Chronic pain impact on rodents’ behavioral repertoire

Neuroscience & Biobehavioral Reviews - Tập 119 - Trang 101-127 - 2020
Ana Margarida Cunha1,2, Joana Pereira-Mendes1,2, Armando Almeida1,3, Marco Rafael Guimarães1,2, Hugo Leite-Almeida1,3
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal
2ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
3ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal

Tài liệu tham khảo

Abdulmajeed, 2016, Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain, J. Basic Clin. Physiol. Pharmacol., 27, 101, 10.1515/jbcpp-2014-0052 Adams, 1981, Instrumental responding following reinforcer devaluation, Q. J. Exp. Psychol. B, 33, 109, 10.1080/14640748108400816 Aguilar-Avila, 2019, Beta-caryophyllene, a natural sesquiterpene, attenuates neuropathic pain and depressive-like behavior in experimental diabetic mice, J. Med. Food, 22, 460, 10.1089/jmf.2018.0157 Aissouni, 2017, Acid-sensing ion channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis, Sci. Rep., 7, 43617, 10.1038/srep43617 Akintola, 2017, The grimace scale reliably assesses chronic pain in a rodent model of trigeminal neuropathic pain, Neurobiol Pain, 2, 13, 10.1016/j.ynpai.2017.10.001 Alba-Delgado, 2013, Chronic pain leads to concomitant noradrenergic impairment and mood disorders, Biol. Psychiatry, 73, 54, 10.1016/j.biopsych.2012.06.033 Alba-Delgado, 2016, Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: a comparative study with the chronic constriction injury model, Prog. Neuropsychopharmacol. Biol. Psychiatry, 71, 45, 10.1016/j.pnpbp.2016.06.007 Alba-Delgado, 2018, The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain, Pain, 159, 2606, 10.1097/j.pain.0000000000001372 Albert, 2015, Why is depression more prevalent in women?, J. Psychiatry Neurosci., 40, 219, 10.1503/jpn.150205 Albuquerque, 2013, Learning and memory with neuropathic pain: impact of old age and progranulin deficiency, Front. Behav. Neurosci., 7, 174, 10.3389/fnbeh.2013.00174 Almeida, 2006, Medullary control of nociceptive transmission: reciprocal dual communication with the spinal cord, Drug Discov. Today Dis. Mech., 3, 305, 10.1016/j.ddmec.2006.09.001 Amorim, 2014, Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis, Behav. Brain Res., 265, 12, 10.1016/j.bbr.2014.02.003 Amorim, 2017, Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat, Behav. Brain Res., 327, 1, 10.1016/j.bbr.2017.03.003 Andersen, 2009, Increased susceptibility to development of anhedonia in rats with chronic peripheral nerve injury: involvement of sleep deprivation?, Prog. Neuropsychopharmacol. Biol. Psychiatry, 33, 960, 10.1016/j.pnpbp.2009.04.022 Andrew, 2014, The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain, Pain Pract., 14, 79, 10.1111/papr.12050 Andrews, 2012, Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain, Eur. J. Pain, 16, 485, 10.1016/j.ejpain.2011.07.012 Andrews, 2016, Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations, Pain, 157, 901, 10.1097/j.pain.0000000000000458 Apkarian, 2009, Towards a theory of chronic pain, Prog. Neurobiol., 87, 81, 10.1016/j.pneurobio.2008.09.018 Arakawa, 2018, Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models, Neurosci. Res., 135, 1, 10.1016/j.neures.2018.02.001 Arora, 2011, Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences, Psychoneuroendocrinology, 36, 1570, 10.1016/j.psyneuen.2011.04.012 Attal, 1990, Further evidence for 'pain-related' behaviours in a model of unilateral peripheral mononeuropathy, Pain, 41, 235, 10.1016/0304-3959(90)90022-6 Austin, 2010, Peripheral nerve injury differentially regulates dopaminergic pathways in the nucleus accumbens of rats with either’ pain alone’ or’ pain and disability’, Neuroscience, 171, 329, 10.1016/j.neuroscience.2010.08.040 Austin, 2015, Injury-dependent and disability-specific lumbar spinal gene regulation following sciatic nerve injury in the rat, PLoS One, 10, 10.1371/journal.pone.0124755 Austin, 2015, Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury, J. Neuroinflammation, 12, 96, 10.1186/s12974-015-0318-4 Avila-Martin, 2014, Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury, Eur. J. Pain Baastrup, 2011, Pregabalin attenuates place escape/avoidance behavior in a rat model of spinal cord injury, Brain Res., 1370, 129, 10.1016/j.brainres.2010.11.008 Bair, 2003, Depression and pain comorbidity: a literature review, Arch. Intern. Med., 163, 2433, 10.1001/archinte.163.20.2433 Balleine, 2010, Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action, Neuropsychopharmacology, 35, 48, 10.1038/npp.2009.131 Barcelon, 2019, Brain microglial activation in chronic pain-associated affective disorder, Front. Neurosci., 13, 213, 10.3389/fnins.2019.00213 Bari, 2008, The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats, Nat. Protoc., 3, 759, 10.1038/nprot.2008.41 Barnes, 1979, Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat, J. Comp. Physiol. Psychol., 93, 74, 10.1037/h0077579 Barrot, 2012, Tests and models of nociception and pain in rodents, Neuroscience, 211, 39, 10.1016/j.neuroscience.2011.12.041 Barthas, 2015, The anterior cingulate cortex is a critical hub for pain-induced depression, Biol. Psychiatry, 77, 236, 10.1016/j.biopsych.2014.08.004 Barthas, 2017, Cingulate overexpression of mitogen-activated protein kinase phosphatase-1 as a key factor for depression, Biol. Psychiatry, 82, 370, 10.1016/j.biopsych.2017.01.019 Bell, 2018, Meta-analysis of cognitive performance in fibromyalgia, J. Clin. Exp. Neuropsychol., 40, 698, 10.1080/13803395.2017.1422699 Belovicova, 2017, Animal tests for anxiety-like and depression-like behavior in rats, Interdiscip. Toxicol., 10, 40, 10.1515/intox-2017-0006 Benbouzid, 2008, Sciatic nerve cuffing in mice: a model of sustained neuropathic pain, Eur. J. Pain, 12, 591, 10.1016/j.ejpain.2007.10.002 Bennett, 1988, A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man, Pain, 33, 87, 10.1016/0304-3959(88)90209-6 Benson, 2015, Voluntary wheel running delays disease onset and reduces pain hypersensitivity in early experimental autoimmune encephalomyelitis (EAE), Exp. Neurol., 271, 279, 10.1016/j.expneurol.2015.05.017 Berryman, 2014, Do people with chronic pain have impaired executive function? A meta-analytical review, Clin. Psychol. Rev., 34, 563, 10.1016/j.cpr.2014.08.003 Biessels, 1996, Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats, Diabetes, 45, 1259, 10.2337/diab.45.9.1259 Biessels, 1998, Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment, Brain Res., 800, 125, 10.1016/S0006-8993(98)00510-1 Birmann, 2019, 3-(4-Chlorophenylselanyl)-1-methyl-1H-indole promotes recovery of neuropathic pain and depressive-like behavior induced by partial constriction of the sciatic nerve in mice, J. Trace Elem. Med. Biol., 54, 126, 10.1016/j.jtemb.2019.04.014 Birrell, 2000, Medial frontal cortex mediates perceptual attentional set shifting in the rat, J. Neurosci., 20, 4320, 10.1523/JNEUROSCI.20-11-04320.2000 Boadas-Vaello, 2018, Graded photochemical spinal cord injury results in chronic hyperalgesia and depression-like behaviour but no anxiety exacerbation in female BALB/c mice, Neurosci. Lett., 664, 98, 10.1016/j.neulet.2017.11.007 Boccella, 2019, Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway, Neurobiol. Dis., 121, 106, 10.1016/j.nbd.2018.09.023 Boissier, 1962, La reaction dexploration chez la souris, Therapie, 17, 1225 Borges, 2014, Reversal of monoarthritis-induced affective disorders by diclofenac in rats, Anesthesiology, 120, 1476, 10.1097/ALN.0000000000000177 Borges, 2015, Corticotropin-releasing factor mediates pain-induced anxiety through the ERK1/2 signaling cascade in locus coeruleus neurons, Int. J. Neuropsychopharmacol., 18, 10.1093/ijnp/pyv019 Borges, 2017, Activation of extracellular signal-regulated kinases (ERK 1/2) in the locus coeruleus contributes to pain-related anxiety in arthritic male rats, Int. J. Neuropsychopharmacol., 20, 463, 10.1093/ijnp/pyx005 Bourin, 2003, The mouse light/dark box test, Eur. J. Pharmacol., 463, 55, 10.1016/S0014-2999(03)01274-3 Bovenkerk, 2015, The use of animal models in behavioural neuroscience research, Curr. Top. Behav. Neurosci., 19, 17, 10.1007/7854_2014_329 Bravo, 2012, Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression, Anesthesiology, 117, 613, 10.1097/ALN.0b013e3182657b3e Breivik, 2006, Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment, Eur. J. Pain, 10, 287, 10.1016/j.ejpain.2005.06.009 Broekkamp, 1986, Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice, Eur. J. Pharmacol., 126, 223, 10.1016/0014-2999(86)90051-8 Brown, 2016, Attentional set-shifting across species, Curr. Top. Behav. Neurosci., 28, 363, 10.1007/7854_2015_5002 Brudzynski, 2013, Ethotransmission: communication of emotional states through ultrasonic vocalization in rats, Curr. Opin. Neurobiol., 23, 310, 10.1016/j.conb.2013.01.014 Brunori, 2018, Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats, Pain, 159, 2179, 10.1097/j.pain.0000000000001318 Bura, 2018, Operant self-administration of pregabalin in a mouse model of neuropathic pain, Eur. J. Pain, 22, 763, 10.1002/ejp.1161 Burgdorf, 2019, Rat ultrasonic vocalizations as a measure of the emotional component of chronic pain, Neuroreport, 30, 863, 10.1097/WNR.0000000000001282 Burke, 2017, Specific 50-kHz vocalizations are tightly linked to particular types of behavior in juvenile rats anticipating play, PLoS One, 12, 10.1371/journal.pone.0175841 Cai, 2019, Comorbidity of pain and depression in a lumbar disc herniation model: biochemical alterations and the effects of fluoxetine, Front. Neurol., 10, 1022, 10.3389/fneur.2019.01022 Cain, 1997, Pain-related disability and effects of chronic morphine in the adjuvant-induced arthritis model of chronic pain, Physiol. Behav., 62, 199, 10.1016/S0031-9384(97)00158-3 Callahan, 2015, Attention. Handb Exp Pharmacol, 228, 161, 10.1007/978-3-319-16522-6_5 Calvino, 1996, Ultrasonic vocalization (22-28 kHz) in a model of chronic pain, the arthritic rat: effects of analgesic drugs, Neuroreport, 7, 581, 10.1097/00001756-199601310-00049 Carcole, 2019, Blockade of the Sigma-1 receptor relieves cognitive and emotional impairments associated to chronic osteoarthritis pain, Front. Pharmacol., 10, 468, 10.3389/fphar.2019.00468 Cardenas, 2019, Persistent pain intensifies recall of consolidated fear memories, Neurobiol. Stress, 10, 10.1016/j.ynstr.2019.100163 Cardoso-Cruz, 2013, Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity, J. Neurosci., 33, 2465, 10.1523/JNEUROSCI.5197-12.2013 Cardoso-Cruz, 2013, Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain, Pain, 154, 2397, 10.1016/j.pain.2013.07.020 Cardoso-Cruz, 2014, Activation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury, J. Neurosci., 34, 5861, 10.1523/JNEUROSCI.0021-14.2014 Cardoso-Cruz, 2018, Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats, Eur. J. Pain, 22, 1002, 10.1002/ejp.1186 Cardoso-Cruz, 2019, Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain, Pain, 160, 805, 10.1097/j.pain.0000000000001457 Carli, 1983, Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal, Behav. Brain Res., 9, 361, 10.1016/0166-4328(83)90138-9 Caspani, 2014, Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats, Pharmacol. Biochem. Behav., 124, 290, 10.1016/j.pbb.2014.06.018 Castanheira, 2018, Anxiety assessment in pre-clinical tests and in clinical trials: a critical review, Curr. Top. Med. Chem., 18, 1656, 10.2174/1568026618666181115102518 Castorina, 2019, PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury, Neuropeptides, 74, 60, 10.1016/j.npep.2018.12.002 Chabout, 2012, Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment, PLoS One, 7, 10.1371/journal.pone.0029401 Chen, 2015, Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation, Am. J. Physiol. Regul. Integr. Comp. Physiol., 308, R18, 10.1152/ajpregu.00298.2014 Chen, 2018, Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats, Pharmacol. Res. Perspect., 6, 10.1002/prp2.367 Chen, 2019, Amygdaloid administration of tetrapentylammonium attenuates development of pain and anxiety-like behavior following peripheral nerve injury, Pharmacol. Rep., 71, 54, 10.1016/j.pharep.2018.08.005 Chenaf, 2018, Prevalence of chronic pain with or without neuropathic characteristics in France using the capture-recapture method: a population-based study, Pain, 159, 2394, 10.1097/j.pain.0000000000001347 Chun, 2018, Alleviation of irritable bowel syndrome-like symptoms and control of gut and brain responses with oral administration of Dolichos lablab L. In a mouse model, Nutrients, 10, 10.3390/nu10101475 Chung, 2017, Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats, Sci. Rep., 7, 9743, 10.1038/s41598-017-09991-8 Clark, 2016, Preclinical pain research: can we do better?, Anesthesiology, 125, 846, 10.1097/ALN.0000000000001340 Cobos, 2013, Bedside-to-Bench" behavioral outcomes in animal models of pain: beyond the evaluation of reflexes, Curr. Neuropharmacol., 11, 560, 10.2174/1570159X113119990041 Cobos, 2012, Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia, Pain, 153, 876, 10.1016/j.pain.2012.01.016 Coutinho, 1996, Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors, Brain Res., 736, 7, 10.1016/0006-8993(96)00661-0 Cowen, 2018, Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats, Pain, 159, 1403, 10.1097/j.pain.0000000000001226 Crawley, 1981, Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines, Pharmacol. Biochem. Behav., 15, 695, 10.1016/0091-3057(81)90007-1 Crawley, 1980, Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines, Pharmacol. Biochem. Behav., 13, 167, 10.1016/0091-3057(80)90067-2 Cryan, 2005, The ascent of mouse: advances in modelling human depression and anxiety, Nat. Rev. Drug Discov., 4, 775, 10.1038/nrd1825 Cryan, 2011, The age of anxiety: role of animal models of anxiolytic action in drug discovery, Br. J. Pharmacol., 164, 1129, 10.1111/j.1476-5381.2011.01362.x Cryan, 2005, The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice, Neurosci. Biobehav. Rev., 29, 571, 10.1016/j.neubiorev.2005.03.009 Cunha, 2020, High trait impulsivity potentiates the effects of chronic pain on impulsive behavior, Neurobiol Pain, 7, 10.1016/j.ynpai.2019.100042 D’Aniello, 2017, d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces beta-amyloid Abeta1-42 peptide in a long lasting model of neuropathic pain, Neurosci. Lett., 651, 151, 10.1016/j.neulet.2017.04.041 Dalley, 2017, Fractionating impulsivity: neuropsychiatric implications, Nat. Rev. Neurosci., 18, 158, 10.1038/nrn.2017.8 Dalley, 2012, Dopamine, serotonin and impulsivity, Neuroscience, 215, 42, 10.1016/j.neuroscience.2012.03.065 Dalley, 2011, Impulsivity, compulsivity, and top-down cognitive control, Neuron, 69, 680, 10.1016/j.neuron.2011.01.020 Dalziel, 2004, Allodynia in rats infected with varicella zoster virus--a small animal model for post-herpetic neuralgia, Brain Res. Brain Res. Rev., 46, 234, 10.1016/j.brainresrev.2004.07.008 Das, 2015, An introduction to pain pathways and pain “targets”, Prog. Mol. Biol. Transl. Sci., 131, 1, 10.1016/bs.pmbts.2015.01.003 De Gregorio, 2019, Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain, Pain, 160, 136, 10.1097/j.pain.0000000000001386 de Souza, 2017, Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks, Nutr. Neurosci., 20, 23, 10.1179/1476830514Y.0000000145 Deacon, 2006, Burrowing in rodents: a sensitive method for detecting behavioral dysfunction, Nat. Protoc., 1, 118, 10.1038/nprot.2006.19 Deacon, 2006, Digging and marble burying in mice: simple methods for in vivo identification of biological impacts, Nat. Protoc., 1, 122, 10.1038/nprot.2006.20 Deacon, 2009, Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents, Behav. Brain Res., 200, 128, 10.1016/j.bbr.2009.01.007 Deacon, 2006, T-maze alternation in the rodent, Nat. Protoc., 1, 7, 10.1038/nprot.2006.2 Deacon, 2001, Burrowing into prion disease, Neuroreport, 12, 2053, 10.1097/00001756-200107030-00052 Decosterd, 2000, Spared nerve injury: an animal model of persistent peripheral neuropathic pain, Pain, 87, 149, 10.1016/S0304-3959(00)00276-1 Dellarole, 2014, Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling, Brain Behav. Immun., 41, 65, 10.1016/j.bbi.2014.04.003 Denenberg, 1969, Open-field behavior in the rat: what does it mean?, Ann. N. Y. Acad. Sci., 159, 852, 10.1111/j.1749-6632.1969.tb12983.x Descalzi, 2017, Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression, Sci. Signal., 10, 10.1126/scisignal.aaj1549 Deuis, 2017, Methods used to evaluate pain behaviors in rodents, Front. Mol. Neurosci., 10, 284, 10.3389/fnmol.2017.00284 Dexter, 1969, Role of contextual discrimination in fear conditioning, J. Comp. Physiol. Psychol., 69, 677, 10.1037/h0028210 Diaz, 2019, Analgesic and antidepressant effects of oltipraz on neuropathic pain in mice by modulating microglial activation, J. Clin. Med., 8, 10.3390/jcm8060890 Dietz, 2017, From the rodent spinal cord injury model to human application: promises and challenges, J. Neurotrauma, 34, 1826, 10.1089/neu.2016.4513 Dimitrov, 2014, Anxiety- and depression-like behavior and impaired neurogenesis evoked by peripheral neuropathy persist following resolution of prolonged tactile hypersensitivity, J. Neurosci., 34, 12304, 10.1523/JNEUROSCI.0312-14.2014 do Nascimento, 2014, Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint, Physiol. Behav., 125, 1, 10.1016/j.physbeh.2013.11.009 Dolan, 2013, Goals and habits in the brain, Neuron, 80, 312, 10.1016/j.neuron.2013.09.007 Donaldson, 1993, A discrete adjuvant-induced monoarthritis in the rat: effects of adjuvant dose, J. Neurosci. Methods, 49, 5, 10.1016/0165-0270(93)90103-X Du, 2017, The effect of electroacupuncture on PKMzeta in the ACC in regulating anxiety-like behaviors in rats experiencing chronic inflammatory pain, Neural Plast., 2017, 10.1155/2017/3728752 Ducottet, 2003, Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice, Prog. Neuropsychopharmacol. Biol. Psychiatry, 27, 625, 10.1016/S0278-5846(03)00051-4 Dudchenko, 2004, An overview of the tasks used to test working memory in rodents, Neurosci. Biobehav. Rev., 28, 699, 10.1016/j.neubiorev.2004.09.002 Duenas, 2016, A review of chronic pain impact on patients, their social environment and the health care system, J. Pain Res., 9, 457, 10.2147/JPR.S105892 Dunnett, 1985, Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats, Psychopharmacology (Berl.), 87, 357, 10.1007/BF00432721 Eagle, 2003, Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task, Behav. Brain Res., 146, 131, 10.1016/j.bbr.2003.09.022 Ellenbroek, 2016, Rodent models in neuroscience research: is it a rat race?, Dis. Model. Mech., 9, 1079, 10.1242/dmm.026120 Elliott, 1999, The epidemiology of chronic pain in the community, Lancet, 354, 1248, 10.1016/S0140-6736(99)03057-3 Ennaceur, 1988, A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data, Behav. Brain Res., 31, 47, 10.1016/0166-4328(88)90157-X Ewan, 2014, Differential suppression of intracranial self-stimulation, food-maintained operant responding, and open field activity by paw incision and spinal nerve ligation in rats, Anesth. Analg., 118, 854, 10.1213/ANE.0000000000000119 Fang, 2018, Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury, Eur. Arch. Psychiatry Clin. Neurosci. Fang, 2019, Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model, Brain Res. Bull., 146, 192, 10.1016/j.brainresbull.2019.01.008 Fang, 2019, Abnormalities in inflammatory cytokines confer susceptible to chronic neuropathic pain-related anhedonia in a rat model of spared nerve injury, Clin. Psychopharmacol. Neurosci., 17, 189, 10.9758/cpn.2019.17.2.189 Faure, 2017, Social behaviors and acoustic vocalizations in different strains of mice, Behav. Brain Res., 320, 383, 10.1016/j.bbr.2016.11.003 Ferreira, 2018, Depression assessment in clinical trials and pre-clinical tests: a critical review, Curr. Top. Med. Chem., 18, 1677, 10.2174/1568026618666181115095920 Ferreira-Chamorro, 2018, Sulforaphane inhibited the nociceptive responses, anxiety- and depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice, Front. Pharmacol., 9, 1332, 10.3389/fphar.2018.01332 File, 1980, The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs, J. Neurosci. Methods, 2, 219, 10.1016/0165-0270(80)90012-6 File, 1978, Can social interaction be used to measure anxiety?, Br. J. Pharmacol., 62, 19, 10.1111/j.1476-5381.1978.tb07001.x File, 2003, A review of 25 years of the social interaction test, Eur. J. Pharmacol., 463, 35, 10.1016/S0014-2999(03)01273-1 Filho, 2016, Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: long-lasting effect, Prog. Neuropsychopharmacol. Biol. Psychiatry, 64, 44, 10.1016/j.pnpbp.2015.06.016 Fiore, 2018, Glial-cytokine-neuronal adaptations in the ventral Hippocampus of rats with affective behavioral changes following peripheral nerve injury, Neuroscience, 390, 119, 10.1016/j.neuroscience.2018.08.010 Fukuhara, 2012, Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF), Cell. Mol. Neurobiol., 32, 971, 10.1007/s10571-011-9782-2 Fusco, 2019, Melatonin plus folic acid treatment ameliorates reserpine-induced fibromyalgia: an evaluation of pain, oxidative stress, and inflammation, Antioxidants (Basel), 8 Gabriel, 2010, Enriched environment and the recovery from inflammatory pain: social versus physical aspects and their interaction, Behav. Brain Res., 208, 90, 10.1016/j.bbr.2009.11.015 Gai, 2014, Depression-related behavior and mechanical allodynia are blocked by 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene in a mouse model of neuropathic pain induced by partial sciatic nerve ligation, Neuropharmacology, 79, 580, 10.1016/j.neuropharm.2014.01.020 Galan-Arriero, 2014, Oral administration of the p38alpha MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury, Pain, 155, 2188, 10.1016/j.pain.2014.08.030 Galan-Arriero, 2015, Early treatment with UR13870, a novel inhibitor of p38alpha mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain, Neurosci. Lett., 604, 69, 10.1016/j.neulet.2015.07.044 Gambeta, 2018, Anxiety- but not depressive-like behaviors are related to facial hyperalgesia in a model of trigeminal neuropathic pain in rats, Physiol. Behav., 191, 131, 10.1016/j.physbeh.2018.04.025 Garg, 2017, Possible modulation of PPAR-gamma cascade against depression caused by neuropathic pain in rats, J. Basic Clin. Physiol. Pharmacol., 28, 593, 10.1515/jbcpp-2016-0108 George, 2019, Use of the rat grimace scale to evaluate visceral pain in a model of chemotherapy-induced mucositis, Animals (Basel), 9 Ghoreishi-Haack, 2018, NYX-2925 is a novel N-Methyl-d-Aspartate receptor modulator that induces rapid and long-lasting analgesia in rat models of neuropathic pain, J. Pharmacol. Exp. Ther., 366, 485, 10.1124/jpet.118.249409 Gibbs, 2013, Paradoxical surrogate markers of dental injury-induced pain in the mouse, Pain, 154, 1358, 10.1016/j.pain.2013.04.018 Goffer, 2013, Calcium-permeable AMPA receptors in the nucleus accumbens regulate depression-like behaviors in the chronic neuropathic pain state, J. Neurosci., 33, 19034, 10.1523/JNEUROSCI.2454-13.2013 Gonçalves, 2008, Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat, Exp. Neurol., 213, 48, 10.1016/j.expneurol.2008.04.043 Gong, 2018, Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury, J. Neuroinflammation, 15, 262, 10.1186/s12974-018-1301-7 Gonzalez-Sepulveda, 2016, Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice, J. Psychopharmacol., 30, 188, 10.1177/0269881115622238 Grace, 2014, Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain, J. Pain, 15, 121, 10.1016/j.jpain.2013.10.001 Grace, 2016, Prior voluntary wheel running attenuates neuropathic pain, Pain, 157, 2012, 10.1097/j.pain.0000000000000607 Grace, 2017, Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy, Brain Behav. Immun., 59, 49, 10.1016/j.bbi.2016.05.012 Gregoire, 2012, Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin, Pain, 153, 1657, 10.1016/j.pain.2012.04.023 Gregoire, 2014, Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine, Eur. J. Pharmacol., 735, 1, 10.1016/j.ejphar.2014.03.056 Gregoire, 2017, Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice, Pain, 158, 802, 10.1097/j.pain.0000000000000811 Guan, 2019, Dihydromyricetin alleviates diabetic neuropathic pain and depression comorbidity symptoms by inhibiting P2X7 receptor, Front. Psychiatry, 10, 770, 10.3389/fpsyt.2019.00770 Gui, 2016, Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents, Mol. Pain, 12, 10.1177/1744806916646784 Guida, 2015, Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice, Mol. Brain, 8, 47, 10.1186/s13041-015-0139-5 Guimaraes, 2019, Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model, Genes Brain Behav., 18, 10.1111/gbb.12542 Hakim, 2020, Mu-opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury, Behav. Brain Res., 381, 10.1016/j.bbr.2019.112416 Hall, 1934, Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality, J Comp Psychol, 18, 385, 10.1037/h0071444 Hall, 1934, Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity, J Comp Psychol, 22, 345, 10.1037/h0059253 Hall, 1932, A study of the rat’s behavior in a field: a contribution to method in comparative psychology, University of California Publication in Psychology, 6, 1 Hamann, 2016, Antinociceptive and antidepressant-like effects of the crude extract of Vitex megapotamica in rats, J. Ethnopharmacol., 192, 210, 10.1016/j.jep.2016.07.045 Hansra, 2000, Carrageenan-induced arthritis in the rat, Inflammation, 24, 141, 10.1023/A:1007033610430 Harro, 2018, Animals, anxiety, and anxiety disorders: how to measure anxiety in rodents and why, Behav. Brain Res., 352, 81, 10.1016/j.bbr.2017.10.016 Hasnie, 2007, Further characterization of a rat model of varicella zoster virus-associated pain: relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs, Neuroscience, 144, 1495, 10.1016/j.neuroscience.2006.11.029 Hasnie, 2007, Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour, Br. J. Anaesth., 98, 816, 10.1093/bja/aem087 Heckman, 2016, Determinants of the mouse ultrasonic vocal structure and repertoire, Neurosci. Biobehav. Rev., 65, 313, 10.1016/j.neubiorev.2016.03.029 Higgins, 2015, Enduring attentional deficits in rats treated with a peripheral nerve injury, Behav. Brain Res., 286, 347, 10.1016/j.bbr.2015.02.050 Hisaoka-Nakashima, 2019, High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain, Prog. Neuropsychopharmacol. Biol. Psychiatry, 92, 347, 10.1016/j.pnpbp.2019.02.005 Hodos, 1961, Progressive ratio as a measure of reward strength, Science, 134, 943, 10.1126/science.134.3483.943 Hore, 2019, Neuroimmune interactions in chronic pain - an interdisciplinary perspective, Brain Behav. Immun., 79, 56, 10.1016/j.bbi.2019.04.033 Hu, 2009, Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833, Pain, 143, 206, 10.1016/j.pain.2009.02.018 Hu, 2010, Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory, Eur. J. Anaesthesiol., 27, 162, 10.1097/EJA.0b013e328331a3d5 Hu, 2016, Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain, Neurosci. Lett., 619, 162, 10.1016/j.neulet.2016.03.019 Hu, 2017, The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain, Brain Behav. Immun., 64, 180, 10.1016/j.bbi.2017.03.005 Huang, 2013, A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy, Pain, 154, 560, 10.1016/j.pain.2012.12.023 Huang, 2015, Effect of herbal-partitioned moxibustion at Tianshu (ST 25) and Qihai (CV 6) on pain-related behavior and emotion in rats with chronic inflammatory visceral pain, J. Acupunct. Tuina Sci., 13, 1, 10.1007/s11726-015-0814-1 Hubbard, 2015, Behavioral, metabolic and functional brain changes in a rat model of chronic neuropathic pain: a longitudinal MRI study, Neuroimage, 107, 333, 10.1016/j.neuroimage.2014.12.024 Inglis, 2008, Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system, Arthritis Rheum., 58, 3110, 10.1002/art.23870 Ishikawa, 2014, 4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and TrkB-related signaling in anterior cingulate cortex in chronic pain with depression-like behavior, Neuroreport, 25, 226, 10.1097/WNR.0000000000000072 Iversen, 1996, Headache induced by a nitric oxide donor (nitroglycerin) responds to sumatriptan. A human model for development of migraine drugs, Cephalalgia, 16, 412, 10.1046/j.1468-2982.1996.1606412.x Ji, 2010, Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation, J. Neurosci., 30, 5451, 10.1523/JNEUROSCI.0225-10.2010 Ji, 2017, 5-HT2C receptor knockdown in the amygdala inhibits neuropathic-pain-Related plasticity and behaviors, J. Neurosci., 37, 1378, 10.1523/JNEUROSCI.2468-16.2016 Ji, 2018, Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats, Mol. Pain, 14, 10.1177/1744806918804441 Jiang, 2014, Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats, Mol. Brain, 7, 72, 10.1186/s13041-014-0072-z Jiang, 2018, Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain, Neurosci. Lett., 662, 36, 10.1016/j.neulet.2017.09.064 Jiang, 2018, Cholinergic neurons in medial septum maintain anxiety-like behaviors induced by chronic inflammatory pain, Neurosci. Lett., 671, 7, 10.1016/j.neulet.2018.01.041 Jiang, 2019, Inhibition of fatty acid amide hydrolase improves depressive-like behaviors independent of its peripheral antinociceptive effects in a rat model of neuropathic pain, Anesth. Analg., 129, 587, 10.1213/ANE.0000000000003563 Jirkof, 2014, Burrowing and nest building behavior as indicators of well-being in mice, J. Neurosci. Methods, 234, 139, 10.1016/j.jneumeth.2014.02.001 Johnson, 2015, Changes in rat 50-kHz ultrasonic vocalizations during dopamine denervation and aging: relevance to neurodegeneration, Curr. Neuropharmacol., 13, 211, 10.2174/1570159X1302150525122416 Joseph, 2004, Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat, Pain, 107, 147, 10.1016/j.pain.2003.10.010 Jourdan, 2002, Analysis of ultrasonic vocalisation does not allow chronic pain to be evaluated in rats, Pain, 95, 165, 10.1016/S0304-3959(01)00394-3 Kalman, 2014, Different patterns of morphological changes in the hippocampus and dentate gyrus accompany the differential expression of disability following nerve injury, J. Anat., 225, 591, 10.1111/joa.12238 Kalueff, 2004, Grooming analysis algorithm for neurobehavioural stress research, Brain Res. Brain Res. Protoc., 13, 151, 10.1016/j.brainresprot.2004.04.002 Kamal, 2000, Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing, Diabetologia, 43, 500, 10.1007/s001250051335 Kamei, 1991, Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli, Pharmacol. Biochem. Behav., 39, 541, 10.1016/0091-3057(91)90224-P Kami, 2018, Activation of mesolimbic reward system via laterodorsal tegmental nucleus and hypothalamus in exercise-induced hypoalgesia, Sci. Rep., 8, 11540, 10.1038/s41598-018-29915-4 Kandasamy, 2017, Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats, J. Headache Pain, 18, 5, 10.1186/s10194-017-0721-6 Karl, 2017, Differential impact of miR-21 on pain and associated affective and cognitive behavior after spared nerve injury in B7-H1 ko mouse, Front. Mol. Neurosci., 10, 219, 10.3389/fnmol.2017.00219 Karl, 2019, Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice, BMC Neurosci., 20, 16, 10.1186/s12868-019-0498-4 Kawasaki, 2008, Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain, Nat. Med., 14, 331, 10.1038/nm1723 Kilburn-Watt, 2010, Altered thyroid hormones and behavioural change in a sub-population of rats following chronic constriction injury, J. Neuroendocrinol., 22, 960 Kim, 1992, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain, 50, 355, 10.1016/0304-3959(92)90041-9 Kim, 2012, Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression, J. Clin. Invest., 122, 2940, 10.1172/JCI61884 King, 2014, Preclinical assessment of pain: improving models in discovery research, Curr. Top. Behav. Neurosci., 10.1007/7854_2014_330 Kisko, 2017, From play to aggression: high-frequency 50-kHz ultrasonic vocalizations as play and appeasement signals in rats, Curr. Top. Behav. Neurosci., 30, 91, 10.1007/7854_2015_432 Klune, 2019, Comparing the Rat Grimace Scale and a composite behaviour score in rats, PLoS One, 14, 10.1371/journal.pone.0209467 Kniffin, 2015, Persistent neuropathic pain influences persistence behavior in rats, J. Oral Facial Pain Headache, 29, 183, 10.11607/ofph.1300 Koewler, 2007, Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur, J. Bone Miner. Res., 22, 1732, 10.1359/jbmr.070711 Kontinen, 1999, Behavioural measures of depression and anxiety in rats with spinal nerve ligation-induced neuropathy, Pain, 80, 341, 10.1016/S0304-3959(98)00230-9 Kontinen, 2003, Sleep and EEG patterns in the chronic constriction injury model of neuropathic pain, Physiol. Behav., 78, 241, 10.1016/S0031-9384(02)00966-6 Krackow, 2010, Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage, Genes Brain Behav., 9, 722, 10.1111/j.1601-183X.2010.00606.x Kraeuter, 2019, The Y-Maze for assessment of spatial working and reference memory in mice, Methods Mol. Biol., 1916, 105, 10.1007/978-1-4939-8994-2_10 Kurejova, 2010, An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain, Mol. Pain, 6, 18, 10.1186/1744-8069-6-18 La Porta, 2016, Effects of pregabalin on the nociceptive, emotional and cognitive manifestations of neuropathic pain in mice, Eur. J. Pain, 20, 1454, 10.1002/ejp.868 Lalonde, 2002, The neurobiological basis of spontaneous alternation, Neurosci. Biobehav. Rev., 26, 91, 10.1016/S0149-7634(01)00041-0 Langford, 2010, Coding of facial expressions of pain in the laboratory mouse, Nat. Methods, 7, 447, 10.1038/nmeth.1455 Larson, 1986, Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse, Pharmacol. Biochem. Behav., 24, 49, 10.1016/0091-3057(86)90043-2 Lau, 2013, A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain, Neuropharmacology, 73, 204, 10.1016/j.neuropharm.2013.05.023 Laumet, 2017, Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain, Brain Behav. Immun., 66, 94, 10.1016/j.bbi.2017.07.008 Le, 2014, AMPAkines have novel analgesic properties in rat models of persistent neuropathic and inflammatory pain, Anesthesiology, 121, 1080, 10.1097/ALN.0000000000000351 Lee, 2000, An animal model of neuropathic pain employing injury to the sciatic nerve branches, Neuroreport, 11, 657, 10.1097/00001756-200003200-00002 Lee, 2012, Periaqueductal gray stimulation suppresses spontaneous pain behavior in rats, Neurosci. Lett., 514, 42, 10.1016/j.neulet.2012.02.053 Leite-Almeida, 2009, The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats, Pain, 144, 57, 10.1016/j.pain.2009.02.024 Leite-Almeida, 2012, Differential effects of left/right neuropathy on rats’ anxiety and cognitive behavior, Pain, 153, 2218, 10.1016/j.pain.2012.07.007 Leite-Almeida, 2013, Variable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats, Front. Behav. Neurosci., 7, 154, 10.3389/fnbeh.2013.00154 Leite-Almeida, 2013, 39 Leite-Almeida, 2014, Asymmetric c-fos expression in the ventral orbital cortex is associated with impaired reversal learning in a right-sided neuropathy, Mol. Pain, 10, 41, 10.1186/1744-8069-10-41 Leite-Almeida, 2015, Animal models for the study of comorbid pain and psychiatric disorders, Mod. Trends Pharmacopsychiatry, 1 Leung, 2019, Performance of behavioral assays: the Rat Grimace Scale, burrowing activity and a composite behavior score to identify visceral pain in an acute and chronic colitis model, Pain Rep., 4, e718, 10.1097/PR9.0000000000000712 Li, 2014, Effects of chronic electroacupuncture on depression- and anxiety-like behaviors in rats with chronic neuropathic pain, Evid. Complement. Alternat. Med., 2014 Li, 2017, Role of the lateral habenula in pain-associated depression, Front. Behav. Neurosci., 11, 31, 10.3389/fnbeh.2017.00031 Li, 2018, Role of Keap1-Nrf2 signaling in anhedonia symptoms in a rat model of chronic neuropathic pain: improvement with sulforaphane, Front. Pharmacol., 9, 887, 10.3389/fphar.2018.00887 Li, 2019, Hippocampal PKR/NLRP1 inflammasome pathway is required for the depression-like behaviors in rats with neuropathic pain, Neuroscience, 412, 16, 10.1016/j.neuroscience.2019.05.025 Li, 2019, Morphine exacerbates postfracture nociceptive sensitization, functional impairment, and microglial activation in mice, Anesthesiology, 130, 292, 10.1097/ALN.0000000000002495 Li, 2019, Ginsenoside Rf relieves mechanical hypersensitivity, depression-like behavior, and inflammatory reactions in chronic constriction injury rats, Phytother. Res., 33, 1095, 10.1002/ptr.6303 Li, 2019, 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain, Neuroreport, 30, 681, 10.1097/WNR.0000000000001260 Liang, 2019, Paclitaxel induces sex-biased behavioral deficits and changes in gene expression in mouse prefrontal cortex, Neuroscience Lima, 2014, Sex-related long-term behavioral and hippocampal cellular alterations after nociceptive stimulation throughout postnatal development in rats, Neuropharmacology, 77, 268, 10.1016/j.neuropharm.2013.10.007 Lima, 2017, Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms, Pain, 158, 1697, 10.1097/j.pain.0000000000000967 Lindner, 1999, Chronic morphine reduces pain-related disability in a rodent model of chronic, inflammatory pain, Exp. Clin. Psychopharmacol., 7, 187, 10.1037/1064-1297.7.3.187 Lindner, 2006, Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy, Exp. Clin. Psychopharmacol., 14, 42, 10.1037/1064-1297.14.1.42 Lister, 1990, Ethologically-based animal models of anxiety disorders, Pharmacol. Ther., 46, 321, 10.1016/0163-7258(90)90021-S Liu, 2014, Preclinical research on pain comorbidity with affective disorders and cognitive deficits: challenges and perspectives, Prog. Neurobiol., 116, 13, 10.1016/j.pneurobio.2014.01.003 Liu, 2014, Acid-induced hyperalgesia and anxio-depressive comorbidity in rats, Physiol. Behav., 131, 105, 10.1016/j.physbeh.2014.03.030 Liu, 2015, Activation of GPR30 attenuates chronic pain-related anxiety in ovariectomized mice, Psychoneuroendocrinology, 53, 94, 10.1016/j.psyneuen.2014.12.021 Liu, 2015, Persistent, comorbid pain and anxiety can be uncoupled in a mouse model, Physiol. Behav., 151, 55, 10.1016/j.physbeh.2015.07.004 Llorca-Torralba, 2018, Behavioral effects of combined morphine and MK-801 administration to the locus coeruleus of a rat neuropathic pain model, Prog. Neuropsychopharmacol. Biol. Psychiatry, 84, 257, 10.1016/j.pnpbp.2018.03.007 Llorca-Torralba, 2019, Chemogenetic silencing of the locus coeruleus-basolateral amygdala pathway abolishes pain-induced anxiety and enhanced aversive learning in rats, Biol. Psychiatry, 85, 1021, 10.1016/j.biopsych.2019.02.018 Lolignier, 2011, Nav1.9 channel contributes to mechanical and heat pain hypersensitivity induced by subacute and chronic inflammation, PLoS One, 6, 10.1371/journal.pone.0023083 Low, 2012, Nerve injury causes long-term attentional deficits in rats, Neurosci. Lett., 529, 103, 10.1016/j.neulet.2012.09.027 Lyons, 2015, Trigeminal Inflammatory Compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors, Neuroscience, 295, 126, 10.1016/j.neuroscience.2015.03.051 Ma, 2012, Orofacial neuropathic pain mouse model induced by Trigeminal Inflammatory Compression (TIC) of the infraorbital nerve, Mol. Brain, 5, 44, 10.1186/1756-6606-5-44 Maldonado-Bouchard, 2016, Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury, Brain Behav. Immun., 51, 176, 10.1016/j.bbi.2015.08.009 Mao, 2009, Translational pain research: achievements and challenges, J. Pain, 10, 1001, 10.1016/j.jpain.2009.06.002 Marker, 2012, The monosodium iodoacetate model of osteoarthritis pain in the rat, Methods Mol. Biol., 851, 239, 10.1007/978-1-61779-561-9_18 Martinez-Navarro, 2019, Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice, Br. J. Pharmacol. Martinez-Navarro, 2019, Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain, Neuropharmacology, 148, 291, 10.1016/j.neuropharm.2019.01.012 Mathias, 2018, Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis, Sleep Med., 52, 198, 10.1016/j.sleep.2018.05.023 Matsuzawa-Yanagida, 2008, Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites, Neuropsychopharmacology, 33, 1952, 10.1038/sj.npp.1301590 Mazza, 2018, A comprehensive literature review of chronic pain and memory, Prog. Neuropsychopharmacol. Biol. Psychiatry, 87, 183, 10.1016/j.pnpbp.2017.08.006 Medeiros, 2019, Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice, J. Neurosci. Res. Mills, 2019, Chronic pain: a review of its epidemiology and associated factors in population-based studies, Br. J. Anaesth., 123, e273, 10.1016/j.bja.2019.03.023 Missig, 2017, Parabrachial pituitary adenylate cyclase-activating polypeptide activation of amygdala endosomal extracellular signal-regulated kinase signaling regulates the emotional component of pain, Biol. Psychiatry, 81, 671, 10.1016/j.biopsych.2016.08.025 Mogil, 2009, Animal models of pain: progress and challenges, Nat. Rev. Neurosci., 10, 283, 10.1038/nrn2606 Mogil, 2005, The case for the inclusion of female subjects in basic science studies of pain, Pain, 117, 1, 10.1016/j.pain.2005.06.020 Mogil, 2010, The necessity of animal models in pain research, Pain, 151, 12, 10.1016/j.pain.2010.07.015 Mogil, 2010, Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice, Mol. Pain, 6, 34, 10.1186/1744-8069-6-34 Monassi, 2003, A subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury, Eur. J. Neurosci., 17, 1907, 10.1046/j.1460-9568.2003.02627.x Mor, 2013, Differential regulation of glucocorticoid receptor expression in distinct columns of periaqueductal grey in rats with behavioural disability following nerve injury, Cell. Mol. Neurobiol., 33, 953, 10.1007/s10571-013-9962-3 Mor, 2010, Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve, Neuroscience, 166, 1167, 10.1016/j.neuroscience.2010.01.045 Mor, 2011, Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve, J. Chem. Neuroanat., 41, 158, 10.1016/j.jchemneu.2011.01.004 Mor, 2015, Recruitment of dorsal midbrain catecholaminergic pathways in the recovery from nerve injury evoked disabilities, Mol. Pain, 11, 50, 10.1186/s12990-015-0049-7 Mor, 2017, Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat, Behav. Brain Res., 328, 123, 10.1016/j.bbr.2017.04.003 Morel, 2013, Memantine, a promising drug for the prevention of neuropathic pain in rat, Eur. J. Pharmacol., 721, 382, 10.1016/j.ejphar.2013.06.020 Moriarty, 2011, The effect of pain on cognitive function: a review of clinical and preclinical research, Prog. Neurobiol., 93, 385, 10.1016/j.pneurobio.2011.01.002 Moriarty, 2016, Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain, Scand. J. Pain, 10, 61, 10.1016/j.sjpain.2015.09.008 Morris, 1981, Spatial localization does not require the presence of local cues, Learn. Motiv., 12, 239, 10.1016/0023-9690(81)90020-5 Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat, J. Neurosci. Methods, 11, 47, 10.1016/0165-0270(84)90007-4 Morris, 1989, Hapten-induced model of chronic inflammation and ulceration in the rat colon, Gastroenterology, 96, 795, 10.1016/0016-5085(89)90904-9 Moy, 2004, Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice, Genes Brain Behav., 3, 287, 10.1111/j.1601-1848.2004.00076.x Murad, 2015, Co-administration of pioglitazone improves fluoxetine’s antinociceptive, neuroprotective, and antidepressant effects in chronic constriction injury in rats, Pain Physician, 18, 609, 10.36076/ppj.2015/18/609 Muralidharan, 2016, Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain, Front. Behav. Neurosci., 10, 88, 10.3389/fnbeh.2016.00088 Murasawa, 2019, Anxiolytic effects of the novel alpha2delta ligand mirogabalin in a rat model of chronic constriction injury, an experimental model of neuropathic pain, Psychopharmacology (Berl.) Mutso, 2012, Abnormalities in hippocampal functioning with persistent pain, J. Neurosci., 32, 5747, 10.1523/JNEUROSCI.0587-12.2012 Nadler, 2004, Automated apparatus for quantitation of social approach behaviors in mice, Genes Brain Behav., 3, 303, 10.1111/j.1601-183X.2004.00071.x Nagakura, 2009, Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: a putative animal model of fibromyalgia, Pain, 146, 26, 10.1016/j.pain.2009.05.024 Nagakura, 2019, Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia, Eur. J. Pharmacol., 864, 10.1016/j.ejphar.2019.172716 Nakae, 2011, The animal model of spinal cord injury as an experimental pain model, J. Biomed. Biotechnol., 2011, 10.1155/2011/939023 Narita, 2006, Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala, Neuropsychopharmacology, 31, 739, 10.1038/sj.npp.1300858 Narita, 2006, Chronic pain-induced emotional dysfunction is associated with astrogliosis due to cortical delta-opioid receptor dysfunction, J. Neurochem., 97, 1369, 10.1111/j.1471-4159.2006.03824.x Nascimento, 2015, Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice, Neuroscience., 10.1016/j.neuroscience.2015.06.044 Negrete, 2017, Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice, Neuropharmacology, 116, 315, 10.1016/j.neuropharm.2016.08.026 Nishinaka, 2015, Sex differences in depression-like behavior after nerve injury are associated with differential changes in brain-derived neurotrophic factor levels in mice subjected to early life stress, Neurosci. Lett., 592, 32, 10.1016/j.neulet.2015.02.053 Norman, 2010, Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin, Psychosom. Med., 72, 519, 10.1097/PSY.0b013e3181de8678 Nyuyki, 2018, Altered brain excitability and increased anxiety in mice with experimental colitis: consideration of Hyperalgesia and sex differences, Front. Behav. Neurosci., 12, 58, 10.3389/fnbeh.2018.00058 Okayasu, 1990, A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice, Gastroenterology, 98, 694, 10.1016/0016-5085(90)90290-H Okun, 2016, Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain, Pain, 157, 2731, 10.1097/j.pain.0000000000000695 Olton, 1976, Remembrance of places passed: spatial memory in rats, J Exp Psychol. Animal Behavioral Processes, 2, 97, 10.1037/0097-7403.2.2.97 Omorogbe, 2018, Jobelyn((R)) attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice, Biomed. Pharmacother., 98, 585, 10.1016/j.biopha.2017.12.098 Pais-Vieira, 2009, Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain, Neuroscience, 161, 671, 10.1016/j.neuroscience.2009.04.011 Pais-Vieira, 2012, Inflammatory pain disrupts the orbitofrontal neuronal activity and risk-assessment performance in a rodent decision-making task, Pain, 153, 1625, 10.1016/j.pain.2012.04.011 Palazzo, 2015, MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice, Pain, 156, 1060, 10.1097/j.pain.0000000000000150 Palazzo, 2016, D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice, Amino Acids, 48, 1553, 10.1007/s00726-016-2205-4 Pan, 2018, Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression, Neuroreport, 29, 863, 10.1097/WNR.0000000000001045 Parent, 2012, Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain, Behav. Brain Res., 229, 160, 10.1016/j.bbr.2012.01.001 Patel, 2013, Effect of Urtica dioica on memory dysfunction and hypoalgesia in an experimental model of diabetic neuropathy, Neurosci. Lett., 552, 114, 10.1016/j.neulet.2013.07.029 Pellow, 1985, Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat, J. Neurosci. Methods, 14, 149, 10.1016/0165-0270(85)90031-7 Pfau, 2012, Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications, Curr. Pain Headache Rep., 16, 199, 10.1007/s11916-012-0261-3 Piccinelli, 2015, Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, alpha-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model, Nutr. Neurosci., 18, 217, 10.1179/1476830514Y.0000000119 Pinel, 1978, Burying as a defensive response in rats, J. Comp. Physiol. Psychol., 92, 708, 10.1037/h0077494 Pitzer, 2016, EXPRESS: voluntary and evoked behavioral correlates in neuropathic pain states under different housing conditions, Mol. Pain, 12, 10.1177/1744806916656635 Pitzer, 2016, Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions, Pain Rep., 1, e564, 10.1097/PR9.0000000000000564 Pitzer, 2019, Inflammatory and neuropathic pain conditions do not primarily evoke anxiety-like behaviours in C57BL/6 mice, Eur. J. Pain, 23, 285, 10.1002/ejp.1303 Planchez, 2019, Animal models of major depression: drawbacks and challenges, J. Neural Transm. Vienna (Vienna), 126, 1383, 10.1007/s00702-019-02084-y Polo, 2019, Treatment with the delta opioid agonist UFP-512 alleviates chronic inflammatory and neuropathic pain: mechanisms implicated, Front. Pharmacol., 10, 283, 10.3389/fphar.2019.00283 Polomano, 2001, A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel, Pain, 94, 293, 10.1016/S0304-3959(01)00363-3 Porsolt, 1977, Behavioral despair in mice: a primary screening test for antidepressants, Arch. Int. Pharmacodyn. Ther., 229, 327 Porsolt, 1977, Depression: a new animal model sensitive to antidepressant treatments, Nature, 266, 730, 10.1038/266730a0 Prut, 2003, The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review, Eur. J. Pharmacol., 463, 3, 10.1016/S0014-2999(03)01272-X Racz, 2015, CB1 receptors modulate affective behaviour induced by neuropathic pain, Brain Res. Bull., 114, 42, 10.1016/j.brainresbull.2015.03.005 Redivo, 2016, Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes, Behav. Brain Res., 298, 57, 10.1016/j.bbr.2015.10.058 Refsgaard, 2016, Modelling affective pain in mice: effects of inflammatory hypersensitivity on place escape/avoidance behaviour, anxiety and hedonic state, J. Neurosci. Methods, 262, 85, 10.1016/j.jneumeth.2016.01.019 Reid, 2011, Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact, Curr. Med. Res. Opin., 27, 449, 10.1185/03007995.2010.545813 Ren, 2011, Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-alpha in rodents, Neuropsychopharmacology, 36, 979, 10.1038/npp.2010.236 Rice, 2008, Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards, Pain, 139, 243, 10.1016/j.pain.2008.08.017 Roberts, 1962, Alternation and exploration in rats with hippocampal lesions, J. Comp. Physiol. Psychol., 55, 695, 10.1037/h0045168 Robinson, 2012, Use of dynamic weight bearing as a novel end-point for the assessment of Freund’s Complete Adjuvant induced hypersensitivity in mice, Neurosci. Lett., 524, 107, 10.1016/j.neulet.2012.07.017 Roelfsema, 2014, Basic neuroscience research with nonhuman primates: a small but indispensable component of biomedical research, Neuron, 82, 1200, 10.1016/j.neuron.2014.06.003 Roeska, 2008, Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin, Pain, 139, 349, 10.1016/j.pain.2008.05.003 Roeska, 2009, Effect of high trait anxiety on mechanical hypersensitivity in male rats, Neurosci. Lett., 464, 160, 10.1016/j.neulet.2009.08.031 Roizenblatt, 2010, Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams, Eur. J. Pain, 14, 985, 10.1016/j.ejpain.2010.03.008 Rutten, 2014, Pharmacological validation of a refined burrowing paradigm for prediction of analgesic efficacy in a rat model of sub-chronic knee joint inflammation, Eur. J. Pain, 18, 213, 10.1002/j.1532-2149.2013.00359.x Rutten, 2014, Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation, Eur. J. Pain, 18, 204, 10.1002/j.1532-2149.2013.00358.x Rutten, 2018, Standard analgesics reverse burrowing deficits in a rat CCI model of neuropathic pain, but not in models of type 1 and type 2 diabetes-induced neuropathic pain, Behav. Brain Res., 350, 129, 10.1016/j.bbr.2018.04.049 Saffarpour, 2017, In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain, Physiol. Behav., 175, 97, 10.1016/j.physbeh.2017.03.025 Sahbaie, 2018, Nociceptive and cognitive changes in a murine model of polytrauma, J. Pain, 19, 1392, 10.1016/j.jpain.2018.06.004 Sandkuhler, 2009, Models and mechanisms of hyperalgesia and allodynia, Physiol. Rev., 89, 707, 10.1152/physrev.00025.2008 Sang, 2018, Plastic change of prefrontal cortex mediates anxiety-like behaviors associated with chronic pain in neuropathic rats, Mol. Pain, 14, 10.1177/1744806918783931 Satyanarayanan, 2019, miR-200a-3p modulates gene expression in comorbid pain and depression: molecular implication for central sensitization, Brain Behav. Immun., 82, 230, 10.1016/j.bbi.2019.08.190 Sawada, 2014, Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice, Pain, 155, 1762, 10.1016/j.pain.2014.05.031 Schoenfeld, 2017, Variants of the Morris water maze task to comparatively assess human and rodent place navigation, Neurobiol. Learn. Mem., 139, 117, 10.1016/j.nlm.2016.12.022 Scholz, 2010, Preclinical research on persistent postsurgical pain: what we don’t know, but should start studying, Anesthesiology, 112, 511, 10.1097/ALN.0b013e3181cf4266 Sellmeijer, 2018, Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced anxiodepressive-like consequences, J. Neurosci., 38, 3102, 10.1523/JNEUROSCI.3195-17.2018 Seltzer, 1990, A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury, Pain, 43, 205, 10.1016/0304-3959(90)91074-S Seminowicz, 2009, MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain, Neuroimage, 47, 1007, 10.1016/j.neuroimage.2009.05.068 Seno, 2018, The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy, Sci. Rep., 8, 13608, 10.1038/s41598-018-31962-w Shalini, 2017, The analgesic and anxiolytic effect of Souvenaid, a novel nutraceutical, is mediated by Alox15 activity in the prefrontal cortex, Mol. Neurobiol., 54, 6032, 10.1007/s12035-016-0138-2 Shang, 2015, Temporal dynamics of anxiety phenotypes in a dental pulp injury model, Mol. Pain, 11, 40 Shao, 2015, Strong manual acupuncture stimulation of “Huantiao” (GB 30) reduces pain-induced anxiety and p-ERK in the anterior cingulate cortex in a rat model of neuropathic pain, Evid. Complement. Alternat. Med., 2015 Sheahan, 2017, Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain, Neurobiol Pain, 2, 1, 10.1016/j.ynpai.2017.09.001 Shepherd, 1994, Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety, Psychopharmacology (Berl.), 116, 56, 10.1007/BF02244871 Shepherd, 2018, Deficits in burrowing behaviors are associated with mouse models of neuropathic but not inflammatory pain or migraine, Front. Behav. Neurosci., 12, 124, 10.3389/fnbeh.2018.00124 Sieberg, 2018, Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients, Pain Rep., 3, e651, 10.1097/PR9.0000000000000651 Siemian, 2019, Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats, Behav. Pharmacol., 30, 429, 10.1097/FBP.0000000000000454 Silva, 2008, Sleep pattern in an experimental model of osteoarthritis, Pain, 140, 446, 10.1016/j.pain.2008.09.025 Silva, 2011, Sex differences in sleep pattern of rats in an experimental model of osteoarthritis, Eur. J. Pain, 15, 545, 10.1016/j.ejpain.2010.10.009 Simola, 2019, Ultrasonic vocalizations as a tool in studying emotional states in rodent models of social behavior and brain disease, Neuropharmacology, 159, 10.1016/j.neuropharm.2018.11.008 Slattery, 2014, The ups and downs of modelling mood disorders in rodents, ILAR J., 55, 297, 10.1093/ilar/ilu026 Sluka, 1993, Behavioral and immunohistochemical changes in an experimental arthritis model in rats, Pain, 55, 367, 10.1016/0304-3959(93)90013-F Sluka, 2001, Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia, Muscle Nerve, 24, 37, 10.1002/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8 Soares, 2018, Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats, Sci. Rep., 8, 17666, 10.1038/s41598-018-35537-7 Soubrie, 1975, Effects of antianxiety drugs on the food intake in trained and untrained rats and mice (author’s transl), Psychopharmacologia, 45, 203 Sousa, 2006, A hitchhiker’s guide to behavioral analysis in laboratory rodents, Genes Brain Behav., 5, 5, 10.1111/j.1601-183X.2006.00228.x Sousa, 2018, Alpha- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: behavioral, biochemical and molecular docking evidences, Brain Res. Bull., 142, 129, 10.1016/j.brainresbull.2018.07.007 Sperry, 2018, Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model, Sci. Rep., 8, 13894, 10.1038/s41598-018-32297-2 Stafford, 1998, Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review, Psychopharmacology (Berl.), 139, 169, 10.1007/s002130050702 Steru, 1985, The tail suspension test: a new method for screening antidepressants in mice, Psychopharmacology (Berl.), 85, 367, 10.1007/BF00428203 Su, 2015, Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens, Mol. Brain, 8, 46, 10.1186/s13041-015-0140-z Sun, 2016, Gastrodin relieved complete Freund’s adjuvant-induced spontaneous pain by inhibiting inflammatory response, Int. Immunopharmacol., 41, 66, 10.1016/j.intimp.2016.10.020 Suto, 2014, Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain, Pain, 155, 1935, 10.1016/j.pain.2014.05.014 Suzuki, 2007, Experimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression, Anesth. Analg., 104, 1570, 10.1213/01.ane.0000261514.19946.66 Tait, 2018, Assessment of intradimensional/extradimensional attentional set-shifting in rats, Neurosci. Biobehav. Rev., 89, 72, 10.1016/j.neubiorev.2018.02.013 Tajerian, 2013, Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex, PLoS One, 8, 10.1371/journal.pone.0055259 Tajerian, 2014, Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome, Anesthesiology, 121, 852, 10.1097/ALN.0000000000000403 Tajerian, 2015, Sex differences in a murine model of complex regional pain syndrome, Neurobiol. Learn. Mem., 123, 100, 10.1016/j.nlm.2015.06.004 Takebayashi, 2001, Effect of nucleus pulposus on the neural activity of dorsal root ganglion, Spine (Phila Pa 1976), 26, 940, 10.1097/00007632-200104150-00018 Tanila, 2018, Testing cognitive functions in rodent disease models: present pitfalls and future perspectives, Behav. Brain Res., 352, 23, 10.1016/j.bbr.2017.05.040 Tansley, 2019, Modulation of social behavior and dominance status by chronic pain in mice, Genes Brain Behav., 18, 10.1111/gbb.12514 Tappe-Theodor, 2014, Studying ongoing and spontaneous pain in rodents - challenges and opportunities, Eur. J. Neurosci., 39, 1881, 10.1111/ejn.12643 Tappe-Theodor, 2019, Pros and cons of clinically relevant methods to assess pain in rodents, Neurosci. Biobehav. Rev., 100, 335, 10.1016/j.neubiorev.2019.03.009 Terzi, 2014, RGS9-2 modulates sensory and mood related symptoms of neuropathic pain, Neurobiol. Learn. Mem., 10.1016/j.nlm.2014.08.005 Tetreault, 2011, Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats, Physiol. Behav., 104, 495, 10.1016/j.physbeh.2011.05.015 Thompson, 2018, Small conductance calcium activated potassium (SK) channel dependent and independent effects of riluzole on neuropathic pain-related amygdala activity and behaviors in rats, Neuropharmacology, 138, 219, 10.1016/j.neuropharm.2018.06.015 Thompson, 2018, Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat, Pain, 159, 1856, 10.1097/j.pain.0000000000001282 Tian, 2017, Anxiolytic-like effects of alpha-asarone in a mouse model of chronic pain, Metab. Brain Dis., 32, 2119, 10.1007/s11011-017-0108-z Tokunaga, 2007, Changes of sleep patterns in rats with chronic constriction injury under aversive conditions, Biol. Pharm. Bull., 30, 2088, 10.1248/bpb.30.2088 Turk, 2008, Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with pain, Pain, 137, 276, 10.1016/j.pain.2007.09.002 Turner, 2019, A review of pain assessment methods in laboratory rodents, Comp. Med., 69, 451, 10.30802/AALAS-CM-19-000042 Tuttle, 2017, Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes, Proc Natl Acad Sci U S A, 114, 5515, 10.1073/pnas.1703477114 Tyrtyshnaia, 2017, Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment, Acta Histochem., 119, 812, 10.1016/j.acthis.2017.10.007 Tyrtyshnaia, 2019, Neuroinflammation and adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment in aged mice, Int. J. Mol. Med., 43, 2153 Urban, 2011, Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity, Pain, 152, 990, 10.1016/j.pain.2010.12.003 Vachon, 2013, Alleviation of chronic neuropathic pain by environmental enrichment in mice well after the establishment of chronic pain, Behav. Brain Funct., 9, 22, 10.1186/1744-9081-9-22 van den Bos, 2006, Toward a rodent model of the Iowa gambling task, Behav. Res. Methods, 38, 470, 10.3758/BF03192801 van Hecke, 2013, Chronic pain epidemiology and its clinical relevance, Br. J. Anaesth., 111, 13, 10.1093/bja/aet123 van Hecke, 2014, Neuropathic pain in the general population: a systematic review of epidemiological studies, Pain, 155, 654, 10.1016/j.pain.2013.11.013 Vichaya, 2019, Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase, Neuropsychopharmacology, 44, 364, 10.1038/s41386-018-0075-z Vorhees, 2006, Morris water maze: procedures for assessing spatial and related forms of learning and memory, Nat. Protoc., 1, 848, 10.1038/nprot.2006.116 Vorhees, 2014, Assessing spatial learning and memory in rodents, ILAR J., 55, 310, 10.1093/ilar/ilu013 Vos, 1994, Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat’s infraorbital nerve, J. Neurosci., 14, 2708, 10.1523/JNEUROSCI.14-05-02708.1994 Wallace, 2005, Ultrasound vocalisation by rodents does not correlate with behavioural measures of persistent pain, Eur. J. Pain, 9, 445, 10.1016/j.ejpain.2004.10.006 Wallace, 2007, Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy, Pain, 133, 47, 10.1016/j.pain.2007.02.015 Wallace, 2007, Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain, Brain, 130, 2688, 10.1093/brain/awm195 Wallace, 2008, Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain, Neurosci. Lett., 448, 153, 10.1016/j.neulet.2008.10.005 Wang, 2011, A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats, Anesthesiology, 115, 812, 10.1097/ALN.0b013e31822f16ae Wang, 2012, Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors, Pain, 153, 2448, 10.1016/j.pain.2012.08.016 Wang, 2013, Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-alpha, Pain Physician, 16, E563 Wang, 2015, Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain, Mol. Pain, 11, 16, 10.1186/s12990-015-0013-6 Wang, 2015, Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety, Nat. Commun., 6, 7660, 10.1038/ncomms8660 Wang, 2015, Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons, Front. Cell. Neurosci., 9, 493, 10.3389/fncel.2015.00493 Wang, 2015, Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats, BMC Neurosci., 16, 14, 10.1186/s12868-015-0150-x Wang, 2017, Pain vulnerability and DNA methyltransferase 3a involved in the affective dimension of chronic pain, Mol. Pain, 13, 10.1177/1744806917726713 Wang, 2019, Subanesthetic dose of ketamine improved CFA-induced inflammatory pain and depression-like behaviors via Caveolin-1 in mice, J. Neurosurg. Anesthesiol. Wang, 2019, Environmental enrichment improves pain sensitivity, depression-like phenotype, and memory deficit in mice with neuropathic pain: role of NPAS4, Psychopharmacology (Berl.), 236, 1999, 10.1007/s00213-019-5187-6 Wang, 2019, Effects of CPEB1 in the anterior cingulate cortex on visceral pain in mice, Brain Res., 1712, 55, 10.1016/j.brainres.2019.02.001 Whitehead, 2017, Chronic sciatic neuropathy in rat reduces voluntary wheel-running activity with concurrent chronic mechanical allodynia, Anesth. Analg., 124, 346, 10.1213/ANE.0000000000001662 Wilkerson, 2018, Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice, Pain, 159, 1155, 10.1097/j.pain.0000000000001199 Willner, 1987, Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant, Psychopharmacology (Berl.), 93, 358, 10.1007/BF00187257 Wodarski, 2016, Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study, Pain, 157, 2350, 10.1097/j.pain.0000000000000657 Wright, 2010, Identification of multiple call categories within the rich repertoire of adult rat 50-kHz ultrasonic vocalizations: effects of amphetamine and social context, Psychopharmacology (Berl.), 211, 1, 10.1007/s00213-010-1859-y Wu, 2014, Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment. Involvement of cell cycle activation, Cell Cycle, 13, 2446, 10.4161/cc.29420 Wu, 2014, Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways, J. Neurosci., 34, 10989, 10.1523/JNEUROSCI.5110-13.2014 Wu, 2015, Trigeminal neuralgia induced by cobra venom in the rat leads to deficits in abilities of spatial learning and memory, Pain Physician, 18, E207 Wu, 2017, Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats, J. Pain Res., 10, 2585, 10.2147/JPR.S139679 Wu, 2018, Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell, Neuropsychopharmacology, 43, 2320, 10.1038/s41386-018-0115-8 Xie, 2017, Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine, Sci. Rep., 7, 3124, 10.1038/s41598-017-03590-3 Xu, 2017, Spared nerve injury increases the expression of microglia M1 markers in the prefrontal cortex of rats and provokes depression-like behaviors, Front. Neurosci., 11, 209, 10.3389/fnins.2017.00209 Xu, 2018, Misaligned feeding may aggravate pain by disruption of sleep-awake rhythm, Anesth. Analg., 127, 255, 10.1213/ANE.0000000000002727 Yalcin, 2011, A time-dependent history of mood disorders in a murine model of neuropathic pain, Biol. Psychiatry, 70, 946, 10.1016/j.biopsych.2011.07.017 Yalcin, 2014, Emotional consequences of neuropathic pain: insight from preclinical studies, Neurosci. Biobehav. Rev., 47C, 154, 10.1016/j.neubiorev.2014.08.002 Yang, 2019, Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain, Transl. Psychiatry, 9, 57, 10.1038/s41398-019-0379-8 Yang, 2019, HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression, Brain Res., 1717, 204, 10.1016/j.brainres.2019.03.036 Yasuda, 2014, Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor, Cell. Mol. Neurobiol., 34, 1199, 10.1007/s10571-014-0097-y Yates, 2019, Examining the neurochemical underpinnings of animal models of risky choice: methodological and analytic considerations, Exp. Clin. Psychopharmacol., 27, 178, 10.1037/pha0000239 You, 2018, Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability, Pain, 159, 1518, 10.1097/j.pain.0000000000001233 Yue, 2018, Anxiolytic effect of CPEB1 knockdown on the amygdala of a mouse model of inflammatory pain, Brain Res. Bull., 137, 156, 10.1016/j.brainresbull.2017.12.002 Zeng, 2008, Exacerbated mechanical allodynia in rats with depression-like behavior, Brain Res., 1200, 27, 10.1016/j.brainres.2008.01.038 Zhang, 2014, Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain, Mol. Brain, 7, 47, 10.1186/1756-6606-7-47 Zhang, 2014, Persistent nociception induces anxiety-like behavior in rodents:role of endogenous neuropeptide S, Pain, 10.1016/j.pain.2014.04.026 Zhang, 2016, Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model, Neurosci. Lett., 631, 7, 10.1016/j.neulet.2016.08.006 Zhang, 2017, Trigeminal neuralgia induced by cobra venom leads to cognitive deficits associated with downregulation of CREB/BDNF pathway, Pain Physician, 20, 53 Zhang, 2017, Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury, J. Neurochem., 141, 137, 10.1111/jnc.13965 Zhang, 2019, The gap junction inhibitor INI-0602 attenuates mechanical allodynia and depression-like behaviors induced by spared nerve injury in rats, Neuroreport, 30, 369, 10.1097/WNR.0000000000001209 Zhao, 2015, Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system, Sci. Rep., 5, 9043, 10.1038/srep09043 Zhao, 2017, Plant natural product puerarin ameliorates depressive behaviors and chronic pain in mice with spared nerve injury (SNI), Mol. Neurobiol., 54, 2801, 10.1007/s12035-016-9870-x Zhao, 2018, Anxiety specific response and contribution of active hippocampal neural stem cells to chronic pain through Wnt/beta-Catenin signaling in mice, Front. Mol. Neurosci., 11, 296, 10.3389/fnmol.2018.00296 Zheng, 2017, Adult hippocampal neurogenesis along the dorsoventral Axis Contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice, J. Neurosci., 37, 4145, 10.1523/JNEUROSCI.3333-16.2017 Zhou, 2015, Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice, Brain Behav. Immun., 46, 147, 10.1016/j.bbi.2015.01.013 Zhou, 2019, A neural circuit for comorbid depressive symptoms in chronic pain, Nat. Neurosci., 22, 1649, 10.1038/s41593-019-0468-2 Zhu, 2014, Antinociceptive effects of sinomenine in a rat model of neuropathic pain, Sci. Rep., 4, 7270, 10.1038/srep07270 Zong, 2018, The antidepressant effects of rosiglitazone on rats with depression induced by neuropathic pain, Life Sci., 203, 315, 10.1016/j.lfs.2018.04.057