Modularized Functions of the Fanconi Anemia Core Complex

Cell Reports - Tập 7 - Trang 1849-1857 - 2014
Yaling Huang1, Justin W.C. Leung1, Megan Lowery2, Nobuko Matsushita3, Yucai Wang1, Xi Shen1, Do Huong1, Minoru Takata4, Junjie Chen1, Lei Li1,5
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
3Laboratory of Molecular Biochemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Tokyo 192-0392, Japan
4Laboratory of DNA Damage Signaling, Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Kyoto 606-8501, Japan
5Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Tài liệu tham khảo

Ali, 2012, FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway, Blood, 119, 3285, 10.1182/blood-2011-10-385963 Alpi, 2008, Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI, Mol. Cell, 32, 767, 10.1016/j.molcel.2008.12.003 Blom, 2004, Multiple TPR motifs characterize the Fanconi anemia FANCG protein, DNA Repair (Amst.), 3, 77, 10.1016/j.dnarep.2003.09.007 Bogliolo, 2013, Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia, Am. J. Hum. Genet., 92, 800, 10.1016/j.ajhg.2013.04.002 D’Andrea, 2010, Susceptibility pathways in Fanconi’s anemia and breast cancer, N. Engl. J. Med., 362, 1909, 10.1056/NEJMra0809889 Deans, 2009, FANCM connects the genome instability disorders Bloom’s Syndrome and Fanconi Anemia, Mol. Cell, 36, 943, 10.1016/j.molcel.2009.12.006 Garcia-Higuera, 1999, Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex, Mol. Cell. Biol., 19, 4866, 10.1128/MCB.19.7.4866 Garcia-Higuera, 2001, Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway, Mol. Cell, 7, 249, 10.1016/S1097-2765(01)00173-3 Gordon, 2005, FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway, J. Biol. Chem., 280, 36118, 10.1074/jbc.M507758200 Hodson, 2014, Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection, Structure, 22, 337, 10.1016/j.str.2013.12.004 Huang, 2010, The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response, Mol. Cell, 39, 259, 10.1016/j.molcel.2010.07.005 Knipscheer, 2009, The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair, Science, 326, 1698, 10.1126/science.1182372 Kratz, 2010, Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents, Cell, 142, 77, 10.1016/j.cell.2010.06.022 Kruyt, 1999, Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain, J. Biol. Chem., 274, 34212, 10.1074/jbc.274.48.34212 Langevin, 2011, Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice, Nature, 475, 53, 10.1038/nature10192 Leung, 2012, Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair, Proc. Natl. Acad. Sci. USA, 109, 4491, 10.1073/pnas.1118720109 Léveillé, 2004, The Fanconi anemia gene product FANCF is a flexible adaptor protein, J. Biol. Chem., 279, 39421, 10.1074/jbc.M407034200 Ling, 2007, FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway, EMBO J., 26, 2104, 10.1038/sj.emboj.7601666 Liu, 2010, FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair, Science, 329, 693, 10.1126/science.1192656 Longerich, 2009, FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL, J. Biol. Chem., 284, 23182, 10.1074/jbc.C109.038075 MacKay, 2010, Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2, Cell, 142, 65, 10.1016/j.cell.2010.06.021 Medhurst, 2006, Evidence for subcomplexes in the Fanconi anemia pathway, Blood, 108, 2072, 10.1182/blood-2005-11-008151 Meetei, 2003, A novel ubiquitin ligase is deficient in Fanconi anemia, Nat. Genet., 35, 165, 10.1038/ng1241 Metzger, 2012, HECT and RING finger families of E3 ubiquitin ligases at a glance, J. Cell Sci., 125, 531, 10.1242/jcs.091777 Neveling, 2009, Genotype-phenotype correlations in Fanconi anemia, Mutat. Res., 668, 73, 10.1016/j.mrfmmm.2009.05.006 Park, 2013, FANCD2 activates transcription of TAp63 and suppresses tumorigenesis, Mol. Cell, 50, 908, 10.1016/j.molcel.2013.05.017 Pulliam-Leath, 2010, Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia, Blood, 116, 2915, 10.1182/blood-2009-08-240747 Rajendra, 2014, The genetic and biochemical basis of FANCD2 monoubiquitination, Mol. Cell, 54, 10.1016/j.molcel.2014.05.001 Reuter, 2000, Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system, Blood, 95, 719, 10.1182/blood.V95.2.719 Rosado, 2011, Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway, Nat. Struct. Mol. Biol., 18, 1432, 10.1038/nsmb.2173 Sato, 2012, DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI, Nucleic Acids Res., 40, 4553, 10.1093/nar/gks053 Shen, 2009, Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication, Mol. Cell, 35, 716, 10.1016/j.molcel.2009.06.034 Smogorzewska, 2007, Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair, Cell, 129, 289, 10.1016/j.cell.2007.03.009 Smogorzewska, 2010, A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair, Mol. Cell, 39, 36, 10.1016/j.molcel.2010.06.023 Taniguchi, 2002, S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51, Blood, 100, 2414, 10.1182/blood-2002-01-0278 Waisfisz, 1999, A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA, Proc. Natl. Acad. Sci. USA, 96, 10320, 10.1073/pnas.96.18.10320 Wang, 2013, Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response, Cell Res., 23, 1215, 10.1038/cr.2013.124 Wang, 2013, FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions, Mol. Cell, 49, 997, 10.1016/j.molcel.2012.12.010 Yamamoto, 2003, Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells, Mol. Cell. Biol., 23, 5421, 10.1128/MCB.23.15.5421-5430.2003 Yan, 2012, A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network, Mol. Cell, 47, 61, 10.1016/j.molcel.2012.05.026 Yuan, 2012, Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms, J. Biol. Chem., 287, 4800, 10.1074/jbc.M111.315366 Zimmerman, 2010, Structural assembly of cullin-RING ubiquitin ligase complexes, Curr. Opin. Struct. Biol., 20, 714, 10.1016/j.sbi.2010.08.010