A phase II study of sequential methotrexate and 5-fluorouracil in colorectal carcinoma

Springer Science and Business Media LLC - Tập 5 - Trang 239-241 - 1988
M. J. Harding1, S. B. Kaye1, M. Soukop2, J. C. Ferguson3
1Department of Medical Oncology, University of Glasgow, Glasgow
2Department of Oncology, Glasgow Royal Infirmary, Glasgow
3Heathfield Hospital, Ayr, UK

Tóm tắt

Nineteen patients with locally recurrent or metastatic colorectal carcinomas were treated with 3-weekly cycles of methotrexate (MTX) given as a loading dose of 100 mg m−2 and a subsequent 12 h infusion of 400 mg m−2, followed by 5-fluorouracil (5-FU) 900 mg m−2 as a bolus injection on completion of infusion. No objective responses were seen in 14 evaluable patients. One early death was treatment related, and four patients were withdrawn from the study after a single course as toxicity was considered unacceptable. The results suggest that in this regimen of sequential MTX and 5-FU, any synergism may be restricted to drug toxicity as no therapeutic benefit was evident.

Tài liệu tham khảo

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