Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

The Lancet Infectious Diseases - Tập 17 - Trang 726-734 - 2017
Belén Gutiérrez-Gutiérrez1, Elena Salamanca1, Marina de Cueto1, Po-Ren Hsueh2, Pierluigi Viale3, José Ramón Paño-Pardo4,5, Mario Venditti6, Mario Tumbarello7, George Daikos8, Rafael Cantón9, Yohei Doi10, Felipe Francisco Tuon11, Ilias Karaiskos12, Elena Pérez-Nadales13,14, Mitchell J Schwaber15,16, Özlem Kurt Azap17, Maria Souli18, Emmanuel Roilides19, Spyros Pournaras20, Murat Akova21
1Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Seville, Spain
2National Taiwan University Hospital, Zhongzheng District, Taipei City, Taiwan
3Teaching Hospital Policlinico S Orsola Malpighi, Bologna, Italy
4Hospital Universitario La Paz-Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain
5Hospital Clínico Universitario “Lozano Blesa”-Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain
6Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
7Infectious Diseases Department, Catholic University of the Sacred Heart, Rome, Italy
8Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
9Hospital Ramón y Cajal, Madrid, Spain
10Infectious Diseases Division, University of Pittsburgh, Pittsburgh, PA, USA
11Hospital da Universidade Federal do Parana, Curitiba, Brazil
12Hygeia General Hospital, Athens, Greece
13Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba, Spain
14Unidad Clínica de Enfermedades Infecciosas, University of Córdoba, Córdoba, Spain
15Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
16National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
17Baskent University Faculty of Medicine, Ankara, Turkey
18University General Hospital Attikon, Chaidiri, Greece
19Hippokration Hospital Thessaloniki, Thessaloniki, Greece
20Medical School, National and Kapodistrian University of Athens, Athens, Greece
21Hacettepe University, School of Medicine, Ankara, Turkey

Tài liệu tham khảo

Tzouvelekis, 2012, Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions, Clin Microbiol Rev, 25, 682, 10.1128/CMR.05035-11 Falagas, 2014, Deaths attributable to carbapenem-resistant Enterobacteriaceae infections, Emerg Infect Dis, 20, 1170, 10.3201/eid2007.121004 Fraenkel-Wandel, 2016, Mortality due to blaKPC Klebsiella pneumoniae bacteraemia, J Antimicrob Chemother, 71, 1083, 10.1093/jac/dkv414 Tumbarello, 2012, Predictors of mortality in bloodstream infections caused by KPC-producing Klebsiella pneumoniae: importance of combination therapy, Clin Infect Dis, 55, 943, 10.1093/cid/cis588 Qureshi, 2012, Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens, Antimicrob Agents Chemother, 56, 2108, 10.1128/AAC.06268-11 Daikos, 2014, Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems, Antimicrob Agents Chemother, 58, 2322, 10.1128/AAC.02166-13 Palacios-Baena, 2016, Comprehensive clinical and epidemiological assessment of colonisation and infection due to carbapenemase-producing Enterobacteriaceae in Spain, J Infect, 72, 152, 10.1016/j.jinf.2015.10.008 Lee, 2016, Global dissemination of carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic context, treatment options, and detection methods, Front Microbiol, 7, 895, 10.3389/fmicb.2016.00895 Paul, 2014, Combination therapy for carbapenem-resistant Gram-negative bacteria, J Antimicrob Chemother, 69, 2305, 10.1093/jac/dku168 Gomez-Simmonds, 2016, Combination regimens for treatment of carbapenem-resistant Klebsiella pneumoniae bloodstream infections, Antimicrob Agents Chemother, 60, 3601, 10.1128/AAC.03007-15 Rodríguez-Baño, 2015, Diagnosis and antimicrobial treatment of invasive infections due to multidrug-resistant Enterobacteriaceae. Guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology, Enferm Infecc Microbiol Clin, 33, 337.e1, 10.1016/j.eimc.2014.11.009 Gutiérrez-Gutiérrez, 2016, A predictive model of mortality in patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae, Mayo Clin Proc, 91, 1362, 10.1016/j.mayocp.2016.06.024 Charlson, 1987, A new method of classifying prognostic co-morbidity in longitudinal studies: development and validation, J Chron Dis, 40, 373, 10.1016/0021-9681(87)90171-8 Hilf, 1989, Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients, Am J Med, 87, 540, 10.1016/S0002-9343(89)80611-4 Levy, 2003, 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definition Conference, Crit Care Med, 31, 1250, 10.1097/01.CCM.0000050454.01978.3B 2012 Tumbarello, 2015, Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study, J Antimicrob Chemother, 70, 2133, 10.1093/jac/dkv086 Daikos, 2011, Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?, Clin Microbiol Infect, 17, 1135, 10.1111/j.1469-0691.2011.03553.x Viale, 2013, Predictors of mortality in multidrug-resistant Klebsiella pneumoniae bloodstream infections, Expert Rev Anti Infect Ther, 11, 1053, 10.1586/14787210.2013.836057 Zarkotou, 2011, Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment, Clin Microbiol Infect, 17, 1798, 10.1111/j.1469-0691.2011.03514.x Falcone, 2016, Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae, Clin Microbiol Infect, 22, 444, 10.1016/j.cmi.2016.01.016 Dickstein, 2016, Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA): a study protocol, BMJ Open, 6, e009956, 10.1136/bmjopen-2015-009956