(–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties

Journal of Pharmacology and Experimental Therapeutics - Tập 323 Số 1 - Trang 265-276 - 2007
Thomas Tzschentke1, Thomas Christoph, Babette Kögel, Klaus Schiene, H.‐H. Hennies, Werner Englberger, Michael Haurand, Ulrich Jahnel, Thomas I.F.H. Cremers, Elmar Friderichs, Jean De Vry
1Department of Pharmacology, Grünenthal GmbH, Aachen, Germany. [email protected]

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Tài liệu tham khảo

10.1056/NEJMra025411

10.1016/S0014-2999(98)00241-6

10.1016/0304-3959(88)90209-6

10.1056/NEJMra041867

10.1002/hup.621

Buschmann H, Christoph T, Friderichs E, Maul C, and Sundermann B (eds) (2002) Analgesics. From Chemistry and Pharmacology to Clinical Application. Wiley-VHC, Weinheim, Germany.

2002, Curr Opin Investig Drugs, 3, 454

Casy AF and Parfitt RT (1986) Opioid Analgesics. Plenum Press, New York.

10.1016/0304-3959(93)90059-X

10.1038/sj.npp.1301287

1941, J Pharmacol Exp Ther, 72, 74

1953, J Pharmacol Exp Ther, 107, 385

Friderichs E and Buschmann H (2002) Opioids with clinical relevance, in Analgesics. From Chemistry and Pharmacology to Clinical Application (Buschmann H, Christoph T, Friderichs E, Maul C, and Sundermann B, eds) pp 171–245, Wiley-VHC, Weinheim, Germany.

1996, Arzneimittelforschung, 46, 1029

10.1007/s002100000266

1959, J Pharmacol Exp Ther, 125, 237

10.1016/j.pain.2004.09.019

10.1016/0304-3959(92)90041-9

10.1016/S0304-3959(01)00275-5

10.1016/0304-3959(86)90220-4

1981, Arzneimittelforschung, 31, 1932

1949, J Pharmacol Exp Ther, 96, 99

10.1016/S0304-3940(99)00998-2

2001, J Pharmacol Exp Ther, 299, 811

10.1038/383819a0

Maul C, Buschmann H, and Sundermann B (2002) Synthetic opioids, in Analgesics. From Chemistry and Pharmacology to Clinical Application (Buschmann H, Christoph T, Friderichs E, Maul C and Sundermann B eds) pp 159–169, Wiley-VHC, Weinheim, Germany.

1992, N Engl J Med, 326, 1250, 10.1056/NEJM199205073261904

1982, Arch Int Pharmacodyn, 259, 222

Paxinos G and Watson C (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.

1996, J Pain Symptom Manage, 11, 203

10.1016/S0009-9236(96)90211-8

1992, J Pharmacol Exp Ther, 260, 275

1993, J Pharmacol Exp Ther, 267, 331

1957, Arch Int Pharmacodyn Ther, 111, 409

2006, J Pain, 7, S26

10.1007/s002130000416

Tzschentke TM (2002) NA and 5-HT reuptake inhibitors and α2 agonists, in Analgesics. From Chemistry and Pharmacology to Clinical Application (Buschmann H, Christoph T, Friderichs E, Maul C and Sundermann B eds) pp 264–284, Wiley-VHC, Weinheim, Germany.

10.1358/dof.2006.031.12.1047744

10.1016/0304-3959(90)91068-T

10.1016/0304-3959(83)90201-4