The kainic acid model of temporal lobe epilepsy

Akaike, 2001, Kainic acid-induced dorsal and ventral hippocampal seizures in rats, Brain Res., 900, 65, 10.1016/S0006-8993(01)02252-1 Albala, 1984, Kainic-acid-induced seizures: a developmental study, Brain Res., 315, 139, 10.1016/0165-3806(84)90085-3 Araki, 2002, Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse, J. Neurosci. Res., 69, 614, 10.1002/jnr.10356 Arabadzisz, 2005, Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus, Exp. Neurol., 194, 76, 10.1016/j.expneurol.2005.01.029 Arida, 1999, The course of untreated seizures in the pilocarpine model of epilepsy, Epilepsy Res., 34, 99, 10.1016/S0920-1211(98)00092-8 Ashwood, 1986, Loss of inhibition in the CA1 region of the kainic acid lesioned hippocampus is not associated with changes in postsynaptic responses to GABA, Brain Res., 367, 390, 10.1016/0006-8993(86)91625-2 Ashwood, 1986, Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat, Exp. Brain Res. Exp. Hirnforsch. Expérimentation Cérébrale, 62, 189 Ben-Ari, 1985, Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy, Neuroscience, 14, 375, 10.1016/0306-4522(85)90299-4 Ben-Ari, 2002, Excitatory actions of gaba during development: the nature of the nurture, Nat. Rev. Neurosci., 3, 728, 10.1038/nrn920 Ben-Ari, 2000, Kainate, a double agent that generates seizures: two decades of progress, Trends Neurosci., 23, 580, 10.1016/S0166-2236(00)01659-3 Ben-Ari, 2005, The multiple facets of gamma-aminobutyric acid dysfunction in epilepsy, Curr. Opin. Neurol., 18, 141, 10.1097/01.wco.0000162855.75391.6a Ben-Ari, 1978, [Epileptogenic action of intra-amygdaloid injection of kainic acid], Comptes Rendus Hebd. Séances Acad. Sci. Série Sci. Nat., 287, 813 Ben-Ari, 1978, Diazepam pretreatment reduces distant hippocampal damage induced by intra-amygdaloid injections of kainic acid, Eur. J. Pharmacol., 52, 419, 10.1016/0014-2999(78)90302-3 Ben-Ari, 1979, A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures, Brain Res., 163, 176, 10.1016/0006-8993(79)90163-X Ben-Ari, 1979, [Primary and secondary cerebral lesions produced by kainic acid injections in the rat], Comptes Rendus Hebd. Séances Acad. Sci Série Sci. Nat., 288, 991 Ben-Ari, 1980, The role of epileptic activity in hippocampal and “remote” cerebral lesions induced by kainic acid, Brain Res., 191, 79, 10.1016/0006-8993(80)90316-9 Ben-Ari, 1980, Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy, Neuroscience, 5, 515, 10.1016/0306-4522(80)90049-4 Ben-Ari, 1981, Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy, Neuroscience, 6, 1361, 10.1016/0306-4522(81)90193-7 Ben-Ari, 1989, Giant synaptic potentials in immature rat CA3 hippocampal neurones, J. Physiol., 416, 303, 10.1113/jphysiol.1989.sp017762 Ben-Ari, 2007, GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations, Physiol. Rev., 87, 1215, 10.1152/physrev.00017.2006 Ben-Ari, 2008, Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses, Epilepsy Curr. Am. Epilepsy Soc., 8, 68, 10.1111/j.1535-7511.2008.00241.x Babb, 1996, Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy, Epilepsy Res., 26, 193, 10.1016/S0920-1211(96)00053-8 Bahn, 1994, Kainate receptor gene expression in the developing rat brain, J. Neurosci. Off. J. Soc. Neurosci., 14, 5525, 10.1523/JNEUROSCI.14-09-05525.1994 Bartolomei, 2008, Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG, Brain, 131, 1818, 10.1093/brain/awn111 Berger, 1989, Limbic seizures without brain damage after injection of low doses of kainic acid into the amygdala of freely moving rats, Brain Res., 489, 261, 10.1016/0006-8993(89)90859-7 Berkovic, 1991, Hippocampal sclerosis in temporal lobe epilepsy demonstrated by magnetic resonance imaging, Ann. Neurol., 29, 175, 10.1002/ana.410290210 Bernard, 1999, Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation, Eur. J. Neurosci., 11, 604, 10.1046/j.1460-9568.1999.00479.x Best, 1993, Changes in parvalbumin-immunoreactive neurons in the rat hippocampus following a kainic acid lesion, Neurosci. Lett., 155, 1, 10.1016/0304-3940(93)90660-D Best, 1994, Ultrastructure of parvalbumin-immunoreactive neurons in the CA1 area of the rat hippocampus following a kainic acid injection, Acta Neuropathol. (Berl.), 87, 187, 10.1007/BF00296189 Bloss, 2010, Hippocampal kainate receptors, Vitam. Horm., 82, 167, 10.1016/S0083-6729(10)82009-6 Bortel, 2010, Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system, Neurobiol. Dis., 40, 478, 10.1016/j.nbd.2010.07.015 Bortolato, 2010, Involvement of GABA in mirror focus: a case report, Epilepsy Res., 90, 300, 10.1016/j.eplepsyres.2010.05.012 Bouilleret, 1999, Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy, Neuroscience, 89, 717, 10.1016/S0306-4522(98)00401-1 Bouilleret, 2000, Early loss of interneurons and delayed subunit-specific changes in GABAA-receptor expression in a mouse model of mesial temporal lobe epilepsy, Hippocampus, 10, 305, 10.1002/1098-1063(2000)10:3<305::AID-HIPO11>3.0.CO;2-I Bragin, 1999, Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection, Epilepsia, 40, 1210, 10.1111/j.1528-1157.1999.tb00849.x Bragin, 2000, Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis, Epilepsia, 41, S144, 10.1111/j.1528-1157.2000.tb01573.x Bragin, 2004, High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis, Epilepsia, 45, 1017, 10.1111/j.0013-9580.2004.17004.x Bragin, 2005, Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats, Epilepsia, 46, 1592, 10.1111/j.1528-1167.2005.00268.x Bragin, 2009, The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset, J. Neurosci. Off. J. Soc. Neurosci., 29, 3660, 10.1523/JNEUROSCI.5309-08.2009 Buckmaster, 2012, Mossy fiber sprouting in the dentate gyrus Buzsáki, 2002, Theta oscillations in the hippocampus, Neuron, 33, 325, 10.1016/S0896-6273(02)00586-X Carriero, 2012, A guinea pig model of mesial temporal lobe epilepsy following nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid, Epilepsia, 53, 1917, 10.1111/j.1528-1167.2012.03669.x Cavalheiro, 1982, Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures, Electroencephalogr. Clin. Neurophysiol., 53, 581, 10.1016/0013-4694(82)90134-1 Cavalheiro, 1991, Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures, Epilepsia, 32, 778, 10.1111/j.1528-1157.1991.tb05533.x Cavazos, 1994, Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures, J. Neurosci. Off. J. Soc. Neurosci., 14, 3106, 10.1523/JNEUROSCI.14-05-03106.1994 Cepeda, 1982, Limbic status epilepticus: behaviour and sleep alterations after intra-amygdaloid kainic acid microinjections in Papio Papio baboons, Electroencephalogr. Clin. Neurophysiol., 54, 603, 10.1016/0013-4694(82)90114-6 Chauvière, 2012, Changes in interictal spike features precede the onset of temporal lobe epilepsy, Ann. Neurol., 71, 805, 10.1002/ana.23549 Cherubini, 1983, Behavioral and electrographic patterns induced by systemic administration of kainic acid in developing rats, Brain Res., 285, 69, 10.1016/0165-3806(83)90110-4 Cherubini, 1991, GABA: an excitatory transmitter in early postnatal life, Trends Neurosci., 14, 515, 10.1016/0166-2236(91)90003-D Collins, 1980, Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies, Life Sci., 27, 855, 10.1016/0024-3205(80)90080-6 Cornish, 1989, Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat, Neuroscience, 28, 563, 10.1016/0306-4522(89)90005-5 Coyle, 1976, Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea, Nature, 263, 244, 10.1038/263244a0 Coyle, 1977, Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: correlates with a new animal model, Prog. Neuropsychopharmacol., 1, 13, 10.1016/0364-7722(77)90025-X Curia, 2008, The pilocarpine model of temporal lobe epilepsy, J. Neurosci. Methods, 172, 143, 10.1016/j.jneumeth.2008.04.019 Daniels, 1990, The effect of intrahippocampal injection of kainic acid on corticosterone release in rats, Neurochem. Res., 15, 495, 10.1007/BF00966206 Davenport, 1990, GABAergic neurons are spared after intrahippocampal kainate in the rat, Epilepsy Res., 5, 28, 10.1016/0920-1211(90)90063-2 Davis, 2002 Dawson, 1992, Kainic acid-induced seizures in aged rats: neurochemical correlates, Brain Res. Bull., 29, 459, 10.1016/0361-9230(92)90083-A Drexel, 2011, Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures, Neuroscience, 189, 316, 10.1016/j.neuroscience.2011.05.021 Drexel, 2012, Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex, Neuropharmacology, 63, 806, 10.1016/j.neuropharm.2012.06.009 Dugladze, 2007, Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy, Proc. Natl. Acad. Sci. U.S.A., 104, 17530, 10.1073/pnas.0708301104 Dunleavy, 2010, Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis, Am. J. Pathol., 176, 330, 10.2353/ajpath.2010.090119 Dzhala, 2003, Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus, J. Neurosci., 23, 1840, 10.1523/JNEUROSCI.23-05-01840.2003 Dzhala, 2012, Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain, J. Neurosci. Off. J. Soc. Neurosci., 32, 4017, 10.1523/JNEUROSCI.5139-11.2012 Engel, 1996, Introduction to temporal lobe epilepsy, Epilepsy Res., 26, 141, 10.1016/S0920-1211(96)00043-5 Engel, 2012, Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial, JAMA J. Am. Med. Assoc., 307, 922, 10.1001/jama.2012.220 Epsztein, 2005, Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats, J. Neurosci. Off. J. Soc. Neurosci., 25, 8229, 10.1523/JNEUROSCI.1469-05.2005 Fisahn, 2004, Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations, J. Neurosci. Off. J. Soc. Neurosci., 24, 9658, 10.1523/JNEUROSCI.2973-04.2004 Franck, 1985, Do kainate-lesioned hippocampi become epileptogenic?, Brain Res., 329, 309, 10.1016/0006-8993(85)90540-2 French, 1982, Intrahippocampal kainic acid, seizures and local neuronal degeneration: relationships assessed in unanesthetized rats, Neuroscience, 7, 2525, 10.1016/0306-4522(82)90212-3 Friedman, 1994, Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study, J. Neurosci. Off. J. Soc. Neurosci., 14, 2697, 10.1523/JNEUROSCI.14-05-02697.1994 Fritsch, 2009, Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis, Neuroscience, 163, 415, 10.1016/j.neuroscience.2009.06.034 Furtado, 2002, Behavioral, morphologic, and electroencephalographic evaluation of seizures induced by intrahippocampal microinjection of pilocarpine, Epilepsia, 43, 37, 10.1046/j.1528-1157.43.s.5.41.x Giorgi, 2005, Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood, Epilepsia, 46, 490, 10.1111/j.0013-9580.2005.42304.x Gloor, 1997 Goddard, 1969, A permanent change in brain function resulting from daily electrical stimulation, Exp. Neurol., 25, 295, 10.1016/0014-4886(69)90128-9 Goffin, 2007, Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat, Exp. Neurol., 205, 501, 10.1016/j.expneurol.2007.03.008 Golden, 1995, Rat strain and age differences in kainic acid induced seizures, Epilepsy Res., 20, 151, 10.1016/0920-1211(94)00079-C Goldin, 2007, Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency, J. Neurosci. Off. J. Soc. Neurosci., 27, 9560, 10.1523/JNEUROSCI.1237-07.2007 Gouder, 2003, Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy, Epilepsia, 44, 877, 10.1046/j.1528-1157.2003.03603.x Gröticke, 2008, Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate, Exp. Neurol., 213, 71, 10.1016/j.expneurol.2008.04.036 Gurbanova, 2008, Intra-amygdaloid injection of kainic acid in rats with genetic absence epilepsy: the relationship of typical absence epilepsy and temporal lobe epilepsy, J. Neurosci. Off. J. Soc. Neurosci., 28, 7828, 10.1523/JNEUROSCI.1097-08.2008 Haas, 2001, Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling, Hippocampus, 11, 615, 10.1002/hipo.1076 Hájos, 2000, Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations, Eur. J. Neurosci., 12, 3239, 10.1046/j.1460-9568.2000.00217.x Harroud, 2012, Temporal lobe epilepsy surgery failures: a review, Epilepsy Res. Treat., 2012, 10.1155/2012/201651 Hasegawa, 2002, Complex partial status epilepticus induced by a microinjection of kainic acid into unilateral amygdala in dogs and its brain damage, Brain Res., 955, 174, 10.1016/S0006-8993(02)03430-3 Heggli, 1982, Systemic injection of kainic acid: effect on neurotransmitter markers in piriform cortex, amygdaloid complex and hippocampus and protection by cortical lesioning and anticonvulsants, Neuroscience, 7, 1257, 10.1016/0306-4522(82)91132-0 Hellier, 1999, Spontaneous motor seizures of rats with kainate-induced epilepsy: effect of time of day and activity state, Epilepsy Res., 35, 47, 10.1016/S0920-1211(98)00127-2 Hellier, 2005, Chemoconvulsant model of chronic spontaneous seizures, Curr. Protoc. Neurosci., 10.1002/0471142301.ns0919s31 Hellier, 1998, Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy, Epilepsy Res., 31, 73, 10.1016/S0920-1211(98)00017-5 Holmes, 1988, Effects of kainic acid on seizure susceptibility in the developing brain, Brain Res., 467, 51, 10.1016/0165-3806(88)90066-1 Hynd, 2004, Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease, Neurochem. Int., 45, 583, 10.1016/j.neuint.2004.03.007 Jackson, 1990, Hippocampal sclerosis can be reliably detected by magnetic resonance imaging, Neurology, 40, 1869, 10.1212/WNL.40.12.1869 Jin, 2011, Localization and functions of kainate receptors in the basal ganglia, Adv. Exp. Med. Biol., 717, 27, 10.1007/978-1-4419-9557-5_3 Jinde, 2009, Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death, Eur. J. Neurosci., 30, 1036, 10.1111/j.1460-9568.2009.06896.x Kahle, 2008, Roles of the cation-chloride cotransporters in neurological disease, Nat. Clin. Pract. Neurol., 4, 490, 10.1038/ncpneuro0883 Kar, 1997, Systemic administration of kainic acid induces selective time dependent decrease in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in adult rat hippocampal formation, Neuroscience, 80, 1041, 10.1016/S0306-4522(97)00185-1 Kasugai, 2007, Differences in two mice strains on kainic acid-induced amygdalar seizures, Biochem. Biophys. Res. Commun., 357, 1078, 10.1016/j.bbrc.2007.04.067 Khalilov, 2003, In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures, Nat. Neurosci., 6, 1079, 10.1038/nn1125 Khazipov, 2004, Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus, Eur. J. Neurosci., 19, 590, 10.1111/j.0953-816X.2003.03152.x Klausberger, 2003, Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo, Nature, 421, 844, 10.1038/nature01374 Lacaille, 1987, Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology, J. Neurosci. Off. J. Soc. Neurosci., 7, 1979, 10.1523/JNEUROSCI.07-07-01979.1987 Lado, 2006, Chronic bilateral stimulation of the anterior thalamus of kainate-treated rats increases seizure frequency, Epilepsia, 47, 27, 10.1111/j.1528-1167.2006.00366.x Lancaster, 1982, A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus, J. Comp. Neurol., 211, 105, 10.1002/cne.902110202 Lancaster, 1984, Chronic failure of inhibition of the CA1 area of the hippocampus following kainic acid lesions of the CA3/4 area, Brain Res., 295, 317, 10.1016/0006-8993(84)90980-6 Leite, 1996, Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats, Epilepsy Res., 26, 219, 10.1016/S0920-1211(96)00055-1 Lévesque, 2009, Synchronized gamma oscillations (30–50Hz) in the amygdalo-hippocampal network in relation with seizure propagation and severity, Neurobiol. Dis., 35, 209, 10.1016/j.nbd.2009.04.011 Lévesque, 2011, High-frequency (80–500Hz) oscillations and epileptogenesis in temporal lobe epilepsy, Neurobiol. Dis., 42, 231, 10.1016/j.nbd.2011.01.007 Lévesque, 2012, Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy, J. Neurosci. Off. J. Soc. Neurosci., 32, 13264, 10.1523/JNEUROSCI.5086-11.2012 Li, 2010, Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions, Brain Res., 1311, 166, 10.1016/j.brainres.2009.11.024 Li, 2008, Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice, J. Clin. Invest., 118, 571 Li, 2012, Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?, Glia, 60, 83, 10.1002/glia.21250 Longo, 1999, Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting, Epilepsy Res., 36, 233, 10.1016/S0920-1211(99)00054-6 Lothman, 1981, Kainic acid-induced limbic seizures: electrophysiologic studies, Neurology, 31, 806, 10.1212/WNL.31.7.806 Lu, 2011, In vitro hippocampal gamma oscillation power as an index of in vivo CA3 gamma oscillation strength and spatial reference memory, Neurobiol. Learn. Mem., 95, 221, 10.1016/j.nlm.2010.11.008 Maccaferri, 1995, Passive propagation of LTD to stratum oriens-alveus inhibitory neurons modulates the temporoammonic input to the hippocampal CA1 region, Neuron, 15, 137, 10.1016/0896-6273(95)90071-3 Magloczky, 1993, Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield, Neuroscience, 56, 317, 10.1016/0306-4522(93)90334-C Marchi, 2007, In vivo and in vitro effects of pilocarpine: relevance to ictogenesis, Epilepsia, 48, 1934, 10.1111/j.1528-1167.2007.01185.x Marchi, 2011, The etiological role of blood–brain barrier dysfunction in seizure disorders, Cardiovasc. Psychiatry Neurol., 2011, 10.1155/2011/482415 Mathern, 1993, Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model, Electroencephalogr. Clin. Neurophysiol., 87, 326, 10.1016/0013-4694(93)90186-Y Mathern, 1998, Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients, Neurobiol. Dis., 5, 151, 10.1006/nbdi.1998.0200 McNamara, 1984, Kindling: an animal model of complex partial epilepsy, Ann. Neurol., 16, S72, 10.1002/ana.410160712 Medvedev, 2000, Kainic acid induces distinct types of epileptiform discharge with differential involvement of hippocampus and neocortex, Brain Res. Bull., 52, 89, 10.1016/S0361-9230(00)00239-2 Meier, 1992, Persistent hyperexcitability in isolated hippocampal CA1 of kainate-lesioned rats, J. Neurophysiol., 68, 2120, 10.1152/jn.1992.68.6.2120 Menini, 1980, Sustained limbic seizures induced by intraamygdaloid kainic acid in the baboon: symptomatology and neuropathological consequences, Ann. Neurol., 8, 501, 10.1002/ana.410080507 Meredith, 2009, Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease, Exp. Neurol., 219, 334, 10.1016/j.expneurol.2009.06.005 Mikati, 2003, Stages of status epilepticus in the developing brain, Epilepsy Res., 55, 9, 10.1016/S0920-1211(03)00089-5 Morin, 1998, Selective loss of GABA neurons in area CA1 of the rat hippocampus after intraventricular kainate, Epilepsy Res., 32, 363, 10.1016/S0920-1211(98)00033-3 Mouri, 2008, Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice, Brain Res., 1213, 140, 10.1016/j.brainres.2008.03.061 Mulle, 1998, Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice, Nature, 392, 601, 10.1038/33408 Murakami, 1953, Studies on the effective principles of Diagenea simplex Aq. I. Separation of the effective fraction by liquid chromatography, J. Pharm. Soc. Jpn., 73, 1026, 10.1248/yakushi1947.73.9_1026 Nadler, 1979, Kainic acid: neurophysiological and neurotoxic actions, Life Sci., 24, 289, 10.1016/0024-3205(79)90325-4 Nadler, 1978, Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells, Nature, 271, 676, 10.1038/271676a0 Nadler, 1981, Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy, Life Sci., 29, 2031, 10.1016/0024-3205(81)90659-7 Nadler, 1980, Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways, Brain Res., 195, 47, 10.1016/0006-8993(80)90865-3 Najm, 2013, Temporal patterns and mechanisms of epilepsy surgery failure, Epilepsia, 54, 772, 10.1111/epi.12152 Nitecka, 1984, Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae, Neuroscience, 13, 1073, 10.1016/0306-4522(84)90289-6 Okazaki, 1988, Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration, Neuroscience, 26, 763, 10.1016/0306-4522(88)90097-8 Okazaki, 1999, Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth, J. Neurophysiol., 81, 1645, 10.1152/jn.1999.81.4.1645 Patel, 1986, Distribution of [3H]kainic acid and binding sites in the rat brain: in vivo and in vitro receptor autoradiography, Neurosci. Lett., 70, 301, 10.1016/0304-3940(86)90569-0 Pernot, 2011, Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy, Epilepsia, 52, 2315, 10.1111/j.1528-1167.2011.03273.x Pitt, 2000, Glutamate excitotoxicity in a model of multiple sclerosis, Nat. Med., 6, 67, 10.1038/71555 Pont, 1995, Early and transient increase of rat hippocampal blood–brain barrier permeability to amino acids during kainic acid-induced seizures, Neurosci. Lett., 184, 52, 10.1016/0304-3940(94)11166-G Racine, 1972, Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroencephalogr. Clin. Neurophysiol., 32, 281, 10.1016/0013-4694(72)90177-0 Raedt, 2009, Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat, Acta Neurol. Scand., 119, 293, 10.1111/j.1600-0404.2008.01108.x Raol, 2012, Experimental models of seizures and epilepsies, Prog. Mol. Biol. Transl. Sci., 105, 57, 10.1016/B978-0-12-394596-9.00003-2 Redler, 2012, The complex molecular biology of amyotrophic lateral sclerosis (ALS), Prog. Mol. Biol. Transl. Sci., 107, 215, 10.1016/B978-0-12-385883-2.00002-3 Renaud, 2002, AIDA, a class I metabotropic glutamate-receptor antagonist limits kainate-induced hippocampal dysfunction, Epilepsia, 43, 1306, 10.1046/j.1528-1157.2002.10402.x Represa, 1987, Kainate binding sites in the hippocampal mossy fibers: localization and plasticity, Neuroscience, 20, 739, 10.1016/0306-4522(87)90237-5 Riban, 2002, Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy, Neuroscience, 112, 101, 10.1016/S0306-4522(02)00064-7 Rogawski, 2003, GluR5 kainate receptors, seizures, and the amygdala, Ann. N.Y. Acad. Sci., 985, 150, 10.1111/j.1749-6632.2003.tb07079.x Rose Priel, 1996, Developmental aspects of the pilocarpine model of epilepsy, Epilepsy Res., 26, 115, 10.1016/S0920-1211(96)00047-2 Saija, 1992, Blood–brain barrier dysfunctions following systemic injection of kainic acid in the rat, Life Sci., 51, 467, 10.1016/0024-3205(92)90023-I Sanon, 2005, Short-term effects of kainic acid on CA1 hippocampal interneurons differentially vulnerable to excitotoxicity, Epilepsia, 46, 837, 10.1111/j.1528-1167.2005.21404.x Sarkisian, 1997, Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory, Epilepsia, 38, 1157, 10.1111/j.1528-1157.1997.tb01211.x Schwob, 1980, Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study, Neuroscience, 5, 991, 10.1016/0306-4522(80)90181-5 Sharma, 2007, Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions, Toxicol. Pathol., 35, 984, 10.1080/01926230701748305 Sharma, 2008, Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy, Toxicol. Pathol., 36, 932, 10.1177/0192623308326093 Sharman, 2013, IUPHAR-DB: updated database content and new features, Nucleic Acids Res., 41, D1083, 10.1093/nar/gks960 Shinoda, 2004, Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse, J. Neurosci. Res., 76, 121, 10.1002/jnr.20064 Shinozaki, 1970, Actions of several anthelmintics and insecticides on rat cortical neurones, Brain Res., 24, 368, 10.1016/0006-8993(70)90122-8 Sloviter, 2005, The neurobiology of temporal lobe epilepsy: too much information, not enough knowledge, C. R. Biol., 328, 143, 10.1016/j.crvi.2004.10.010 Sloviter, 1981, On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage, Neuropharmacology, 20, 1003, 10.1016/0028-3908(81)90088-5 Spencer, 2002, Neural networks in human epilepsy: evidence of and implications for treatment, Epilepsia, 43, 219, 10.1046/j.1528-1157.2002.26901.x Spencer, 1994, Entorhinal–hippocampal interactions in medial temporal lobe epilepsy, Epilepsia, 35, 721, 10.1111/j.1528-1157.1994.tb02502.x Sperk, 1983, Kainic acid induced seizures: neurochemical and histopathological changes, Neuroscience, 10, 1301, 10.1016/0306-4522(83)90113-6 Sperk, 1985, Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical and histopathological changes, Brain Res., 338, 289, 10.1016/0006-8993(85)90159-3 Stafstrom, 1992, Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures, Brain Res. Dev. Brain Res., 65, 227, 10.1016/0165-3806(92)90184-X Strain, 1991, Hippocampal damage produced by systemic injections of domoic acid in mice, Neuroscience, 44, 343, 10.1016/0306-4522(91)90059-W Suarez, 2012, Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency, PLoS One, 7, e48128, 10.1371/journal.pone.0048128 Tabb, 2007, Rats bred for susceptibility to depression-like phenotypes have higher kainic acid-induced seizure mortality than their depression-resistant counterparts, Epilepsy Res., 74, 140, 10.1016/j.eplepsyres.2007.02.006 Tanaka, 1982, Electroclinical features of kainic acid-induced status epilepticus in freely moving cats. Microinjection into the dorsal hippocampus, Electroencephalogr. Clin. Neurophysiol., 54, 288, 10.1016/0013-4694(82)90178-X Tanaka, 1985, Spontaneous secondarily generalized seizures induced by a single microinjection of kainic acid into unilateral amygdala in cats, Electroencephalogr. Clin. Neurophysiol., 61, 422, 10.1016/0013-4694(85)91034-X Telfeian, 2000, Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro, Neurobiol. Dis., 7, 362, 10.1006/nbdi.2000.0294 Théorêt, 1988, The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain, Brain Res., 449, 341, 10.1016/0006-8993(88)91050-5 Thorn, 1997, Neuropathologic findings in postmortem studies of sudden death in epilepsy, Epilepsia, 38, S32, 10.1111/j.1528-1157.1997.tb06123.x Tremblay, 1983, Intra-amygdaloid injections of kainic acid: regional metabolic changes and their relation to the pathological alterations, Neuroscience, 8, 299, 10.1016/0306-4522(83)90068-4 Turski, 1983, Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study, Behav. Brain Res., 9, 315, 10.1016/0166-4328(83)90136-5 Tuunanen, 1996, Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex, Eur. J. Neurosci., 8, 2711, 10.1111/j.1460-9568.1996.tb01566.x Uva, 2008, Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood–brain barrier permeability, Neuroscience, 151, 303, 10.1016/j.neuroscience.2007.10.037 Velísek, 1992, Action of antiepileptic drugs against kainic acid-induced seizures and automatisms during ontogenesis in rats, Epilepsia, 33, 987, 10.1111/j.1528-1157.1992.tb01748.x Vincent, 2009, Kainate receptors in epilepsy and excitotoxicity, Neuroscience, 158, 309, 10.1016/j.neuroscience.2008.02.066 Werner, 1991, Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells, Nature, 351, 742, 10.1038/351742a0 White, 2010, EEG spike activity precedes epilepsy after kainate-induced status epilepticus, Epilepsia, 51, 371, 10.1111/j.1528-1167.2009.02339.x Williams, 2006, The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy, J. Neurosci. Methods, 155, 39, 10.1016/j.jneumeth.2005.12.035 Williams, 2009, Development of spontaneous recurrent seizures after kainate-induced status epilepticus, J. Neurosci. Off. J. Soc. Neurosci., 29, 2103, 10.1523/JNEUROSCI.0980-08.2009 Wisden, 1993, A complex mosaic of high-affinity kainate receptors in rat brain, J. Neurosci. Off. J. Soc. Neurosci., 13, 3582, 10.1523/JNEUROSCI.13-08-03582.1993 Wozniak, 1991, Age-related sensitivity to kainate neurotoxicity, Exp. Neurol., 114, 250, 10.1016/0014-4886(91)90042-B Wyler, 1995, Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study, Neurosurgery, 37, 982, 10.1227/00006123-199511000-00019 Ying, 1998, Increased densities of AMPA GluR1 subunit proteins and presynaptic mossy fiber sprouting in the fascia dentata of human hippocampal epilepsy, Brain Res., 798, 239, 10.1016/S0006-8993(98)00421-1 Zhang, 2002, Relations between brain pathology and temporal lobe epilepsy, J. Neurosci. Off. J. Soc. Neurosci., 22, 6052, 10.1523/JNEUROSCI.22-14-06052.2002 Zucker, 1983, Blood–brain barrier changes with kainic acid-induced limbic seizures, Exp. Neurol., 79, 422, 10.1016/0014-4886(83)90223-6