Is It Exertional Heatstroke or Something More? A Case Report

Carsana, 2013, Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations, ScientificWorldJournal, 2013, 531465, 10.1155/2013/531465 Hirshey Dirksen, 2011, Special article: future directions in malignant hyperthermia research and patient care, Anesth Analg, 113, 1108, 10.1213/ANE.0b013e318222af2e Rosenberg, 2003, Malignant hyperthermia susceptibility Capacchione, 2009, The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia, Anesth Analg, 109, 1065, 10.1213/ane.0b013e3181a9d8d9 Thomas, 2013, Exertional heat stroke, rhabdomyolysis and susceptibility to malignant hyperthermia, Intern Med J, 43, 1035, 10.1111/imj.12232 Dinarello, 2012, Fever and hyperthermia Larach, 2010, Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006, Anesth Analg, 110, 498, 10.1213/ANE.0b013e3181c6b9b2 Butterworth, 2013, Thermoregulation, hypothermia, & malignant hyperthermia, 1183 Barrett, 2012, Excitable tissue: muscle Mickelson, 1996, Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects, Physiol Rev, 76, 537, 10.1152/physrev.1996.76.2.537 Tobin, 2001, Malignant hyperthermia and apparent heat stroke, JAMA, 286, 168, 10.1001/jama.286.2.168 Capacchione, 2010, Exertional rhabdomyolysis and malignant hyperthermia in a patient with ryanodine receptor type 1 gene, L-type calcium channel alpha-1 subunit gene, and calsequestrin-1 gene polymorphisms, Anesthesiology, 112, 239, 10.1097/ALN.0b013e3181c29504 Durham, 2008, RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice, Cell, 133, 53, 10.1016/j.cell.2008.02.042 Wappler, 2001, Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis, Anesthesiology, 94, 95, 10.1097/00000542-200101000-00019 Krause, 2004, Dantrolene—a review of its pharmacology, therapeutic use and new developments, Anaesthesia, 59, 364, 10.1111/j.1365-2044.2004.03658.x Hadad, 2005, Clinical review: treatment of heat stroke: should dantrolene be considered?, Crit Care, 9, 86, 10.1186/cc2923 Casa, 2012, National athletic trainers' association position statement: preventing sudden death in sports, J Athl Train, 47, 96, 10.4085/1062-6050-47.1.96 FDA News Alert. FDA grants fast track designation to RYANODEX for treatment of exertional heat stroke. Available at: http://www.fdanewsalert.com/the-fda-grants-a-fast-track-designation-for-ryanodex-from-eagle-pharmaceuticals-nasdaqegrx/851287/.