Arias, 2012, Infectious agents associated with schizophrenia: A meta-analysis, Schizophr Res, 136, 128, 10.1016/j.schres.2011.10.026
Ripke, 2014, Biological insights from 108 schizophrenia-associated genetic loci, Nature, 511, 421, 10.1038/nature13595
Upthegrove, 2014, Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis, Schizophr Res, 155, 101, 10.1016/j.schres.2014.03.005
Akhondzadeh, 2007, Celecoxib as adjunctive therapy in schizophrenia: A double-blind, randomized and placebo-controlled trial, Schizophr Res, 90, 179, 10.1016/j.schres.2006.11.016
Müller, 2010, Celecoxib treatment in an early stage of schizophrenia: Results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment, Schizophr Res, 121, 118, 10.1016/j.schres.2010.04.015
Rapaport, 2005, Celecoxib augmentation of continuously ill patients with schizophrenia, Biol Psychiatry, 57, 1594, 10.1016/j.biopsych.2005.02.024
Ory, 2015, PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide, Nucl Med Biol, 42, 753, 10.1016/j.nucmedbio.2015.06.010
Toth, 2016, Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: Longitudinal positron emission tomography and immunofluorescent tracking, Brain Struct Funct, 221, 1279, 10.1007/s00429-014-0970-y
Venneti, 2013, Molecular imaging of microglia/macrophages in the brain, Glia, 61, 10, 10.1002/glia.22357
Doorduin, 2009, Neuroinflammation in schizophrenia-related psychosis: A PET study, J Nucl Med, 50, 1801, 10.2967/jnumed.109.066647
Van Berckel, 2008, Microglia activation in recent-onset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study, Biol Psychiatry, 64, 820, 10.1016/j.biopsych.2008.04.025
Jučaite, 2012, Kinetic analysis and test–retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain—A PET study in control subjects, EJNMMI Res, 2, 15, 10.1186/2191-219X-2-15
Slifstein, 2001, Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers, Nucl Med Biol, 28, 595, 10.1016/S0969-8051(01)00214-1
Varnäs, 2013, Modeling of PET data in CNS drug discovery and development, J Pharmacokinet Pharmacodyn, 40, 267, 10.1007/s10928-013-9320-6
Holmes, 2016, In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: A [11C](R)-PK11195 positron emission tomography study, Mol Psychiatry, 21, 1672, 10.1038/mp.2016.180
van der Doef, 2016, In vivo (R)-[11C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis, NPJ Schizophr, 2, 16031, 10.1038/npjschz.2016.31
Di Biase, 2017, PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia, Transl Psychiatry, 7, 10.1038/tp.2017.193
Fujita, 2017, Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—Based on recent publications that measured specific-to-non-displaceable ratios, EJNMMI Res, 7, 84, 10.1186/s13550-017-0334-8
Kobayashi, 2018, 11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195, J Cereb Blood Flow Metab, 38, 393, 10.1177/0271678X17699223
Kreisl, 2010, Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker, NeuroImage, 49, 2924, 10.1016/j.neuroimage.2009.11.056
Wilson, 2008, Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors, Nucl Med Biol, 35, 305, 10.1016/j.nucmedbio.2007.12.009
Bloomfield, 2016, Microglial activity in people at ultra high risk of psychosis and in schizophrenia: An [11C]PBR28 PET brain imaging study, Am J Psychiatry, 173, 44, 10.1176/appi.ajp.2015.14101358
Collste, 2017, Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28, Mol Psychiatry, 22, 850, 10.1038/mp.2016.247
Coughlin, 2016, In vivo markers of inflammatory response in recent-onset schizophrenia: A combined study using [11C]DPA-713 PET and analysis of CSF and plasma, Transl Psychiatry, 6, 10.1038/tp.2016.40
Hafizi, 2017, Imaging microglial activation in untreated first-episode psychosis: A PET study with [18F]FEPPA, Am J Psychiatry, 174, 118, 10.1176/appi.ajp.2016.16020171
Kenk, 2015, Imaging neuroinflammation in gray and white matter in schizophrenia: An in-vivo PET study with [18F]-FEPPA, Schizophr Bull, 41, 85, 10.1093/schbul/sbu157
Collste, 2016, Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects, Eur J Nucl Med Mol Imaging, 43, 173, 10.1007/s00259-015-3149-8
Kreisl, 2013, A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation, J Cereb Blood Flow Metab, 33, 53, 10.1038/jcbfm.2012.131
Owen, 2012, An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28, J Cereb Blood Flow Metab, 32, 1, 10.1038/jcbfm.2011.147
Owen, 2011, Mixed-affinity binding in humans with 18-kDa translocator protein ligands, J Nucl Med, 52, 24, 10.2967/jnumed.110.079459
Drzyzga, 2006, Cytokines in schizophrenia and the effects of antipsychotic drugs, Brain Behav Immun, 20, 532, 10.1016/j.bbi.2006.02.002
Stewart, 2015, Preferred reporting items for a systematic review and meta-analysis of individual participant data: The PRISMA-IPD statement, JAMA, 313, 1657, 10.1001/jama.2015.3656
Maeda, 2004, Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: An imaging tool for glial cells in the brain, Synapse, 52, 283, 10.1002/syn.20027
Vehtari, 2017, Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC, Stat Comput, 27, 1413, 10.1007/s11222-016-9696-4
Jeffreys, 1961
Kass, 1995, Bayes factors, J Am Stat Assoc, 90, 773, 10.1080/01621459.1995.10476572
Morey, 2014, Simple relation between Bayesian order-restricted and point-null hypothesis tests, Statist Probab Lett, 92, 121, 10.1016/j.spl.2014.05.010
Cohen, 1998
Dienes, 2014, Using Bayes to get the most out of non-significant results, Front Psychol, 5, 781, 10.3389/fpsyg.2014.00781
Gelman, 2006, Prior distributions for variance parameters in hierarchical models (comment on article by Browne and Draper), Bayesian Anal, 1, 515, 10.1214/06-BA117A
Carpenter, 2017, Stan: A probabilistic programming language, J Stat Softw, 76
Buerkner, 2016, brms: An R package for Bayesian multilevel models using Stan, J Stat Softw, 80, 1
Bates, 2015, Fitting linear mixed-effects models using lme4, J Stat Softw, 67, 1
Kalk, 2013, Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?, Synapse, 67, 909, 10.1002/syn.21681
Monji, 2013, Neuroinflammation in schizophrenia especially focused on the role of microglia, Prog Neuropsychopharmacol Biol Psychiatry, 42, 115, 10.1016/j.pnpbp.2011.12.002
Danovich, 2008, The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production, Eur Neuropsychopharmacol, 18, 24, 10.1016/j.euroneuro.2007.04.005
Miller, 2011, Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects, Biol Psychiatry, 70, 663, 10.1016/j.biopsych.2011.04.013
Howes, 2017, Inflammation and the neural diathesis-stress hypothesis of schizophrenia: A reconceptualization, Transl Psychiatry, 7, 10.1038/tp.2016.278
Mizrahi, 2016, Social stress and psychosis risk: Common neurochemical substrates?, Neuropsychopharmacology, 41, 666, 10.1038/npp.2015.274
Laskaris, 2016, Microglial activation and progressive brain changes in schizophrenia, Br J Pharmacol, 173, 666, 10.1111/bph.13364
Trépanier, 2016, Postmortem evidence of cerebral inflammation in schizophrenia: A systematic review, Mol Psychiatry, 21, 1009, 10.1038/mp.2016.90
van Kesteren, 2017, Immune involvement in the pathogenesis of schizophrenia: A meta-analysis on postmortem brain studies, Transl Psychiatry, 7, 10.1038/tp.2017.4
Lavisse, 2012, Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging, J Neurosci, 32, 10809, 10.1523/JNEUROSCI.1487-12.2012
Kurumaji, 1997, Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics, J Neural Transm, 104, 1361, 10.1007/BF01294737
Notter, 2018, Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia, Mol Psychiatry, 23, 323, 10.1038/mp.2016.248
Liddelow, 2017, Neurotoxic reactive astrocytes are induced by activated microglia, Nature, 541, 481, 10.1038/nature21029
Prinz, 2014, Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease, Nat Rev Neurosci, 15, 300, 10.1038/nrn3722
Narayan, 2017, The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory “M1” human macrophages, PLoS One, 12, 10.1371/journal.pone.0185767
Owen, 2017, Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans, J Cereb Blood Flow Metab, 37, 2679, 10.1177/0271678X17710182
Forsberg, 2017, The immune response of the human brain to abdominal surgery, Ann Neurol, 81, 572, 10.1002/ana.24909
Banati, 2014, Positron emission tomography and functional characterization of a complete PBR/TSPO knockout, Nat Commun, 5, 5452, 10.1038/ncomms6452
Ryu, 2005, Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum, Neurobiol Dis, 20, 550, 10.1016/j.nbd.2005.04.010
Leaver, 2012, Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum, ACS Chem Neurosci, 3, 114, 10.1021/cn200099e
Wang, 2016, Lentiviral-mediated overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus ameliorates LPS-induced cognitive impairment in mice, Front Pharmacol, 7, 384, 10.3389/fphar.2016.00384
Doble, 1987, Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: Anatomical and subcellular distribution, Brain Res Bull, 18, 49, 10.1016/0361-9230(87)90033-5
Owen, 2014, Determination of [11C]PBR28 binding potential in vivo: A first human TSPO blocking study, J Cereb Blood Flow Metab, 34, 989, 10.1038/jcbfm.2014.46
Park, 2015, 11C-PBR28 imaging in multiple sclerosis patients and healthy controls: Test–retest reproducibility and focal visualization of active white matter areas, Eur J Nucl Med Mol Imaging, 42, 1081, 10.1007/s00259-015-3043-4
Hafizi, 2017, Imaging microglial activation in individuals at clinical high risk for psychosis: An in vivo PET study with [18F]FEPPA, Neuropsychopharmacology, 42, 2474, 10.1038/npp.2017.111
Matheson, 2017, Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data, EJNMMI Res, 7, 58, 10.1186/s13550-017-0304-1
Veronese, 2018, Kinetic modelling of [11C]PBR28 for 18kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis, J Cereb Blood Flow Metab, 38, 1227, 10.1177/0271678X17712388
Zhang, 2016, Elevated neurosteroids in the lateral thalamus relieve neuropathic pain in rats with spared nerve injury, Neurosci Bull, 32, 311, 10.1007/s12264-016-0044-7
Cumming, 2017, Sifting through the surfeit of neuroinflammation tracers, J Cereb Blood Flow Metab, 38, 204, 10.1177/0271678X17748786
Tudur Smith, 2016, Individual participant data meta-analyses compared with meta-analyses based on aggregate data, Cochrane Database Syst Rev 2016 Sep 6, 9, MR000007
Van Erp, 2014, Converting positive and negative symptom scores between PANSS and SAPS/SANS, Schizophr Res, 152, 289, 10.1016/j.schres.2013.11.013