Pharmacological activity of peroral chitosan–insulin nanoparticles in diabetic rats

Aboubakar, 2000, Insulin-loaded nanocapsules for oral administration: in vitro and in vivo investigation, Drug Dev. Res., 49, 109, 10.1002/(SICI)1098-2299(200002)49:2<109::AID-DDR4>3.0.CO;2-# Barichello, 1999, Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method, Drug Dev. Ind. Pharm., 25, 471, 10.1081/DDC-100102197 Carino, 2000, Nanosphere based oral insulin delivery, J. Contr. Rel., 65, 261, 10.1016/S0168-3659(99)00247-3 Csáky, 1981, Intestinal sugar transport in experimental diabetes, Diabetes, 30, 568, 10.2337/diabetes.30.7.568 Démage, 1988, New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier, Diabetes, 37, 246, 10.2337/diabetes.37.2.246 Fernandez-Urrusuno, 1999, Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm. Res., 16, 1576, 10.1023/A:1018908705446 Gallo-Payet, 1984, Insulin receptors in isolated adult mouse intestinal cells: studies in vivo and in organ culture, Endocrinology, 114, 1885, 10.1210/endo-114-5-1885 Huang, 2002, Uptake of FITC-chitosan nanoparticles by A549 cells, Pharm. Res., 19, 1488, 10.1023/A:1020404615898 Illum, 1994, Chitosan as a novel nasal delivery system for peptide drugs, Pharm. Res., 11, 1186, 10.1023/A:1018901302450 Jamal, 1983, Regulation of mucosal phosphofructokinase in the small intestine of streptozotocin-diabetic rat, Diabetologia, 25, 355, 10.1007/BF00253201 Kotéz, 1997, Chitosan for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers, Int. J. Pharm., 159, 243, 10.1016/S0378-5173(97)00287-1 Lee, 1990, Penetration and enzymatic barriers to peptide and protein absorption, Adv. Drug Deliv. Rev., 4, 171, 10.1016/0169-409X(89)90018-5 Lehr, 1992, In vitro evaluation of mucoadhesive properties of chitosan and some other neutral polymers, Int. J. Pharm., 78, 43, 10.1016/0378-5173(92)90353-4 Leung, 1991, Mucoadhesive dosage forms for peptide and protein drug delivery, 741 Lowe, 1994, Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats, J. Pharm. Pharmacol., 46, 547, 10.1111/j.2042-7158.1994.tb03854.x Lueßen, 1997, Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancer of peptide transport across intestinal mucosae in vitro, J. Contr. Rel., 45, 15, 10.1016/S0168-3659(96)01536-2 Ma, 2002, Formulation pH modulates the interaction of insulin with chitosan nanoparticles, J. Pharm. Sci., 91, 1396, 10.1002/jps.10149 Mathiowitz, 1997, Biologically erodable microspheres as oral drug delivery system, Nature, 386, 410, 10.1038/386410a0 Pan, 2002, Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo, Int. J. Pharm., 249, 139, 10.1016/S0378-5173(02)00486-6 Schipper, 1997, Chitosan as absorption enhancers for poorly absorbable drugs. 2. Mechanism of absorption enhancement, Pharm. Res., 14, 923, 10.1023/A:1012160102740 Schipper, 1996, Chitosan as absorption enhancers for poorly absorbable drugs. 1. Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells, Pharm. Res., 13, 1686, 10.1023/A:1016444808000 Tan, 1998, The degree of deacetylation of chitosan: advocating the first derivative UV-spectrophometry method of determination, Talanta, 45, 713, 10.1016/S0039-9140(97)00288-9 Wang, 1991, Determination of the Mark–Houwink equation for chitosans with different degree of deacetylation, Int. J. Biol. Macromol., 13, 281, 10.1016/0141-8130(91)90027-R