Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells

Journal of Immunology - Tập 161 Số 4 - Trang 1853-1859 - 1998
Susan Adams1, Luc J. W. van der Laan2, Elizabeth Vernon-Wilson1, Chantal Renardel de Lavalette2, Ed A. Döpp2, Christine D. Dijkstra2, David L. Simmons3, Timo K. van den Berg2
1*Cell Adhesion Laboratory, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;
2†Department of Cell Biology and Immunology, Faculty of Medicine, Vrije University, Amsterdam, The Netherlands; and
3‡Department of Neuroscience, SmithKline Beecham, Harlow, United Kingdom

Tóm tắt

AbstractSignal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC, and a cytoplasmic domain with two immunoreceptor with tyrosine-based inhibition motifs that can interact with src homology 2 domain-containing phosphatases. SIRP have previously been shown to inhibit signaling through receptor tyrosine kinases, but their physiologic function is unknown. Here we demonstrate by expression cloning that the mAbs ED9, ED17, and MRC-OX41 recognize rat SIRP. In addition, we show for the first time that rat SIRP is selectively expressed by myeloid cells (macrophages, monocytes, granulocytes, dendritic cells) and neurons. Moreover, SIRP ligation induces nitric oxide production by macrophages. This implicates SIRP as a putative recognition/signaling receptor in both immune and nervous systems.

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Journal of Immunology

Tập 161 Số 4

1853-1859

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