ABCG5/ABCG8 in cholesterol excretion and atherosclerosis

Barton, 2013, Cholesterol and atherosclerosis: modulation by oestrogen, Curr Opin Lipidol, 24, 214, 10.1097/MOL.0b013e3283613a94 Kihara, 2013, Dyslipidemia, Nihon Rinsho, 71, 275 Wellington, 2004, Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism, Clin Genet, 66, 1, 10.1111/j.0009-9163.2004.00280.x Robichon, 2007, De novo cholesterol synthesis at the crossroads of adaptive response to extracellular stress through SREBP, Biochimie, 89, 260, 10.1016/j.biochi.2006.09.015 Wang, 1821, Niemann–Pick C1-Like 1 and cholesterol uptake, Biochim Biophys Acta, 2012, 964 Brown, 2009, Opposing gatekeepers of apical sterol transport: Niemann–Pick C1-Like 1 (NPC1L1) and ATP-binding cassette transporters G5 and G8 (ABCG5/ABCG8), Immunol Endocr Metab Agents Med Chem, 9, 18, 10.2174/187152209788009797 Brown, 2010, Protein mediators of sterol transport across intestinal brush border membrane, Subcell Biochem, 51, 337, 10.1007/978-90-481-8622-8_12 Calandra, 2011, Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk, J Lipid Res, 52, 1885, 10.1194/jlr.R017855 Dikkers, 2010, Biliary cholesterol secretion: more than a simple ABC, World J Gastroenterol, 16, 5936 Sabeva, 2007, Defects in the leptin axis reduce abundance of the ABCG5–ABCG8 sterol transporter in liver, J Biol Chem, 282, 22397, 10.1074/jbc.M702236200 Okiyoneda, 2006, Calreticulin facilitates the cell surface expression of ABCG5/G8, Biochem Biophys Res Commun, 347, 67, 10.1016/j.bbrc.2006.06.032 Graf, 2002, Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface, J Clin Invest, 110, 659, 10.1172/JCI0216000 Hirata, 2009, Molecular mechanisms of subcellular localization of ABCG5 and ABCG8, Biosci Biotechnol Biochem, 73, 619, 10.1271/bbb.80694 Graf, 2004, Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking, J Biol Chem, 279, 24881, 10.1074/jbc.M402634200 Zhang, 2006, Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8, J Biol Chem, 281, 4507, 10.1074/jbc.M512277200 Wang, 2011, Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport, J Biol Chem, 286, 7308, 10.1074/jbc.M110.210880 Yu, 2002, Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion, Proc Natl Acad Sci U S A, 99, 16237, 10.1073/pnas.252582399 Plosch, 2004, Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor, Gastroenterology, 126, 290, 10.1053/j.gastro.2003.10.074 Wang, 2007, Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(−/−) mice, Hepatology, 45, 998, 10.1002/hep.21579 Yu, 2002, Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol, J Clin Invest, 110, 671, 10.1172/JCI0216001 Coy, 2010, ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats, Am J Physiol Gastrointest Liver Physiol, 299, G228, 10.1152/ajpgi.00502.2009 Groen, 2008, Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice, Gastroenterology, 134, 2091, 10.1053/j.gastro.2008.02.097 Vrins, 2007, The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux, FEBS Lett, 581, 4616, 10.1016/j.febslet.2007.08.052 Langheim, 2005, ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile, J Lipid Res, 46, 1732, 10.1194/jlr.M500115-JLR200 Duan, 2004, Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice, J Lipid Res, 45, 1312, 10.1194/jlr.M400030-JLR200 Wu, 2009, The effects of phytosterols/stanols on blood lipid profiles: a systematic review with meta-analysis, Asia Pac J Clin Nutr, 18, 179 Brufau, 2011, A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice, PLoS One, 6, e21576, 10.1371/journal.pone.0021576 Renner, 2013, Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease, BMC Gastroenterol, 13, 1, 10.1186/1471-230X-13-30 Wei, 2011, Interactions between CYP7A1 A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin, J Clin Pharm Ther, 36, 725, 10.1111/j.1365-2710.2010.01227.x Miwa, 2005, ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects, Clin Sci (Lond), 109, 183, 10.1042/CS20050030 Koeijvoets, 2009, ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia, Atherosclerosis, 204, 453, 10.1016/j.atherosclerosis.2008.09.018 Garcia-Rios, 2010, Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia, Atherosclerosis, 210, 486, 10.1016/j.atherosclerosis.2010.01.010 Caamano, 2008, Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls, Clin Chem Lab Med, 46, 1581, 10.1515/CCLM.2008.311 Yoon, 2013, ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder, Dig Dis Sci, 58, 431, 10.1007/s10620-012-2481-0 Gonzalez-Granillo, 2012, Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice, Diabetologia, 55, 2469, 10.1007/s00125-012-2599-9 Calpe-Berdiel, 2008, Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8, J Lipid Res, 49, 1904, 10.1194/jlr.M700470-JLR200 van der Veen, 2007, Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha, J Lipid Res, 48, 337, 10.1194/jlr.M600170-JLR200 Back, 2013, Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor, BMB Rep, 46, 322, 10.5483/BMBRep.2013.46.6.246 Bonde, 2012, Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex, Hepatology, 56, 1828, 10.1002/hep.25861 Sumi, 2007, Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8, Mol Cell Biol, 27, 4248, 10.1128/MCB.01894-06 Kim, 2012, Endogenously synthesized n−3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease, Biochem Pharmacol, 84, 1359, 10.1016/j.bcp.2012.08.029 de Souza, 2012, The hypocholesterolemic activity of acai (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat, Nutr Res, 32, 976, 10.1016/j.nutres.2012.10.001 Takahashi, 2011, Soy protein and fish oil independently decrease serum lipid concentrations but interactively reduce hepatic enzymatic activity and gene expression involved in fatty acid synthesis in rats, J Nutr Sci Vitaminol (Tokyo), 57, 56, 10.3177/jnsv.57.56 Tremblay, 2011, Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men, J Lipid Res, 52, 558, 10.1194/jlr.M011080 Lodowska, 2013, The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin — a review of its biosynthesis, function, and placement in the lipopolysaccharide core, Can J Microbiol, 59, 645, 10.1139/cjm-2013-0490 Khovidhunkit, 2003, Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR, J Lipid Res, 44, 1728, 10.1194/jlr.M300100-JLR200 Yamazaki, 2011, Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi, Drug Metab Pharmacokinet, 26, 442, 10.2133/dmpk.DMPK-11-RG-025 Kim, 2013, Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells, J Nutr Biochem, 24, 1564, 10.1016/j.jnutbio.2013.01.005 Liu, 2012, miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1, Am J Pathol, 181, 1823, 10.1016/j.ajpath.2012.07.009 Salen, 2002, Sitosterolemia, Cardiovasc Drug Rev, 20, 255, 10.1111/j.1527-3466.2002.tb00096.x Kanaji, 2013, Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia, Blood, 122, 2732, 10.1182/blood-2013-06-510461 Berge, 2000, Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters, Science, 290, 1771, 10.1126/science.290.5497.1771 Tsubakio-Yamamoto, 2010, Current therapy for patients with sitosterolemia—effect of ezetimibe on plant sterol metabolism, J Atheroscler Thromb, 17, 891, 10.5551/jat.4614 Tang, 2009, Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8, J Lipid Res, 50, 293, 10.1194/jlr.M800439-JLR200 Salen, 2004, Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia, Circulation, 109, 966, 10.1161/01.CIR.0000116766.31036.03 Lutjohann, 2008, Long-term efficacy and safety of ezetimibe 10mg in patients with homozygous sitosterolemia: a 2-year, open-label extension study, Int J Clin Pract, 62, 1499, 10.1111/j.1742-1241.2008.01841.x Wilund, 2004, High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr−/− mice, J Lipid Res, 45, 1429, 10.1194/jlr.M400167-JLR200 Wei, 2013, Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis, Acta Physiol (Oxf), 207, 299, 10.1111/apha.12005 Li, 2012, Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains, Genet Sel Evol, 44, 20, 10.1186/1297-9686-44-20 McGillicuddy, 2009, Inflammation impairs reverse cholesterol transport in vivo, Circulation, 119, 1135, 10.1161/CIRCULATIONAHA.108.810721 Ikewaki, 2007, Sitosterolemia, Nihon Rinsho, 65, 371 Xu, 2011, Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet, Lipids Health Dis, 10, 96, 10.1186/1476-511X-10-96 Horenstein, 2013, The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish, Arterioscler Thromb Vasc Biol, 33, 413, 10.1161/ATVBAHA.112.245480 Wilund, 2004, No association between plasma levels of plant sterols and atherosclerosis in mice and men, Arterioscler Thromb Vasc Biol, 24, 2326, 10.1161/01.ATV.0000149140.00499.92 Singh, 2013, Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters, Br J Nutr, 110, 437, 10.1017/S0007114512005363 Ji, 2008, Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats, J Pharm Pharmacol, 60, 1207, 10.1211/jpp.60.9.0013 Ji, 2007, Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats, J Ethnopharmacol, 113, 318, 10.1016/j.jep.2007.06.022 Wu, 2004, Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice, J Biol Chem, 279, 22913, 10.1074/jbc.M402838200 Basso, 2007, Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited, J Lipid Res, 48, 114, 10.1194/jlr.M600353-JLR200