Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress

Free Radical Biology and Medicine - Tập 91 - Trang 188-202 - 2016
Mohamed A. Abdelmegeed1, Youngshim Choi1, Seung-Kwon Ha1, Byoung-Joon Song1
1Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA

Tài liệu tham khảo

Kirkwood, 2005, Understanding the odd science of aging, Cell, 120, 437, 10.1016/j.cell.2005.01.027 Medvedev, 1990, An attempt at a rational classification of theories of ageing, Biol. Rev. Camb. Philos. Soc., 65, 375, 10.1111/j.1469-185X.1990.tb01428.x Sergiev, 2015, Theories of aging: an ever-evolving field, Acta Naturae, 7, 9, 10.32607/20758251-2015-7-1-9-18 Cefalu, 2011, Theories and mechanisms of aging, Clin. Geriatr. Med., 27, 491, 10.1016/j.cger.2011.07.001 Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J. Gerontol., 11, 298, 10.1093/geronj/11.3.298 Gladyshev, 2014, The free radical theory of aging is dead. Long live the damage theory!, Antioxid. Redox Signal., 20, 727, 10.1089/ars.2013.5228 Muller, 2007, Trends in oxidative aging theories, Free Radic. Biol. Med., 43, 477, 10.1016/j.freeradbiomed.2007.03.034 Hamilton, 2001, Does oxidative damage to DNA increase with age?, Proc. Natl. Acad. Sci. USA, 98, 10469, 10.1073/pnas.171202698 Nie, 2013, Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues, Oxid. Med. Cell. Longev., 2013, 303181, 10.1155/2013/303181 Schmucker, 1998, Aging and the liver: an update, J. Gerontol. A: Biol. Sci. Med. Sci., 53, B315, 10.1093/gerona/53A.5.B315 Kim, 2015, Aging and liver disease, Curr. Opin. Gastroenterol., 31, 184, 10.1097/MOG.0000000000000176 Mak, 2012, Hepatic steatosis, fibrosis, and cancer in elderly cadavers, Anat. Rec. (Hoboken), 295, 40, 10.1002/ar.21525 Colantoni, 2001, Evidence of oxidative injury during aging of the liver in a mouse model, J. Am. Aging Assoc., 24, 51 Lebel, 2011, Metabolism, genomics, and DNA repair in the mouse aging liver, Curr. Gerontol. Geriatr. Res., 2011, 859415, 10.1155/2011/859415 Aubert, 2011, Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role, Clin. Res. Hepatol. Gastroenterol., 35, 630, 10.1016/j.clinre.2011.04.015 Song, 1996, Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 update, Alcohol Clin. Exp. Res., 20, 138A, 10.1111/j.1530-0277.1996.tb01764.x Caro, 2004, Oxidative stress, toxicology, and pharmacology of CYP2E1, Annu. Rev. Pharmacol. Toxicol., 44, 27, 10.1146/annurev.pharmtox.44.101802.121704 Novak, 2000, The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression, Arch. Pharm. Res., 23, 267, 10.1007/BF02975435 Kim, 2007, The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression, Pharmacol. Ther., 113, 88, 10.1016/j.pharmthera.2006.07.004 Abdelmegeed, 2014, Functional roles of protein nitration in acute and chronic liver diseases, Oxid. Med. Cell. Longev., 2014, 149627, 10.1155/2014/149627 Cederbaum, 2003, Iron and CYP2E1-dependent oxidative stress and toxicity, Alcohol, 30, 115, 10.1016/S0741-8329(03)00104-6 Hunt, 1990, Effect of normal aging on the activity of human hepatic cytochrome P450IIE1, Biochem. Pharmacol., 40, 1666, 10.1016/0006-2952(90)90470-6 Wauthier, 2004, Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?, Arch. Toxicol., 78, 131, 10.1007/s00204-003-0526-z Yun, 2010, Age-related changes in hepatic expression and activity of cytochrome P450 in male rats, Arch. Toxicol., 84, 939, 10.1007/s00204-010-0520-1 Kwak, 2015, Effects of age increase on hepatic expression and activity of cytochrome P450 in male C57BL/6 mice, Arch. Pharm. Res., 38, 857, 10.1007/s12272-014-0452-z Sheedfar, 2013, Liver diseases and aging: friends or foes?, Aging Cell, 12, 950, 10.1111/acel.12128 Gregg, 2012, A mouse model of accelerated liver aging caused by a defect in DNA repair, Hepatology, 55, 609, 10.1002/hep.24713 Lee, 1996, Role of CYP2E1 in the hepatotoxicity of acetaminophen, J. Biol. Chem., 271, 12063, 10.1074/jbc.271.20.12063 Abdelmegeed, 2011, PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver, J. Nutr., 141, 603, 10.3945/jn.110.135210 Abdelmegeed, 2012, Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis, J. Hepatol., 57, 860, 10.1016/j.jhep.2012.05.019 Abdelmegeed, 2009, Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress, Free Radic. Biol. Med., 47, 767, 10.1016/j.freeradbiomed.2009.06.017 Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883 Abdelmegeed, 2010, Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity, Biochem. Pharmacol., 79, 57, 10.1016/j.bcp.2009.07.016 Song, 2013, Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease, Oxid. Med. Cell. Longev., 2013, 781050, 10.1155/2013/781050 Muller-Hocker, 1997, Defects of the respiratory chain in the normal human liver and in cirrhosis during aging, Hepatology, 26, 709, 10.1002/hep.510260324 Larsson, 2010, Somatic mitochondrial DNA mutations in mammalian aging, Annu. Rev. Biochem., 79, 683, 10.1146/annurev-biochem-060408-093701 Ortuno-Sahagun, 2014, Oxidative stress in aging: advances in proteomic approaches, Oxid. Med. Cell. Longev., 2014, 573208, 10.1155/2014/573208 Liu, 2013, Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice, Redox Biol., 1, 110, 10.1016/j.redox.2012.11.011 Franco, 2013, Nitration of Hsp90 induces cell death, Proc. Natl. Acad. Sci. USA, 110, E1102, 10.1073/pnas.1215177110 Sasaki, 2013, Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality, Exp. Gerontol., 48, 457, 10.1016/j.exger.2013.02.015 Begriche, 2006, Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it, Mitochondrion, 6, 1, 10.1016/j.mito.2005.10.004 Koga, 2011, Protein homeostasis and aging: the importance of exquisite quality control, Ageing Res. Rev., 10, 205, 10.1016/j.arr.2010.02.001 Breusing, 2009, Inverse correlation of protein oxidation and proteasome activity in liver and lung, Mech. Ageing Dev., 130, 748, 10.1016/j.mad.2009.09.004 Gohlke, 2014, Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities, Age, 36, 57, 10.1007/s11357-013-9543-x Wang, 1995, Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis, Am. J. Physiol., 269, G297 Park, 2015, Short-term treatment of daumone improves hepatic inflammation in aged mice, Korean J. Physiol. Pharmacol.: Off. J. Korean Physiol. Soc. Korean Soc. Pharmacol., 19, 269, 10.4196/kjpp.2015.19.3.269 Konstandi, 2013, Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver, Am. J. Physiol. Endocrinol. Metab., 304, E1118, 10.1152/ajpendo.00585.2012 Lu, 2008, Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice, Hepatology, 1483, 10.1002/hep.22222 Suh, 2004, Identification of oxidized mitochondrial proteins in alcohol-exposed human hepatoma cells and mouse liver, Proteomics, 4, 3401, 10.1002/pmic.200400971 Bradford, 2005, Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver, Hepatology, 41, 336, 10.1002/hep.20532 Lieber, 2004, Model of nonalcoholic steatohepatitis, Am. J. Clin. Nutr., 79, 502, 10.1093/ajcn/79.3.502 Ramesh, 2012, Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats, Exp. Gerontol., 47, 979, 10.1016/j.exger.2012.09.003 Safwat, 2014, Ozone ameliorates age-related oxidative stress changes in rat liver and kidney: effects of pre- and post-ageing administration, Biochemistry (Moscow), 79, 450, 10.1134/S0006297914050095 Sobocanec, 2008, Differential response to lipid peroxidation in male and female mice with age: correlation of antioxidant enzymes matters, Biogerontology, 9, 335, 10.1007/s10522-008-9145-7 Bhattacharya, 2011, Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant?, Aging Cell, 10, 720, 10.1111/j.1474-9726.2011.00712.x Sadowska-Bartosz, 2014, Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination, Free Radic. Res., 48, 1267, 10.3109/10715762.2014.953494 Lieber, 1997, Cytochrome P-4502E1: its physiological and pathological role, Physiol. Rev., 77, 517, 10.1152/physrev.1997.77.2.517 Abdelmegeed, 2013, CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis, Free Radic. Biol. Med., 65, 1238, 10.1016/j.freeradbiomed.2013.09.009 Adams, 2005, The natural history of nonalcoholic fatty liver disease: a population-based cohort study, Gastroenterology, 129, 113, 10.1053/j.gastro.2005.04.014 Bonomini, 2015, Metabolic syndrome, aging and involvement of oxidative stress, Aging Dis., 6, 109, 10.14336/AD.2014.0305 Moon, 2008, Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion, Gastroenterology, 135, 1344, 10.1053/j.gastro.2008.06.048 Radi, 2004, Nitric oxide, oxidants, and protein tyrosine nitration, Proc. Natl. Acad. Sci. USA, 101, 4003, 10.1073/pnas.0307446101 Abdelmegeed, 2013, Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury, Free Radic. Biol. Med., 60, 211, 10.1016/j.freeradbiomed.2013.02.018 Song, 2014, Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications, Redox Biol., 3, 109, 10.1016/j.redox.2014.10.004 Sohal, 1991, Hydrogen peroxide release by mitochondria increases during aging, Mech. Ageing Dev., 57, 187, 10.1016/0047-6374(91)90034-W Lambert, 2007, Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms, Aging Cell, 6, 607, 10.1111/j.1474-9726.2007.00312.x Anantharaju, 2002, Aging liver. A review, Gerontology, 48, 343, 10.1159/000065506 Romano, 2014, Bioenergetics and mitochondrial dysfunction in aging: recent insights for a therapeutical approach, Curr. Pharm. Des., 20, 2978, 10.2174/13816128113196660700 Meister, 1983, Glutathione, Annu. Rev. Biochem., 52, 711, 10.1146/annurev.bi.52.070183.003431 Gong, 2004, Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity, Free Radic. Biol. Med., 36, 307, 10.1016/j.freeradbiomed.2003.10.017 Immenschuh, 2005, Complementary regulation of heme oxygenase-1 and peroxiredoxin I gene expression by oxidative stress in the liver, Cell. Mol. Biol., 51, 471 Stojkovski, 2013, Age and heat exposure-dependent changes in antioxidant enzymes activities in rat's liver and brain mitochondria: role of alpha-tocopherol, Physiol. Res., 62, 503, 10.33549/physiolres.932514 Jiang, 2013, The age-related change of glutathione antioxidant system in mice liver, Toxicol. Mech. Methods, 23, 396, 10.3109/15376516.2013.769655 Grune, 2004, Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and’‘aggresomes’ during oxidative stress, aging, and disease, Int. J. Biochem. Cell. Biol., 36, 2519, 10.1016/j.biocel.2004.04.020 Goto, 1997, Age-associated, oxidatively modified proteins: a critical evaluation, Age (Omaha), 20, 81, 10.1007/s11357-997-0008-y Hussong, 2010, Immunoproteasome deficiency alters retinal proteasome's response to stress, J. Neurochem., 113, 1481 Suh, 2004, Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid, Proc. Natl. Acad. Sci. USA, 101, 3381, 10.1073/pnas.0400282101 Jang, 2015, Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury, Redox Biol., 6, 552, 10.1016/j.redox.2015.09.040