Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727–729 (1999)

Cerwenka, A., Baron, J. L. & Lanier, L. L. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumour in vivo. Proc. Natl Acad. Sci. USA 98, 11521–11526 (2001)

Diefenbach, A., Jensen, E. R., Jamieson, A. M. & Raulet, D. H. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413, 165–171 (2001)

Long, E. O. Tumor cell recognition by natural killer cells. Sem. Cancer Biol. 12, 57–61 (2002)

Pardoll, D. M. Stress, NK receptors, and immune surveillance. Science 294, 534–536 (2002)

Groh, V. et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl Acad. Sci. USA 93, 12445–12450 (1996)

Groh, V., Steinle, A., Bauer, S. & Spies, T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279, 1737–1740 (1998)

Groh, V. et al. Broad tumour-associated expression and recognition by tumour-derived γδ T cells of MICA and MICB. Proc. Natl Acad. Sci. USA 96, 6879–6884 (1999)

Das, H. et al. MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function. Immunity 15, 83–93 (2001)

Groh, V. et al. Costimulation of CD8 αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature Immunol. 2, 255–260 (2001)

Tieng, V. et al. Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl Acad. Sci. USA 99, 2977–2982 (2002)

Linsley, P. S., Bradshaw, J., Urnes, M., Grosmaire, L. & Ledbetter, J. A. CD28 engagement by B7/BB-1 induces transient down-modulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling. J. Immunol. 150, 3161–3169 (1993)

Valitutti, S., Muller, S., Salio, M. & Lanzavecchia, A. Degradation of T cell receptor (TCR)–CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185, 1859–1864 (1997)

Huard, B. & Karlsson, L. KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement. Nature 403, 325–328 (2000)

Li, P. et al. Complex structure of the actiavting immunoreceptor NKG2D and its MHC class I–like ligand MICA. Nature Immunol. 2, 443–451 (2001)

Steinle, A. et al. Interactions of human NKG2D with its ligands MICA and MICB and homologs of the mouse RAE-1 protein family. Immunogenetics 53, 279–287 (2001)

Wu, J. et al. An activating immmunoreceptor complex formed by NKG2D and DAP10. Science 285, 730–732 (1999)

Yee, C., Savage, P. A., Lee, P. P., Davis, M. M. & Greenberg, P. D. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162, 2227–2234 (1999)

Schatz, P. J. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13 residue consensus peptide specifies biotinylation in Escherichia coli. Biotechnology 11, 1138–1143 (1993)

Knappik, A. & Pluckthun, A. An improved affinity tag based on the FLAG peptide for detection and purification of recombinant antibody fragments. Biotechniques 17, 754–761 (1994)