CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies

Seminars in Hematology - Tập 47 - Trang 107-114 - 2010
Stephen A. Beers1, Claude H.T. Chan1, Ruth R. French1, Mark S. Cragg1, Martin J. Glennie1
1Tenovus Laboratory, Cancer Sciences Division, University of Southampton School of Medicine, General Hospital, Southampton, UK

Tài liệu tham khảo

Stashenko, 1980, Characterization of a human B lymphocyte-specific antigen, J Immunol, 125, 1678, 10.4049/jimmunol.125.4.1678 Tedder, 1994, CD20: a regulator of cell-cycle progression of B lymphocytes, Immunol Today, 15, 450, 10.1016/0167-5699(94)90276-3 Nadler, 1981, A unique cell surface antigen identifying lymphoid malignancies of B cell origin, J Clin Invest, 67, 134, 10.1172/JCI110005 Oettgen, 1983, Further biochemical studies of the human B-cell differentiation antigens B1 and B2, Hybridoma, 2, 17, 10.1089/hyb.1983.2.17 Ishibashi, 2001, Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor, Gene, 264, 87, 10.1016/S0378-1119(00)00598-9 Liang, 2001, Structural organization of the human MS4A gene cluster on chromosome 11q12, Immunogenetics, 53, 357, 10.1007/s002510100339 Tedder, 1988, Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes, Proc Natl Acad Sci U S A, 85, 208, 10.1073/pnas.85.1.208 Polyak, 1998, Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment, J Immunol, 161, 3242, 10.4049/jimmunol.161.7.3242 Ernst, 2005, Isolation and characterization of the B-cell marker CD20, Biochemistry, 44, 15150, 10.1021/bi0511078 Tedder, 1988, Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes, J Biol Chem, 263, 10009, 10.1016/S0021-9258(19)81618-6 Clark, 1989, Activation of human B cells, J Immunol, 143, 3873, 10.4049/jimmunol.143.12.3873 Teeling, 2006, The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20, J Immunol, 177, 362, 10.4049/jimmunol.177.1.362 Polyak, 2002, Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure, Blood, 99, 3256, 10.1182/blood.V99.9.3256 Du, 2009, Structure of the Fab fragment of therapeutic antibody ofatumumab provides insights into the recognition mechanism with CD20, Mol Immunol, 46, 2419, 10.1016/j.molimm.2009.04.009 Du, 2007, Structural basis for recognition of CD20 by therapeutic antibody rituximab, J Biol Chem, 282, 15073, 10.1074/jbc.M701654200 Polyak, 2008, CD20 homo-oligomers physically associate with the B cell antigen receptor, J Biol Chem, 283, 18545, 10.1074/jbc.M800784200 Li, 2004, The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism, J Biol Chem, 279, 19893, 10.1074/jbc.M400525200 Polyak, 2003, A cholesterol-dependent CD20 epitope detected by the FMC7 antibody, Leukemia, 17, 1384, 10.1038/sj.leu.2402978 Szollosi, 1996, Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY, J Immunol, 157, 2939, 10.4049/jimmunol.157.7.2939 Leveille, 1999, CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines, Eur J Immunol, 29, 65, 10.1002/(SICI)1521-4141(199901)29:01<65::AID-IMMU65>3.0.CO;2-E Petrie, 2002, Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts, J Immunol, 169, 2886, 10.4049/jimmunol.169.6.2886 Walshe, 2008, Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling, J Biol Chem, 283, 16971, 10.1074/jbc.M708459200 O'Keefe, 1998, Mice carrying a CD20 gene disruption, Immunogenetics, 48, 125, 10.1007/s002510050412 Uchida, 2004, Mouse CD20 expression and function, Int Immunol, 16, 119, 10.1093/intimm/dxh009 Bubien, 1993, Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes, J Cell Biol, 121, 1121, 10.1083/jcb.121.5.1121 Kanzaki, 1995, Expression of calcium-permeable cation channel CD20 accelerates progression through the G1 phase in Balb/c 3T3 cells, J Biol Chem, 270, 13099, 10.1074/jbc.270.22.13099 Li, 2003, Store-operated cation entry mediated by CD20 in membrane rafts, J Biol Chem, 278, 42427, 10.1074/jbc.M308802200 Golay, 1985, The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle, J Immunol, 135, 3795, 10.4049/jimmunol.135.6.3795 Cragg, 2004, Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents, Blood, 103, 2738, 10.1182/blood-2003-06-2031 Deans, 1998, Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment, J Biol Chem, 273, 344, 10.1074/jbc.273.1.344 Lim, 2010, Anti-CD20 monoclonal antibodies—historical and future perspectives, Haematologica, 95, 135, 10.3324/haematol.2008.001628 Cragg, 2003, Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts, Blood, 101, 1045, 10.1182/blood-2002-06-1761 Chan, 2003, CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts, Cancer Res, 63, 5480 Ivanov, 2009, Homotypic adhesion and lysosome-mediated cell death evoked by anti-CD20 (tositumomab) and HLA DR monoclonal antibodies, J Clin Invest, 119 Ivanov, 2008, Radiation therapy with tositumomab (B1) anti-CD20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-activated protein kinase-dependent cell death that overcomes resistance to apoptosis, Clin Cancer Res, 14, 4925, 10.1158/1078-0432.CCR-07-5072 Glennie, 2007, Mechanisms of killing by anti-CD20 monoclonal antibodies, Mol Immunol, 44, 3823, 10.1016/j.molimm.2007.06.151 Umana, 2009 Ghetie, 2001, Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin, Blood, 97, 1392, 10.1182/blood.V97.5.1392 Goldenberg, 2009, Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody, Blood, 113, 1062, 10.1182/blood-2008-07-168146 Di Gaetano, 2003, Complement activation determines the therapeutic activity of rituximab in vivo, J Immunol, 171, 1581, 10.4049/jimmunol.171.3.1581 Golay, 2006, The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes, Haematologica, 91, 176 Hamaguchi, 2005, The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice, J Immunol, 174, 4389, 10.4049/jimmunol.174.7.4389 Minard-Colin, 2008, Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV, Blood, 112, 1205, 10.1182/blood-2008-01-135160 Uchida, 2004, The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy, J Exp Med, 199, 1659, 10.1084/jem.20040119 Gong, 2005, Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy, J Immunol, 174, 817, 10.4049/jimmunol.174.2.817 Beers, 2008, Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation, Blood, 112, 4170, 10.1182/blood-2008-04-149161 Hamaguchi, 2006, Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy, J Exp Med, 203, 743, 10.1084/jem.20052283 Li, 2007, Rituximab-CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models, J Immunol, 179, 4263, 10.4049/jimmunol.179.6.4263 Racila, 2008, A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma, Clin Cancer Res, 14, 6697, 10.1158/1078-0432.CCR-08-0745 Wang, 2008, NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement, Blood, 111, 1456, 10.1182/blood-2007-02-074716 Wang, 2009, Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model, Blood, 114, 5322, 10.1182/blood-2009-01-200469 Jilani, 2003, Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia, Blood, 102, 3514, 10.1182/blood-2003-01-0055 Michel, 2002, Intracellular accumulation of the anti-CD20 antibody 1F5 in B-lymphoma cells, Clin Cancer Res, 8, 2701 Press, 1987, Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas, Blood, 69, 584, 10.1182/blood.V69.2.584.584 Cragg, 2004, Apparent modulation of CD20 by rituximab: an alternative explanation, Blood, 103, 3989, 10.1182/blood-2003-12-4384 Austin, 2004, Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin, Mol Biol Cell, 15, 5268, 10.1091/mbc.E04-07-0591 Tefferi, 1996, Heterogeneity and clinical relevance of the intensity of CD20 and immunoglobulin light-chain expression in B-cell chronic lymphocytic leukemia, Am J Clin Pathol, 106, 457, 10.1093/ajcp/106.4.457 Beum, 2006, The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes, J Immunol, 176, 2600, 10.4049/jimmunol.176.4.2600 Lin, 2003, Rituximab in B-cell chronic lymphocytic leukemia, Semin Oncol, 30, 483, 10.1016/S0093-7754(03)00239-2