Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Nature Genetics - Tập 49 Số 12 - Trang 1752-1757 - 2017
Manuel A. R. Ferreira1, Judith M. Vonk2, Hansjörg Baurecht3, Ingo Marenholz4, Chao Tian5, Joshua Hoffman6, Quinta Helmer7, Annika Tillander8, Vilhelmina Ullemar8, Jenny van Dongen7, Yi Lu8, Franz Rüschendorf4, Jorge Esparza-Gordillo4, Chris Medway9, Edward Mountjoy9, Kimberley Burrows9, Oliver Hummel4, Sarah Grosche10, Ben Brumpton9, John S. Witte11, Jouke‐Jan Hottenga7, Gonneke Willemsen7, Jie Zheng9, Elke Rodríguez3, Melanie Hotze3, André Franke12, Joana Revez1, Jonathan Beesley1, Melanie C. Matheson13, Shyamali C. Dharmage13, Lisa Bain1, Lars G. Fritsche14, Maiken E. Gabrielsen14, Brunilda Balliu15, Jonas B. Nielsen16, Wei Zhou17, Kristian Hveem14, Arnulf Langhammer18, Oddgeir L. Holmen14, Mari Løset14, Gonçalo R. Abecasis14, Cristen J. Willer14, Andreas Arnold19, Georg Homuth20, Carsten Oliver Schmidt21, Philip J. Thompson22, Nicholas G. Martin1, David L. Duffy1, Natalija Novak23, Holger Schulz24, Stefan Karrasch24, Christian Gieger25, Konstantin Strauch26, Ronald B. Melles27, David A. Hinds5, Norbert Hübner4, Stephan Weidinger3, Patrik K. E. Magnusson8, Rick Jansen28, Eric Jorgenson27, Young‐Ae Lee10, Dorret I. Boomsma7, Catarina Almqvist29, Robert Karlsson8, Gerard H. Koppelman30, Lavinia Paternoster9
1Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
2Epidemiology, University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands
3Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
4Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany
5Research, 23andMe, Mountain View, California, USA
6Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California USA
7Department of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, The Netherlands
8Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
9MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
10Clinic for Pediatric Allergy, Experimental and Clinical Research Center of Charité Universitätsmedizin Berlin and Max Delbrück Center, Berlin, Germany
11Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
12Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
13Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
14Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
15Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
16Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
17Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
18Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
19Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany
20Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany
21Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany
22Institute for Respiratory Health, Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands, Western Australia, Australia
23Department of Dermatology and Allergology, University Hospital Bonn, Bonn, Germany
24Institute of Epidemiology I, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
25Research Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
26Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
27Division of Research, Kaiser Permanente Northern California, Oakland, California, USA;
28Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
29Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
30GlaxoSmithKline, Stevenage, UK

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Nature Genetics

Tập 49 Số 12

1752-1757

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