RelB mediated by GSK3β/IκBα as a potential therapeutic target in pilocarpine seizure model rats and drug-resistant epilepsy patients

Spiciarich, 2019, Global health and epilepsy: update and future directions, Curr Neurol Neurosci Rep, 19, 30, 10.1007/s11910-019-0947-6 Sultana, 2021, Incidence and prevalence of drug-resistant epilepsy: a systematic review and meta-analysis, Neurology, 96, 805, 10.1212/WNL.0000000000011839 Vergonjeanne, 2021, Epidemiology of epilepsy in low- and middle-income countries: experience of a standardized questionnaire over the past two decades, Neuroepidemiology, 55, 369, 10.1159/000517065 French, 2021, Antiepileptogenesis and disease modification: clinical and regulatory issues, Epilepsia Open, 6, 483, 10.1002/epi4.12526 Paudel, 2019, High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches, J Neurochem, 151, 542, 10.1111/jnc.14663 Kwon, 2013, Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain, J Neuroinflammation, 10, 30, 10.1186/1742-2094-10-30 Rana, 2018, The role of inflammation in the development of epilepsy, J Neuroinflammation, 15, 144, 10.1186/s12974-018-1192-7 Cai, 2022, The function of NF-kappa B during epilepsy, a potential therapeutic target, Front Neurosci, 16, 10.3389/fnins.2022.851394 Oeckinghaus, 2009, The NF-kappaB family of transcription factors and its regulation, Cold Spring Harb Perspect Biol, 1, a000034, 10.1101/cshperspect.a000034 Mitchell, 2016, Signaling via the NFκB system, Wiley Interdiscip Rev Syst Biol Med, 8, 227, 10.1002/wsbm.1331 Engelmann, 2020, Identification of undescribed Relb expression domains in the murine brain by new Relb: cre-katushka reporter mice, Dev Dyn, 249, 983, 10.1002/dvdy.170 Cildir, 2016, Noncanonical NF-κB signaling in health and disease, Trends Mol Med, 22, 414, 10.1016/j.molmed.2016.03.002 Singh, 2020, Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach, Curr Neuropharmacol, 18, 918, 10.2174/1570159X18666200207120949 Lanzillotta, 2010, The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury, Cell Death Dis, 1, e96, 10.1038/cddis.2010.76 Scorza, 2018, Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis, Neurosci Lett, 668, 169, 10.1016/j.neulet.2017.02.049 Kovács, 2011, Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats, Brain Res Bull, 85, 410, 10.1016/j.brainresbull.2011.05.003 Listwak, 2013, Minimal NF-κB activity in neurons, Neuroscience, 250, 282, 10.1016/j.neuroscience.2013.07.013 Hayden, 2012, NF-κB, the first quarter-century: remarkable progress and outstanding questions, Genes Dev, 26, 203, 10.1101/gad.183434.111 Yilmaz, 2003, RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF, EMBO J, 22, 121, 10.1093/emboj/cdg004 Moorthy, 2007, X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites, J Mol Biol, 373, 723, 10.1016/j.jmb.2007.08.039 Millet, 2013, RelB: an outlier in leukocyte biology, J Leukoc Biol, 94, 941, 10.1189/jlb.0513305 Mockenhaupt, 2021, RelB and neuroinflammation, Cells, 10, 1609, 10.3390/cells10071609 Mitra, 2016, Alteration of nuclear factor-kappaB pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine treatment, Neurosci Lett, 616, 86, 10.1016/j.neulet.2016.01.046 Riphagen, 2020, Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology, Neurobiol Aging, 85, 96, 10.1016/j.neurobiolaging.2019.09.020 Zhao, 2007, Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression, J Neurochem, 101, 652, 10.1111/j.1471-4159.2006.04414.x Waters, 2019, RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme, Oncogenesis, 8, 37, 10.1038/s41389-019-0146-y Racine, 1972, Modification of seizure activity by electrical stimulation. 3. Mechanisms, Electroencephalogr Clin Neurophysiol, 32, 295, 10.1016/0013-4694(72)90178-2 Neumann, 2011, Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation, Oncogene, 30, 2485, 10.1038/onc.2010.580 Liang, 2020, HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy, Life Sci, 241, 10.1016/j.lfs.2019.117146 Bhardwaj, 2015, RelB/p50 complexes regulate cytokine-induced YKL-40 expression, J Immunol, 194, 2862, 10.4049/jimmunol.1400874 Bren, 2001, Transcription of the RelB gene is regulated by NF-kappaB, Oncogene, 20, 7722, 10.1038/sj.onc.1204868 Gupta, 2019, RelB controls adaptive responses of astrocytes during sterile inflammation, Glia, 67, 1449, 10.1002/glia.23619 Schaafsma, 2015, Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing, Brain Behav Immun, 48, 205, 10.1016/j.bbi.2015.03.013 Murphy, 2022, Peripheral NF-κB dysregulation in people with schizophrenia drives inflammation: putative anti-inflammatory functions of NF-κB kinases, Transl Psychiatry, 12, 21, 10.1038/s41398-021-01764-2 Forde, 2007, Glycogen synthase kinase 3: a key regulator of cellular fate, Cell Mol Life Sci, 64, 1930, 10.1007/s00018-007-7045-7 Liu, 2017, N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5, Discov Med, 23, 221 Talos, 2018, Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy, Ann Neurol, 83, 311, 10.1002/ana.25149 Campa, 2014, A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer, Oncotarget, 5, 8173, 10.18632/oncotarget.2303