REGULATION OF SECRETION OF MUCUS FROM THE GASTRIC ANTRUM*

Annals of the New York Academy of Sciences - Tập 140 Số 2 - Trang 797-803 - 1967
René Menguy1, A.E. Thompson2
1Department of Surgery, University of Chicago School of Medicine, Chicago, Ill.
2St Mary's Hospital, London, England

Tóm tắt

SummaryGastric secretion of mucus was studied in dogs by collecting secretions from vagally‐denervated or ‐innervated gastric antral pouches. Mucous secretions were studied for volume and for concentration of nitrogen, hexsoses, hexsosamines, L‐fucose and sialic acid concentrations in dialyzed, lyophilized mucosubstance. Gastric mucosal content of mucus of rats was measured by analyzing the concentration of hexsosamine and sialic acid in freeze‐dried gastric mucosal scrapings. Vagal stimulation of the gastric antrum and administration of cholinomime‐tic agents had no detectable influence on either the volume or the biochemical composition of antral mucus. Insulin‐induced hypoglycemia appeared to depress the secretion of mucus. Adrenergic stimulation was without influence. Serotonin had a strong stimulatory effect on the volume of mucus secretion but did not alter its biochemical composition. Cortisone had a profound inhibitory influence on the secretion of mucus and altered its biochemical composition by decreasing the concentration of sialic acid. Parathyroid extract was found to increase gastric mucosal content of mucus in rats.

Từ khóa


Tài liệu tham khảo

Glass G. J. B., 1950, Patterns of response of gastric mucoprotein and acid to insulin; correlation with the underlying disease in nonoperated stomach in man, Gastroenterology, 15, 438, 10.1016/S0016-5085(50)80135-X

10.1113/expphysiol.1941.sp000842

Graef J., 1964, Secrétion de protéines et de mucoprotéines par la muqueuse gastrique chez le chien, 7th Cong. Int. de Gastroentérologie., 11, 98

Menguy R., 1963, Effect of cortisone on mucoprotein secretion by gastric antrum of dogs: pathogenesis of steroid ulcer, Surgery, 54, 19

Menguy R., 1965, Effects of aspirin on gastric mucous secretion, Surg. Gynec. Obst., 120, 92

Dische Z., 1950, An apectrophotometric method for the micro‐ determination of hexsosamines, J. Biol. Chem., 184, 517, 10.1016/S0021-9258(19)50982-6

Dische Z., 1948, A specific color reaction of methyl pentoses and a spectrophotometric micromethod for their determination, J. Biol. Chem., 175, 595, 10.1016/S0021-9258(18)57178-7

10.1016/S0021-9258(18)69851-5

10.1016/S0016-5085(65)80114-7

Ivy A. C., 1921, Studies on the secretion of the pars pylorica gastri, Am. J. Phys., 57, 51

10.1016/S0016-5085(60)80136-9

10.1016/S0016-5085(19)35540-4

Thông tin
Thông tin xuất bản

Annals of the New York Academy of Sciences

Tập 140 Số 2

797-803

Thông tin tác giả