Psychological Impact of Peyronie's Disease: A Review

The Journal of Sexual Medicine - Tập 10 Số 3 - Trang 653-660 - 2013
Christian J. Nelson1,2, John P. Mulhall3,2
1Department of Psychiatry and Behavioral Sciences, New York, USA
2Memorial Sloan-Kettering Cancer Center, New York, USA
3Male Sexual and Reproductive Medicine Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

Tóm tắt

ABSTRACT Introduction Peyronie's disease (PD) is characterized by an accumulation of scar tissue in the tunica albuginea of the penis that causes curvature and deformity. PD can result in psychological distress, depression, or anxiety, which often goes untreated. Aims To review the current literature on the psychological impact of PD, educate healthcare providers about the psychological components of the disease, and propose interventions that address the psychological and sexual challenges patients and their partners may encounter. Methods We performed a MEDLINE search, limited to English, using the terms “Peyronie's disease” AND “psychological” OR “psychosocial,” and select references were included for review. Main Outcome Measure Critical review of the currently available English language literature. Results PD and its associated deformity often impairs sexual relations and frequently leads to psychological and psychosocial sequelae for affected individuals. Many men experience depression, low self-esteem, and emotional distress; these problems markedly diminish the quality of life for affected individuals. The literature suggests that as many as 81% of men report “emotional difficulties,” 48% report clinically meaningful depression (26% moderate; 21% severe), and 54% report relationship problems due to PD. The challenges imposed by PD include alterations in sexual relationships, restrictions on intimacy, social isolation, and stigmatization, all of which are linked and reinforce each other. Physicians may be unaware of the psychological sequelae suffered by patients and their partners. Conclusions Improved awareness and education about the psychological consequences and treatment options for PD are necessary among healthcare providers. To best help patients and optimize outcomes, a team-based approach is needed that includes psychosocial assessment and appropriate resource referrals for the patient and his sexual partner.

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Tài liệu tham khảo

Pryor, 2004, Peyronie's disease, J Sex Med, 1, 110, 10.1111/j.1743-6109.2004.10116.x

Rosen, 2008, Impact of Peyronie's disease on sexual and psychosocial functioning: Qualitative findings in patients and controls, J Sex Med, 5, 1977, 10.1111/j.1743-6109.2008.00883.x

Mulhall, 2003, Expanding the paradigm for plaque development in Peyronie's disease, Int J Impot Res, 15, S93, 10.1038/sj.ijir.3901082

Gholami, 2001, Peyronie's disease, Urol Clin North Am, 28, 377, 10.1016/S0094-0143(05)70146-4

Greenfield, 2005, Peyronie's disease: Etiology, epidemiology and medical treatment, Urol Clin North Am, 32, 469, 10.1016/j.ucl.2005.08.011

Stember, 2011, Concordance between patient and physician assessment of Peyronie's disease deformity [abstract], J Urol, 185, e729

Ralph, 2010, The management of Peyronie's disease: Evidence-based 2010 guidelines, J Sex Med, 7, 2359, 10.1111/j.1743-6109.2010.01850.x

Mulhall, 2006, An analysis of the natural history of Peyronie's disease, J Urol, 175, 2115, 10.1016/S0022-5347(06)00270-9

LaRochelle, 2007, A survey of primary-care physicians and urologists regarding Peyronie's disease, J Sex Med, 4, 1167, 10.1111/j.1743-6109.2007.00537.x

Mulhall, 2010, Predicting delay in presentation in men with Peyronie's disease, J Sex Med, 7, 2226, 10.1111/j.1743-6109.2010.01785.x

Levine, 1994, Intralesional verapamil injection for the treatment of Peyronie's disease, J Urol, 151, 1522, 10.1016/S0022-5347(17)35291-6

Levine, 2008, Penile traction therapy for treatment of Peyronie's disease: A single-center pilot study, J Sex Med, 5, 1468, 10.1111/j.1743-6109.2008.00814.x

Gontero, 2009, Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease: Results of a phase II prospective study, J Sex Med, 6, 558, 10.1111/j.1743-6109.2008.01108.x

Dang, 2004, Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease, South Med J, 97, 42, 10.1097/01.SMJ.0000056658.60032.D3

Gelbard, 2012, Phase 2b study of clinical efficacy and safety of collagenase clostridium histolyticum in patients with Peyronie's disease, J Urol, 187, 2268, 10.1016/j.juro.2012.01.032

Fitch, 2007, Topical verapamil HCl, topical trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie's disease—A placebo-controlled pilot study, J Sex Med, 4, 477, 10.1111/j.1743-6109.2006.00417.x

Larsen, 2011, Peyronie's disease: Review of nonsurgical treatment options, Urol Clin North Am, 38, 195, 10.1016/j.ucl.2011.02.006

Bella, 2007, Peyronie's disease (CME), J Sex Med, 4, 1527, 10.1111/j.1743-6109.2007.00614.x

Gelbard, 1990, The natural history of Peyronie's disease, J Urol, 144, 1376, 10.1016/S0022-5347(17)39746-X

Nelson, 2008, The chronology of depression and distress in men with Peyronie's disease, J Sex Med, 5, 1985, 10.1111/j.1743-6109.2008.00895.x

Smith, 2008, Risk factors for emotional and relationship problems in Peyronie's disease, J Sex Med, 5, 2179, 10.1111/j.1743-6109.2008.00949.x

Chevret, 2004, Impact of erectile dysfunction (ED) on sexual life of female partners: Assessment with the Index of Sexual Life (ISL) questionnaire, J Sex Marital Ther, 30, 157, 10.1080/00926230490262366

Fisher, 2005, Sexual experience of female partners of men with erectile dysfunction: The female experience of men's attitudes to life events and sexuality (FEMALES) study, J Sex Med, 2, 675, 10.1111/j.1743-6109.2005.00118.x

Fisher, 2009, Erectile dysfunction (ED) is a shared sexual concern of couples I: Couple conceptions of ED, J Sex Med, 6, 2746, 10.1111/j.1743-6109.2009.01457.x

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Thông tin xuất bản

The Journal of Sexual Medicine

Tập 10 Số 3

653-660

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