Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations
Tài liệu tham khảo
Adhikari, 2003, Surface stickiness of drops of carbohydrate and organic acid solutions during convective drying: experiments and modeling, Dry. Technol., 21, 839, 10.1081/DRT-120021689
Aınaoui, 1998, Modelling the plasma drug level with oral controlled release dosage forms with lipidic Gelucire, Int. J. Pharm., 169, 155, 10.1016/S0378-5173(98)00105-7
Al-Obaidi, 2009, Anomalous properties of spray dried solid dispersions, J. Pharm. Sci., 98, 4724, 10.1002/jps.21782
Al-Obaidi, 2009, Evaluation of griseofulvin binary and ternary solid dispersions with HPMCAS, AAPS PharmSciTech., 10, 1172, 10.1208/s12249-009-9319-x
Al-Obaidi, 2011, Characterization and stability of ternary solid dispersions with PVP and PHPMA, Int. J. Pharm., 419, 20, 10.1016/j.ijpharm.2011.06.052
Albers, 2011, Evaluation of predictive models for stable solid solution formation, J. Pharm. Sci., 100, 667, 10.1002/jps.22313
Alexander, 1985, Factors governing surface morphology of spray-dried amorphous substances, Dry. Technol., 3, 321, 10.1080/07373938508916275
Alhalaweh, 2010, Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying, Cryst. Growth Des., 10, 3302, 10.1021/cg100451q
Alonzo, 2011, Dissolution and precipitation behavior of amorphous solid dispersions, J. Pharm. Sci., 100, 3316, 10.1002/jps.22579
Alves, 2004, Phospholipid dry powders produced by spray drying processing: structural, thermodynamic and physical properties, Powder Technol., 145, 139, 10.1016/j.powtec.2004.06.008
Ambike, 2004, Stability study of amorphous valdecoxib, Int. J. Pharm., 282, 151, 10.1016/j.ijpharm.2004.06.009
Ambike, 2005, Spray-dried amorphous solid dispersions of simvastatin, a low Tg drug: In Vitro and in Vivo evaluations, Pharm. Res., 22, 990, 10.1007/s11095-005-4594-z
Ambühl, M., Haeberlin, B., Lückel, B., Meinzer, A., Lambert, O., Marchal, L., 2010. Pharmaceutical composition. United States Patent and Trademark Office, US 2010/0215734 A1.
Ansari, 2008, Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone, Arch. Pharm. Res., 31, 390, 10.1007/s12272-001-1169-6
Araújo, 2010, The preparation of ternary solid dispersions of an herbal drug via spray drying of liquid feed, Dry. Technol., 28, 412, 10.1080/07373931003648540
Arnum, 2010, Green drug delivery: spray-dried solid amorphous dispersions with a cellulosic exicpient, Pharm. Technol.
Ayenew, 2012, Can compression induce demixing in amorphous solid dispersions? A case study of naproxen – PVP K25, Eur. J. Pharm. Biopharm., 81, 207, 10.1016/j.ejpb.2012.01.007
Baek, 2011, Enhanced solubility and bioavailability of flurbiprofen by cycloamylose, Arch. Pharm. Res., 34, 391, 10.1007/s12272-011-0306-x
Bain, 1999, Solvent influence on spray-dried biodegradable microspheres, J. Microencapsul., 16, 453, 10.1080/026520499288915
Baird, 2012, Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state, Pharm. Res., 1, 271, 10.1007/s11095-011-0540-4
Balakrishnan, 2009, Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS), Eur. J. Pharm. Biopharm., 72, 539, 10.1016/j.ejpb.2009.03.001
Baldinger, 2011, Quality by design approach in the optimization of the spray-drying process, Pharm. Dev. Technol.
Bee, 2010, Using polymer technology to enhance bioavailability, Pharm. Technol.
Benmore, 2011, Amorphization of molecular liquids of pharmaceutical drugs by acoustic levitation, Phys. Rev. X, 1, 110041, 10.1103/PhysRevX.1.011004
Bercea, 2009, Islands of immiscibility for solutions of compatible polymers in a common solvent: experiment and theory, Macromolecules, 42, 3620, 10.1021/ma9002769
Bercea, 2009, Vapor pressures of polymer solutions and the modeling of their composition dependence, Ind. Eng. Chem. Res., 48, 4603, 10.1021/ie801965h
Beyerinck, R.A., Diebele, H.L.M., Dobry, D.E., Ray, R.J., Settell, D.M., Spence, K.R., 2005. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus. United States Patent & Trademark Office, US20110277339.
Beyerinck, R.A., Diebele, H.L.M., Dobry, D.E., Ray, R.J., Settell, D.M., Spence, K.R., 2005. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus. United States Patent & Trademark Office, US6973741B2.
Beyerinck, R.A., Dobry, D.E., Friesen, D.T., Settell, D.M., Ray, R.J., 2005. Spray drying processes for forming solid amorphous dispersions of drugs and polymers. WO Patent WO/2005,011,636.
Beyerinck, R.A., Ray, R.J., Dobry, D.E.,Settell, D.M., 2010. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles. United States Patent & Trademark Office, US7780988.
Bhende, 2012, Moringa coagulant as a stabilizer for amorphous solids: Part I, AAPS PharmSciTech., 1
Bikiaris, 2011, Solid dispersions Part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs, Expert Opin. Drug Deliv., 8, 1501, 10.1517/17425247.2011.618181
Biradar, 2006, A comparative study of approaches used to improve solubility of roxithromycin, Powder Technol., 169, 22, 10.1016/j.powtec.2006.07.016
Bittorf, K.J., Katstra, J.P., Gaspar, F., 2009. Fluidized spray drying. United States Patent and Treademark Office, US20100011610.
Bittorf, K.J., Katstra, J.P., Gaspar, F., 2009. Pharmaceutical compositions. United States Patent and Trademark Office, US20090247468.
Bodmeier, 1988, Solvent selection in the preparation of poly (dl-lactide) microspheres prepared by the solvent evaporation method, Int. J. Pharm., 43, 179, 10.1016/0378-5173(88)90073-7
Boghra, 2011, Solubility, dissolution rate and bioavailability enhancement of irbesartan by solid dispersion technique, Chem. Pharm. Bull., 59, 438, 10.1248/cpb.59.438
Bohr, 2011, Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying, Int. J. Pharm., 412, 59, 10.1016/j.ijpharm.2011.04.005
Bohr, 2012, Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug, J. R. Soc. Interface, 10.1098/rsif.2012.0166
Bothiraja, 2009, Evaluation of molecular pharmaceutical and in vivo properties of spray-dried isolated andrographolide—PVP, J. Pharm. Pharmacol., 61, 1465, 10.1211/jpp.61.11.0005
Bothiraja, 2009, Evaluation of molecular pharmaceutical and in vivo properties of spray-dried isolated andrographolide-PVP, J. Pharm. Pharmacol., 61, 1465, 10.1211/jpp.61.11.0005
Buhler, 2005, Soluble polyvinylpyrrolidone (povidone)
Cal, 2010, Spray drying technique. I. Hardware and process parameters, J. Pharm. Sci., 99, 575, 10.1002/jps.21886
Caron, 2011, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Mol. Pharm., 8, 532, 10.1021/mp1003674
Celik, 2007, Spray drying and pharmaceutical applications, 129
Chauhan, 2005, Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique, AAPS PharmSciTech, 6, E405, 10.1208/pt060350
Chiou, 1971, Pharmaceutical application of solid dispersion system, J. Pharm. Sci., 60, 1281, 10.1002/jps.2600600902
Chen, 2008, Preparation of functional composite particles of salbutamol sulfate using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 56, 254, 10.1248/cpb.56.254
Chen, 2004, Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 52, 1066, 10.1248/cpb.52.1066
Chen, 2006, Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique, Chem. Pharm. Bull. (Tokyo), 54, 1486, 10.1248/cpb.54.1486
Chiou, 2007, Partial crystallization behavior during spray drying: simulations and experiments, Dry. Technol., 26, 27, 10.1080/07373930701781181
Chow, L.C., Sun, L., 2010. Nanostructured bioactive materials prepared by dual nozzle spray drying techniques. United States Patent & Trademark Office, US7670579B2.
Cilurzo, 2008, Characterization and physical stability of fast-dissolving microparticles containing nifedipine, Eur. J. Pharm. Biopharm., 68, 579, 10.1016/j.ejpb.2007.06.012
Cilurzo, 2007, Binary polymeric blends to microencapsulate nitroflurbiprofen: physicochemical and in silico studies, Eur. J. Pharm. Sci., 31, 202, 10.1016/j.ejps.2007.03.010
Corrigan, 2003, The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials, Int. J. Pharm., 262, 125, 10.1016/S0378-5173(03)00338-7
Corrigan, 2004, T Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems, Int. J. Pharm., 273, 171, 10.1016/j.ijpharm.2004.01.005
Corrigan, 1995, Thermal analysis of spray dried products, Thermochim. Acta, 248, 245, 10.1016/0040-6031(94)01891-J
Corrigan, 2002, Comparative physicochemical properties of hydrocortisone–PVP composites prepared using supercritical carbon dioxide by the GAS anti-solvent recrystallization process, by coprecipitation and by spray drying, Int. J. Pharm., 245, 75, 10.1016/S0378-5173(02)00326-5
Corrigan, 1983, Physicochemical properties of spray dried drugs: phenobarbitone and hydroflumethiazide, Ind. Pharm., 9, 1, 10.3109/03639048309048541
Corrigan, 1984, Amorphous spray-dried hydroflumethiazide-polyvinylpyrrolidone systems: physicochemical properties, J. Pharm. Pharmacol., 36, 217, 10.1111/j.2042-7158.1984.tb04353.x
Corrigan, 1985, Mechanisms of dissolution of fast release solid dispersions, Drug Dev. Ind. Pharm., 11, 697, 10.3109/03639048509056896
Craig, 2002, The mechanisms of drug release from solid dispersions in water-soluble polymers, Int. J. Pharm., 231, 131, 10.1016/S0378-5173(01)00891-2
Cui, Y., Murphy, M., Dinehart, K., Hurter, P., Connelly, P., 2006. Pharmaceutical compositions. US Patent Application, 20,060,089,385.
Curatolo, 2009, Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu, Pharm. Res., 26, 1419, 10.1007/s11095-009-9852-z
Dahlberg, C., 2010. Doctoral Thesis. Drugs and polymers in dissolving solid dispersions: NMR imaging and spectroscopy. Royal Institute of Technology, Stockholm.
Dahlberg, 2008, Surface composition and contact angle relationships for differently prepared solid dispersions, Eur. J. Pharm. Biopharm., 70, 478, 10.1016/j.ejpb.2008.05.026
Dahlberg, 2010, Relationships between solid dispersion preparation process, particle size and drug release–an NMR and NMR microimaging study, Eur. J. Pharm. Biopharm., 76, 311, 10.1016/j.ejpb.2010.06.006
Dahlberg, 2010, Polymer–drug interactions and wetting of solid dispersions, Eur. J. Pharm. Sci., 39, 125, 10.1016/j.ejps.2009.11.005
Dhumal, 2009, Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability, J. Pharm. Pharmacol., 61, 743, 10.1211/jpp.61.06.0006
Dhumal, 2007, Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers, Acta Pharm., 57, 287, 10.2478/v10007-007-0023-7
Dobry, D., 2011. Spray-dried dispersion background and science of scale. AAPS Annual Meeting & Exposition.
Dobry, 2009, A model-based methodology for spray-drying process development, J. Pharm. Innov., 4, 133, 10.1007/s12247-009-9064-4
Dontireddy, 2011, A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions, Drug Dev. Ind. Pharm., 37, 1, 10.3109/03639045.2011.562213
Duret, 2012, Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties, Int. J. Pharm., 428, 103, 10.1016/j.ijpharm.2012.03.002
El-Badry, 2010, Improvement of the in vitro release of omeprazole from suppository bases using Kollicoat IR, J. Drug Del. Sci. Tech., 20, 391, 10.1016/S1773-2247(10)50064-9
E.L-Badry, 2010, Effects of Kollicoat IR® and hydroxypropyl-β-cyclodextrin on the dissolution rate of omeprazole from its microparticles and enteric-coated capsules, Pharm. Dev. Technol., 15, 500, 10.3109/10837450903300171
Elversson, 2005, Particle size and density in spray drying—effects of carbohydrate properties, J. Pharm. Sci., 94, 2049, 10.1002/jps.20418
Engers, 2010, A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion, J. Pharm. Sci., 99, 3901, 10.1002/jps.22233
Fogler, 1938, Spray drying, Ind. Eng. Chem. Res., 30, 1372, 10.1021/ie50348a007
Fouad, 2011, The use of spray-drying to enhance celecoxib solubility, Drug Dev. Ind. Pharm., 37, 1463, 10.3109/03639045.2011.587428
Friesen, 2008, Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions. An overview, Mol. Pharm., 5, 1003, 10.1021/mp8000793
Gad, 2012, Preparation and characterisation of novel spray-dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, J. Pharm. Pharmacol., 10.1201/b12007
Ghebremeskel, 2007, Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer–surfactant combinations using solubility parameters and testing the processability, Int. J. Pharm., 328, 119, 10.1016/j.ijpharm.2006.08.010
Goddeeris, 2008, Formulation of fast disintegrating tablets of ternary solid dispersions consisting of TPGS 1000 and HPMC 2910 or PVPVA 64 to improve the dissolution of the anti-HIV drug UC 781, Eur. J. Pharm. Sci., 34, 293, 10.1016/j.ejps.2008.05.005
Gonnissen, 2007, Development of directly compressible powders via co-spray drying, Eur. J. Pharm. Biopharm., 67, 220, 10.1016/j.ejpb.2006.12.021
Gonnissen, 2008, Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs, Eur. J. Pharm. Biopharm., 69, 320, 10.1016/j.ejpb.2007.11.009
Greenhalgh, 1999, Solubility parameters as predictors of miscibility in solid dispersions, J. Pharm. Sci., 88, 1182, 10.1021/js9900856
Grisedale, 2012, An investigation into water interactions with amorphous and milled salbutamol sulphate: the development of predictive models for uptake and recrystallization, Int. J. Pharm., 422, 220, 10.1016/j.ijpharm.2011.10.055
Guns, 2011, Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol, Pharm. Res., 28, 673, 10.1007/s11095-010-0324-2
Guns, 2010, Characterization of the copolymer poly (ethyleneglycol-g-vinylalcohol) as a potential carrier in the formulation of solid dispersions, Eur. J. Pharm. Biopharm., 74, 239, 10.1016/j.ejpb.2009.09.009
Gupta, 2005, Spray drying for generation of a ternary amorphous system of celecoxib, PVP, and meglumine, Pharm. Dev. Technol., 10, 273, 10.1081/PDT-54460
Hasegawa, 1985, Physical properties of solid dispersions of poorly water-soluble drugs with enteric coating agents, Chem. Pharm. Bull. (Tokyo), 33, 3429, 10.1248/cpb.33.3429
Heng, 2011, The nano spray dryer B-90, Expert Opin. Drug Deliv., 8, 965, 10.1517/17425247.2011.588206
Huang, 2011, Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers, Int. J. Pharm., 420, 59, 10.1016/j.ijpharm.2011.08.021
ICHQ3(R5), 2011. Impurities guideline for residual solvents, International Conference on Harmonisation, Geneva.
ICHQ8(R2), 2009. Pharmaceutical Development, International Conference on Harmonisation, Geneva.
Imamura, 2011, Influence of compression on water sorption, glass transition, and enthalpy relaxation behavior of freeze-dried amorphous sugar matrices, Int. J. Pharm., 408, 76, 10.1016/j.ijpharm.2011.01.052
Islam, 2010, The effect of different atomizing gases and drying media on the crystallization behavior of spray-dried powders, Dry. Technol., 28, 1035, 10.1080/07373937.2010.505513
Islam, 2010, An investigation into lactose crystallization under high temperature conditions during spray drying, Food Res. Int., 43, 46, 10.1016/j.foodres.2009.08.010
Ivanov, 2009, Effect of chirality on PVP/drug interaction within binary physical mixtures of ibuprofen, ketoprofen, and naproxen. A DSC study, Chirality, 21, 719, 10.1002/chir.20671
Jachowicz, 2008, Preparation and evaluation of piroxicam-HPMCAS solid dispersions for ocular use, Pharm. Dev. Technol., 13, 495, 10.1080/10837450802282462
Jachowicz, 1997, Enhanced release of oxazepam from tablets containing solid dispersions, Int. J. Pharm., 159, 149, 10.1016/S0378-5173(97)00279-2
Jachowicz, 1993, Solid dispersions of oxazepam, Int. J. Pharm., 99, 321, 10.1016/0378-5173(93)90375-P
Janssens, 2009, Spray drying from complex solvent systems broadens the applicability of Kollicoat IR as a carrier in the formulation of solid dispersions, Eur. J. Pharm. Sci., 37, 241, 10.1016/j.ejps.2009.02.020
Janssens, 2007, The use of a new hydrophilic polymer, Kollicoat IR, in the formulation of solid dispersions of Itraconazole, Eur. J. Pharm. Sci., 30, 288, 10.1016/j.ejps.2006.11.015
Janssens, 2008, Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5, J. Pharm. Sci., 97, 2110, 10.1002/jps.21128
Janssens, 2010, Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and eudragit E100, Pharm. Res., 27, 775, 10.1007/s11095-010-0069-y
Janssens, 2008, Influence of polyethylene glycol chain length on compatibility and release characteristics of ternary solid dispersions of itraconazole in polyethylene glycol/hydroxypropylmethylcellulose 2910 E5 blends, Eur. J. Pharm. Sci., 35, 203, 10.1016/j.ejps.2008.06.014
Janssens, 2008, Evaluation of the formulation of solid dispersions by co-spray drying itraconazole with Inutec SP1, a polymeric surfactant, in combination with PVPVA 64, Eur. J. Pharm. Biopharm., 70, 500, 10.1016/j.ejpb.2008.05.025
Janssens, 2008, Formulation and characterization of ternary solid dispersions made up of itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study, Eur. J. Pharm. Biopharm., 69, 158, 10.1016/j.ejpb.2007.11.004
Jung, 1999, Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique, Int. J. Pharm., 187, 209, 10.1016/S0378-5173(99)00191-X
Kai, 1996, Oral absorption improvement of poorly soluble drug using solid dispersion technique, Chem. Pharm. Bull. (Tokyo), 44, 568, 10.1248/cpb.44.568
Kamlet, 1983, Linear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, .pi.*, .alpha., and .beta., and some methods for simplifying the generalized solvatochromic equation, J. Org. Chem., 48, 2877, 10.1021/jo00165a018
Kang, 2011, Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS), Eur. J. Pharm. Biopharm., 80, 289, 10.1016/j.ejpb.2011.11.005
Karavas, 2007, Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug–polymer interactions, Eur. J. Pharm. Biopharm., 66, 334, 10.1016/j.ejpb.2006.11.020
Kawashima, 1975, Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique, J. Pharm. Pharmcol., 27, 1, 10.1111/j.2042-7158.1975.tb09369.x
Ke, 2012, Investigation of preparation methods on surface/bulk structural relaxation and glass fragility of amorphous solid dispersions, Int. J. Pharm., 422, 170, 10.1016/j.ijpharm.2011.10.047
Kennedy, 2008, Enhanced bioavailability of a poorly soluble VR1 antagonist using an amorphous solid dispersion approach. A case study, Mol. Pharm., 5, 981, 10.1021/mp800061r
Kiil, 2011, Mathematical modelling of simultaneous solvent evaporation and chemical curing in thermoset coatings. A parameter study, Prog. Org. Coat., 70, 192, 10.1016/j.porgcoat.2010.08.013
Kim, 2003, On the mechanisms of surface formation and the surface compositions of industrial milk powders, Dry. Technol., 21, 265, 10.1081/DRT-120017747
Kim, 2008, Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process, Int. J. Pharm., 359, 211, 10.1016/j.ijpharm.2008.04.006
Kim, 2011, New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs, Int. J. Pharm., 415, 129, 10.1016/j.ijpharm.2011.05.059
Konno, 2006, Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine, J. Pharm. Sci., 95, 2692, 10.1002/jps.20697
Kudra, 2008, Pulse-combustion drying: status and potentials, Dry. Technol., 26, 1409, 10.1080/07373930802458812
Langrish, 2007, New engineered particles from spray dryers. Research needs in spray drying, Dry. Technol., 25, 971, 10.1080/07373930701396766
Langrish, 2008, Assessing the rate of solid-phase crystallization for lactose: the effect of the difference between material and glass-transition temperatures, Food Res. Int., 41, 630, 10.1016/j.foodres.2008.04.010
Law, 2001, Physicochemical considerations in the preparation of amorphous ritonavir–poly (ethylene glycol) 8000 solid dispersions, J. Pharm. Sci., 90, 1015, 10.1002/jps.1054
Leane, 2012, Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant, Pharm. Dev. Technol., Early Online, 1
Lebrun, 2012, Design space approach in the optimization of the spray-drying process, Eur. J. Pharm. Biopharm., 80, 226, 10.1016/j.ejpb.2011.09.014
Lee, 2001, Bioavailability of cyclosporin A dispersed in sodium lauryl sulfate–dextrin based solid microspheres, Int. J. Pharm., 218, 125, 10.1016/S0378-5173(01)00621-4
Lee, 2010, Interaction between physical aging, deformation, and segmental mobility in poly (methyl methacrylate) glasses, J. Chem. Phys., 133, 014901, 10.1063/1.3450318
Lee, 2009, Deformation-induced mobility in polymer glasses during multistep creep experiments and simulations, Macromolecules, 42, 4328, 10.1021/ma900394n
Lee, 2011, Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy, Int. J. Pharm., 403, 192, 10.1016/j.ijpharm.2010.10.012
Lee, T., 2003. Chemical screening method. United States Patent & Trademark Office, US20030129753.
Lee, 2003, Drug-carrier screening on a chip, Pharma. Technol,, 27, 40
Leiterer, 2008, Structure analysis using acoustically levitated droplets, Anal. Bioanal. Chem., 391, 1221, 10.1007/s00216-008-2011-2
Leuner, 2000, Improving drug solubility for oral delivery using solid dispersions, Eur. J. Pharm. Biopharm., 50, 47, 10.1016/S0939-6411(00)00076-X
Li, 2011, Formation of bicalutamide nanodispersion for dissolution rate enhancement, Int. J. Pharm., 404, 257, 10.1016/j.ijpharm.2010.11.015
Li, 2010, Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium, Biol. Pharm. Bull., 33, 279, 10.1248/bpb.33.279
Li, 2010, Nanoparticles by spray drying using innovative new technology: the Buchi Nano Spray Dryer B-90, J. Controlled Release, 147, 304, 10.1016/j.jconrel.2010.07.113
Lim, 2010, Development of novel sibutramine base-loaded solid dispersion with gelatin and HPMC: physicochemical characterization and pharmacokinetics in beagle dogs, Int. J. Pharm., 397, 225, 10.1016/j.ijpharm.2010.07.013
Lindfors, 2008, Nucleation and crystal growth in supersaturated solutions of a model drug, J. Colloid Interface Sci., 325, 404, 10.1016/j.jcis.2008.05.034
Littringer, 2012, Spray drying of mannitol as a drug carrier—the impact of process parameters on product properties, Dry. Technol., 30, 114, 10.1080/07373937.2011.620726
Loebmann, 2011, Co-amorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen, Mol. Pharm., 8, 1919, 10.1021/mp2002973
Lubach, 2007, Investigation of the effects of pharmaceutical processing upon solid-state NMR relaxation times and implications to solid-state formulation stability, J. Pharm. Sci., 96, 777, 10.1002/jps.20684
Maas, 2011, The impact of spray drying outlet temperature on the particle morphology of mannitol, Powder Technol., 213, 27, 10.1016/j.powtec.2011.06.024
Mahlin, 2011, Toward in silico prediction of glass-forming ability from molecular structure alone. A screening tool in early drug development, Mol. Pharm., 8, 498, 10.1021/mp100339c
Malavolta, 2002, Solvation of polymers as model for solvent effect investigation: proposition of a novel polarity scale, Tetrahedron, 58, 4383, 10.1016/S0040-4020(02)00417-9
Mansky, 2007, Screening method to identify preclinical liquid and semi-solid formulations for low solubility compounds: miniaturization and automation of solvent casting and dissolution testing, J. Pharm. Sci., 96, 1548, 10.1002/jps.20799
Marin, 2011, Order-to-disorder transition in ring-shaped colloidal stains, Phys. Rev. Lett., 107, 855021, 10.1103/PhysRevLett.107.085502
Mitchnick, 2011, Solumer™ technology: a viable oral dosage form option for BCS class II molecules, ONdrugDelivery, 1, 861
Marsac, 2009, Estimation of drug–polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters, Pharm. Res., 26, 139, 10.1007/s11095-008-9721-1
Martins, 2012, Microstructured ternary solid dispersions to improve carbamazepine solubility, Powder Technol., 215-216, 156, 10.1016/j.powtec.2011.09.041
Matsuda, 1992, Amorphism and physicochemical stability of spray-dried frusemide, J. Pharm. Pharmacol., 44, 627, 10.1111/j.2042-7158.1992.tb05483.x
Maury, 2005, Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer, Eur. J. Pharm. Biopharm., 59, 565, 10.1016/j.ejpb.2004.10.002
Miller, 2012, Spray-drying technology, vol. 3, 363
Millqvist-Fureby, 1999, Spray-drying of trypsin—surface characterisation and activity preservation, Int. J. Pharm., 188, 243, 10.1016/S0378-5173(99)00226-4
Miyazaki, 2011, Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP, Int. J. Pharm., 407, 111, 10.1016/j.ijpharm.2011.01.035
Mizoe, 2007, One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier, J. Controlled Release, 120, 205, 10.1016/j.jconrel.2007.05.002
Mizoe, 2008, Application of a four-fluid nozzle spray drier to prepare inhalable rifampicin-containing mannitol microparticles, AAPS PharmSciTech., 9, 755, 10.1208/s12249-008-9109-x
Mizuno, 2005, Inhibition of a solid phase reaction among excipients that accelerates drug release from a solid dispersion with aging, Int. J. Pharm., 305, 37, 10.1016/j.ijpharm.2005.08.021
Molyneux, 1961, The interaction of polyvinylpyrrolidone with aromatic compounds in aqueous solution. Part 1I.l The effect of the interaction on the molecular size of the polymer2, J. Am. Chem. Soc., 83, 3175, 10.1021/ja01476a002
Mosén, 2006, The apparent plasticizing effect of polyethylene glycol (PEG) on the crystallinity of spray dried lactose/PEG composites, Eur. J. Pharm. Biopharm., 64, 206, 10.1016/j.ejpb.2006.05.015
Murtomaa, 2004, Static electrification of powders during spray drying, J. Electrost., 62, 63, 10.1016/j.elstat.2004.05.001
Nagy, 2009, Process parameter analysis and process understanding—some industrial examples, Powder Technol., 189, 343, 10.1016/j.powtec.2008.04.032
Nair, 2001, Influence of various drugs on the glass transition temperature of poly (vinylpyrrolidone): a thermodynamic and spectroscopic investigation, Int. J. Pharm., 225, 83, 10.1016/S0378-5173(01)00767-0
Nandiyanto, 2011, Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges, Adv. Powder Technol., 22, 1, 10.1016/j.apt.2010.09.011
Newman, 2012, Assessing the performance of amorphous solid dispersions, J. Pharm. Sci., 101, 1355, 10.1002/jps.23031
Nollenberger, 2009, Using polymers to enhance solubility of poorly soluble drugs, Pharma. Technol.
Oakley, 2004, Spray dryer modeling in theory and practice, Dry. Technol., 22, 1371, 10.1081/DRT-120038734
Oh, 2011, Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change, Drug Deliv., 18, 46, 10.3109/10717544.2010.509365
Ohashi, 2009, One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis, J. Controlled Release, 135, 19, 10.1016/j.jconrel.2008.11.027
Ohta, 2005, A study of the differences between two amorphous spray-dried samples of cefditoren pivoxil which exhibited different physical stabilities, Int. J. Pharm., 289, 31, 10.1016/j.ijpharm.2004.09.029
Orienti, 2002, Polyvinylalcohol substituted with triethyleneglycolmonoethylether as a new material for preparation of solid dispersions of hydrophobic drugs, Eur. J. Pharm. Biopharm., 54, 229, 10.1016/S0939-6411(02)00055-3
Otsuka, 1993, Hygroscopic stability and dissolution properties of spray-dried solid dispersions of furosemide with eudragit, J. Pharm. Sci., 82, 32, 10.1002/jps.2600820108
Ozer, R.W., Lockwood Jr, H., Kimball, G.J., Pikus, I., 1993. Pulse combustion drying system. United States Patent & Trademark Office, US5252061.
Palmieri, 2002, Lonidamine solid dispersions: in vitro and in vivo evaluation, Drug Dev. Ind. Pharm., 28, 1241, 10.1081/DDC-120015357
Paradkar, 2004, Characterization of curcumin–PVP solid dispersion obtained by spray drying, Int. J. Pharm., 271, 281, 10.1016/j.ijpharm.2003.11.014
Paramita, 2010, Effect of additives on the morphology of spray-dried powder, Dry. Technol., 28, 323, 10.1080/07373931003627098
Paramita, 2010, Effect of feed liquid temperature on the structural morphologies of d-limonene microencapsulated powder and its preservation, J. Food Sci., 75, E39, 10.1111/j.1750-3841.2009.01406.x
Park, 2009, Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution, Arch. Pharm. Res., 32, 767, 10.1007/s12272-009-1516-3
Park, 2009, Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate, Arch. Pharm. Res., 32, 893, 10.1007/s12272-009-1611-5
Park, 2010, Development of novel itraconazole-loaded solid dispersion without crystalline change with improved bioavailability, Arch. Pharm. Res., 33, 1217, 10.1007/s12272-010-0812-2
Patel, 2012, Preparation and structural characterization of amorphous spray-dried dispersions of tenoxicam with enhanced dissolution, J. Pharm. Sci., 101, 641, 10.1002/jps.22800
Patel, 2005, Prediction of spray-dried product quality using two simple drying kinetics models, J. Food Process Eng., 28, 567, 10.1111/j.1745-4530.2005.00039.x
Patterson, 2007, Preparation of glass solutions of three poorly water soluble drugs by spray drying melt extrusion and ball milling, Int. J. Pharm., 336, 22, 10.1016/j.ijpharm.2006.11.030
Patterson, 2008, Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers, Drug Dev. Ind. Pharm., 34, 95, 10.1080/03639040701484627
Paudel, 2012, Influence of solvent composition on the miscibility and physical stability of naproxen/PVP K 25 solid dispersions prepared by cosolvent spray-drying, Pharm. Res., 29, 1, 10.1007/s11095-011-0539-x
Paudel, 2010, Theoretical and experimental investigation on the solid solubility and miscibility of naproxen in poly(vinylpyrrolidone), Mol. Pharm., 7, 1133, 10.1021/mp100013p
Peltonen, 2010, Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles, Expert Opin. Drug Deliv., 7, 705, 10.1517/17425241003716802
Percy, S.R., 1872. Improvement in drying and concentrating liquid substances by atomizing. United States Patent & Trademark Office, US125,406.
Pokharkar, 2006, Development, characterization and stabilization of amorphous form of a low Tg drug, Powder Technol., 167, 20, 10.1016/j.powtec.2006.05.012
Puri, 2011, Investigation of atypical dissolution behavior of an encapsulated amorphous solid dispersion, J. Pharm. Sci., 100, 2460, 10.1002/jps.22462
Puri, 2012, Barrier coated drug layered particles for enhanced performance of amorphous solid dispersion dosage form, J. Pharm. Sci., 101, 342, 10.1002/jps.22743
Puri, 2010, Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug, Eur. J. Pharm. Sci., 40, 84, 10.1016/j.ejps.2010.03.003
Pyo, 2007, Preparation and dissolution profiles of the amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel, Dry. Technol., 25, 1759, 10.1080/07373930701593180
Qian, 2010, Drug–polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development, J. Pharm. Sci., 99, 2941, 10.1002/jps.22074
Qian, 2007, Mechanistic investigation of Pluronic® based nano-crystalline drug-polymer solid dispersions, Pharm. Res., 24, 1551, 10.1007/s11095-007-9275-7
Radnik, 2011, Levitated droplets as model system for spray drying of complex oxides. A simultaneous in situ X-ray diffraction/Raman study, Chem. Mater., 23, 5425, 10.1021/cm202674f
Raith, 2002, Characterization of povidone products by means of 13C-NMR, MALDI-TOF, and electrospray mass spectrometry, Pharm. Res., 19, 556, 10.1023/A:1015172402248
Rane, 2007, Investigations on factors affecting chitosan for dissolution enhancement of oxcarbazepine by spray dried microcrystal formulation with an experimental design approach, Drug Dev. Ind. Pharm., 33, 1008, 10.1080/03639040601179749
Ré, 2006, Formulating drug delivery systems by spray drying, Dry. Technol., 24, 433, 10.1080/07373930600611877
Rizi, 2011, Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties, J. Pharm. Sci., 100, 566, 10.1002/jps.22291
Rumondor, 2009, Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture, Mol. Pharm., 7, 477, 10.1021/mp9002283
Sahoo, 2009, Solubility enhancement of a poorly water-soluble anti-malarial drug: experimental design and use of a modified multifluid nozzle pilot spray drier, J. Pharm. Sci., 98, 281, 10.1002/jps.21399
Sahoo, 2010, Fabrication of composite microparticles of artemisinin for dissolution enhancement, Powder Technol., 203, 277, 10.1016/j.powtec.2010.05.019
Sahoo, 2011, Dissolution enhancement of a poorly water-soluble antimalarial drug by means of a modified multi-fluid nozzle pilot spray drier, Mater. Sci. Eng. C, 31, 391, 10.1016/j.msec.2010.10.018
Sajewicz, 2010, Spontaneous oscillatory in vitro chiral conversion of simple carboxylic acids and its possible mechanism, J. Phys. Org. Chem., 23, 1066, 10.1002/poc.1739
Schmolka, 1991, A comparison of block copolymer surfactant gels, J. Am. Oil Chem. Soc., 68, 206, 10.1007/BF02657771
Shah, N., Sandhu, H., Choi, D. S., Kalb, O., Page, S., Wyttenbach, N., 2012. Structured development approach for amorphous systems. In: Williams III, R.O., Watts, A.B., Miller, D.A., Gil, M. (Eds.), Vol. 3, Formulating Poorly Water Soluble Drugs. pp. 267–310.
Shanbhag, 2008, Method for screening of solid dispersion formulations of low-solubility compounds—miniaturization and automation of solvent casting and dissolution testing, Int. J. Pharm., 351, 209, 10.1016/j.ijpharm.2007.09.042
Shi, 2012, A novel spray-drying technology to improve the bioavailability of biopharmaceutical classification system class II molecules, Drug Dev. Deliv., 12, 26
Shimpi, 2007, Application of polyglycolized glycerides in protection of amorphous form of etoricoxib during compression, Chem. Pharm. Bull. (Tokyo), 55, 1448, 10.1248/cpb.55.1448
Shimpi, 2009, Study on mechanism for amorphous drug stabilization using gelucire 50/13, Chem. Pharm. Bull., 57, 937, 10.1248/cpb.57.937
Singh, 2011, Oral formulation strategies to improve solubility of poorly water-soluble drugs, Expert Opin. Drug Deliv., 8, 1361, 10.1517/17425247.2011.606808
Sollohub, 2010, Spray drying technique: II. Current applications in pharmaceutical technology, J. Pharm. Sci., 99, 587, 10.1002/jps.21963
Sonje, 2011, Effect of counterions on the properties of amorphous atorvastatin salts, Eur. J. Pharm. Sci., 44, 462, 10.1016/j.ejps.2011.08.023
Srinarong, 2011, Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations, Expert Opin. Drug Deliv., 8, 1, 10.1517/17425247.2011.598147
Sun, 2010, Solubilities of crystalline drugs in polymers: an improved analytical method and comparison of solubilities of indomethacin and nifedipine in PVP, PVP/VA, and PVAc, J. Pharm. Sci., 99, 4023, 10.1002/jps.22251
Takeuchi, 1987, Enhancement of the dissolution rate of a poorly water-soluble drug (tolbutamide) by a spray-drying solvent deposition method and disintegrants, J. Pharm. Pharmacol., 39, 769, 10.1111/j.2042-7158.1987.tb05117.x
Thiele, 2011, Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer, Lab Chip, 11, 2362, 10.1039/c1lc20298g
Thybo, 2008, Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion, Pharm. Res., 25, 1610, 10.1007/s11095-008-9565-8
Thybo, 2007, Characterization and physical stability of tolfenamic acid-PVP K30 solid dispersions, Pharm. Dev. Technol., 12, 43, 10.1080/10837450601166577
Thybo, 2008, Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30, Pharm. Dev. Technol., 13, 375, 10.1080/10837450802244843
Tobyn, 2009, Amorphous drug–PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state, J. Pharm. Sci., 98, 3456, 10.1002/jps.21738
Tomasko, 1999, Tailoring of specific interactions to modify the morphology of naproxen, J. Cryst. Growth, 205, 233, 10.1016/S0022-0248(99)00237-7
Tung, 2011, Formulation of solid dispersion of rebamipide evaluated in a rat model for improved bioavailability and efficacy, J. Pharm. Pharmacol., 63, 1539, 10.1111/j.2042-7158.2011.01360.x
Uchiyama, 2011, Fluorescence investigation of a specific structure formed by aggregation of transglycosylated stevias: solubilizing effect of poorly water-soluble drugs, Eur. J. Pharm. Sci., 43, 71, 10.1016/j.ejps.2011.03.014
Uchiyama, 2010, Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with a-glucosyl hesperidin, Int. J. Pharm., 392, 101, 10.1016/j.ijpharm.2010.03.037
Uchiyama, 2010, Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability, Eur. J. Pharm. Biopharm., 76, 238, 10.1016/j.ejpb.2010.07.006
Ueno, 1998, Pharmaceutics: characterization of amorphous ursodeoxycholic acid prepared by spray-drying, J. Pharm. Pharmacol., 50, 1213, 10.1111/j.2042-7158.1998.tb03336.x
Van den Mooter, G., 2011. The use of amorphous solid dispersions: a formulation strategy to overcome poor solubility and dissolution rate. Drug Discov. Today: Technol., in press, http://dx.doi.org/10.1016/j.ddtec.2011.10.002.
Van den Mooter, 2006, Evaluation of Inutec SP1 as a new carrier in the formulation of solid dispersions for poorly soluble drugs, Int. J. Pharm., 316, 1, 10.1016/j.ijpharm.2006.02.025
van Drooge, 2004, Solid dispersions based on inulin for the stabilisation and formulation of (9-tetrahydrocannabinol, Eur. J. Pharm. Sci., 21, 511, 10.1016/j.ejps.2003.11.014
Van Eerdenbrugh, 2011, An ab initio polymer selection methodology to prevent crystallization in amorphous solid dispersions by application of crystal engineering principles, CrystEngComm, 13, 6171, 10.1039/c1ce05183k
Vandecruys, 2007, Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design, Int. J. Pharm., 342, 168, 10.1016/j.ijpharm.2007.05.006
Vehring, 2008, Pharmaceutical particle engineering via spray drying, Pharm. Res., 25, 999, 10.1007/s11095-007-9475-1
Vehring, 2007, Particle formation in spray drying, J. Aerosol Sci., 38, 728, 10.1016/j.jaerosci.2007.04.005
Vogt, 2008, Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations, Eur. J. Pharm. Biopharm., 68, 283, 10.1016/j.ejpb.2007.05.010
Wang, 2009, Effect of process parameters on the performance of spray dried hydroxyapatite microspheres, Powder Technol., 191, 1, 10.1016/j.powtec.2008.10.020
Wang, 2007, Improvement of the dissolution rate of nitrendipine using a new pulse combustion drying method, Chem. Pharm. Bull. (Tokyo), 55, 1119, 10.1248/cpb.55.1119
Wang, 2009, A review of process simulations and the use of additives in spray drying, Food Res. Int., 42, 13, 10.1016/j.foodres.2008.09.006
Weber, 2012, Acoustic levitation: recent developments and emerging opportunities in biomaterials research, Eur. Biophys. J., 41, 397, 10.1007/s00249-011-0767-3
Weuts, 2004, Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64, Eur. J. Pharm. Sci., 22, 375, 10.1016/j.ejps.2004.04.002
Weuts, 2005, Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64, Eur. J. Pharm. Sci., 25, 313, 10.1016/j.ejps.2005.03.012
Weuts, 2005, Study of the physicochemical properties and stability of solid dispersions of loperamide and PEG6000 prepared by spray drying, Eur. J. Pharm. Biopharm., 59, 119, 10.1016/j.ejpb.2004.05.011
Weuts, 2005, Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage, Eur. J. Pharm. Sci., 25, 387, 10.1016/j.ejps.2005.04.011
Weuts, 2011, Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: Etravirine, J. Pharm. Sci., 100, 260, 10.1002/jps.22242
Wong, 2006, Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles, Int. J. Pharm., 317, 61, 10.1016/j.ijpharm.2006.03.001
Wu, 2011, Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability, Eur. J. Pharm. Sci., 44, 610, 10.1016/j.ejps.2011.10.008
Wu, 2007, Inhibiting surface crystallization of amorphous indomethacin by nanocoating, Langmuir, 23, 5148, 10.1021/la070050i
Wulsten, 2009, Levitated single-droplet drying: case study with itraconazole dried in binary organic solvent mixtures, Int. J. Pharm., 378, 116, 10.1016/j.ijpharm.2009.05.060
Xu, 2007, Preparation and evaluation of ibuprofen solid dispersion systems with kollidon particles using a pulse combustion dryer system, Chem. Pharm. Bull. (Tokyo), 55, 1545, 10.1248/cpb.55.1545
Xu, 2009, Improvement of dissolution rate of ibuprofen by solid dispersion systems with Kollicoat IR using a pulse combustion dryer system, J. Drug Del. Sci. Tech., 19, 113, 10.1016/S1773-2247(09)50018-4
Yamaguchi, 1992, Glass formation of 4-O-(4-methoxyphenyl) acetyltylosin and physicochemical stability of the amorphous solid, Int. J. Pharm., 85, 87, 10.1016/0378-5173(92)90137-Q
Yan, 2012, Novel valsartan-loaded solid dispersion with enhanced bioavailability and no crystalline changes, Int. J. Pharm., 422, 202, 10.1016/j.ijpharm.2011.10.053
Yassin, 2009, Preparation and characterization of spironolactone-loaded gelucire microparticles using spray-drying technique, Drug Dev. Ind. Pharm., 35, 297, 10.1080/03639040802302157
Yi, 2008, A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs, Eur. J. Pharm. Biopharm., 70, 439, 10.1016/j.ejpb.2008.05.001
Yin, 2005, Bioavailability enhancement of a COX-2 inhibitor, BMS-347070, from a nanocrystalline dispersion prepared by spray-drying, J. Pharm. Sci., 94, 1598, 10.1002/jps.20366
Yoo, 2009, Miscibility/stability considerations in binary solid dispersion systems composed of functional excipients towards the design of multi-component amorphous systems, J. Pharm. Sci., 98, 4711, 10.1002/jps.21779
Yu, 2011, Solid lipid nanoparticles self-assembled from electrosprayed polymer-based microparticles, J. Mater. Chem., 21, 15957, 10.1039/c1jm12720a
Yu, 2011, Polymer-based nanoparticulate solid dispersions prepared by a modified electrospraying process, J. Biomed. Sci. Eng., 4, 741, 10.4236/jbise.2011.412091
Zalcenstein, 2010, SoluBest‘s Solumer™ solubilising platform: an all in one technology, ONdrugDelivery, 1, 27
Zhang, 2011, A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity, J. Pharm. Sci., 100, 2778, 10.1002/jps.22512
Zhang, 2011, NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs, J. Pharm. Sci., 100, 4421, 10.1002/jps.22606
Zhang, 2011, Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug, Mol. Pharm., 8, 807, 10.1021/mp100401d
Zhu, 2008, Surface-enhanced crystallization of amorphous nifedipine, Mol. Pharm., 5, 921, 10.1021/mp8000638
Zhu, 2012, Modification of crystallization behavior in drug/polyethylene glycol solid dispersions, Mol. Pharm., 9, 546, 10.1021/mp200546p