260, 10.1002/jps.22242 Wong, 2006, Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles, Int. J. Pharm., 317, 61, 10.1016/j.ijpharm.2006.03.001 Wu, 2011, Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability, Eur. J. Pharm. Sci., 44, 610, 10.1016/j.ejps.2011.10.008 Wu, 2007, Inhibiting surface crystallization of amorphous indomethacin by nanocoating, Langmuir, 23, 5148, 10.1021/la070050i Wulsten, 2009, Levitated single-droplet drying: case study with itraconazole dried in binary organic solvent mixtures, Int. J. Pharm., 378, 116, 10.1016/j.ijpharm.2009.05.060 Xu, 2007, Preparation and evaluation of ibuprofen solid dispersion systems with kollidon particles using a pulse combustion dryer system, Chem. Pharm. Bull. (Tokyo), 55, 1545, 10.1248/cpb.55.1545 Xu, 2009, Improvement of dissolution rate of ibuprofen by solid dispersion systems with Kollicoat IR using a pulse combustion dryer system, J. Drug Del. Sci. Tech., 19, 113, 10.1016/S1773-2247(09)50018-4 Yamaguchi, 1992, Glass formation of 4-O-(4-methoxyphenyl) acetyltylosin and physicochemical stability of the amorphous solid, Int. J. Pharm., 85, 87, 10.1016/0378-5173(92)90137-Q Yan, 2012, Novel valsartan-loaded solid dispersion with enhanced bioavailability and no crystalline changes, Int. J. Pharm., 422, 202, 10.1016/j.ijpharm.2011.10.053 Yassin, 2009, Preparation and characterization of spironolactone-loaded gelucire microparticles using spray-drying technique, Drug Dev. Ind. Pharm., 35, 297, 10.1080/03639040802302157 Yi, 2008, A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs, Eur. J. Pharm. Biopharm., 70, 439, 10.1016/j.ejpb.2008.05.001 Yin, 2005, Bioavailability enhancement of a COX-2 inhibitor, BMS-347070, from a nanocrystalline dispersion prepared by spray-drying, J. Pharm. Sci., 94, 1598, 10.1002/jps.20366 Yoo, 2009, Miscibility/stability considerations in binary solid dispersion systems composed of functional excipients towards the design of multi-component amorphous systems, J. Pharm. Sci., 98, 4711, 10.1002/jps.21779 Yu, 2011, Solid lipid nanoparticles self-assembled from electrosprayed polymer-based microparticles, J. Mater. Chem., 21, 15957, 10.1039/c1jm12720a Yu, 2011, Polymer-based nanoparticulate solid dispersions prepared by a modified electrospraying process, J. Biomed. Sci. Eng., 4, 741, 10.4236/jbise.2011.412091 Zalcenstein, 2010, SoluBest‘s Solumer™ solubilising platform: an all in one technology, ONdrugDelivery, 1, 27 Zhang, 2011, A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity, J. Pharm. Sci., 100, 2778, 10.1002/jps.22512 Zhang, 2011, NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs, J. Pharm. Sci., 100, 4421, 10.1002/jps.22606 Zhang, 2011, Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug, Mol. Pharm., 8, 807, 10.1021/mp100401d Zhu, 2008, Surface-enhanced crystallization of amorphous nifedipine, Mol. Pharm., 5, 921, 10.1021/mp8000638 Zhu, 2012, Modification of crystallization behavior in drug/polyethylene glycol solid dispersions, Mol. Pharm., 9, 546, 10.1021/mp200546p