Tumor macrophages as a target for Capsaicin mediated immunotherapy

Singh, 1992, Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells, J. Exp. Med., 175, 139, 10.1084/jem.175.1.139 Ochsenbein, 1999, Immune surveillance against a solid tumor fails because of immunological ignorance, Proc. Natl. Acad. Sci. USA, 96, 2233, 10.1073/pnas.96.5.2233 Ibe, 2001, Tumor rejection by disturbing tumor stroma cell interactions, J. Exp. Med., 194, 1549, 10.1084/jem.194.11.1549 Kammertoens, 2005, Immunotherapy: target the stroma to hit the tumor, Trends Mol. Med., 11, 225, 10.1016/j.molmed.2005.03.002 Spiotto, 2004, Bystander elimination of antigen loss variants in established tumors, Nat. Med., 10, 294, 10.1038/nm999 Spiotto, 2005, Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells, Cancer Immun., 5, 8 Spiotto, 2002, Increasing tumor antigen expression overcomes “ignorance” to solid tumors via crosspresentation by bone marrow-derived stromal cells, Immunity, 17, 737, 10.1016/S1074-7613(02)00480-6 Yu, 2006, The role of stroma in immune recognition and destruction of well-established solid tumors, Curr. Opin. Immunol., 18, 226, 10.1016/j.coi.2006.01.004 Zhang, 2007, Induced sensitization of tumor stroma leads to eradication of established cancer by T cells, J. Exp. Med., 204, 49, 10.1084/jem.20062056 Blankenstein, 2005, The role of tumor stroma in the interaction between tumor and immune system, Curr. Opin. Immunol., 17, 180, 10.1016/j.coi.2005.01.008 Yu, 2005, Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors, J. Exp. Med.., 201, 779, 10.1084/jem.20041684 Basu, 2005, Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells, Proc. Natl. Acad. Sci. USA, 102, 5120, 10.1073/pnas.0407780102 Beltran, 2007, Immunotherapy of tumors with neuroimmune ligand capsaicin, J. Immunol., 178, 3260, 10.4049/jimmunol.178.5.3260 Flemming, 2007, Red chillies tackle tumours, Nat. Rev. Drug Discov., 6, 269, 10.1038/nrd2299 Srivastava, 1986, Tumor rejection antigens of chemically induced sarcomas of inbred mice, Proc. Natl. Acad. Sci. USA, 83, 3407, 10.1073/pnas.83.10.3407 Ghosh, 2009, Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis, Cancer Lett. Kusmartsev, 2002, Immature myeloid cells and cancer-associated immune suppression, Cancer Immunol. Immunother., 51, 293, 10.1007/s00262-002-0280-8 Yang, 2004, Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis, Cancer Cell, 6, 409, 10.1016/j.ccr.2004.08.031 Choi, 2007, Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy, Cancer Res., 67, 8891, 10.1158/0008-5472.CAN-07-1056 Knutson, 2006, IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice, J. Immunol., 177, 84, 10.4049/jimmunol.177.1.84 Nair, 2006, Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors, J. Immunol., 176, 7325, 10.4049/jimmunol.176.12.7325 VanOosten, 2007, Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy, Cancer Res., 67, 11980, 10.1158/0008-5472.CAN-07-1526 Bui, 2006, Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins, Cancer Res., 66, 7301, 10.1158/0008-5472.CAN-06-0556 Nowak, 2002, Gemcitabine exerts a selective effect on the humoral immune response: implications for combination chemo-immunotherapy, Cancer Res., 62, 2353 Suzuki, 2005, Gemcitabine selectively eliminates splenic Gr−1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity, Clin. Cancer Res., 11, 6713, 10.1158/1078-0432.CCR-05-0883 Sinha, 2007, Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response, J. Immunol., 179, 977, 10.4049/jimmunol.179.2.977 van der Most, 2009, Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy, Cancer Immunol. Immunother., 58, 1219, 10.1007/s00262-008-0628-9 Nowak, 2003, Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells, J. Immunol., 170, 4905, 10.4049/jimmunol.170.10.4905 North, 1984, The murine antitumor immune response and its therapeutic manipulation, Adv. Immunol., 35, 89, 10.1016/S0065-2776(08)60575-1 Staveley-O’Carroll, 1998, Induction of antigen-specific T cell anergy: An early event in the course of tumor progression, Proc. Natl. Acad. Sci. USA, 95, 1178, 10.1073/pnas.95.3.1178 Cuenca, 2003, Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens, Cancer Res., 63, 9007 Bursuker, 1984, Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity, J. Exp. Med., 159, 1312, 10.1084/jem.159.5.1312 North, 1982, Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells, J. Exp. Med., 155, 1063, 10.1084/jem.155.4.1063 Koeppen, 1993, CD4-positive and B lymphocytes in transplantation immunity. I. Promotion of tumor allograft rejection through elimination of CD4-positive lymphocytes, Transplantation, 55, 1349, 10.1097/00007890-199306000-00026 Bodo, 2005, A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control, Am. J. Pathol., 166, 985, 10.1016/S0002-9440(10)62320-6 Lu, 2006, Role of cannabinoid receptors in delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila, Eur. J. Pharmacol., 532, 170, 10.1016/j.ejphar.2005.12.040 Amantini, 2004, Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death, Cell Death Differ., 11, 1342, 10.1038/sj.cdd.4401506