Vibrational imaging for label-free cancer diagnosis and classification
Tóm tắt
The first key step in the detection and classification of most cancers is the microscopic assessment of thin tissue slices, the so-called “histopathology”. This procedure is still nowadays, similarly to 150 years ago, performed by staining the tissue with two or more dyes able to bind to specific biological structures, followed by visual inspection by the histopathologist under the bright-field optical microscope. This approach involves long manual procedures which can be accompanied by human errors, subjectivity, and lack of reproducibility. Vibrational microscopies are capable of directly providing chemical and biomolecular information on tissues, identifying them through their fingerprint vibrational spectra without the need of staining and, thus, constitute powerful tools for label-free and objective tumour identification. The two most established techniques, spontaneous Raman microscopy and infrared absorption microscopy, suffer, respectively, from long acquisition times and low spatial resolution. These limitations can be overcome by novel and more technically demanding approaches such coherent Raman scattering and photothermal infrared microscopy. Here we present an extended overview of the major advances in the field of vibrational imaging for cancer diagnosis. We start from a detailed description of the different technologies and then present examples of their applications to tissue imaging for cancer assessment. We critically compare the presented approaches, discussing the steps required to bring these powerful technologies from bench to bedside.
Tài liệu tham khảo
F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre, A. Jemal, CA Cancer J. Clin. 68, 394 (2018)
S. Srivastava, E.J. Koay, A.D. Borowsky, A.M. De Marzo, S. Ghosh, P.D. Wagner, B.S. Kramer, Nat. Rev. Cancer 19, 349 (2019)
A. Trinh, K. Trumpi, F.D.S.E. Melo, X. Wang, J.H. de Jong, E. Fessler, P.J.K. Kuppen, M.S. Reimers, M. Swets, M. Koopman, I.D. Nagtegaal, M. Jansen, G.K.J. Hooijer, G.J.A. Offerhaus, O. Kranenburg, C.J. Punt, J.P. Medema, F. Markowetz, L. Vermeulen, Clin. Cancer Res. 23, 387 (2017)
A.K. Füzéry, J. Levin, M.M. Chan, D.W. Chan, Clin. Proteomics 10, 13 (2013)
A. El-Naggar, J. Chan, T. Takata, J. Grandis, P. Blootweg, WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours (International Agency for Research on Cancer, Lyon, 2017)
S.R. Lakhani, WHO Classification of Tumours of the Breast (International Agency for Research on Cancer, Lyon, 2012)
H. Steven, E.C. Swerdlow, N.L. Harris, E.S. Jaffe, S.A. Pireli, H. Stein, J. Thiele, J.W. Vardiman, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (International Agency for Research on Cancer, Lyon, 2008)
M. Titford, J. Histotechnol. 32, 9 (2009)
A. Heindl, S. Nawaz, Y. Yuan, Lab. Invest. 95, 377 (2015)
S. Mukhopadhyay, M.D. Feldman, E. Abels, R. Ashfaq, S. Beltaifa, N.G. Cacciabeve, H.P. Cathro, L. Cheng, K. Cooper, G.E. Dickey, R.M. Gill, R.P. Heaton, R. Kerstens, G.M. Lindberg, R.K. Malhotra, J.W. Mandell, E.D. Manlucu, A.M. Mills, S.E. Mills, C.A. Moskaluk, M. Nelis, D.T. Patil, C.G. Przybycin, J.P. Reynolds, B.P. Rubin, M.H. Saboorian, M. Salicru, M.A. Samols, C.D. Sturgis, K.O. Turner, M.R. Wick, J.Y. Yoon, P. Zhao, C.R. Taylor, Am. J. Surg. Pathol. 42, 39 (2018)
K. Bera, K.A. Schalper, D.L. Rimm, V. Velcheti, A. Madabhushi, Nat. Rev. Clin. Oncol. 16, 703 (2019)
H.J. Butler, L. Ashton, B. Bird, G. Cinque, K. Curtis, J. Dorney, K. Esmonde-White, N.J. Fullwood, B. Gardner, P.L. Martin-Hirsch, M.J. Walsh, M.R. McAinsh, N. Stone, F.L. Martin, Nat. Protoc. 11, 664 (2016)
M.J. Baker, J. Trevisan, P. Bassan, R. Bhargava, H.J. Butler, K.M. Dorling, P.R. Fielden, S.W. Fogarty, N.J. Fullwood, K.A. Heys, C. Hughes, P. Lasch, P.L. Martin-Hirsch, B. Obinaju, G.D. Sockalingum, J. Sulé-Suso, R.J. Strong, M.J. Walsh, B.R. Wood, P. Gardner, F.L. Martin, Nat. Protoc. 9, 1771 (2014)
C.H. Camp Jr., M.T. Cicerone, Nat. Photonics 9, 295 (2015)
R. Vanna, P. Ronchi, A.T.M. Lenferink, C. Tresoldi, C. Morasso, D. Mehn, M. Bedoni, S. Picciolini, L.W.M.M. Terstappen, F. Ciceri, C. Otto, F. Gramatica, Analyst 140, 1054 (2015)
J.D. Jackson, Classical Electrodynamics, Third (Wiley, New York, 1998)
C. Krafft, B. Dietzek, J. Popp, M. Schmitt, J. Biomed. Opt. 17, 040801 (2012)
D.C. Harris, M.D. Bertolucci, Symmetry and Spectroscopy: An Introduction to Vibrational and Electronic Spectroscopy (Courier Corporation, Chelmsford, 1989)
L. Brillouin, Ann. Phys. 9, 88 (1922)
A. Smekal, Naturwissenschaften 11, 873 (1923)
C.V. Raman, K.S. Krishnan, Nature 121, 501 (1928)
T.H. Maiman, Nature 187, 493 (1960)
M. Delhaye, P. Dhamelincourt, J. Raman Spectrosc. 3, 33 (1975)
P. Dhamelincourt, in Conf Ser Phys (Philadelphia; Institute of Physics; 1999, 2000), pp. 9–10
C. Krafft, I.W. Schie, T. Meyer, M. Schmitt, J. Popp, Chem. Soc. Rev. 45, 1819 (2016)
E. Lee, in Raman Imaging, edited by A. Zoubir and V. D’Ascq (Springer, 2012), pp. 1–37.
G.J. Puppels, F.F. de Mul, C. Otto, J. Greve, M. Robert-Nicoud, D.J. Arndt-Jovin, T.M. Jovin, Nature 347, 301 (1990)
G. Turrell, J. Corset, Raman Microscopy: Developments and Applications (Academic Press, Cambridge, 1996)
Y.-S. Huang, T. Karashima, M. Yamamoto, H. Hamaguchi, J. Raman Spectrosc. 34, 1 (2003)
J. Hutchings, C. Kendall, B. Smith, N. Shepherd, H. Barr, N. Stone, J. Biophotonics 2, 91 (2009)
M. Okada, N.I. Smith, A.F. Palonpon, H. Endo, S. Kawata, M. Sodeoka, K. Fujita, Proc. Natl. Acad. Sci. 109, 28 (2012)
K. Watanabe, A.F. Palonpon, N.I. Smith, L. Chiu, A. Kasai, H. Hashimoto, S. Kawata, K. Fujita, Nat. Commun. 6, 10095 (2015)
S. Stewart, R.J. Priore, M.P. Nelson, P.J. Treado, Annu. Rev. Anal. Chem. 5, 337 (2012)
H.R. Morris, C.C. Hoyt, P. Miller, P.J. Treado, Appl. Spectrosc. 50, 805 (1996)
P.J. Treado, I.W. Levin, E.N. Lewis, Appl. Spectrosc. 46, 1211 (1992)
S. Schlücker, M.D. Schaeberle, S.W. Huffman, I.W. Levin, Anal Chem 75, 4312 (2003)
A. Papour, J.H. Kwak, Z. Taylor, B. Wu, O. Stafsudd, W. Grundfest, Biomed. Opt. Express 6, 3892 (2015)
S. Yang, B. Li, A. Akkus, O. Akkus, L. Lang, Analyst 139, 3107 (2014)
A. Zumbusch, G.R. Holtom, X.S. Xie, Phys. Rev. Lett. 82, 4142 (1999)
C.W. Freudiger, W. Min, B.G. Saar, S. Lu, G.R. Holtom, C. He, J.C. Tsai, J.X. Kang, X.S. Xie, Science 322, 1857 (2008)
P. Nandakumar, A. Kovalev, A. Volkmer, New J. Phys. 11, 033026 (2009)
H. Rigneault, P. Berto, APL Photonics 3, 091101 (2018)
J. Cheng, A. Volkmer, L.D. Book, X.S. Xie, J. Phys. Chem. B 105, 1277 (2001)
B.G. Saar, C.W. Freudiger, J. Reichman, C.M. Stanley, G.R. Holtom, X.S. Xie, Science 330, 1368 (2010)
E.O. Potma, D.J. Jones, J.-X. Cheng, X.S. Xie, J. Ye, Opt. Lett. 27, 1168 (2002)
F. Ganikhanov, S. Carrasco, X.S. Xie, M. Katz, W. Seitz, D. Kopf, Opt. Lett. 31, 1292 (2006)
A. Gambetta, V. Kumar, G. Grancini, D. Polli, R. Ramponi, G. Cerullo, M. Marangoni, Opt. Lett. 35, 226 (2010)
G. Krauss, T. Hanke, A. Sell, D. Träutlein, A. Leitenstorfer, R. Selm, M. Winterhalder, A. Zumbusch, Opt. Lett. 34, 2847 (2009)
E.S. Lamb, S. Lefrancois, M. Ji, W.J. Wadsworth, X.S. Xie, F.W. Wise, Opt. Lett. 38, 4154 (2013)
R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, M. Ji, Optica 4, 44 (2017)
Y. Suzuki, K. Kobayashi, Y. Wakisaka, D. Deng, S. Tanaka, C.-J. Huang, C. Lei, C.-W. Sun, H. Liu, Y. Fujiwaki, S. Lee, A. Isozaki, Y. Kasai, T. Hayakawa, S. Sakuma, F. Arai, K. Koizumi, H. Tezuka, M. Inaba, K. Hiraki, T. Ito, M. Hase, S. Matsusaka, K. Shiba, K. Suga, M. Nishikawa, M. Jona, Y. Yatomi, Y. Yalikun, Y. Tanaka, T. Sugimura, N. Nitta, K. Goda, Y. Ozeki, Proc. Natl. Acad. Sci. 116, 15842 (2019)
D. Polli, V. Kumar, C.M. Valensise, M. Marangoni, G. Cerullo, Laser Photonics Rev. 12, 1800020 (2018)
M. Mohseni, C. Polzer, T. Hellerer, Opt. Express 26, 10230 (2018)
L. Brückner, T. Buckup, M. Motzkus, JOSA B 33, 1482 (2016)
J. Cheng, A. Volkmer, L.D. Book, X.S. Xie, J. Phys. Chem. B 106, 8493 (2002)
H. Kano, H. Hamaguchi, Appl. Phys. Lett. 86, 121113 (2005)
T.W. Kee, M.T. Cicerone, Opt. Lett. 29, 2701 (2004)
M. Müller, J.M. Schins, J. Phys. Chem. B 106, 3715 (2002)
C. Pohling, T. Buckup, A. Pagenstecher, M. Motzkus, Biomed. Opt. Express 2, 2110 (2011)
B. von Vacano, L. Meyer, M. Motzkus, J. Raman Spectrosc. 38, 916 (2007)
C.H. Camp, Y.J. Lee, J.M. Heddleston, C.M. Hartshorn, A.R. Hight Walker, J.N. Rich, J.D. Lathia, M.T. Cicerone, Nat. Photonics 8, 627 (2014)
M.T. Cicerone, K.A. Aamer, Y.J. Lee, E. Vartiainen, J. Raman Spectrosc. 43, 637 (2012)
S. Ruhman, A.G. Joly, K.A. Nelson, IEEE J. Quantum Electron. 24, 460 (1988)
B.-C. Chen, J. Sung, X. Wu, S.-H. Lim, J. Biomed. Opt. 16, 021112 (2011)
E.M. Vartiainen, H.A. Rinia, M. Müller, M. Bonn, Opt. Express 14, 3622 (2006)
Y. Liu, Y.J. Lee, M.T. Cicerone, Opt. Lett. 34, 1363 (2009)
R. Houhou, R. Houhou, P. Barman, M. Schmitt, T. Meyer, T. Meyer, J. Popp, J. Popp, T. Bocklitz, T. Bocklitz, Opt. Express 28, 21002 (2020)
C.M. Valensise, A. Giuseppi, F. Vernuccio, A. De la Cadena, G. Cerullo, D. Polli, APL Photonics 5, 061305 (2020)
D. Pestov, R.K. Murawski, G.O. Ariunbold, X. Wang, M. Zhi, A.V. Sokolov, V.A. Sautenkov, Y.V. Rostovtsev, A. Dogariu, Y. Huang, M.O. Scully, Science 316, 265 (2007)
R. Selm, M. Winterhalder, A. Zumbusch, G. Krauss, T. Hanke, A. Sell, A. Leitenstorfer, Opt. Lett. 35, 3282 (2010)
A. Volkmer, L.D. Book, X.S. Xie, Appl. Phys. Lett. 80, 1505 (2002)
T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, T.W. Hänsch, Nature 502, 355 (2013)
J.P. Ogilvie, E. Beaurepaire, A. Alexandrou, M. Joffre, Opt. Lett. 31, 480 (2006)
M. Tamamitsu, Y. Sakaki, T. Nakamura, G.K. Podagatlapalli, T. Ideguchi, K. Goda, Vib. Spectrosc. 91, 163 (2017)
E.R. Andresen, P. Berto, H. Rigneault, Opt. Lett. 36, 2387 (2011)
H.T. Beier, G.D. Noojin, B.A. Rockwell, Opt. Express 19, 18885 (2011)
V. Schweikhard, A. Baral, V. Krishnamachari, W.C. Hay, M. Fuhrmann, BioRxiv (2019). https://doi.org/10.1101/789248
Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, K. Itoh, Nat. Photonics 6, 845 (2012)
Y. Ozeki, Y. Kitagawa, K. Sumimura, N. Nishizawa, W. Umemura, S. Kajiyama, K. Fukui, K. Itoh, Opt. Express 18, 13708 (2010)
Y. Ozeki, W. Umemura, K. Sumimura, N. Nishizawa, K. Fukui, K. Itoh, Opt. Lett. 37, 431 (2012)
L. Kong, M. Ji, G.R. Holtom, D. Fu, C.W. Freudiger, X.S. Xie, Opt. Lett. 38, 145 (2013)
B. Liu, H.J. Lee, D. Zhang, C.-S. Liao, N. Ji, Y. Xia, J.-X. Cheng, Appl. Phys. Lett. 106, 173704 (2015)
D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, A. Et, Science 254, 1178 (1991)
C.-S. Liao, K.-C. Huang, W. Hong, A.J. Chen, C. Karanja, P. Wang, G. Eakins, J.-X. Cheng, Optica 3, 1377 (2016)
R. He, Z. Liu, Y. Xu, W. Huang, H. Ma, M. Ji, Opt. Lett. 42, 659 (2017)
B. Figueroa, W. Fu, T. Nguyen, K. Shin, B. Manifold, F. Wise, D. Fu, Biomed. Opt. Express 9, 6116 (2018)
D. Fu, W. Yang, X.S. Xie, J. Am. Chem. Soc. 139, 583 (2017)
P. Tournois, Opt. Commun. 140, 245 (1997)
F. Verluise, V. Laude, Z. Cheng, C. Spielmann, P. Tournois, Opt. Lett. 25, 575 (2000)
M.S. Alshaykh, C.-S. Liao, O.E. Sandoval, G. Gitzinger, N. Forget, D.E. Leaird, J.-X. Cheng, A.M. Weiner, Opt. Lett. 42, 1548 (2017)
X. Audier, N. Forget, H. Rigneault, Opt. Express 28, 15505 (2020)
D. Fu, F.-K. Lu, X. Zhang, C. Freudiger, D.R. Pernik, G. Holtom, X.S. Xie, J. Am. Chem. Soc. 134, 3623 (2012)
S.P. Laptenok, V.P. Rajamanickam, L. Genchi, T. Monfort, Y. Lee, I.I. Patel, A. Bertoncini, C. Liberale, J. Biophotonics 12, e201900028 (2019)
B.R. Bachler, M.E. Fermann, J.P. Ogilvie, Opt. Express 20, 835 (2012)
C.W. Freudiger, M.B.J. Roeffaers, X. Zhang, B.G. Saar, W. Min, X.S. Xie, J. Phys. Chem. B 115, 5574 (2011)
W. Rock, M. Bonn, S.H. Parekh, Opt. Express 21, 15113 (2013)
G. Sciortino, A. Ragni, A. De la Cadena, M. Sampietro, G. Cerullo, D. Polli, G. Ferrari, IEEE J. Solid-State Circuits 56, 1859 (2021)
K. Seto, Y. Okuda, E. Tokunaga, T. Kobayashi, Rev. Sci. Instrum. 84, 083705 (2013)
F.-K. Lu, M. Ji, D. Fu, X. Ni, C.W. Freudiger, G. Holtom, X.S. Xie, Mol. Phys. 110, 1927 (2012)
J.-X. Cheng, C.-S. Liao, M.N. Slipchenko, P. Wang, J. Li, S.-Y. Lee, R.A. Oglesbee, Light Sci. Appl. 4, e265 (2015)
M.N. Slipchenko, R.A. Oglesbee, D. Zhang, W. Wu, J.-X. Cheng, J. Biophotonics 5, 801 (2012)
J. Nallala, G.R. Lloyd, M. Hermes, N. Shepherd, N. Stone, Vib. Spectrosc. 91, 83 (2017)
C. Hughes, G. Clemens, B. Bird, T. Dawson, K.M. Ashton, M.D. Jenkinson, A. Brodbelt, M. Weida, E. Fotheringham, M. Barre, J. Rowlette, M.J. Baker, Sci. Rep. 6, 20173 (2016)
S. P. Davis, M. C. Abrams, and J. W. Brault, Fourier Transform Spectrom. Sumner P Davis Al San Diego Calif Acad. Press C2001 (2001)
M.Z. Kastyak-Ibrahim, M.J. Nasse, M. Rak, C. Hirschmugl, M.R. Del Bigio, B.C. Albensi, K.M. Gough, Neuroimage 60, 376 (2012)
L.M. Miller, P. Dumas, Biochim. Biophys. Acta BBA Biomembr. 1758, 846 (2006)
O.J. Old, G.R. Lloyd, J. Nallala, M. Isabelle, L.M. Almond, N.A. Shepherd, C.A. Kendall, A.C. Shore, H. Barr, N. Stone, Analyst 142, 1227 (2017)
D. Perez-Guaita, K. Kochan, M. Martin, D.W. Andrew, P. Heraud, J.S. Richards, B.R. Wood, Vib. Spectrosc. 91, 46 (2017)
A.B. Seddon, Phys. Status Solidi B 250, 1020 (2013)
E. Levenson, P. Lerch, M.C. Martin, Infrared Phys. Technol. 49, 45 (2006)
C. Petibois, M. Cestelli-Guidi, M. Piccinini, M. Moenner, A. Marcelli, Anal. Bioanal. Chem. 397, 2123 (2010)
I. Amenabar, S. Poly, M. Goikoetxea, W. Nuansing, P. Lasch, R. Hillenbrand, Nat. Commun. 8, 14402 (2017)
J. Faist, F. Capasso, D.L. Sivco, C. Sirtori, A.L. Hutchinson, A.Y. Cho, Science 264, 553 (1994)
C. Petibois, G. Déléris, M. Piccinini, M. Cestelli-Guidi, A. Marcelli, Nat. Photonics 3, 179 (2009)
T. Steinle, F. Neubrech, A. Steinmann, X. Yin, H. Giessen, Opt. Express 23, 11105 (2015)
M.J. Nasse, M.J. Walsh, E.C. Mattson, R. Reininger, A. Kajdacsy-Balla, V. Macias, R. Bhargava, C.J. Hirschmugl, Nat. Methods 8, 413 (2011)
S. Slivken, N. Bandyopadhyay, Y. Bai, Q.Y. Lu, M. Razeghi, Appl. Phys. Lett. 103, 231110 (2013)
P.B. Fellgett, JOSA 39, 970 (1949)
P. Jacquinot, Rep. Prog. Phys. 23, 267 (1960)
B. C. Smith, Fundamentals of Fourier Transform Infrared Spectroscopy (Routledge CRC Press. 2011)
F. Siebert, P. Hildebrandt, Vibrational Spectroscopy in Life Science (Wiley, New Jersey, 2008)
D.C. Fernandez, R. Bhargava, S.M. Hewitt, I.W. Levin, Nat. Biotechnol. 23, 469 (2005)
E.N. Lewis, P.J. Treado, R.C. Reeder, G.M. Story, A.E. Dowrey, C. Marcott, I.W. Levin, Anal. Chem. 67, 3377 (1995)
P. Garidel, M. Boese, Microsc. Res. Tech. 70, 336 (2007)
P. Dumas, N. Jamin, J.L. Teillaud, L.M. Miller, B. Beccard, Faraday Discuss. 126, 289 (2004)
J. Nallala, G.R. Lloyd, N. Shepherd, N. Stone, Analyst 141, 630 (2016)
C. Kuepper, A. Kallenbach-Thieltges, H. Juette, A. Tannapfel, F. Großerueschkamp, K. Gerwert, Sci. Rep. 8, 7717 (2018)
S. Mittal, K. Yeh, L.S. Leslie, S. Kenkel, A. Kajdacsy-Balla, R. Bhargava, Proc. Natl. Acad. Sci. 115, E5651 (2018)
S. Junaid, S.C. Kumar, M. Mathez, M. Hermes, N. Stone, N. Shepherd, M. Ebrahim-Zadeh, P. Tidemand-Lichtenberg, C. Pedersen, Optica 6, 702 (2019)
W.B. Jackson, N.M. Amer, A.C. Boccara, D. Fournier, Appl. Opt. 20, 1333 (1981)
M.D. Morris, K. Peck, Anal. Chem. 58, 811A (1986)
J. Wu, T. Kitamori, T. Sawada, Anal. Chem. 63, 217 (1991)
M. Harada, K. Iwamoto, T. Kitamori, T. Sawada, Anal. Chem. 65, 2938 (1993)
D. Boyer, P. Tamarat, A. Maali, B. Lounis, M. Orrit, Science 297, 1160 (2002)
A. Gaiduk, P.V. Ruijgrok, M. Yorulmaz, M. Orrit, Chem. Sci. 1, 343 (2010)
E. Absil, G. Tessier, M. Gross, M. Atlan, N. Warnasooriya, S. Suck, M. Coppey-Moisan, D. Fournier, Opt. Express 18, 780 (2010)
D. Lasne, G.A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, B. Lounis, Biophys. J. 91, 4598 (2006)
P. Zijlstra, P.M.R. Paulo, M. Orrit, Nat. Nanotechnol. 7, 379 (2012)
D. Lasne, G.A. Blab, F.D. Giorgi, F. Ichas, B. Lounis, L. Cognet, Opt. Express 15, 14184 (2007)
J. Miyazaki, Y. Toumon, Biomed. Opt. Express 10, 5852 (2019)
J. Miyazaki, H. Tsurui, K. Kawasumi, T. Kobayashi, Opt. Express 23, 3647 (2015)
E.S. Lee, J.Y. Lee, Appl. Phys. Lett. 94, 261101 (2009)
A. Mërtiri, T. Jeys, V. Liberman, M.K. Hong, J. Mertz, H. Altug, S. Erramilli, Appl. Phys. Lett. 101, 044101 (2012)
P.D. Samolis, M.Y. Sander, Opt. Express 27, 2643 (2019)
D. Zhang, C. Li, C. Zhang, M.N. Slipchenko, G. Eakins, J.-X. Cheng, Sci. Adv. 2, e1600521 (2016)
Y. Bai, D. Zhang, L. Lan, Y. Huang, K. Maize, A. Shakouri, J.-X. Cheng, Sci. Adv. 5, eaav7127 (2019)
R. Chatterjee, I.M. Pavlovetc, K. Aleshire, G.V. Hartland, M. Kuno, ACS Energy Lett. 3, 469 (2018)
Z. Li, K. Aleshire, M. Kuno, G.V. Hartland, J. Phys. Chem. B 121, 8838 (2017)
I.M. Pavlovetc, K. Aleshire, G.V. Hartland, M. Kuno, Phys. Chem. Chem. Phys. 22, 4313 (2020)
C. Li, D. Zhang, M.N. Slipchenko, J.-X. Cheng, Anal. Chem. 89, 4863 (2017)
J.M. Lim, C. Park, J.-S. Park, C. Kim, B. Chon, M. Cho, J. Phys. Chem. Lett. 10, 2857 (2019)
D. Zhang, L. Lan, Y. Bai, H. Majeed, M.E. Kandel, G. Popescu, J.-X. Cheng, Light Sci. Appl. 8, 116 (2019)
K. Toda, M. Tamamitsu, Y. Nagashima, R. Horisaki, T. Ideguchi, Sci. Rep. 9, 9957 (2019)
M. Schnell, S. Mittal, K. Falahkheirkhah, A. Mittal, K. Yeh, S. Kenkel, A. Kajdacsy-Balla, P.S. Carney, R. Bhargava, Proc. Natl. Acad. Sci. 117, 3388 (2020)
M. Tamamitsu, K. Toda, R. Horisaki, R. Horisaki, T. Ideguchi, T. Ideguchi, Opt. Lett. 44, 3729 (2019)
J.L. Abraham, E.S. Etz, Science 206, 716 (1979)
A. Mahadevan-Jansen, R.R. Richards-Kortum, J. Biomed. Opt. 1, 31 (1996)
R. Manoharan, Y. Wang, M.S. Feld, Spectrochim. Acta. A. Mol. Biomol Spectrosc. 52, 215 (1996)
H.J. Butler, P.M. Brennan, J.M. Cameron, D. Finlayson, M.G. Hegarty, M.D. Jenkinson, D.S. Palmer, B.R. Smith, M.J. Baker, Nat. Commun. 10, 1 (2019)
C. Morasso, M. Truffi, R. Vanna, S. Albasini, S. Mazzucchelli, F. Colombo, L. Sorrentino, G. Sampietro, S. Ardizzone, F. Corsi, J. Crohns Colitis 14, 1572 (2020)
C. Otto, C.J. de Grauw, J.J. Duindam, N.M. Sijtsema, J. Greve, J. Raman Spectrosc. 28, 143 (1997)
A. Nijssen, T.C.B. Schut, F. Heule, P.J. Caspers, D.P. Hayes, M.H.A. Neumann, G.J. Puppels, J. Invest. Dermatol. 119, 64 (2002)
I. T. Jolliffe, in Princ. Compon. Anal., edited by I. T. Jolliffe (Springer, New York, NY, 1986), pp. 129–155
A. K. Jain and R. C. Dubes, Algorithms for Clustering Data (Englewood Cliffs Prentice Hall 1988)
M. Stone, J.R. Stat, Soc. Ser. B Methodol. 36, 111 (1974)
S. Koljenović, L.-P. Choo-Smith, T.C.B. Schut, J.M. Kros, H.J. van den Berge, G.J. Puppels, Lab. Invest. 82, 1265 (2002)
K.E. Shafer-Peltier, A.S. Haka, M. Fitzmaurice, J. Crowe, J. Myles, R.R. Dasari, M.S. Feld, J. Raman Spectrosc. 33, 552 (2002)
A.S. Haka, K.E. Shafer-Peltier, M. Fitzmaurice, J. Crowe, R.R. Dasari, M.S. Feld, Proc. Natl. Acad. Sci. U. S. A. 102, 12371 (2005)
G. Shetty, C. Kendall, N. Shepherd, N. Stone, H. Barr, Br. J. Cancer 94, 1460 (2006)
N. Amharref, A. Beljebbar, S. Dukic, L. Venteo, L. Schneider, M. Pluot, M. Manfait, Biochim. Biophys. Acta BBA Biomembr. 1768, 2605 (2007)
M. Larraona-Puy, W. Perkins, I.H. Leach, A.A. Koloydenko, H. Williams, I. Notingher, S. Varma, A. Ghita, A. Zoladek, J. Biomed. Opt. 14, 054031 (2009)
M. D’Acunto, R. Gaeta, R. Capanna, A. Franchi, Sci. Rep. 10, 2155 (2020)
F.L. Cals, T.C.B. Schut, J.A. Hardillo, R.J.B. de Jong, S. Koljenović, G.J. Puppels, Lab. Invest. 95, 1186 (2015)
R. Vanna, C. Morasso, B. Marcinno, F. Piccotti, E. Torti, D. Altamura, S. Albasini, M. Agozzino, L. Villani, L. Sorrentino, O. Bunk, F. Leporati, C. Giannini, F. Corsi, Cancer Res. 80, 1762 (2020)
K. Kong, C.J. Rowlands, S. Varma, W. Perkins, I.H. Leach, A.A. Koloydenko, H.C. Williams, I. Notingher, Proc. Natl. Acad. Sci. 110, 15189 (2013)
K. Kong, F. Zaabar, E. Rakha, I. Ellis, A. Koloydenko, I. Notingher, Phys. Med. Biol. 59, 6141 (2014)
D.W. Shipp, E.A. Rakha, A.A. Koloydenko, R.D. Macmillan, I.O. Ellis, I. Notingher, Breast Cancer Res. 20, 69 (2018)
X. Nan, E.O. Potma, X.S. Xie, Biophys. J. 91, 728 (2006)
Y. Fu, T.B. Huff, H.-W. Wang, H. Wang, J.-X. Cheng, Opt. Express 16, 19396 (2008)
C.L. Evans, E.O. Potma, M. Puoris’haag, D. Côté, C.P. Lin, X.S. Xie, Proc. Natl. Acad. Sci. U. S. A. 102, 16807 (2005)
J.-X. Cheng, X.S. Xie, Science 350, 6264 (2015)
C.L. Evans, X.S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008)
S. Yue, J.-X. Cheng, Curr. Opin. Chem. Biol. 33, 46 (2016)
H. Wang, Y. Fu, P. Zickmund, R. Shi, J.-X. Cheng, Biophys. J. 89, 581 (2005)
T.T. Le, C.W. Rehrer, T.B. Huff, M.B. Nichols, I.G. Camarillo, J.-X. Cheng, Mol. Imaging 6, 7290 (2007)
T. Meyer, N. Bergner, C. Krafft, D. Akimov, B. Dietzek, J. Popp, C. Bielecki, B.F.M. Romeike, R. Reichart, R. Kalff, J. Biomed. Opt. 16, 021113 (2011)
E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, P. Gilch, Appl. Phys. B 87, 389 (2007)
Y. Ozeki, F. Dake, S. Kajiyama, K. Fukui, K. Itoh, Opt. Express 17, 3651 (2009)
C.W. Freudiger, R. Pfannl, D.A. Orringer, B.G. Saar, M. Ji, Q. Zeng, L. Ottoboni, W. Ying, C. Waeber, J.R. Sims, P.L. De Jager, O. Sagher, M.A. Philbert, X. Xu, S. Kesari, X.S. Xie, G.S. Young, Lab. Invest. 92, 1492 (2012)
P.D. Chowdary, Z. Jiang, E.J. Chaney, W.A. Benalcazar, D.L. Marks, M. Gruebele, S.A. Boppart, Cancer Res. 70, 9562 (2010)
M. Ji, D.A. Orringer, C.W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A.J. Golby, I. Norton, M. Hayashi, N.Y.R. Agar, G.S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K.L. Ligon, O. Sagher, X.S. Xie, Sci. Transl. Med. 5, 201ra119 (2013)
O. Uckermann, R. Galli, S. Tamosaityte, E. Leipnitz, K.D. Geiger, G. Schackert, E. Koch, G. Steiner, M. Kirsch, PLoS ONE 9, e107115 (2014)
X. Zhang, M.B.J. Roeffaers, S. Basu, J.R. Daniele, D. Fu, C.W. Freudiger, G.R. Holtom, X.S. Xie, ChemPhysChem 13, 1054 (2012)
F.-K. Lu, S. Basu, V. Igras, M.P. Hoang, M. Ji, D. Fu, G.R. Holtom, V.A. Neel, C.W. Freudiger, D.E. Fisher, X.S. Xie, Proc. Natl. Acad. Sci. 112, 11624 (2015)
F.-K. Lu, D. Calligaris, O.I. Olubiyi, I. Norton, W. Yang, S. Santagata, X.S. Xie, A.J. Golby, N.Y.R. Agar, Cancer Res. 76, 3451 (2016)
S. Heuke, N. Vogler, T. Meyer, D. Akimov, F. Kluschke, H.-J. Röwert-Huber, J. Lademann, B. Dietzek, J. Popp, Healthcare 1, 64 (2013)
S. Heuke, O. Chernavskaia, T. Bocklitz, F.B. Legesse, T. Meyer, D. Akimov, O. Dirsch, G. Ernst, F. von Eggeling, I. Petersen, O. Guntinas-Lichius, M. Schmitt, J. Popp, Head Neck 38, 1545 (2016)
T. Meyer, O. Guntinas-Lichius, F. von Eggeling, G. Ernst, D. Akimov, M. Schmitt, B. Dietzek, J. Popp, Head Neck 35, E280 (2013)
E. Rodner, T. Bocklitz, F. von Eggeling, G. Ernst, O. Chernavskaia, J. Popp, J. Denzler, O. Guntinas-Lichius, Head Neck 41, 116 (2019)
D.A. Orringer, B. Pandian, Y.S. Niknafs, T.C. Hollon, J. Boyle, S. Lewis, M. Garrard, S.L. Hervey-Jumper, H.J.L. Garton, C.O. Maher, J.A. Heth, O. Sagher, D.A. Wilkinson, M. Snuderl, S. Venneti, S.H. Ramkissoon, K.A. McFadden, A. Fisher-Hubbard, A.P. Lieberman, T.D. Johnson, X.S. Xie, J.K. Trautman, C.W. Freudiger, S. Camelo-Piragua, Nat. Biomed. Eng. 1, 1 (2017)
L. Shamir, N. Orlov, D.M. Eckley, T. Macura, J. Johnston, I.G. Goldberg, Source Code Biol. Med. 3, 13 (2008)
T.C. Hollon, S. Lewis, B. Pandian, Y.S. Niknafs, M.R. Garrard, H. Garton, C.O. Maher, K. McFadden, M. Snuderl, A.P. Lieberman, K. Muraszko, S. Camelo-Piragua, D.A. Orringer, Cancer Res. 78, 278 (2018)
K.S. Shin, A.T. Francis, A.H. Hill, M. Laohajaratsang, P.J. Cimino, C.S. Latimer, L.F. Gonzalez-Cuyar, L.N. Sekhar, G. Juric-Sekhar, D. Fu, Sci. Rep. 9, 20392 (2019)
L. Zhang, Y. Wu, B. Zheng, L. Su, Y. Chen, S. Ma, Q. Hu, X. Zou, L. Yao, Y. Yang, L. Chen, Y. Mao, Y. Chen, M. Ji, Theranostics 9, 2541 (2019)
B. Sarri, R. Canonge, X. Audier, E. Simon, J. Wojak, F. Caillol, C. Cador, D. Marguet, F. Poizat, M. Giovannini, H. Rigneault, Sci. Rep. 9, 1 (2019)
T.C. Hollon, B. Pandian, A.R. Adapa, E. Urias, A.V. Save, S.S.S. Khalsa, D.G. Eichberg, R.S. D’Amico, Z.U. Farooq, S. Lewis, P.D. Petridis, T. Marie, A.H. Shah, H.J.L. Garton, C.O. Maher, J.A. Heth, E.L. McKean, S.E. Sullivan, S.L. Hervey-Jumper, P.G. Patil, B.G. Thompson, O. Sagher, G.M. McKhann, R.J. Komotar, M.E. Ivan, M. Snuderl, M.L. Otten, T.D. Johnson, M.B. Sisti, J.N. Bruce, K.M. Muraszko, J. Trautman, C.W. Freudiger, P. Canoll, H. Lee, S. Camelo-Piragua, D.A. Orringer, Nat. Med. 26, 52 (2020)
H. Lin, H.J. Lee, N. Tague, J.-B. Lugagne, C. Zong, F. Deng, W. Wong, M.J. Dunlop, J.-X. Cheng, Nat. Commun. 12, 3052 (2021)
E.R. Blout, R.C. Mellors, Science 110, 137 (1949)
D.L. Woernley, Cancer Res. 12, 516 (1952)
A. Barth, Biochim. Biophys. Acta BBA Bioenerg. 1767, 1073 (2007)
G. Bellisola, C. Sorio, Am. J. Cancer Res. 2, 1 (2011)
M. Diem, S. Boydston-White, L. Chiriboga, Appl. Spectrosc. 53, 148A (1999)
F. Parker, Applications of Infrared Spectroscopy in Biochemistry, Biology, and Medicine (Springer Science & Business Media, Berlin, 2012)
I.W. Levin, R. Bhargava, Annu. Rev. Phys. Chem. 56, 429 (2004)
P. Lasch, D. Naumann, Cell. Mol. Biol. Noisy Gd. Fr. 44, 189 (1998)
E. N. Lewis, I. W. Levin, and P. J. Treado, US5377003A (27 December 1994)
L.H. Kidder, V.F. Kalasinsky, J.L. Luke, I.W. Levin, E.N. Lewis, Nat. Med. 3, 235 (1997)
H. Fabian, P. Lasch, M. Boese, W. Haensch, Biopolymers 67, 354 (2002)
P. Lasch, W. Haensch, E.N. Lewis, L.H. Kidder, D. Naumann, Appl. Spectrosc. 56, 1 (2002)
W. Steller, J. Einenkel, L.-C. Horn, U.-D. Braumann, H. Binder, R. Salzer, C. Krafft, Anal. Bioanal. Chem. 384, 145 (2006)
A.J. Sommer, L.G. Tisinger, C. Marcott, G.M. Story, Appl. Spectrosc. 55, 252 (2001)
M.J. Walsh, S.E. Holton, A. Kajdacsy-Balla, R. Bhargava, Vib. Spectrosc. 60, 23 (2012)
A. Benard, C. Desmedt, M. Smolina, P. Szternfeld, M. Verdonck, G. Rouas, N. Kheddoumi, F. Rothé, D. Larsimont, C. Sotiriou, E. Goormaghtigh, Analyst 139, 1044 (2014)
M.R. Kole, R.K. Reddy, M.V. Schulmerich, M.K. Gelber, R. Bhargava, Anal. Chem. 84, 10366 (2012)
P. Bassan, M.J. Weida, J. Rowlette, P. Gardner, Analyst 139, 3856 (2014)
M.J. Pilling, A. Henderson, P. Gardner, Anal. Chem. 89, 7348 (2017)
A. Mërtiri, A. Totachawattana, Hui Liu, M. K. Hong, T. Gardner, M. Y. Sander, and S. Erramilli, in 2014 Conf. Lasers Electro-Opt. CLEO - Laser Sci. Photonic Appl. (2014), pp. 1–2
A. Spadea, J. Denbigh, M.J. Lawrence, M. Kansiz, P. Gardner, Anal. Chem. 93, 3938 (2021)
T. Kobayashi, K. Nakata, I. Yajima, M. Kato, H. Tsurui, Bioengineering 5, 67 (2018)
A. Totachawattana, M. S. Regan, N. Y. R. Agar, N. Y. R. Agar, S. Erramilli, M. Y. Sander, and M. Y. Sander, in Conf. Lasers Electro-Opt. 2017 Pap. ATu4A3 (Optical Society of America, 2017), p. ATu4A.3
J. Sacharz, D. Perez-Guaita, M. Kansiz, S.S. Nazeer, A. Wesełucha-Birczyńska, S. Petratos, B.R. Wood, P. Heraud, Anal. Methods 12, 4334 (2020)
H.J. Byrne, M. Baranska, G.J. Puppels, N. Stone, B. Wood, K.M. Gough, P. Lasch, P. Heraud, J. Sulé-Suso, G.D. Sockalingum, Analyst 140, 2066 (2015)
J. M. Cameron, C. Rinaldi, S. H. Rutherford, A. Sala, A. G. Theakstone, and M. J. Baker, Clinical Spectroscopy: Lost in Translation? Applied Spectroscopy. (2021). https://doi.org/10.1177/00037028211021846
M. Jackson, Faraday Discuss. 126, 1 (2004)
S. Tanwar, S.K. Paidi, R. Prasad, R. Pandey, I. Barman, Spectrochim. Acta. A. Mol. Biomol Spectrosc. 260, 119957 (2021)
The International Society for Clinical Spectroscopy - CLIRSPEC (https://clirspec.org/, n.d.). Accessed 01 Sept 2021
Raman4clinics.Eu | Raman Spectroscopies for the Clinical Diagnostics (https://www.raman4clinics.eu/, n.d.). Accessed 01 Sept 2021
S. Fornasaro, F. Alsamad, M. Baia, L.A.E. Batista De Carvalho, C. Beleites, H.J. Byrne, A. Chiadò, M. Chis, M. Chisanga, A. Daniel, J. Dybas, G. Eppe, G. Falgayrac, K. Faulds, H. Gebavi, F. Giorgis, R. Goodacre, D. Graham, P. La Manna, S. Laing, L. Litti, F.M. Lyng, K. Malek, C. Malherbe, M.P.M. Marques, M. Meneghetti, E. Mitri, V. Mohaček-Grošev, C. Morasso, H. Muhamadali, P. Musto, C. Novara, M. Pannico, G. Penel, O. Piot, T. Rindzevicius, E.A. Rusu, M.S. Schmidt, V. Sergo, G.D. Sockalingum, V. Untereiner, R. Vanna, E. Wiercigroch, A. Bonifacio, Anal. Chem. 92, 4053 (2020)
S. Guo, C. Beleites, U. Neugebauer, S. Abalde-Cela, N.K. Afseth, F. Alsamad, S. Anand, C. Araujo-Andrade, S. Aškrabić, E. Avci, M. Baia, M. Baranska, E. Baria, L.A.E. Batista de Carvalho, P. de Bettignies, A. Bonifacio, F. Bonnier, E.M. Brauchle, H.J. Byrne, I. Chourpa, R. Cicchi, F. Cuisinier, M. Culha, M. Dahms, C. David, L. Duponchel, S. Duraipandian, S.F. El-Mashtoly, D.I. Ellis, G. Eppe, G. Falgayrac, O. Gamulin, B. Gardner, P. Gardner, K. Gerwert, E.J. Giamarellos-Bourboulis, S. Gizurarson, M. Gnyba, R. Goodacre, P. Grysan, O. Guntinas-Lichius, H. Helgadottir, V.M. Grošev, C. Kendall, R. Kiselev, M. Kölbach, C. Krafft, S. Krishnamoorthy, P. Kubryck, B. Lendl, P. Loza-Alvarez, F.M. Lyng, S. Machill, C. Malherbe, M. Marro, M.P.M. Marques, E. Matuszyk, C.F. Morasso, M. Moreau, H. Muhamadali, V. Mussi, I. Notingher, M.Z. Pacia, F.S. Pavone, G. Penel, D. Petersen, O. Piot, J.V. Rau, M. Richter, M.K. Rybarczyk, H. Salehi, K. Schenke-Layland, S. Schlücker, M. Schosserer, K. Schütze, V. Sergo, F. Sinjab, J. Smulko, G.D. Sockalingum, C. Stiebing, N. Stone, V. Untereiner, R. Vanna, K. Wieland, J. Popp, T. Bocklitz, Anal. Chem. 92, 15745 (2020)