Effect of Eicosapentaenoic Acid on E-type Prostaglandin Synthesis and EP4 Receptor Signaling Human Colorectal Cancer Cells

Eisinger, 2007, The role of cyclooxygenase-2 and prostaglandins in colon cancer, Prostaglandins Other Lipid Mediat, 82, 147, 10.1016/j.prostaglandins.2006.05.026 Wang, 2006, Prostaglandins and cancer, Gut, 55, 115, 10.1136/gut.2004.047100 Wang, 2004, Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ, Cancer Cell, 6, 285, 10.1016/j.ccr.2004.08.011 Kawamori, 2003, Enhancement of colon carcinogenesis by prostaglandin E2 administration, Carcinogenesis, 24, 985, 10.1093/carcin/bgg033 Chapkin, 2007, Colon cancer, fatty acids and anti-inflammatory compounds, Curr Opin Gastroenterol, 23, 48, 10.1097/MOG.0b013e32801145d7 Calviello, 2007, n-3 Polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved, Curr Med Chem, 14, 3059, 10.2174/092986707782793934 Smith, 2005, Cyclooxygenases, peroxide tone and the allure of fish oil, Curr Opin Cell Biol, 17, 174, 10.1016/j.ceb.2005.02.005 Yang, 2004, Formation and antiproliferative effect of prostaglandin E3 from eicosapentaenoic acid in human lung cancer cells, J Lipid Res, 45, 1030, 10.1194/jlr.M300455-JLR200 Funahashi, 2008, Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth, Pancreas, 36, 353, 10.1097/MPA.0b013e31815ccc44 Vanamala, 2008, Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARδ/PGE2 and elevation of PGE3, Carcinogenesis, 29, 790, 10.1093/carcin/bgm256 Sugimoto, 2007, Prostaglandin E receptors, J Biol Chem, 282, 11613, 10.1074/jbc.R600038200 Hull, 2004, Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer?, Mol Cancer Ther, 3, 1031, 10.1158/1535-7163.1031.3.8 Chell, 2006, Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence, Cancer Res, 66, 3106, 10.1158/0008-5472.CAN-05-3702 Hawcroft, 2007, Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells, Oncogene, 26, 3006, 10.1038/sj.onc.1210113 Yang, 2006, Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism, Cancer Res, 66, 9665, 10.1158/0008-5472.CAN-06-1271 Lawson, 1988, Human absorption of fish oil fatty acids as triacylglyercols, free acids or ethyl esters, Biochem Biophys Res Commun, 152, 328, 10.1016/S0006-291X(88)80718-6 West, 2010, Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis, Gut, 10.1136/gut.2009.200642 Fenwick, 2003, The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases, Gastroenterology, 125, 716, 10.1016/S0016-5085(03)01061-8 Shiff, 1996, Nonsteroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis, Exp Cell Res, 222, 179, 10.1006/excr.1996.0023 Elder, 1997, Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression, Clin Cancer Res, 3, 1679 Piazza, 1997, Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest and p53 induction, Cancer Res, 57, 2452 Qia, 1997, Sulindac sulphide inhibits the proliferation of colon cancer cells: diminished expression of the proliferation markers PCNA and Ki-67, Cancer Lett, 115, 229, 10.1016/S0304-3835(97)04740-X Smith, 2000, The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action, Eur J Cancer, 36, 664, 10.1016/S0959-8049(99)00333-0 Ko, 2002, Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells, Oncogene, 21, 7175, 10.1038/sj.onc.1205869 Gardner, 2004, Effect of nonsteroidal anti-inflammatory drugs of β-catenin protein levels and catenin-related transcription in human colorectal cancer cells, B J Cancer, 91, 153, 10.1038/sj.bjc.6601901 Murphey, 2004, Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer, Anal Biochem, 334, 266, 10.1016/j.ab.2004.08.019 Calviello, 2004, n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1α induction pathway, Carcinogenesis, 25, 2303, 10.1093/carcin/bgh265 Castellone, 2005, Prostaglandin E2 promotes colon cancer cell growth through a novel Gs-axin-β-catenin signaling axis, Science, 310, 1504, 10.1126/science.1116221 Shoji, 2004, Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development, Gut, 53, 1151, 10.1136/gut.2003.028787 Courtney, 2007, Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas, Int J Colorectal Dis, 22, 765, 10.1007/s00384-006-0240-4 Wada, 2007, Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products, J Biol Chem, 282, 22254, 10.1074/jbc.M703169200 Belury, 1989, Eicosapentaenoic acid and arachidonic acid: comparison of metabolism and activity in murine epidermal cells, Lipids, 24, 423, 10.1007/BF02535150 Hatala, 1994, Comparison of linoleic acid and eicosapentaenoic acid incorporation into human breast cancer cells, Lipids, 29, 831, 10.1007/BF02536250 Tull, 2009, Omega-3 fatty acids and inflammation. Novel interactions reveal a new step in neutrophil recruitment, PLoS Biol, 7, e1000177, 10.1371/journal.pbio.1000177 Arterburn, 2006, Distribution, interconversion, and dose response of n-3 fatty acids in humans, Am J Clin Nutr, 83, 1467S, 10.1093/ajcn/83.6.1467S Löffler, 2008, Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2, BMC Cancer, 8, 380, 10.1186/1471-2407-8-380 Denkins, 2005, Role of ω-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolismin brain-metastatic melanoma, J Lipid Res, 46, 1278, 10.1194/jlr.M400474-JLR200 Bagga, 2003, Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion, Proc Natl Acad Sci USA, 100, 1751, 10.1073/pnas.0334211100 McKenzie, 1994, ω-3 and ω-6 fatty acids and PGE2 stimulate the growth of normal but not tumour mouse mammary epithelial cells, Prostaglandins Leukot Essent Fatty Acids, 51, 437, 10.1016/0952-3278(94)90062-0 Dommels, 2003, The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE2 synthesis and cytotoxicity in human colorectal carcinoma cell lines, Carcinogenesis, 24, 385, 10.1093/carcin/24.3.385 Aronson, 2001, Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer, Urology, 58, 283, 10.1016/S0090-4295(01)01116-5 Cao, 2006, Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids, Clin Chem, 52, 2265, 10.1373/clinchem.2006.072322