Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis

Journal of Controlled Release - Tập 266 - Trang 226-237 - 2017
Nesrine S. El-Mezayen1, Wessam F. El-Hadidy2, Wessam M. El-Refaie3, Th.I. Shalaby4, Mahmoud M. Khattab5, Aiman S. El-Khatib5
1Department of Pharmacology, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Egypt
2Department of Pharmacology and Experimental Therapeutics, Medical Research Institute, Alexandria University, Egypt
3Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Egypt
4Department of Medical Biophysics, Medical Research Institute, Alexandria University, Egypt
5Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Tài liệu tham khảo

Wang, 2014, The global burden of liver disease: the major impact of China, Hepatology, 60, 2099, 10.1002/hep.27406 Pinzani, 2015, Hepatic fibrosis: a global clinical problem, Stellate Cells Health Dis., 29, 10.1016/B978-0-12-800134-9.00003-8 Dobie, 2016, Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis, F1000Research, 5, 1749, 10.12688/f1000research.8822.1 Ferrarese, 2016, Liver transplantation for viral hepatitis in 2015, World J. Gastroenterol., 22, 1570, 10.3748/wjg.v22.i4.1570 2017, Regression of liver fibrosis Yoneda, 2016, Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence, Exp. Cell Res., 341, 8, 10.1016/j.yexcr.2016.01.012 Iredale, 2013, Extracellular matrix degradation in liver fibrosis: biochemistry and regulation, Biochim. Biophys. Acta (BBA) - Mol. Basis Dis., 1832, 876, 10.1016/j.bbadis.2012.11.002 Schon, 2016, Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis, Front. Pharmacol., 7, 33, 10.3389/fphar.2016.00033 Hayes, 2014, Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis, PLoS One, 9, e92925, 10.1371/journal.pone.0092925 Wagner, 2013, Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks, Sci. Signal., 6, ra58-ra, 10.1126/scisignal.2003994 Czochra, 2006, Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice, J. Hepatol., 45, 419, 10.1016/j.jhep.2006.04.010 Morphy, 2009, Selectively nonselective kinase inhibition: striking the right balance, J. Med. Chem., 53, 1413, 10.1021/jm901132v Qu, 2015, New insight into the anti-liver fibrosis effect of multitargeted tyrosine kinase inhibitors: from molecular target to clinical trials, Front. Pharmacol., 6, 300 Peng, 2005, Clinical pharmacokinetics of imatinib, Clin. Pharmacokinet., 44, 879, 10.2165/00003088-200544090-00001 Olivieri, 2009, Imatinib for refractory chronic graft-versus-host disease with fibrotic features, Blood, 114, 709, 10.1182/blood-2009-02-204156 Elmholdt, 2013, Anti-fibrotic effect after low-dose imatinib mesylate treatment in patients with nephrogenic systemic fibrosis: an open-label non-randomized, uncontrolled clinical trial, J. Eur. Acad. Dermatol. Venereol., 27, 779, 10.1111/j.1468-3083.2011.04398.x Council NR, 1996 Dua, 2012, Liposome: methods of preparation and applications, Int. J. Pharm. Stud. Res., 3, 14 Ye, 2014, Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting, Int. J. Nanomedicine, 9, 2167, 10.2147/IJN.S60178 Sato, 2008, Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone, Nat. Biotechnol., 26, 431, 10.1038/nbt1396 Pereira, 2015, Cationic liposome-multi-walled carbon nanotubes hybrids for dual siPLK1 and doxorubicin delivery in vitro, Pharm. Res., 32, 3293, 10.1007/s11095-015-1707-1 El-Refaie, 2015, Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies, Int. J. Pharm., 486, 88, 10.1016/j.ijpharm.2015.03.052 Patil, 2013, Development of UV-spectrophotometric method for the determination of Imatinib Mesylate (ITM) in bulk and formulation, Asian J. Pharm. Clin. Res., 6, 54 El-Refaie, 2015, Novel self-assembled, gel-core hyaluosomes for non-invasive management of osteoarthritis: in-vitro optimization, ex-vivo and in-vivo permeation, Pharm. Res., 32, 2901, 10.1007/s11095-015-1672-8 Ibrahim, 1991, Spectrophotometric assay of retinol via charge-transfer complexes, Microchim. Acta, 103, 209, 10.1007/BF01309027 Conrad, 2014, Identification of Quercus agrifolia (coast live oak) resistant to the invasive pathogen Phytophthora ramorum in native stands using Fourier-transform infrared (FT-IR) spectroscopy, Front. Plant Sci., 5, 521, 10.3389/fpls.2014.00521 Starkel, 2011, Animal models for the study of hepatic fibrosis, Best Pract. Res. Clin. Gastroenterol., 25, 319, 10.1016/j.bpg.2011.02.004 Kim, 2012, Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate, Liver Int., 32, 1008, 10.1111/j.1478-3231.2012.02806.x Alkharfy, 2013, Quantitative determination of imatinib stability under various stress conditions, J. Pharm. Bioallied Sci., 5, 49, 10.4103/0975-7406.106570 Teoh, 2010, HPLC determination of imatinib in plasma and tissues after multiple oral dose administration to mice, Pak. J. Pharm. Sci., 23, 35 Bancroft, 2008 Ishak, 1994, Chronic hepatitis: morphology and nomenclature, Mod. Pathol., 7, 690 Goodman, 2007, Grading and staging systems for inflammation and fibrosis in chronic liver diseases, J. Hepatol., 47, 598, 10.1016/j.jhep.2007.07.006 Reitman, 1957, A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am. J. Clin. Pathol., 28, 56, 10.1093/ajcp/28.1.56 Doumas, 1997, Albumin standards and the measurement of serum albumin with bromcresol green, Clin. Chim. Acta, 258, 21, 10.1016/S0009-8981(96)06447-9 Biggs, 1962 Fujimoto, 1993, A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies, Clin. Chim. Acta, 221, 91, 10.1016/0009-8981(93)90024-X Kropf, 1997, Immunological measurement of transforming growth factor-beta 1 (TGF-β1) in blood; assay development and comparison, Clin. Chem., 43, 1965, 10.1093/clinchem/43.10.1965 Woessner, 1961, The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid, Arch. Biochem. Biophys., 93, 440, 10.1016/0003-9861(61)90291-0 Kimura, 2008, Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation, Circulation, 118, S65, 10.1161/CIRCULATIONAHA.107.740613 Thampi, 2014, Indian J. Res. Pharm. Biotechnol., 2, 1082 Akagi, 2015, Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension, Int. Heart J., 56, 354, 10.1536/ihj.14-338 Adrian, 2007, A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats, Biochim. Biophys. Biomembr., 1768, 1430, 10.1016/j.bbamem.2007.03.027 Li, 2012, Effects of interferon-gamma liposomes targeted to platelet-derived growth factor receptor–beta on hepatic fibrosis in rats, J. Control. Release, 159, 261, 10.1016/j.jconrel.2011.12.023 Greupink, 2005, Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell, J. Hepatol., 43, 884, 10.1016/j.jhep.2005.04.014 Hagens, 2007, Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated, Pharm. Res., 24, 566, 10.1007/s11095-006-9175-2 Poosti, 2015, Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis, FASEB J., 29, 1029, 10.1096/fj.14-258459 Bansal, 2012, Selective targeting of interferon γ to stromal fibroblasts and pericytes as a novel therapeutic approach to inhibit angiogenesis and tumor growth, Mol. Cancer Ther., 11, 2419, 10.1158/1535-7163.MCT-11-0758 Prakash, 2010, A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier, J. Control. Release, 145, 91, 10.1016/j.jconrel.2010.03.018 Elnaggar, 2014, Lecithin-based nanostructured gels for skin delivery: an update on state of art and recent applications, J. Control. Release, 180, 10, 10.1016/j.jconrel.2014.02.004 Wen, 2016, Nanotechnology-based drug delivery systems for Alzheimer's disease management: technical, industrial, and clinical challenges, J. Control. Release, 245, 95, 10.1016/j.jconrel.2016.11.025 Azuma, 2007, Role of α1-acid glycoprotein in therapeutic anti-fibrotic effects of imatinib with macrolides in mice, Am. J. Respir. Crit. Care Med., 176, 1243, 10.1164/rccm.200702-178OC Li, 2015, Inhibition of liver fibrosis using vitamin A-coupled liposomes to deliver matrix metalloproteinase-2 siRNA in vitro, Mol. Med. Rep., 12, 3453, 10.3892/mmr.2015.3842 Quadro, 1999, Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein, EMBO J., 18, 4633, 10.1093/emboj/18.17.4633 Quadro, 2004, The role of extrahepatic retinol binding protein in the mobilization of retinoid stores, J. Lipid Res., 45, 1975, 10.1194/jlr.M400137-JLR200 Wang, 2015, Diagnostic imaging and therapeutic application of nanoparticles targeting the liver, J. Mater. Chem. B, 3, 939, 10.1039/C4TB01611D Poelstra, 2012, Drug targeting to the diseased liver, J. Control. Release, 161, 188, 10.1016/j.jconrel.2012.02.011 Hernández-Caselles, 1993, Influence of liposome charge and composition on their interaction with human blood serum proteins, Mol. Cell. Biochem., 120, 119, 10.1007/BF00926084 Pereira-Lachataignerais, 2006, Study and formation of vesicle systems with low polydispersity index by ultrasound method, Chem. Phys. Lipids, 140, 88, 10.1016/j.chemphyslip.2006.01.008 Gubernator, 2011, Active methods of drug loading into liposomes: recent strategies for stable drug entrapment and increased in vivo activity, Expert Opin. Drug Deliv., 8, 565, 10.1517/17425247.2011.566552 De Boeck, 1988, NMR study of the interaction of retinoids with phospholipid bilayers, Biochim. Biophys. Act Biomembr., 946, 244, 10.1016/0005-2736(88)90399-9 Wang, 2011, Recent advances of chitosan nanoparticles as drug carriers, Int. J. Nanomedicine, 6, 765 Kim, 2006, Retinol-encapsulated low molecular water-soluble chitosan nanoparticles, Int. J. Pharm., 319, 130, 10.1016/j.ijpharm.2006.03.040 Coates, 2000, Interpretation of infrared spectra, a practical approach Marty, 2009, Structural characterization of cationic lipid–tRNA complexes, Nucleic Acids Res., 37, 5197, 10.1093/nar/gkp543 Svensson, 2007, Retinoid chromophores as probes of membrane lipid order, J. Phys. Chem. B, 111, 10839, 10.1021/jp072890b Wassall, 1988, Electron spin resonance study of the interactions of retinoids with a phospholipid model membrane, Biochim. Biophys. Act Biomembr., 939, 393, 10.1016/0005-2736(88)90085-5 Noy, 1999, Physical-chemical properties and action of retinoids, 3 Hayashi, 2011, Animal models for the study of liver fibrosis: new insights from knockout mouse models, Am. J. Physiol. Gastrointest. Liver Physiol., 300, G729, 10.1152/ajpgi.00013.2011 AST, 2013 Wake, 2006, Hepatic stellate cells: three-dimensional structure, localization, heterogeneity and development, Proc. Jpn Acad. Ser. B, 82, 155, 10.2183/pjab.82.155 Seo, 2016, Hepatic non-parenchymal cells: master regulators of alcoholic liver disease?, World J. Gastroenterol., 22, 1348, 10.3748/wjg.v22.i4.1348 Fv, 2015, Targeted therapies in liver fibrosis: combining the best parts of platelet derived growth factor BB and interferon gamma, Front. Med., 2, 72 Gad, 2011 Cortes, 2016, Evaluating the impact of a switch to nilotinib on imatinib-related chronic low-grade adverse events in patients with CML-CP: The ENRICH Study, Clin. Lymphoma Myeloma Leuk., 16, 286, 10.1016/j.clml.2016.02.002 Darkow, 2007, Treatment interruptions and non-adherence with imatinib and associated healthcare costs, PharmacoEconomics, 25, 481, 10.2165/00019053-200725060-00004 Steegmann, 2012, Off-target effects of BCR–ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemia, Leuk. Lymphoma, 53, 2351, 10.3109/10428194.2012.695779 Chambers, 2017, Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity, Toxicology, 382, 24, 10.1016/j.tox.2017.03.006 Peerzada, 2011, Pulmonary toxicities of tyrosine kinase inhibitors, Clin. Adv. Hematol. Oncol., 9, 824 Spiekermann, 2016, Therapeutic management of acute lymphoblastic leukemia, 65 Kruk, 2013, Transactivation of platelet-derived growth factor receptor type β: mechanisms and potential relevance in, Neurobiology, 5 Contreras-Zentella, 2015, liver enzyme release really associated with cell necrosis induced by oxidant stress?, Oxidative Med. Cell. Longev., 2016, 1, 10.1155/2016/3529149 Salman, 2016, New era for usage of serum liver enzymes as a promising horizon for the prediction of non-alcoholic fatty liver disease, Open Access Macedonian J. Med. Sci., 4, 348, 10.3889/oamjms.2016.092 Giannini, 2005, Liver enzyme alteration: a guide for clinicians, Can. Med. Assoc. J., 172, 367, 10.1503/cmaj.1040752 Qu, 2016, Tyrosine kinase inhibitors: friends or foe in treatment of hepatic fibrosis?, Oncotarget, 7, 67650, 10.18632/oncotarget.11767 Ridruejo, 2007, Imatinib-induced fatal acute liver failure, World J. Gastroenterol., 13, 6608, 10.3748/wjg.v13.i48.6608 Shaker, 2011, Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis, Eur. J. Pharmacol., 670, 593, 10.1016/j.ejphar.2011.08.041 Kim, 2012, Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate, Liver Int., 32, 1008, 10.1111/j.1478-3231.2012.02806.x Zhang, 2015, Potent effects of dioscin against liver fibrosis, Sci Rep, 5, 9713, 10.1038/srep09713 Gressner, 2002, Roles of TGF-beta in hepatic fibrosis, Front. Biosci., 7, d793, 10.2741/A812 Duarte, 2015, Matrix metalloproteinases in liver injury, repair and fibrosis, Matrix Biol., 44, 147, 10.1016/j.matbio.2015.01.004 Yang, 2007, Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene, Comp. Hepatol., 6, 9, 10.1186/1476-5926-6-9 Gressner, 2007, Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options, Comp. Hepatol., 6, 7, 10.1186/1476-5926-6-7 Breitkopf, 2001, Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture, Hepatology, 33, 387, 10.1053/jhep.2001.21996 Takahara, 1997, Dual expression of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase in fibrotic human livers, Hepatology, 26, 1521, 10.1002/hep.510260620