NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Ayala, 2014, Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal, Oxid. Med. Cell Longev., 2014, 360438, 10.1155/2014/360438 Dodson, 2018, Modulating NRF2 in disease: timing Is everything, Annu. Rev. Pharmacol. Toxicol. Dolma, 2003, Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells, Cancer Cell, 3, 285, 10.1016/S1535-6108(03)00050-3 Yang, 2008, Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, Chem. Biol., 15, 234, 10.1016/j.chembiol.2008.02.010 Yin, 2011, Free radical lipid peroxidation: mechanisms and analysis, Chem. Rev., 111, 5944, 10.1021/cr200084z Higdon, 2012, Cell signalling by reactive lipid species: new concepts and molecular mechanisms, Biochem J., 442, 453, 10.1042/BJ20111752 Feng, 2018, Unsolved mysteries: how does lipid peroxidation cause ferroptosis?, PLoS Biol., 16, e2006203, 10.1371/journal.pbio.2006203 Hirschhorn, 2018, The development of the concept of ferroptosis, Free Radic. Biol. Med. Dixon, 2012, Ferroptosis: an iron-dependent form of nonapoptotic cell death, Cell, 149, 1060, 10.1016/j.cell.2012.03.042 Kakhlon, 2002, The labile iron pool: characterization, measurement, and participation in cellular processes(1), Free Radic. Biol. Med., 33, 1037, 10.1016/S0891-5849(02)01006-7 Mancias, 2014, Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy, Nature, 509, 105, 10.1038/nature13148 Hou, 2016, Autophagy promotes ferroptosis by degradation of ferritin, Autophagy, 12, 1425, 10.1080/15548627.2016.1187366 Yang, 2014, Regulation of ferroptotic cancer cell death by GPX4, Cell, 156, 317, 10.1016/j.cell.2013.12.010 Yang, 2016, Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis, Proc. Natl. Acad. Sci. USA, 113, E4966, 10.1073/pnas.1603244113 Cao, 2016, Mechanisms of ferroptosis, Cell Mol. Life Sci., 73, 2195, 10.1007/s00018-016-2194-1 Doll, 2017, ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition, Nat. Chem. Biol., 13, 91, 10.1038/nchembio.2239 Shimada, 2016, Cell-Line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity, Cell Chem. Biol., 23, 225, 10.1016/j.chembiol.2015.11.016 Agmon, 2018, Modeling the effects of lipid peroxidation during ferroptosis on membrane properties, Sci. Rep., 8, 5155, 10.1038/s41598-018-23408-0 Gao, 2015, Glutaminolysis and Transferrin Regulate Ferroptosis, Mol. Cell, 59, 298, 10.1016/j.molcel.2015.06.011 Louandre, 2013, Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib, Int. J. Cancer, 133, 1732, 10.1002/ijc.28159 Wang, 2010, Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in sorafenib-induced cytoskeletal rearrangement in hepatoma cells, J. Cell Physiol., 224, 559, 10.1002/jcp.22160 Kerins, 2017, The roles of NRF2 in modulating cellular iron homeostasis, Antioxid. Redox Signal Agyeman, 2012, Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles, Breast Cancer Res. Treat., 132, 175, 10.1007/s10549-011-1536-9 Harada, 2011, Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages, Arch. Biochem. Biophys., 508, 101, 10.1016/j.abb.2011.02.001 Alam, 1999, Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene, J. Biol. Chem., 274, 26071, 10.1074/jbc.274.37.26071 Chorley, 2012, Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha, Nucleic Acids Res., 40, 7416, 10.1093/nar/gks409 Hubner, 2009, Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking, Mol. Med., 15, 203, 10.2119/molmed.2008.00130 Campbell, 2013, Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway, Oxid. Med Cell Longev., 2013, 120305, 10.1155/2013/120305 Huang, 2010, Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism, Am. J. Physiol. Gastrointest. Liver Physiol., 299, G1211, 10.1152/ajpgi.00322.2010 Cho, 2010, Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice, Am. J. Respir. Crit. Care Med., 182, 170, 10.1164/rccm.200907-1047OC Jung, 2013, Identification of aldo-keto reductases as NRF2-target marker genes in human cells, Toxicol. Lett., 218, 39, 10.1016/j.toxlet.2012.12.026 Thimmulappa, 2002, Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray, Cancer Res., 62, 5196 Yang, 2005, Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1, Mol. Cell Biol., 25, 5933, 10.1128/MCB.25.14.5933-5946.2005 Chan, 2000, Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein, Biochim. Biophys. Acta, 1517, 19, 10.1016/S0167-4781(00)00238-4 Sasaki, 2002, Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression, J. Biol. Chem., 277, 44765, 10.1074/jbc.M208704200 Ishii, 2000, Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages, J. Biol. Chem., 275, 16023, 10.1074/jbc.275.21.16023 Kwak, 2002, Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter, Mol. Cell Biol., 22, 2883, 10.1128/MCB.22.9.2883-2892.2002 Hayes, 2014, The Nrf2 regulatory network provides an interface between redox and intermediary metabolism, Trends Biochem. Sci., 39, 199, 10.1016/j.tibs.2014.02.002 Osburn, 2006, Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion, Arch. Biochem. Biophys., 454, 7, 10.1016/j.abb.2006.08.005 Salazar, 2006, Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2, J. Biol. Chem., 281, 14841, 10.1074/jbc.M513737200 Dinkova-Kostova, 2017, Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants, Arch. Biochem Biophys., 617, 84, 10.1016/j.abb.2016.08.005 Levonen, 2004, Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products, Biochem J., 378, 373, 10.1042/bj20031049 Shiraki, 2005, Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma, J. Biol. Chem., 280, 14145, 10.1074/jbc.M500901200 Backos, 2011, Posttranslational modification and regulation of glutamate-cysteine ligase by the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal, Free Radic. Biol. Med, 50, 14, 10.1016/j.freeradbiomed.2010.10.694 Roede, 2008, In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal, Chem. Res. Toxicol., 21, 2289, 10.1021/tx800244u Perluigi, 2009, Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: role of lipid peroxidation in Alzheimer's disease pathogenesis, Proteom. Clin. Appl., 3, 682, 10.1002/prca.200800161 Moos, 2003, Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase, J. Biol. Chem., 278, 745, 10.1074/jbc.M211134200 Sanchez-Gomez, 2007, Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival, Arch. Biochem. Biophys., 457, 150, 10.1016/j.abb.2006.10.032 Sultana, 2004, Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products, Neurochem. Res., 29, 2215, 10.1007/s11064-004-7028-0 Go, 2007, Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion, Am. J. Pathol., 171, 1670, 10.2353/ajpath.2007.070218 Aldini, 2007, Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement, Biochemistry, 46, 2707, 10.1021/bi0618565 Srivastava, 1999, Structural and kinetic determinants of aldehyde reduction by aldose reductase, Biochemistry, 38, 42, 10.1021/bi981794l Diez-Dacal, 2011, Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity, Cancer Res., 71, 4161, 10.1158/0008-5472.CAN-10-3816 Yoval-Sanchez, 2012, Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts, Chem. Res. Toxicol., 25, 722, 10.1021/tx2005184 Tarangelo, 2018, p53 Suppresses metabolic stress-induced ferroptosis in cancer Cells, Cell Rep., 22, 569, 10.1016/j.celrep.2017.12.077 Stockwell, 2017, A regulated cell death nexus Linking metabolism, Redox Biology, and disease, Cell, 171, 273, 10.1016/j.cell.2017.09.021 Sun, 2016, Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells, Hepatology, 63, 173, 10.1002/hep.28251 Roh, 2017, Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis, Redox Biol., 11, 254, 10.1016/j.redox.2016.12.010 Fan, 2017, Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis, Oncogenesis, 6, e371, 10.1038/oncsis.2017.65 Abdalkader, 2018, Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration, Front. Neurosci., 12, 466, 10.3389/fnins.2018.00466 NaveenKumar, 2018, The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets, ACS Chem. Biol., 13, 1996, 10.1021/acschembio.8b00458 Skouta, 2014, Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models, J. Am. Chem. Soc., 136, 4551, 10.1021/ja411006a Baba, 2018, Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes, Am. J. Physiol. Heart Circ. Physiol., 314, H659, 10.1152/ajpheart.00452.2017