Use of Surface Plasmon Resonance for Real-Time Measurements of the Global Conformational Transition in Human Phenylalanine Hydroxylase in Response to Substrate Binding and Catalytic Activation

Kaufman, 1995, The phenylalanine hydroxylating system, Adv. Enzymol., 70, 103 Kappock, 1996, Pterin-dependent amino acid hydroxylases, Chem. Rev., 96, 2659, 10.1021/cr9402034 Flatmark, 1999, Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms, Chem. Rev., 99, 2137, 10.1021/cr980450y Knappskog, 1995, Tryptophan fluorescence of human phenylalanine hydroxylase produced in Escherichia coli, Biochemistry, 34, 11790, 10.1021/bi00037a017 Phillips, 1984, Spectroscopic investigation of ligand interaction with hepatic phenylalanine hydroxylase: Evidence for a conformational change associated with activation, Biochemistry, 23, 3836, 10.1021/bi00312a007 Shiman, 1979, A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography, J. Biol. Chem., 254, 11300, 10.1016/S0021-9258(19)86484-0 Kappock, 1995, Spectroscopic and kinetic properties of unphosphorylated rat hepatic phenylalanine hydroxylase expressed in Escherichia coli. Comparison of resting and activated states, J. Biol. Chem., 270, 30532, 10.1074/jbc.270.51.30532 Knappskog, 1996, Structure-function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme, Eur. J. Biochem., 235, 813, 10.1111/j.1432-1033.1996.0813r.x Flatmark, 1999, Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection, Eur. J. Biochem., 262, 840, 10.1046/j.1432-1327.1999.00445.x Jönsson, 1991, Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology, BioTechniques, 11, 620 Bjørgo, 1998, Partial characterization and three-dimensional structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria, Eur. J. Biochem., 257, 1, 10.1046/j.1432-1327.1998.2570001.x Døskeland, 1984, The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme, J. Biol. Chem., 259, 11242, 10.1016/S0021-9258(18)90854-9 Bjørgo, 2001, Eur. J. Biochem., 268, 997, 10.1046/j.1432-1327.2001.01958.x Teigen, 1999, The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase: Implications for the catalytic mechanism, J. Mol. Biol., 294, 807, 10.1006/jmbi.1999.3288 Erlandsen, 2000, Crystal structure and site-specific mutagenesis of pterin-bond human phenylalanine hydroxylase, Biochemistry, 39, 2208, 10.1021/bi992531+ Karlsson, 1995, Surface plasmon resonance detection and multispot sensing for direct monitoring of interactions involving low-molecular-weight analytes and for determination of low affinities, Anal. Biochem., 228, 274, 10.1006/abio.1995.1350 Schuck, 1998, Determination of binding constants by equilibrium titration with circulating sample in a surface plasmon resonance biosensor, Anal. Biochem., 265, 79, 10.1006/abio.1998.2872 Karlsson, 2000, Biosensor analysis of drug-target interactions: Direct and competitive binding assays for investigation of interactions between thrombin and thrombin inhibitors, Anal. Biochem., 278, 1, 10.1006/abio.1999.4406 Markgren, 2000, Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology, Anal. Biochem., 279, 71, 10.1006/abio.1999.4467 Sota, 1998, Detection of conformational changes in an immobilized protein using surface plasmon resonance, Anal. Chem., 70, 2019, 10.1021/ac9713666 Boussaad, 2000, High-resolution multiwavelength surface plasmon resonance spectroscopy for probing conformational and electronic changes in redox proteins, Anal. Chem., 72, 222, 10.1021/ac990947n Sefaris, 1989 Davis, 1997, The role of phenylalanine in structure-function relationships of phenylalanine hydroxylase revealed by radiation target analysis, Proc. Natl. Acad. Sci. USA, 94, 491, 10.1073/pnas.94.2.491 Solstad, 2000, Microheterogeneity of recombinant human phenylalanine hydroxylase as a result of nonenzymatic deamidations of labile amide containing amino acids. Effects on catalytic and stability properties, Eur. J. Biochem., 267, 6302, 10.1046/j.1432-1327.2000.01715.x