Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells

Johanna J. Salomon1, Carsten Ehrhardt1
1School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland

Tài liệu tham khảo

Bhaskar, 2010, Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood–brain barrier: perspectives on tracking and neuroimaging, Part, Fibre Toxicol., 7, 3, 10.1186/1743-8977-7-3 Sitterberg, 2010, Using atomic force microscopy for the characterisation of nanoscale drug delivery systems, Eur. J. Pharm. Biopharm., 74, 2, 10.1016/j.ejpb.2009.09.005 Cho, 2008, Therapeutic nanoparticles for drug delivery in cancer, Clin. Cancer Res., 14, 1310, 10.1158/1078-0432.CCR-07-1441 Bakowsky, 2008, Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery, Biochim. Biophys. Acta, 1778, 242, 10.1016/j.bbamem.2007.09.033 Lee, 2005, Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor, J. Control. Release, 103, 405, 10.1016/j.jconrel.2004.12.018 Thomas, 2009, Moving toward exposure and risk evaluation of nanomaterials: challenges and future directions, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 1, 426, 10.1002/wnan.34 Baguley, 2010, Multidrug resistance in cancer, Methods Mol. Biol., 596, 1, 10.1007/978-1-60761-416-6_1 Bauer, 2005, Modulation of p-glycoprotein transport function at the blood–brain barrier, Exp. Biol. Med., 118, 10.1177/153537020523000206 Benet, 2009, The drug transporter-metabolism alliance: uncovering and defining the interplay, Mol. Pharm., 6, 1631, 10.1021/mp900253n Frezard, 2001, P-glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine, Eur. J. Biochem., 268, 1561, 10.1046/j.1432-1327.2001.01989.x Bosquillon, 2009, Drug transporters in the lung-implication in the biopharmaceutics of inhaled drugs, J. Pharm. Sci., 99, 2240, 10.1002/jps.21995 Endter, 2007, P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers, Cell. Tissue Res., 328, 77, 10.1007/s00441-006-0346-6 Francombe, 2008, Functional role of P-gp efflux in limiting pulmonary drug absorption within an intact lung: application of an isolated perfused rat lung model, Respir. Drug Deliv., 11, 461 Manford, 2008, Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a-deficient and mdr1a-competent mice, J. Pharm. Pharmacol., 60, 1305, 10.1211/jpp.60.10.0006 Giard, 1973, In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors, J. Natl. Cancer Inst., 51, 1417, 10.1093/jnci/51.5.1417 Sporty, 2008, In vitro cell culture models for the assessment of pulmonary drug disposition, Expert Opin. Drug Metab. Toxicol., 4, 333, 10.1517/17425255.4.4.333 Hamilton, 2000, P-glycoprotein efflux pump expression and activity in Calu-3 cells, J. Pharm. Sci., 90, 647, 10.1002/1520-6017(200105)90:5<647::AID-JPS1021>3.0.CO;2-G Lehmann, 2001, Expression of MRP1 and related transporters in human lung cells in culture, Toxicology, 167, 59, 10.1016/S0300-483X(01)00458-9 Arvizo, 2010, Effect of nanoparticle surface charge at the plasma membrane and beyond, Nano Lett., 10, 2543, 10.1021/nl101140t Luker, 2001, MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential, J. Biol. Chem., 276, 49053, 10.1074/jbc.M105192200 McCarthy, 2009, Effect of nanoparticulate matter on transepithelial ion fluxes in Calu-3 cells, Am. J. Respir. Crit. Care Med., 179, A5041 Lundqvist, 2008, Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts, Proc. Natl. Acad. Sci. USA, 105, 14265, 10.1073/pnas.0805135105 Lynch, 2007, The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century, Adv. Colloid Interface Sci., 31, 167, 10.1016/j.cis.2007.04.021 Foldbjerg, 2010, Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549, Arch. Toxicol. Kamau, 2005, Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells, In Vitro Cell Dev. Biol. Anim., 41, 207, 10.1290/0502016.1 Lynch, 2009, Protein-nanoparticle interactions: what does the cell see?, Nat. Nanotechnol., 4, 546, 10.1038/nnano.2009.248