The LXRs: a new class of oxysterol receptors

Mangelsdorf, 1995, The nuclear receptor superfamily: the second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X Beato, 1995, Steroid hormone receptors: many actors in search of a plot, Cell, 83, 851, 10.1016/0092-8674(95)90201-5 Kastner, 1995, Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?, Cell, 83, 859, 10.1016/0092-8674(95)90202-3 Thummel, 1995, From embryogenesis to metamorphosis: The regulation and function of Drosophila nuclear receptor superfamily members, Cell, 83, 871, 10.1016/0092-8674(95)90203-1 Enmark, 1996, Orphan nuclear receptors - The first eight years, Mol Endocrinol, 10, 1293, 10.1210/me.10.11.1293 Willy, 1998, Nuclear orphan receptors: the search for novel ligands and signaling pathways, 1, 307 Apfel, 1994, A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily, Mol Cell Biol, 14, 7025, 10.1128/MCB.14.10.7025 Willy, 1995, LXR, a nuclear receptor that defines a distinct retinoid response pathway, Genes Dev, 9, 1033, 10.1101/gad.9.9.1033 Song, 1994, Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors, Proc Natl Acad Sci USA, 91, 10809, 10.1073/pnas.91.23.10809 Shinar, 1994, NER, a new member of the gene family encoding the human steroid hormone nuclear receptor, Gene, 147, 273, 10.1016/0378-1119(94)90080-9 Teboul, 1995, OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor, Proc Natl Acad Sci USA, 92, 2096, 10.1073/pnas.92.6.2096 Seol, 1995, Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors, Mol Endocrinol, 9, 72, 10.1210/me.9.1.72 Auboeuf, 1997, Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans — no alteration in adipose tissue of obese and NIDDM patients, Diabetes, 46, 1319, 10.2337/diabetes.46.8.1319 Song, 1995, Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones, Ann NY Acad Sci, 761, 38, 10.1111/j.1749-6632.1995.tb31367.x Kainu, 1996, Localization and ontogeny of the orphan receptor OR-1 in the rat brain, J Mol Neurosci, 7, 29, 10.1007/BF02736846 Willy, 1997, Unique requirements for retinoid dependent transcriptional activation by the orphan receptor LXR, Genes Dev, 11, 289, 10.1101/gad.11.3.289 Kliewer, 1992, Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors, Nature, 358, 771, 10.1038/358771a0 Forman, 1995, Identification of a nuclear receptor that is activated by farnesol metabolites, Cell, 81, 687, 10.1016/0092-8674(95)90530-8 MacDonald, 1993, Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene, Mol Cell Biol, 13, 5907, 10.1128/MCB.13.9.5907 Forman, 1995, Unique response pathways are established by allosteric interactions among nuclear hormone receptors, Cell, 81, 541, 10.1016/0092-8674(95)90075-6 Minucci, 1997, Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression, Mol Cell Biol, 17, 644, 10.1128/MCB.17.2.644 Wiebel, 1997, Heterodimeric interaction between retinoid X receptor α and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation, Mol Cell Biol, 17, 3977, 10.1128/MCB.17.7.3977 Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXRα, Nature, 383, 728, 10.1038/383728a0 Lehmann, 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J Biol Chem, 272, 3137, 10.1074/jbc.272.6.3137 Forman, 1997, Theorphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism, Proc Natl Acad Sci USA, 94, 10588, 10.1073/pnas.94.20.10588 Spencer, 1985, 24(S),25-Epoxycholesterol: evidence consistent with a role in the regulation of hepatic cholesterogenesis, J Biol Chem, 260, 13391, 10.1016/S0021-9258(17)38732-X Taylor, 1986, 24,25-Epoxycholesterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase, J Biol Chem, 261, 15039, 10.1016/S0021-9258(18)66825-5 Spencer, 1994, The squalene dioxide pathway of steroid biosynthesis, Acc Chem Res, 27, 83, 10.1021/ar00039a004 Lavy, 1977, Bile acid synthesis in man. II. Determination of 7α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium, J Lipid Res, 18, 232, 10.1016/S0022-2275(20)41702-X Dhar, 1973, Biosynthesis of cholest-5-ene-3β, 24-diol (cerebrosterol) by bovine cerebral cortical microsomes, J Neurochem, 21, 51, 10.1111/j.1471-4159.1973.tb04224.x Lütjohann, 1996, Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation, Proc Natl Acad Sci USA, 93, 9799, 10.1073/pnas.93.18.9799 Accad, 1998, Cholesterol homeostasis: a role for oxysterols, Curr Biol, 8, R601, 10.1016/S0960-9822(98)70386-0 Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 Russell, 1992, Bile acid biosynthesis, Biochemistry, 31, 4737, 10.1021/bi00135a001 Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4 Brown, 1974, Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol, J Biol Chem, 249, 7306, 10.1016/S0021-9258(19)42106-6 Kandutsch, 1974, Inhibition of sterol synthesis in cultured mouse cells by cholesterol derivatives oxygenated in the sidechain, J Biol Chem, 249, 6057, 10.1016/S0021-9258(19)42218-7