Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Journal of Allergy and Clinical Immunology - Tập 127 - Trang 661-667 - 2011
Sara J. Brown1,2,3, Yuka Asai4,5, Heather J. Cordell6, Linda E. Campbell1, Yiwei Zhao1, Haihui Liao1, Kate Northstone7, John Henderson7, Reza Alizadehfar8, Moshe Ben-Shoshan5,8, Kenneth Morgan9, Graham Roberts10, Laury J.N. Masthoff11, Suzanne G.M.A. Pasmans11, Peter C. van den Akker, Cisca Wijmenga12, Jonathan O’B. Hourihane13, Colin N.A. Palmer14, Gideon Lack15, Ann Clarke5,16
1Epithelial Genetics Group, Division of Molecular Medicine, University of Dundee, Dundee, United Kingdom
2Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom
3Trinity College Dublin, College Green, Dublin, Ireland
4Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
5Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
6Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
7Department of Social Medicine, University of Bristol, Bristol, United Kingdom
8Division of Clinical Immunology/Allergy, Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada
9Departments of Human Genetics and Medicine, McGill University and Research Institute of McGill University Health Centre, Montreal, Quebec, Canada
10University of Southampton School of Medicine and Respiratory Biomedical Research Unit, Southampton, United Kingdom
11Department of Pediatric Dermatology/Allergology, Wilhelmina's Children Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
12Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
13Department of Paediatrics and Child Health, University College Cork, Cork, Ireland
14Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
15Paediatric Allergy, King's College London, London, United Kingdom
16Division of Clinical Immunology/Allergy, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada

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