Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase

Redox Biology - Tập 2 - Trang 694-701 - 2014
Beili Shao1, Ulvi Bayraktutan1
1Stroke, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK

Tài liệu tham khảo

Baird, 2002, The influence of diabetes mellitus and hyperglycaemia on stroke incidence and outcome, Journal of Clinical Neuroscience, 9, 618, 10.1054/jocn.2002.1081 Du, 1998, Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species, Diabetologia, 41, 249, 10.1007/s001250050900 Nakagami, 2001, Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells, Diabetes, 50, 1472, 10.2337/diabetes.50.6.1472 Yang, 2008, Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose, Apoptosis, 13, 1331, 10.1007/s10495-008-0257-y Cifarelli, 2011, C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells, Diabetologia, 54, 2702, 10.1007/s00125-011-2251-0 Deng, 2012, Inhibition of protein kinase C β2 prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits, Journal of Vascular Research, 49, 144, 10.1159/000332337 van, 2010, Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus, Mediators of Inflammation, 2010, 792393 Allen, 2009, Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability, Diabetes, Obesity and Metabolism, 11, 480, 10.1111/j.1463-1326.2008.00987.x Bayraktutan, 1998, Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells, Cardiovascular Research, 38, 256, 10.1016/S0008-6363(98)00003-0 Beckman, 2002, Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans, Circulation Research, 90, 107, 10.1161/hh0102.102359 Cipolla, 2011, Inhibition of protein kinase Cβ reverses increased blood–brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo, Stroke, 42, 3252, 10.1161/STROKEAHA.111.623991 Geraldes, 2009, Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy, Nature Medicine, 15, 1298, 10.1038/nm.2052 Allen, 2010, Small GTPase RhoA and its effector Rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction, Stroke, 41, 2056, 10.1161/STROKEAHA.109.574939 Shao, 2013, Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β, Diabetes, Obesity and Metabolism, 15, 993, 10.1111/dom.12120 Ho, 2006, High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-κB and c-Jun NH2−terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway, Cellular Signalling, 18, 391, 10.1016/j.cellsig.2005.05.009 Kapitulnik, 2012, Endothelial cells derived from the blood–brain barrier and islets of Langerhans differ in their response to the effects of bilirubin on oxidative stress under hyperglycemic conditions, Frontiers in Pharmacology, 3, 131, 10.3389/fphar.2012.00131 Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309 Leto, 2009, Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases, Antioxidants and Redox Signaling, 11, 2607, 10.1089/ars.2009.2637 Petry, 2010, Receptor activation of NADPH oxidases, Antioxidants and Redox Signaling, 13, 467, 10.1089/ars.2009.3026 Rakkar, 2014, Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase, European Journal of Neuroscience, 10.1111/ejn.12552 Bayraktutan, 2004, Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth, Journal of Molecular and Cellular Cardiology, 36, 277, 10.1016/j.yjmcc.2003.11.005 Bayraktutan, 2005, Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox, Free Radical Biology and Medicine, 39, 1342, 10.1016/j.freeradbiomed.2005.06.016 Demirci, 2008, The bimodal regulation of vascular function by superoxide anion: role of endothelium, BMB Reports, 41, 223, 10.5483/BMBRep.2008.41.3.223 Chen, 2009, Inhibition of NADPH oxidase is neuroprotective after ischemia–reperfusion, Journal of Cerebral Blood Flow and Metabolism, 29, 1262, 10.1038/jcbfm.2009.47 Nisimoto, 2008, Activation of NADPH oxidase 1 in tumour colon epithelial cells, Biochemical Journal, 415, 57, 10.1042/BJ20080300 Muzaffar, 2008, Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells, Journal of Vascular Research, 45, 521, 10.1159/000129686 Kroviarski, 2010, Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation, FASEB Journal, 24, 2077, 10.1096/fj.09-147629 Dutta, 2010, Regulation of NOXO1 activity through reversible interactions with p22phox and NOXA1, PLoS ONE, 5, e10478, 10.1371/journal.pone.0010478 Rivera, 2010, Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models, Redox Report, 15, 50, 10.1179/174329210X12650506623401 Chen, 2013, Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress, CNS Neuroscience and Therapeutics, 19, 675, 10.1111/cns.12131 Wu, 2010, Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation, Molecular and Cellular Biology, 30, 3553, 10.1128/MCB.01445-09 Lener, 2009, The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells, Biochemical Journal, 423, 363, 10.1042/BJ20090666 Schilder, 2009, NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells, Free Radical Biology and Medicine, 46, 1598, 10.1016/j.freeradbiomed.2009.03.013 Jha, 2014, Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy, Journal of the American Society of Nephrology, 10.1681/ASN.2013070810 Manea, 2010, JAK/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells, Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 105, 10.1161/ATVBAHA.109.193896 Schröder, 2010, Isoform specific functions of Nox protein-derived reactive oxygen species in the vasculature, Current Opinion in Pharmacology, 10, 122, 10.1016/j.coph.2010.01.002 Datla, 2007, Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro, Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 2319, 10.1161/ATVBAHA.107.149450 Basuroy, 2011, Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis, American Journal of Physiology—Cell Physiology, 300, C256, 10.1152/ajpcell.00272.2010 Edderkaoui, 2011, NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox, Journal of Biological Chemistry, 286, 7779, 10.1074/jbc.M110.200063 Lee, 2007, NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases, Gastroenterology, 133, 1637, 10.1053/j.gastro.2007.08.022 Wang, 2014, NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro, Free Radical Biology and Medicine, 69, 278, 10.1016/j.freeradbiomed.2014.01.027 Serrander, 2007, NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation, Biochimie, 89, 1159, 10.1016/j.biochi.2007.05.004 Jagnandan, 2007, Novel mechanism of activation of NADPH oxidase5. Calcium sensitization via phosphorylation, Journal of Biological Bhemistry, 282, 6494, 10.1074/jbc.M608966200 Jay, 2008, Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells, Free Radical Biology and Medicine, 45, 329, 10.1016/j.freeradbiomed.2008.04.024 Schulz, 2008, NOX5, a new "radical" player in human atherosclerosis?, Journal of the American College of Cardiology, 1810, 10.1016/j.jacc.2008.08.040 Inoguchi, 1992, Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation, Proceedings of the National Academy of Sciences of the USA, 89, 11059, 10.1073/pnas.89.22.11059 Shiba, 1993, Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation, American Journal of Physiology, 265, E783 Wei, 2010, A PKC-beta inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats, Apoptosis, 15, 488, 10.1007/s10495-009-0439-2 Aiello, 2006, Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients, Investigative Ophthalmology and Visual Science, 47, 86, 10.1167/iovs.05-0757 Kelly, 2003, Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension, Diabetes, 52, 512, 10.2337/diabetes.52.2.512 Chen, 2014, Regulation of NADPH oxidase 5 by protein kinase C isoforms, PLoS ONE, 9, e88405, 10.1371/journal.pone.0088405 Heo, 2011, PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation, Journal of Cell Biology, 193, 867, 10.1083/jcb.201010051 Kowluru, 2011, Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage, Diabetes, 60, 3023, 10.2337/db11-0816 Srivastava, 2013, PKC-β exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA/Rho-kinase/MLC2 pathway, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 33, 1928, 10.1038/jcbfm.2013.151 van, 2008, Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia–reperfusion-induced endothelial cell apoptosis, Apoptosis, 13, 404, 10.1007/s10495-007-0173-6