Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

Journal of the American College of Cardiology - Tập 70 Số 1 - Trang 115-117 - 2017
Kafa Walweel, Nieves Gómez‐Hurtado, Ye Win Oo, Nicole A. Beard, Cristobal G. dos Remedios, Christopher N. Johnson, Walter Chazin, Dirk van Helden, Björn C. Knollmann, Derek R. Laver

Tóm tắt

Từ khóa


Tài liệu tham khảo

Xu, 2004, Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor), Biophys J, 86, 797, 10.1016/S0006-3495(04)74155-7

Gomez-Hurtado, 2016, Novel CPVT-associated calmodulin mutation in CALM3 (CALM3-A103V) activates arrhythmogenic Ca waves and sparks, Circ Arrhythm Electrophysiol, 9, e004161, 10.1161/CIRCEP.116.004161

Hwang, 2014, Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants, Circ Res, 114, 1114, 10.1161/CIRCRESAHA.114.303391

Walweel, 2014, Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum, J Gen Physiol, 144, 263, 10.1085/jgp.201311157