Neural and cellular mechanisms of fear and extinction memory formation

Neuroscience & Biobehavioral Reviews - Tập 36 Số 7 - Trang 1773-1802 - 2012
Caitlin A. Orsini1, Stephen Maren1,2
1Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA
2Neuroscience Program, University of Michigan, Ann Arbor, MI 48109-1043, USA

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Abel, 1997, Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory, Cell, 88, 615, 10.1016/S0092-8674(00)81904-2

Adams, 2002, Molecular psychology: roles for the ERK MAP kinase cascade in memory, Annu. Rev. Pharmacol. Toxicol., 42, 135, 10.1146/annurev.pharmtox.42.082701.145401

Akirav, 2006, Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala, Eur. J. Neurosci., 23, 758, 10.1111/j.1460-9568.2006.04603.x

Alberini, 2005, Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes?, Trends Neurosci., 28, 51, 10.1016/j.tins.2004.11.001

Alonso, 2004, ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons, Learn. Mem., 11, 172, 10.1101/lm.67804

Amano, 2010, Synaptic correlates of fear extinction in the amygdala, Nat. Neurosci., 13, 489, 10.1038/nn.2499

Amir, 2011, Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons, J. Neurophysiol., 105, 3054, 10.1152/jn.00136.2011

Anagnostaras, 1999, Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination, J. Neurosci., 19, 1106, 10.1523/JNEUROSCI.19-03-01106.1999

Apergis-Schoute, 2005, Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system, J. Neurosci., 25, 5730, 10.1523/JNEUROSCI.0096-05.2005

Atkins, 1998, The MAPK cascade is required for mammalian associative learning, Nat. Neurosci., 1, 602, 10.1038/2836

Azad, 2008, Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala, Learn. Mem., 15, 143, 10.1101/lm.741908

Baker, 1996, The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning, Behav. Neurosci., 110, 618, 10.1037/0735-7044.110.3.618

Bamji, 2006, BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta catenin interactions, J. Cell Biol., 174, 289, 10.1083/jcb.200601087

Bannerman, 2003, Ventral hippocampal lesions affect anxiety but not spatial learning, Behav. Brain Res., 139, 197, 10.1016/S0166-4328(02)00268-1

Barot, 2008, Visualizing stimulus convergence in amygdala neurons during associative learning, PNAS, 105, 20959, 10.1073/pnas.0808996106

Barot, 2009, Functional imaging of stimulus convergence in amygdalar neurons during Pavlovian fear conditioning, PLoS ONE, 4, e6156, 10.1371/journal.pone.0006156

Barria, 1997, Identification of the Ca2+/calmodulin dependent protein kinase II regulatory phosphorylation site in the alpha- amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor, J. Biol. Chem., 272, 32727, 10.1074/jbc.272.52.32727

Bast, 2001, The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol, Exp. Brain Res., 139, 39, 10.1007/s002210100746

Bauer, 2002, NMDA receptors and L-type voltage gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala, J. Neurosci., 22, 5239, 10.1523/JNEUROSCI.22-12-05239.2002

Bayer, 2001, Interaction with the NMDA receptor locks CaMKII in an active conformation, Nature, 411, 801, 10.1038/35081080

Berman, 2001, Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex, Science, 291, 2417, 10.1126/science.1058165

Bernard, 1993, The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: a Phaseolus vulgaris leucoagglutinin (PHA-L) study in the rat, J. Comp. Neurol., 329, 201, 10.1002/cne.903290205

Berretta, 2005, Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala, Neuroscience, 132, 943, 10.1016/j.neuroscience.2005.01.020

Bevilaqua, 2006, The entorhinal cortex plays a role in extinction, Neurobiol. Learn. Mem., 85, 192, 10.1016/j.nlm.2005.10.001

Biedenkapp, 2009, Hippocampal and extrahippocampal systems compete for control of contextual fear: role of ventral subiculum and amygdala, Learn. Mem., 16, 38, 10.1101/lm.1099109

Bissiere, 2003, Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition, Nat. Neurosci., 6, 587, 10.1038/nn1058

Bissiere, 2011, Electrical synapses control hippocampal contributions to fear learning and memory, Science, 331, 87, 10.1126/science.1193785

Blair, 2001, Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning, Learn. Mem., 8, 229, 10.1101/lm.30901

Blanchard, 1972, Innate and conditioned reactions to threat in rats with amygdaloid lesions, J. Comp. Physiol. Psychol., 81, 281, 10.1037/h0033521

Bliss, 1993, A synaptic model of memory: long-term potentiation in the hippocampus, Nature, 361, 31, 10.1038/361031a0

Bliss, 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path, J. Physiol., 232, 357, 10.1113/jphysiol.1973.sp010274

Bliss, 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol., 232, 331, 10.1113/jphysiol.1973.sp010273

Blum, 2006, A role for the prefrontal cortex in recall of recent and remote memories, Neuroreport, 17, 341, 10.1097/01.wnr.0000201509.53750.bc

Bolles, 1970, Species-specific defense reactions and avoidance learning, Psychol. Rev., 77, 32, 10.1037/h0028589

Bordi, 1992, Sensory tuning beyond the sensory system: an initial analysis of auditory response properties of neurons in the lateral amygdaloid nucleus and overlying areas of the striatum, J. Neurosci., 12, 2493, 10.1523/JNEUROSCI.12-07-02493.1992

Borowski, 1998, The effects of cocaine, amphetamine, and the dopamine D1 receptor agonist SKF 38393 on fear extinction as measured with potentiated startle: implications for psychomotor stimulant psychosis, Behav. Neurosci., 112, 952, 10.1037/0735-7044.112.4.952

Bourtchuladze, 1994, Deficient long-term memory in mice with a targeted mutation of the cAMP responsive element-binding protein, Cell, 79, 59, 10.1016/0092-8674(94)90400-6

Bouton, 1988, Context and ambiguity in the extinction of emotional learning: implications for exposure therapy, Behav. Res. Ther., 26, 137, 10.1016/0005-7967(88)90113-1

Bouton, 1993, Context, time and memory retrieval in the interference paradigms of Pavlovian learning, Psychol. Bull., 114, 80, 10.1037/0033-2909.114.1.80

Bouton, 2004, Context and behavioral processes in extinction, Learn. Mem., 11, 485, 10.1101/lm.78804

Bouton, 1985, Contexts event-memories and extinction, 133

Bouton, 1989, Slow reacquisition following extinction: context, encoding, and retrieval mechanisms, J. Exp. Psychol. Anim. Behav. Process., 15, 43, 10.1037/0097-7403.15.1.43

Bouton, 2008, D-cycloserine facilitates context-specific fear extinction learning, Neurobiol. Learn. Mem., 90, 504, 10.1016/j.nlm.2008.07.003

Brady, 1954, Subcortical mechanisms in emotional behavior; the effect of rhinencephalic injury upon the acquisition and retention of a conditioned avoidance response in cats, J. Comp. Physiol. Psychol., 47, 179, 10.1037/h0055426

Brambilla, 1997, A role for the Ras signalling pathway in synaptic transmission and long-term memory, Nature, 390, 281, 10.1038/36849

Bredy, 2007, Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear, Learn. Mem., 14, 268, 10.1101/lm.500907

Brunzell, 2001, Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats, Behav. Neurosci., 115, 365, 10.1037/0735-7044.115.2.365

Burgos-Robles, 2009, Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure, J. Neurosci., 29, 8474, 10.1523/JNEUROSCI.0378-09.2009

Burgos-Robles, 2007, Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex, Neuron, 53, 871, 10.1016/j.neuron.2007.02.021

Busquet, 2008, Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear, Learn. Mem., 15, 378, 10.1101/lm.886208

Cain, 2002, L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice, J. Neurosci., 22, 9113, 10.1523/JNEUROSCI.22-20-09113.2002

Cain, 2005, The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice, Learn. Mem., 12, 277, 10.1101/lm.88805

Campeau, 1995, Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli, J. Neurosci., 15, 2301, 10.1523/JNEUROSCI.15-03-02301.1995

Campeau, 1992, Intra-amygdala infusion of the N methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus, Behav. Neurosci., 106, 569, 10.1037/0735-7044.106.3.569

Cannich, 2004, CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice, Learn. Mem., 11, 625, 10.1101/lm.77904

Canteras, 1992, Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: a PHAL anterograde tract-tracing study in the rat, J. Comp. Neurol., 324, 180, 10.1002/cne.903240204

Cenquizca, 2007, Spatial organization of direct hippocampal field CA1 axonal projections to the rest of the cerebral cortex, Brain Res. Rev., 56, 1, 10.1016/j.brainresrev.2007.05.002

Chan, 2010, Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning, Learn. Mem., 17, 512, 10.1101/lm.1912510

Chang, 2010, Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats, PLoS ONE, 5, e11971, 10.1371/journal.pone.0011971

Chang, 2009, Early extinction after fear conditioning yields a context independent and short-term suppression of conditional freezing in rats, Learn. Mem., 16, 62, 10.1101/lm.1085009

Chang, 2011, Medial prefrontal cortex activation facilitates re extinction of fear in rats, Learn. Mem., 18, 221, 10.1101/lm.2070111

Chaudhuri, 1997, Neural activity mapping with inducible transcription factors, Neuroreport, 8, iii, 10.1097/00001756-199709080-00002

Chhatwal, 2005, Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear, Neuropsychopharmacology, 30, 516, 10.1038/sj.npp.1300655

Chhatwal, 2009, Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning, Neuropsychopharmacology, 34, 509, 10.1038/npp.2008.97

Chhatwal, 2005, Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction, J. Neurosci., 25, 502, 10.1523/JNEUROSCI.3301-04.2005

Chhatwal, 2007, Modulation of fear and anxiety by the endogenous cannabinoid system, CNS Spectr., 12, 211, 10.1017/S1092852900020939

Chhatwal, 2006, Amygdala BDNF signaling is required for consolidation but not encoding of extinction, Nat. Neurosci., 9, 870, 10.1038/nn1718

Cho, 1999, Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice, Behav. Brain Res., 98, 77, 10.1016/S0166-4328(98)00054-0

Ciocchi, 2010, Encoding of conditioned fear in central amygdala inhibitory circuits, Nature, 468, 277, 10.1038/nature09559

Clem, 2010, Calcium-permeable AMPA receptor dynamics mediate fear memory erasure, Science, 330, 1108, 10.1126/science.1195298

Clugnet, 1990, Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body, J. Neurosci., 10, 2818, 10.1523/JNEUROSCI.10-08-02818.1990

Clugnet, 1990, Unit responses evoked in the amygdala and striatum by electrical stimulation of the medial geniculate body, J. Neurosci., 10, 1055, 10.1523/JNEUROSCI.10-04-01055.1990

Colbran, 2004, Calcium/calmodulin-dependent protein kinase II and synaptic plasticity, Curr. Opin. Neurobiol., 14, 318, 10.1016/j.conb.2004.05.008

Collingridge, 1983, The antagonism of amino acid induced excitations of rat hippocampal CA1 neurones in vitro, J. Physiol., 334, 19, 10.1113/jphysiol.1983.sp014477

Corcoran, 2005, Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction, J. Neurosci., 25, 8978, 10.1523/JNEUROSCI.2246-05.2005

Corcoran, 2001, Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction, J. Neurosci., 21, 1720, 10.1523/JNEUROSCI.21-05-01720.2001

Corcoran, 2004, Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction, Learn. Mem., 11, 598, 10.1101/lm.78704

Corcoran, 2007, Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears, J. Neurosci., 27, 840, 10.1523/JNEUROSCI.5327-06.2007

Cox, 1994, The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesic responses in the rat, Q. J. Exp. Psychol. B, 47, 187

Cruikshank, 1992, Stimulation at a site of auditory-somatosensory convergence in the medial geniculate nucleus is an effective unconditioned stimulus for fear conditioning, Behav. Neurosci., 106, 471, 10.1037/0735-7044.106.3.471

Dalton, 2008, Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear, Neuropsychopharmacology, 33, 2416, 10.1038/sj.npp.1301642

Davis, 1994, Neurotransmission in the rat amygdala related to fear and anxiety, Trends Neurosci., 17, 208, 10.1016/0166-2236(94)90106-6

Davis, 2001, The amygdala: vigilance and emotion, Mol. Psychiatry, 6, 13, 10.1038/sj.mp.4000812

Debiec, 2006, Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala, Proc. Natl. Acad. Sci. U.S.A., 103, 3428, 10.1073/pnas.0507168103

Debiec, 2002, Cellular and systems reconsolidation in the hippocampus, Neuron, 36, 527, 10.1016/S0896-6273(02)01001-2

Delamater, 2004, Experimental extinction in Pavlovian conditioning: behavioural and neuroscience perspectives, Q. J. Exp. Psychol. B, 57, 97, 10.1080/02724990344000097

Denniston, 2003, The role of temporal variables in inhibition produced through extinction, Learn. Behav., 31, 35, 10.3758/BF03195969

Depaulis, 1997, Anxiogenic-like consequences in animal models of complex partial seizures, Neurosci. Biobehav. Rev., 21, 767, 10.1016/S0149-7634(96)00060-7

Derkach, 1999, Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionate type glutamate receptors, Proc. Natl. Acad. Sci. U.S.A., 96, 3269, 10.1073/pnas.96.6.3269

Dong, 2009, Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1, Proc. Natl. Acad. Sci. U.S.A., 106, 11794, 10.1073/pnas.0812608106

Doron, 1999, Organization of projections to the lateral amygdala from auditory and visual areas of the thalamus in the rat, J. Comp. Neurol., 412, 383, 10.1002/(SICI)1096-9861(19990927)412:3<383::AID-CNE2>3.0.CO;2-5

Doyere, 2007, Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala, Nat. Neurosci., 10, 414, 10.1038/nn1871

Duvarci, 2004, Characterization of fear memory reconsolidation, J. Neurosci., 24, 9269, 10.1523/JNEUROSCI.2971-04.2004

Duvarci, 2005, Activation of extracellular signal-regulated kinase-mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning, Eur. J. Neurosci., 21, 283, 10.1111/j.1460-9568.2004.03824.x

Ehrlich, 2009, Amygdala inhibitory circuits and the control of fear memory, Neuron, 62, 757, 10.1016/j.neuron.2009.05.026

El-Ghundi, 2001, Prolonged fear responses in mice lacking dopamine D1 receptor, Brain Res., 892, 86, 10.1016/S0006-8993(00)03234-0

English, 1996, Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation, J. Biol. Chem., 271, 24329, 10.1074/jbc.271.40.24329

English, 1997, A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation, J. Biol. Chem., 31, 19103, 10.1074/jbc.272.31.19103

Esclassan, 2009, Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning, Hippocampus, 19, 33, 10.1002/hipo.20473

Falls, 1992, Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala, J. Neurosci., 12, 854, 10.1523/JNEUROSCI.12-03-00854.1992

Fanselow, 1986, Associative vs. topographical accounts of the immediate shock freezing deficit in rats: implications for the response selection rules governing species-specific defensive reactions, Learn. Motiv., 17, 16, 10.1016/0023-9690(86)90018-4

Fanselow, 1990, Factors governing one-trial contextual conditioning, Anim. Learn. Behav., 18, 264, 10.3758/BF03205285

Fanselow, 2010, From contextual fear to a dynamic view of memory systems, Trends Cogn. Sci., 14, 7, 10.1016/j.tics.2009.10.008

Fanselow, 2010, Are the dorsal and ventral hippocampus functionally distinct structures?, Neuron, 65, 7, 10.1016/j.neuron.2009.11.031

Fanselow, 1994, Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5 phosphonovaleric acid to the basolateral amygdala, Behav. Neurosci., 108, 210, 10.1037/0735-7044.108.1.210

Fanselow, 2005, The neuroscience of mammalian associative learning, Annu. Rev. Psychol., 56, 207, 10.1146/annurev.psych.56.091103.070213

Farinelli, 2006, Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions, Learn. Mem., 13, 329, 10.1101/lm.204806

Fendt, 1999, The neuroanatomical and neurochemical basis of conditioned fear, Neurosci. Biobehav. Rev., 23, 743, 10.1016/S0149-7634(99)00016-0

Fernandez Espejo, 2003, Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory, Neuropsychopharmacology, 28, 490, 10.1038/sj.npp.1300066

Fischer, 2007, Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior, Neurobiol. Learn. Mem., 87, 149, 10.1016/j.nlm.2006.08.003

Fonberg, 1972, Control of emotional behavior through the hypothalamus and amygdaloid complex, Ciba Found. Symp., 8, 131

Frankland, 2004, The involvement of the anterior cingulate cortex in remote contextual fear memory, Science, 304, 881, 10.1126/science.1094804

Frohardt, 2000, The effects of neurotoxic hippocampal lesions on two effects of context after fear extinction, Behav. Neurosci., 114, 227, 10.1037/0735-7044.114.2.227

Fukazawa, 2003, Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo, Neuron, 38, 447, 10.1016/S0896-6273(03)00206-X

Gale, 2004, Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats, J. Neurosci., 24, 3810, 10.1523/JNEUROSCI.4100-03.2004

Garcia, 2006, Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear, Learn. Mem., 13, 14, 10.1101/lm.60406

Gass, 1998, Deficits in memory tasks of mice with CREB mutations depend on gene dosage, Learn. Mem., 5, 274, 10.1101/lm.5.4.274

Giese, 1998, Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning, Science, 279, 870, 10.1126/science.279.5352.870

Gisquet-Verrier, 1999, Effects of lesions to the hippocampus on contextual fear: evidence for a disruption of freezing and avoidance behavior but not context conditioning, Behav. Neurosci., 113, 507, 10.1037/0735-7044.113.3.507

Goddard, 1964, Functions of the amygdala, Psychol. Bull., 62, 89, 10.1037/h0044853

Gogolla, 2009, Perineuronal nets protect fear memories from erasure, Science, 325, 1258, 10.1126/science.1174146

Golstein, 1965, Effects of hippocampal, amygdala, hypothalamic and parietal lesions on a classically conditioned fear response, Psychol. Rep., 16, 211, 10.2466/pr0.1965.16.1.211

Goosens, 2000, A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats, Behav. Brain Res., 114, 145, 10.1016/S0166-4328(00)00224-2

Goosens, 2001, Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats, Learn. Mem., 8, 148, 10.1101/lm.37601

Goosens, 2002, Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning, Hippocampus, 12, 592, 10.1002/hipo.10099

Goosens, 2003, Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias?, Neuron, 40, 1013, 10.1016/S0896-6273(03)00728-1

Goosens, 2003, Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear, Behav. Neurosci., 117, 738, 10.1037/0735-7044.117.4.738

Goosens, 2004, NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala, Eur. J. Neurosci., 20, 537, 10.1111/j.1460-9568.2004.03513.x

Goshen, 2011, Dynamics of retrieval strategies for remote memories, Cell, 147, 678, 10.1016/j.cell.2011.09.033

Grace, 2002, Regulation of conditioned responses of basolateral amygdala neurons, Physiol. Behav., 77, 489, 10.1016/S0031-9384(02)00909-5

Gunther, 1998, Conducting exposure treatment in multiple contexts can prevent relapse, Behav. Res. Ther., 36, 75, 10.1016/S0005-7967(97)10019-5

Guzowski, 2000, Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory, J. Neurosci., 20, 3993, 10.1523/JNEUROSCI.20-11-03993.2000

Guzowski, 2005, Mapping behaviorally relevant neural circuits with immediate-early gene expression, Curr. Opin. Neurobiol., 15, 599, 10.1016/j.conb.2005.08.018

Guzowski, 2001, Cellular compartment analysis of temporal activity by fluorescence in situ hybridization (catFISH), Curr. Protoc. Neurosci., 10.1002/0471142301.ns0108s15

Hall, 2001, Cellular imaging of zif268 expression in the hippocampus and amygdala during contextual and cued fear memory retrieval: selective activation of hippocampal CA1 neurons during the recall of contextual memories, J. Neurosci., 21, 2186, 10.1523/JNEUROSCI.21-06-02186.2001

Han, 2007, Neuronal competition and selection during memory formation, Science, 316, 457, 10.1126/science.1139438

Han, 2009, Selective erasure of a fear memory, Science, 323, 1492, 10.1126/science.1164139

Harris, 1998, Evidence that GABA transmission mediates context-specific extinction of learned fear, Psychopharmacology, 140, 105, 10.1007/s002130050745

Hartley, 2010, Changing fear: the neurocircuitry of emotion regulation, Neuropsychopharmacology, 35, 136, 10.1038/npp.2009.121

Haubensak, 2010, Genetic dissection of an amygdala microcircuit that gates conditioned fear, Nature, 468, 270, 10.1038/nature09553

Hayashi, 2000, Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction, Science, 287, 2262, 10.1126/science.287.5461.2262

Hefner, 2008, Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain, J. Neurosci., 28, 8074, 10.1523/JNEUROSCI.4904-07.2008

Heldt, 2007, Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear, Eur. J. Neurosci., 26, 3631, 10.1111/j.1460-9568.2007.05970.x

Heldt, 2007, Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories, Mol. Psychiatry, 12, 656, 10.1038/sj.mp.4001957

Herkenham, 1990, Cannabinoid receptor localization in brain, Proc. Natl. Acad. Sci. U.S.A., 87, 1932, 10.1073/pnas.87.5.1932

Hernandez, 2003, Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory, J. Biol. Chem., 278, 40305, 10.1074/jbc.M307065200

Hernandez, 2008, The role of protein synthesis in memory consolidation: progress amid decades of debate, Neurobiol. Learn. Mem., 89, 293, 10.1016/j.nlm.2007.09.010

Hernandez, 2002, Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens, Nat. Neurosci., 5, 1327, 10.1038/nn973

Herry, 2008, Switching on and off fear by distinct neuronal circuits, Nature, 454, 600, 10.1038/nature07166

Herry, 2010, Neuronal circuits of fear extinction, Eur. J. Neurosci., 31, 599, 10.1111/j.1460-9568.2010.07101.x

Herry, 2002, Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice, J. Neurosci., 22, 577, 10.1523/JNEUROSCI.22-02-00577.2002

Herry, 2004, Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala, Eur. J. Neurosci., 20, 781, 10.1111/j.1460-9568.2004.03542.x

Herry, 2006, Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala, Eur. J. Neurosci., 24, 261, 10.1111/j.1460-9568.2006.04893.x

Hikind, 2008, Microinfusion of the D1 antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning, Neurobiol. Learn. Mem., 90, 217, 10.1016/j.nlm.2008.03.003

Hobin, 2003, Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction, J. Neurosci., 23, 8410, 10.1523/JNEUROSCI.23-23-08410.2003

Hobin, 2006, Ventral hippocampal muscimol disrupts context specific fear memory retrieval after extinction in rats, Hippocampus, 16, 174, 10.1002/hipo.20144

Holtzman-Assif, 2010, Blockade of dopamine activity in the nucleus accumbens impairs learning extinction of conditioned fear, Learn. Mem., 17, 71, 10.1101/lm.1668310

Hoover, 2007, Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat, Brain Struct. Funct., 212, 149, 10.1007/s00429-007-0150-4

Huang, 2007, Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites, J. Neurosci., 27, 9054, 10.1523/JNEUROSCI.2410-07.2007

Huang, 1998, Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala, Neuron, 21, 169, 10.1016/S0896-6273(00)80524-3

Hugues, 2006, Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction associated prefrontal synaptic plasticity and decreases prefrontal ERK2 phosphorylation, Synapse, 60, 280, 10.1002/syn.20291

Hugues, 2004, Postextinction infusion of a mitogen activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear, Learn. Mem., 11, 540, 10.1101/lm.77704

Huh, 2009, Hippocampal Erk mechanisms linking prediction error to fear extinction: roles of shock expectancy and contextual aversive valence, Learn. Mem., 16, 273, 10.1101/lm.1240109

Humeau, 2005, Dendritic spine heterogeneity determines afferent-specific Hebbian plasticity in the amygdala, Neuron, 45, 119, 10.1016/j.neuron.2004.12.019

Humeau, 2003, Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain, Nature, 426, 841, 10.1038/nature02194

Impey, 1996, Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus, Neuron, 16, 973, 10.1016/S0896-6273(00)80120-8

Impey, 1999, Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity, Neuron, 23, 11, 10.1016/S0896-6273(00)80747-3

Impey, 1998, Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation, Neuron, 21, 869, 10.1016/S0896-6273(00)80602-9

Impey, 1998, Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning, Nat. Neurosci., 1, 595, 10.1038/2830

Inda, 2011, Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction, J. Neurosci., 31, 1635, 10.1523/JNEUROSCI.4736-10.2011

Iwata, 1986, Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli, Brain Res., 383, 195, 10.1016/0006-8993(86)90020-X

Jasnow, 2005, Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala, Behav. Neurosci., 119, 1125, 10.1037/0735-7044.119.4.1125

Jay, 1991, Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin, J. Comp. Neurol., 313, 574, 10.1002/cne.903130404

Josselyn, 2010, Continuing the search for the engram: examining the mechanism of fear memories, J. Psychiatry Neurosci., 35, 221, 10.1503/jpn.100015

Josselyn, 2004, Inducible repression of CREB function disrupts amygdala-dependent memory, Neurobiol. Learn. Mem., 82, 159, 10.1016/j.nlm.2004.05.008

Josselyn, 2001, Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala, J. Neurosci., 21, 2404, 10.1523/JNEUROSCI.21-07-02404.2001

Jungling, 2008, Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala, Neuron, 59, 298, 10.1016/j.neuron.2008.07.002

Kamprath, 2004, Nonassociative learning processes determine expression and extinction of conditioned fear in mice, Learn. Mem., 11, 770, 10.1101/lm.86104

Kamprath, 2006, Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes, J. Neurosci., 26, 6677, 10.1523/JNEUROSCI.0153-06.2006

Kandel, 2001, The molecular biology of memory storage: a dialog between genes and synapses, Biosci. Rep., 21, 565, 10.1023/A:1014775008533

Kang, 1995, Neurotrophin-induced modulation of synaptic transmission in the adult hippocampus, J. Physiol. Paris, 89, 11, 10.1016/0928-4257(96)80547-X

Katona, 2001, Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission, J. Neurosci., 21, 9506, 10.1523/JNEUROSCI.21-23-09506.2001

Kellicutt, 1963, Formation of a conditioned emotional response (CER) folowing lesions of the amygdaloid complex in rats, Psychol. Rep., 12, 351, 10.2466/pr0.1963.12.2.351

Kessels, 2009, Synaptic AMPA receptor plasticity and behavior, Neuron, 61, 340, 10.1016/j.neuron.2009.01.015

Kida, 2002, CREB required for the stability of new and reactivated fear memories, Nat. Neurosci., 5, 348, 10.1038/nn819

Kim, 2007, Amygdala depotentiation and fear extinction, Proc. Natl. Acad. Sci. U.S.A., 104, 20955, 10.1073/pnas.0710548105

Kim, 2009, Fear extinction across development: the involvement of the medial prefrontal cortex as assessed by temporary inactivation and immunohistochemistry, J. Neurosci., 29, 10802, 10.1523/JNEUROSCI.0596-09.2009

Kim, 2007, A developmental dissociation in reinstatement of an extinguished fear response in rats, Neurobiol. Learn. Mem., 88, 48, 10.1016/j.nlm.2007.03.004

Kim, 2007, A developmental dissociation of context and GABA effects on extinguished fear in rats, Behav. Neurosci., 121, 131, 10.1037/0735-7044.121.1.131

Kim, 2008, The effect of temporary amygdala inactivation on extinction and reextinction of fear in the developing rat: unlearning as a potential mechanism for extinction early in development, J. Neurosci., 28, 1282, 10.1523/JNEUROSCI.4736-07.2008

Kim, 2010, New findings on extinction of conditioned fear early in development: theoretical and clinical implications, Biol. Psychiatry, 67, 297, 10.1016/j.biopsych.2009.09.003

Kim, 1992, Modality-specific retrograde amnesia of fear, Science, 256, 675, 10.1126/science.1585183

Kluver, 1937, Psychic blindness and other symotoms following bilateral temporal lobectomy in rhesus monkeys, Am. J. Physiol., 119, 352

Knapska, 2009, Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear, Learn. Mem., 16, 486, 10.1101/lm.1463909

Kogan, 1997, Spaced training induces normal long-term memory in CREB mutant mice, Curr. Biol., 7, 1, 10.1016/S0960-9822(06)00022-4

Konorski, 1967

Koo, 2004, Selective neurotoxic lesions of basolateral and central nuclei of the amygdala produce differential effects on fear conditioning, J. Neurosci., 24, 7654, 10.1523/JNEUROSCI.1644-04.2004

Korte, 1995, Hippocampal long-term potentiation is impaired in mice lacking brain derived neurotrophic factor, Proc. Natl. Acad. Sci. U.S.A., 92, 8856, 10.1073/pnas.92.19.8856

Korte, 1998, A role for BDNF in the late phase of hippocampal long-term potentiation, Neuropharmacology, 37, 553, 10.1016/S0028-3908(98)00035-5

Krettek, 1978, A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections, J. Comp. Neurol., 178, 255, 10.1002/cne.901780205

Kwapis, 2009, Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus, Behav. Neurosci., 123, 844, 10.1037/a0016343

Lang, 1997, Synaptic and synaptically activated intrinsic conductances underlie inhibitory potentials in cat lateral amygdaloid projection neurons in vivo, J. Neurophysiol., 77, 353, 10.1152/jn.1997.77.1.353

Lang, 1998, Synaptic responsiveness of interneurons of the cat lateral amygdaloid nucleus, Neuroscience, 83, 877, 10.1016/S0306-4522(97)00420-X

Langton, 2007, The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat, Learn. Mem., 14, 665, 10.1101/lm.692407

Langton, 2008, D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions, Neuropsychopharmacology, 33, 3096, 10.1038/npp.2008.32

Langton, 2010, The effect of D-cycloserine on immediate vs delayed extinction of learned fear, Learn. Mem., 17, 547, 10.1101/lm.1927310

Lanuza, 2008, Unconditioned stimulus pathways to the amygdala: effects of lesions of the posterior intralaminar thalamus on foot-shock-induced c-Fos expression in the subdivisions of the lateral amygdala, Neuroscience, 155, 959, 10.1016/j.neuroscience.2008.06.028

Lanuza, 2004, Unconditioned stimulus pathways to the amygdala: effects of posterior thalamic and cortical lesions on fear conditioning, Neuroscience, 125, 305, 10.1016/j.neuroscience.2003.12.034

Laurent, 2008, The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear, Learn. Mem., 15, 304, 10.1101/lm.928208

Lebron, 2004, Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex, Learn. Mem., 11, 544, 10.1101/lm.78604

Ledgerwood, 2003, Effects of D-cycloserine on extinction of conditioned freezing, Behav. Neurosci., 117, 341, 10.1037/0735-7044.117.2.341

Ledgerwood, 2004, D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement, Behav. Neurosci., 118, 505, 10.1037/0735-7044.118.3.505

Ledgerwood, 2005, D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction, Biol. Psychiatry, 57, 841, 10.1016/j.biopsych.2005.01.023

LeDoux, 1990, The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning, J. Neurosci., 10, 1062, 10.1523/JNEUROSCI.10-04-01062.1990

LeDoux, 1986, Disruption of auditory but not visual learning by destruction of intrinsic neurons in the rat medial geniculate body, Brain Res., 371, 395, 10.1016/0006-8993(86)90383-5

LeDoux, 1985, Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat, J. Comp. Neurol., 242, 182, 10.1002/cne.902420204

LeDoux, 1984, Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli, J. Neurosci., 4, 683, 10.1523/JNEUROSCI.04-03-00683.1984

Lee, 2008, Memory reconsolidation mediates the strengthening of memories by additional learning, Nat. Neurosci., 11, 1264, 10.1038/nn.2205

Lee, 2004, Independent cellular processes for hippocampal memory consolidation and reconsolidation, Science, 304, 839, 10.1126/science.1095760

Lee, 2006, Reconsolidation and extinction of conditioned fear: inhibition and potentiation, J. Neurosci., 26, 10051, 10.1523/JNEUROSCI.2466-06.2006

Lee, 1996, Lack of a temporal gradient of retrograde amnesia following NMDA-induced lesions of the basolateral amygdala assessed with the fear-potentiated startle paradigm, Behav. Neurosci., 110, 836, 10.1037/0735-7044.110.4.836

Lehmann, 2007, Complete or partial hippocampal damage produces equivalent retrograde amnesia for remote contextual fear memories, Eur. J. Neurosci., 25, 1278, 10.1111/j.1460-9568.2007.05374.x

Lessmann, 2003, Neurotrophin secretion: current facts and future prospects, Prog. Neurobiol., 69, 341, 10.1016/S0301-0082(03)00019-4

Li, 1996, GABAA and GABAB receptors differentially regulate synaptic transmission in the auditory thalamo-amygdala pathway: an in vivo microiontophoretic study and a model, Synapse, 24, 115, 10.1002/(SICI)1098-2396(199610)24:2<115::AID-SYN3>3.0.CO;2-I

Li, 2009, Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning, Proc. Natl. Acad. Sci. U.S.A., 106, 21918, 10.1073/pnas.0906941106

Likhtik, 2005, Prefrontal control of the amygdala, J. Neurosci., 25, 7429, 10.1523/JNEUROSCI.2314-05.2005

Likhtik, 2008, Amygdala intercalated neurons are required for expression of fear extinction, Nature, 454, 642, 10.1038/nature07167

Lin, 2003, Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory, Mol. Pharmacol., 63, 44, 10.1124/mol.63.1.44

Lin, 2003, Identification of calcineurin as a key signal in the extinction of fear memory, J. Neurosci., 23, 1574, 10.1523/JNEUROSCI.23-05-01574.2003

Lin, 2003, The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory, J. Neurosci., 23, 8310, 10.1523/JNEUROSCI.23-23-08310.2003

Lin, 2008, Chronic cannabinoid administration in vivo compromises extinction of fear memory, Learn. Mem., 15, 867, 10.1101/lm.1081908

Lin, 2009, Block of gamma-aminobutyric acid-A receptor insertion in the amygdala impairs extinction of conditioned fear, Biol. Psychiatry, 66, 665, 10.1016/j.biopsych.2009.04.003

Lin, 2009, The role of prefrontal cortex CB1 receptors in the modulation of fear memory, Cereb. Cortex, 19, 165, 10.1093/cercor/bhn075

Lin, 2010, Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory, Int. J. Neuropsychopharmacol., 13, 335, 10.1017/S1461145709990678

Ling, 2006, Protein kinase Mzeta enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors, Hippocampus, 16, 443, 10.1002/hipo.20171

Ling, 2002, Protein kinase Mzeta is necessary and sufficient for LTP maintenance, Nat. Neurosci., 5, 295, 10.1038/nn829

Linke, 2000, Differential projection of the posterior paralaminar thalamic nuclei to the amygdaloid complex in the rat, Exp. Brain Res., 134, 520, 10.1007/s002210000475

Lisman, 2002, The molecular basis of CaMKII function in synaptic and behavioural memory, Nat. Rev. Neurosci., 3, 175, 10.1038/nrn753

Liu, 2009, A NMDA receptor antagonist, MK-801 impairs consolidating extinction of auditory conditioned fear responses in a Pavlovian model, PLoS ONE, 4, e7548, 10.1371/journal.pone.0007548

Lu, 2001, Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear potentiated startle, J. Neurosci., 21, RC162, 10.1523/JNEUROSCI.21-16-j0005.2001

Luthi, 1997, Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation, J. Neurosci., 17, 4688, 10.1523/JNEUROSCI.17-12-04688.1997

MacLean, 1949, Psychosomatic disease and the visceral brain; recent developments bearing on the Papez theory of emotion, Psychosom. Med., 11, 338, 10.1097/00006842-194911000-00003

Mahanty, 1998, Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala, Nature, 394, 683, 10.1038/29312

Mahanty, 1999, Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala, Eur. J. Neurosci., 11, 1217, 10.1046/j.1460-9568.1999.00528.x

Makino, 2009, AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis, Neuron, 64, 381, 10.1016/j.neuron.2009.08.035

Malkani, 2004, An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning, Learn. Mem., 11, 617, 10.1101/lm.73104

Mamiya, 2009, Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory, J. Neurosci., 29, 402, 10.1523/JNEUROSCI.4639-08.2009

Maren, 1999, Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats, J. Neurosci., 19, 8696, 10.1523/JNEUROSCI.19-19-08696.1999

Maren, 1999, Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats, Behav. Neurosci., 113, 283, 10.1037/0735-7044.113.2.283

Maren, 2001, Neurobiology of Pavlovian fear conditioning, Annu. Rev. Neurosci., 24, 897, 10.1146/annurev.neuro.24.1.897

Maren, 2003, The amygdala, synaptic plasticity, and fear memory, Ann. N. Y. Acad. Sci., 985, 106, 10.1111/j.1749-6632.2003.tb07075.x

Maren, 2005, Synaptic mechanisms of associative memory in the amygdala, Neuron, 47, 783, 10.1016/j.neuron.2005.08.009

Maren, 2008, Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats, Eur. J. Neurosci., 28, 1661, 10.1111/j.1460-9568.2008.06485.x

Maren, 2011, Seeking a spotless mind: extinction, depotentiation, and erasure of fear memory, Neuron, 70, 83, 10.1016/j.neuron.2011.04.023

Maren, 1996, Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient, Behav. Neurosci., 110, 718, 10.1037/0735-7044.110.4.718

Maren, 1997, Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats, Behav. Brain Res., 88, 261, 10.1016/S0166-4328(97)00088-0

Maren, 1996, N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats, Behav. Neurosci., 110, 1365, 10.1037/0735-7044.110.6.1365

Maren, 2006, Recent fear is resistant to extinction, Proc. Natl. Acad. Sci. U.S.A., 103, 18020, 10.1073/pnas.0608398103

Maren, 1995, Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo, J. Neurosci., 15, 7548, 10.1523/JNEUROSCI.15-11-07548.1995

Maren, 2003, Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats, Eur. J. Neurosci., 18, 3080, 10.1111/j.1460-9568.2003.03063.x

Maren, 2007, Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala, Learn. Mem., 14, 318, 10.1101/lm.477007

Maren, 2004, Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus, Behav. Neurosci., 118, 97, 10.1037/0735-7044.118.1.97

Maren, 1991, Basolateral amygdaloid multi-unit neuronal correlates of discriminative avoidance learning in rabbits, Brain Res., 549, 311, 10.1016/0006-8993(91)90473-9

Maren, 2004, Neuronal signalling of fear memory, Nat. Rev. Neurosci., 5, 844, 10.1038/nrn1535

Maren, 1993, Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo, Proc. Natl. Acad. Sci. U.S.A., 90, 9654, 10.1073/pnas.90.20.9654

Marsicano, 1999, Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain, Eur. J. Neurosci., 11, 4213, 10.1046/j.1460-9568.1999.00847.x

Marsicano, 2002, The endogenous cannabinoid system controls extinction of aversive memories, Nature, 418, 530, 10.1038/nature00839

Matsuzaki, 2004, Structural basis of long-term potentiation in single dendritic spines, Nature, 429, 761, 10.1038/nature02617

Mayford, 1996, Control of memory formation through regulated expression of a CAMKII transgene, Science, 274, 1678, 10.1126/science.274.5293.1678

McDonald, 1982, Cytoarchitecture of the central amygdaloid nucleus of the rat, J. Comp. Neurol., 208, 401, 10.1002/cne.902080409

McDonald, 1982, Neurons of the lateral and basolateral amygdaloid nuclei: a Golgi study in the rat, J. Comp. Neurol., 212, 293, 10.1002/cne.902120307

McDonald, 1985, Immunohistochemical identification of gamma-aminobutyric acid-containing neurons in the rat basolateral amygdala, Neurosci. Lett., 53, 203, 10.1016/0304-3940(85)90186-7

McDonald, 1996, Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat, Neuroscience, 71, 55, 10.1016/0306-4522(95)00417-3

McKernan, 1997, Fear conditioning induces a lasting potentiation of synaptic currents in vitro, Nature, 390, 607, 10.1038/37605

McKinney, 2006, The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation but not extinction, of contextually conditioned fear in mice, Learn. Mem., 13, 584, 10.1101/lm.279006

McKinney, 2008, L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis, Learn. Mem., 15, 326, 10.1101/lm.893808

McNally, 2005, Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibor of enkephalin-degrading enzymes, Behav. Neurosci., 119, 1672, 10.1037/0735-7044.119.6.1672

McNally, 2006, Opiod receptors in the midbrain periaqueductal gray regulate prediction errors during Pavlovian fear conditioning, Behav. Neurosci., 120, 313, 10.1037/0735-7044.120.2.313

McNally, 2005, The midbrain periaqueductal gray and fear extinction: opiod receptor subtype and roles of cyclic AMP, protein kinase A, and mitogen-activated protein kinase, Behav. Neurosci., 119, 1023, 10.1037/0735-7044.119.4.1023

McNally, 2004, Opioid receptors in the midbrain periaqueductal gray regulate extinction of pavlovian fear conditioning, J. Neurosci., 24, 6912, 10.1523/JNEUROSCI.1828-04.2004

McNally, 2003, Opioid receptors regulate the extinction of Pavlovian fear conditioning, Behav. Neurosci., 117, 1292, 10.1037/0735-7044.117.6.1292

McNaughton, 1978, Synaptic enhancement in fascia dentata: cooperativity among coactive afferents, Brain Res., 157, 277, 10.1016/0006-8993(78)90030-6

McSweeney, 2002, Common processes may contribute to extinction and habituation, J. Gen. Psychol., 129, 364, 10.1080/00221300209602103

Meins, 2010, Impaired fear extinction in mice lacking protease nexin-1, Eur. J. Neurosci., 31, 2033, 10.1111/j.1460-9568.2010.07221.x

Merino, 2006, Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory, Eur. J. Neurosci., 23, 196, 10.1111/j.1460-9568.2005.04546.x

Messaoudi, 2007, Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo, J. Neurosci., 27, 10445, 10.1523/JNEUROSCI.2883-07.2007

Messaoudi, 2002, Brain derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo, J. Neurosci., 22, 7453, 10.1523/JNEUROSCI.22-17-07453.2002

Milad, 2002, Neurons in medial prefrontal cortex signal memory for fear extinction, Nature, 420, 70, 10.1038/nature01138

Milad, 2006, Fear extinction in rats: implications for human brain imaging and anxiety disorders, Biol. Psychol., 73, 61, 10.1016/j.biopsycho.2006.01.008

Milad, 2004, Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner, Behav. Neurosci., 118, 389, 10.1037/0735-7044.118.2.389

Miller, 1995, Assessment of the Rescorla-Wagner model, Psychol. Bull., 117, 363, 10.1037/0033-2909.117.3.363

Millhouse, 1986, The intercalated cells of the amygdala, J. Comp. Neurol., 247, 246, 10.1002/cne.902470209

Mineka, 2002, Phobias and preparedness: the selective, automatic, and encapsulated nature of fear, Biol. Psychiatry, 52, 927, 10.1016/S0006-3223(02)01669-4

Miserendino, 1990, Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala, Nature, 345, 716, 10.1038/345716a0

Miyashita, 2008, Networks of neurons, networks of genes: an integrated view of memory consolidation, Neurobiol. Learn. Mem., 89, 269, 10.1016/j.nlm.2007.08.012

Monfils, 2009, Extinction reconsolidation boundaries: key to persistent attenuation of fear memories, Science, 324, 951, 10.1126/science.1167975

Mueller, 2010, Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses, Biol. Psychiatry, 68, 1055, 10.1016/j.biopsych.2010.08.014

Mueller, 2008, Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction, J. Neurosci., 28, 369, 10.1523/JNEUROSCI.3248-07.2008

Muigg, 2008, Impaired extinction of learned fear in rats selectively bred for high anxiety – evidence of altered neuronal processing in prefrontal amygdala pathways, Eur. J. Neurosci., 28, 2299, 10.1111/j.1460-9568.2008.06511.x

Myers, 2007, Mechanisms of fear extinction, Mol. Psychiatry, 12, 120, 10.1038/sj.mp.4001939

Myers, 2006, Different mechanisms of fear extinction dependent on length of time since fear acquisition, Learn. Mem., 13, 216, 10.1101/lm.119806

Nader, 1999, The dopaminergic modulation of fear: quinpirole impairs the recall of emotional memories in rats, Behav. Neurosci., 113, 152, 10.1037/0735-7044.113.1.152

Nader, 2000, Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval, Nature, 406, 722, 10.1038/35021052

Nakazawa, 2006, NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity, EMBO J., 25, 2867, 10.1038/sj.emboj.7601156

Ohman, 2001, Fears, phobias, and preparedness: toward an evolved module of fear and fear learning, Psychol. Rev., 108, 483, 10.1037/0033-295X.108.3.483

Ohno, 2001, Inducible, pharmacogenetic approaches to the study of learning and memory, Nat. Neurosci., 4, 1238, 10.1038/nn771

Ohno, 2002, A pharmacogenetic inducible approach to the study of NMDA/alpha CaMKII signaling in synaptic plasticity, Curr. Biol., 12, 654, 10.1016/S0960-9822(02)00767-4

Orsini, 2011, Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction, J. Neurosci., 23, 17269, 10.1523/JNEUROSCI.4095-11.2011

Osten, 1996, Protein synthesis-dependent formation of protein kinase Mzeta in long-term potentiation, J. Neurosci., 16, 2444, 10.1523/JNEUROSCI.16-08-02444.1996

Ou, 2006, Regulation of amygdala-dependent learning by brain derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol-3-kinase, Neuropsychopharmacology, 31, 287, 10.1038/sj.npp.1300830

Ou, 2007, Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory, Mol. Pharmacol., 72, 350, 10.1124/mol.107.034934

Pamplona, 2006, The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats, Psychopharmacology (Berl), 188, 641, 10.1007/s00213-006-0514-0

Pape, 2010, Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear, Physiol. Rev., 90, 419, 10.1152/physrev.00037.2009

Papez, 1937, A proposed mechanism of emotion, Arch. Neurol. Psychiatry, 38, 725, 10.1001/archneurpsyc.1937.02260220069003

Pare, 1993, The intercalated cell masses project to the central and medial nuclei of the amygdala in cats, Neuroscience, 57, 1077, 10.1016/0306-4522(93)90050-P

Pare, 1998, Intrinsic circuitry of the amygdaloid complex: common principles of organization in rats and cats, Trends Neurosci., 21, 240, 10.1016/S0166-2236(98)01240-5

Parsons, 2011, Temporary disruption of fear-potentiated startle following PKMzeta inhibition in the amygdala, Nat. Neurosci., 14, 295, 10.1038/nn.2745

Parsons, 2006, Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons, J. Neurosci., 26, 12977, 10.1523/JNEUROSCI.4209-06.2006

Paul, 2007, The striatal enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala, Biol. Psychiatry, 61, 1049, 10.1016/j.biopsych.2006.08.005

Pavlov, 1927

Pearce, 1980, A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli, Psychol. Rev., 87, 532, 10.1037/0033-295X.87.6.532

Pedreira, 2003, Protein synthesis subserves reconsolidation or extinction depending on reminder duration, Neuron, 38, 863, 10.1016/S0896-6273(03)00352-0

Peters, 2010, Induction of fear extinction with hippocampal-infralimbic BDNF, Science, 328, 1288, 10.1126/science.1186909

Phelps, 2005, Contributions of the amygdala to emotion processing: from animal models to human behavior, Neuron, 48, 175, 10.1016/j.neuron.2005.09.025

Phillips, 1992, Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning, Behav. Neurosci., 106, 274, 10.1037/0735-7044.106.2.274

Pitkanen, 2000, Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review, Ann. N. Y. Acad. Sci., 911, 369, 10.1111/j.1749-6632.2000.tb06738.x

Pitkanen, 1997, Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala, Trends Neurosci., 20, 517, 10.1016/S0166-2236(97)01125-9

Plath, 2006, Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories, Neuron, 52, 437, 10.1016/j.neuron.2006.08.024

Ploski, 2010, Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala, J. Neurochem., 112, 636, 10.1111/j.1471-4159.2009.06491.x

Ploski, 2008, The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala, J. Neurosci., 28, 12383, 10.1523/JNEUROSCI.1662-08.2008

Ponnusamy, 2005, Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice, Learn. Mem., 12, 399, 10.1101/lm.96605

Ponnusamy, 2007, Amygdala-dependent and amygdala-independent pathways for contextual fear conditioning, Neuroscience, 147, 919, 10.1016/j.neuroscience.2007.04.026

Poulos, 2009, Persistance of fear memory across time requires the basolateral amygdala complex, Proc. Natl. Acad. Sci. U.S.A., 106, 11737, 10.1073/pnas.0905257106

Poulos, 2010, Compensation in the neural circuitry of fear conditioning awakens learning circuits in the bed nuclei of the stria terminalis, Proc. Natl. Acad. Sci. U.S.A., 107, 14881, 10.1073/pnas.1005754107

Quirk, 2002, Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery, Learn. Mem., 9, 402, 10.1101/lm.49602

Quirk, 1997, Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala, Neuron, 19, 613, 10.1016/S0896-6273(00)80375-X

Quirk, 2003, Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons, J. Neurosci., 23, 8800, 10.1523/JNEUROSCI.23-25-08800.2003

Quirk, 2008, Neural mechanisms of extinction learning and retrieval, Neuropsychopharmacology, 33, 56, 10.1038/sj.npp.1301555

Quirk, 1995, Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat, Neuron, 15, 1029, 10.1016/0896-6273(95)90092-6

Quirk, 2000, The role of ventromedial prefrontal cortex in the recovery of extinguished fear, J. Neurosci., 20, 6225, 10.1523/JNEUROSCI.20-16-06225.2000

Racine, 1983, Long-term potentiation phenomena in the rat limbic forebrain, Brain Res., 260, 217, 10.1016/0006-8993(83)90676-5

Radley, 2007, Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines, Brain Res., 1134, 87, 10.1016/j.brainres.2006.11.045

Radulovic, 1998, Relationship between fos production and classical fear conditioning: effects of novelty, latent inhibition, and unconditioned stimulus preexposure, J. Neurosci., 18, 7452, 10.1523/JNEUROSCI.18-18-07452.1998

Radwanska, 2002, Differential response of two subdivisions of lateral amygdala to aversive conditioning as revealed by c-Fos and P-ERK mapping, Neuroreport, 13, 2241, 10.1097/00001756-200212030-00015

Rasmusson, 1997, Animal models of relevance to PTSD, Ann. N. Y. Acad. Sci., 821, 332, 10.1111/j.1749-6632.1997.tb48290.x

Rattiner, 2004, Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning, J. Neurosci., 24, 4796, 10.1523/JNEUROSCI.5654-03.2004

Raught, 2001, The target of rapamycin (TOR) proteins, Proc. Natl. Acad. Sci. U.S.A., 98, 7037, 10.1073/pnas.121145898

Repa, 2001, Two different lateral amygdala cell populations contribute to the initiation and storage of memory, Nat. Neurosci., 4, 724, 10.1038/89512

Rescorla, 1988, Pavlovian conditioning. It's not what you think it is, Am. Psychol., 43, 151, 10.1037/0003-066X.43.3.151

Rescorla, 2004, Spontaneous recovery, Learn. Mem., 11, 501, 10.1101/lm.77504

Rescorla, 1975, Reinstatement of fear to an extinguished conditioned stimulus, J. Exp. Psychol. Anim. Behav. Process., 1, 88, 10.1037/0097-7403.1.1.88

Rescorla, 1972, A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement, 64

Ressler, 2002, Regulation of synaptic plasticity genes during consolidation of fear conditioning, J. Neurosci., 22, 7892, 10.1523/JNEUROSCI.22-18-07892.2002

Ressler, 2004, Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear, Arch. Gen. Psychiatry, 61, 1136, 10.1001/archpsyc.61.11.1136

Richmond, 1999, Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning, Behav. Neurosci., 113, 1189, 10.1037/0735-7044.113.6.1189

Robinson, 1963, Effect of amygdalectomy on fear-motivated behavior in rats, J. Comp. Physiol. Psychol., 56, 814, 10.1037/h0045711

Roche, 2007, The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats, Eur. J. Neurosci., 26, 2643, 10.1111/j.1460-9568.2007.05861.x

Rodrigues, 2004, Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin dependent protein kinase II at lateral amygdala synapses, J. Neurosci., 24, 3281, 10.1523/JNEUROSCI.5303-03.2004

Rodrigues, 2001, Intra-amygdala blockade of the NR2 B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning, J. Neurosci., 21, 6889, 10.1523/JNEUROSCI.21-17-06889.2001

Rodriguez, 2005, Long- term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia, Eur. J. Neurosci., 21, 2384, 10.1111/j.1460-9568.2005.04068.x

Rogan, 2005, Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse, Neuron, 46, 309, 10.1016/j.neuron.2005.02.017

Rogan, 1997, AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired, J. Neurosci., 17, 5928, 10.1523/JNEUROSCI.17-15-05928.1997

Rogan, 1997, Fear conditioning induces associative long-term potentiation in the amygdala, Nature, 390, 604, 10.1038/37601

Romanski, 1993, Somatosensory and auditory convergence in the lateral nucleus of the amygdala, Behav. Neurosci., 107, 444, 10.1037/0735-7044.107.3.444

Romanski, 1992, Equipotentiality of thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning, J. Neurosci., 12, 4501, 10.1523/JNEUROSCI.12-11-04501.1992

Rosas, 1998, Context change and retention interval can have additive, rather than interactive, effects after taste aversion extinction, Psychon. Bull. Rev., 5, 79, 10.3758/BF03209459

Rosenkranz, 2001, Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats, J. Neurosci., 21, 4090, 10.1523/JNEUROSCI.21-11-04090.2001

Rosenkranz, 2003, The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli, J. Neurosci., 23, 11054, 10.1523/JNEUROSCI.23-35-11054.2003

Royer, 1999, An inhibitory interface gates impulse traffic between the input and output stations of the amygdala, J. Neurosci., 19, 10575, 10.1523/JNEUROSCI.19-23-10575.1999

Royer, 2000, Bistable behavior of inhibitory neurons controlling impulse traffic through the amygdala: role of a slowly deinactivating K+ current, J. Neurosci., 20, 9034, 10.1523/JNEUROSCI.20-24-09034.2000

Royer, 2002, Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses, Neuroscience, 115, 455, 10.1016/S0306-4522(02)00455-4

Rudy, 2002, Hippocampal formation supports conditioning to memory of a context, Behav. Neurosci., 116, 530, 10.1037/0735-7044.116.4.530

Rudy, 1999, Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus, Behav. Neurosci., 113, 867, 10.1037/0735-7044.113.5.867

Rumpel, 2005, Postsynaptic receptor trafficking underlying a form of associative learning, Science, 308, 83, 10.1126/science.1103944

Sacktor, 1993, Persistent activation of the zeta isoform of protein kinase C in the maintenance of long- term potentiation, Proc. Natl. Acad. Sci. U.S.A., 90, 8342, 10.1073/pnas.90.18.8342

Sacktor, 2008, PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage, Prog. Brain Res., 169, 27, 10.1016/S0079-6123(07)00002-7

Sah, 2003, The amygdaloid complex: anatomy and physiology, Physiol. Rev., 83, 803, 10.1152/physrev.00002.2003

Samson, 2005, Activity-dependent synaptic plasticity in the central nucleus of the amygdala, J. Neurosci., 25, 1847, 10.1523/JNEUROSCI.3713-04.2005

Santini, 2004, Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex, J. Neurosci., 24, 5704, 10.1523/JNEUROSCI.0786-04.2004

Santini, 2001, Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory, J. Neurosci., 21, 9009, 10.1523/JNEUROSCI.21-22-09009.2001

Santini, 2008, Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons, J. Neurosci., 28, 4028, 10.1523/JNEUROSCI.2623-07.2008

Sara, 2000, Strengthening the shaky trace through retrieval, Nat. Rev. Neurosci., 1, 212, 10.1038/35044575

Schafe, 2000, Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning, J. Neurosci., 20, 8177, 10.1523/JNEUROSCI.20-21-08177.2000

Schafe, 2005, Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage, J. Neurosci., 25, 10010, 10.1523/JNEUROSCI.3307-05.2005

Schafe, 2000, Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala, J. Neurosci., 20, RC96, 10.1523/JNEUROSCI.20-18-j0003.2000

Schafe, 1999, Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase, Learn. Mem., 6, 97, 10.1101/lm.6.2.97

Schafe, 2001, Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective, Trends Neurosci., 24, 540, 10.1016/S0166-2236(00)01969-X

Schafe, 2008, Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo, Learn. Mem., 15, 55, 10.1101/lm.746808

Schinder, 2000, The neurotrophin hypothesis for synaptic plasticity, Trends Neurosci., 23, 639, 10.1016/S0166-2236(00)01672-6

Scoville, 1957, Loss of recent memory after bilateral hippocampal lesions, J. Neurol. Neurosurg. Psychiatry, 20, 11, 10.1136/jnnp.20.1.11

Selcher, 2001, Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning, Learn. Mem., 8, 11, 10.1101/lm.37001

Selden, 1991, Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues, Neuroscience, 42, 335, 10.1016/0306-4522(91)90379-3

Serrano, 2008, PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories, PLoS Biol., 6, 2698, 10.1371/journal.pbio.0060318

Serrano, 2005, Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation, J. Neurosci., 25, 1979, 10.1523/JNEUROSCI.5132-04.2005

Shi, 1999, Pain pathways involved in fear conditioning measured with fear-potentiated startle: lesion studies, J. Neurosci., 19, 420, 10.1523/JNEUROSCI.19-01-00420.1999

Shi, 1998, Cascade projections from somatosensory cortex to the rat basolateral amygdala via the parietal insular cortex, J. Comp. Neurol., 399, 469, 10.1002/(SICI)1096-9861(19981005)399:4<469::AID-CNE3>3.0.CO;2-#

Sierra-Mercado, 2006, Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction, Eur. J. Neurosci., 24, 1751, 10.1111/j.1460-9568.2006.05014.x

Sierra-Mercado, 2010, Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear, Neuropsychopharmacology, 36, 529, 10.1038/npp.2010.184

Sledjeski, 2008, Does number of lifetime traumas explain the relationship between PTSD and chronic medical conditions? Answers from the National Comorbidity Survey-Replication (NCS-R), J. Behav. Med., 31, 341, 10.1007/s10865-008-9158-3

Slipczuk, 2009, BDNF activates mTOR to regulate GluR1 expression required for memory formation, PLoS ONE, 4, e6007, 10.1371/journal.pone.0006007

Silva, 1992, Deficient hippocampal long- term potentiation in alpha-calcium-calmodulin kinase II mutant mice, Science, 257, 201, 10.1126/science.1378648

Soliman, 2010, A genetic variant BDNF polymorphism alters extinction learning in both mouse and human, Science, 327, 863, 10.1126/science.1181886

Sotres-Bayon, 2007, Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala, Neuropsychopharmacology, 32, 1929, 10.1038/sj.npp.1301316

Sotres-Bayon, 2009, Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution, Cereb. Cortex, 19, 474, 10.1093/cercor/bhn099

Sparks, 2011, Between-systems memory interference during retrieval, Eur. J. Neurosci., 34, 780, 10.1111/j.1460-9568.2011.07796.x

Stanciu, 2001, Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production, Brain Res. Mol. Brain Res., 94, 15, 10.1016/S0169-328X(01)00174-7

Stork, 2002, Reduction of extracellular GABA in the mouse amygdala during and following confrontation with a conditioned fear stimulus, Neurosci. Lett., 327, 138, 10.1016/S0304-3940(02)00387-7

Storsve, 2010, US habituation, like CS extinction, produces a decrement in conditioned fear responding that is NMDA dependent and subject to renewal and reinstatement, Neurobiol. Learn. Mem., 93, 463, 10.1016/j.nlm.2009.12.011

Sutherland, 2011, Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents, Curr. Opin. Neurobiol., 21, 446, 10.1016/j.conb.2011.04.007

Sutherland, 2008, Absence of systems consolidation of fear memories after dorsal, ventral, or complete hippocampal damage, Hippocampus, 18, 710, 10.1002/hipo.20431

Sutherland, 2010, Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation, Neuropsychologia, 48, 2357, 10.1016/j.neuropsychologia.2010.04.015

Suzuki, 2004, Memory reconsolidation and extinction have distinct temporal and biochemical signatures, J. Neurosci., 24, 4787, 10.1523/JNEUROSCI.5491-03.2004

Swanson, 1981, A direct projection from Ammon's horn to prefrontal cortex in the rat, Brain Res., 27, 150, 10.1016/0006-8993(81)90192-X

Swanson, 1998, What is the amygdala?, Trends Neurosci., 21, 323, 10.1016/S0166-2236(98)01265-X

Szapiro, 2003, The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear, Hippocampus, 13, 53, 10.1002/hipo.10043

Szinyei, 2000, Putative cortical and thalamic inputs elicit convergent excitation in a population of GABAergic interneurons of the lateral amygdala, J. Neurosci., 20, 8909, 10.1523/JNEUROSCI.20-23-08909.2000

Szinyei, 2007, Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice, Eur. J. Neurosci., 25, 1205, 10.1111/j.1460-9568.2007.05349.x

Szinyei, 2003, Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons, J. Neurosci., 23, 2549, 10.1523/JNEUROSCI.23-07-02549.2003

Takei, 2004, Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites, J. Neurosci., 24, 9760, 10.1523/JNEUROSCI.1427-04.2004

Tang, 2002, A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus, Proc. Natl. Acad. Sci. U.S.A., 99, 467, 10.1073/pnas.012605299

Tang, 1999, Genetic enhancement of learning and memory in mice, Nature, 401, 63, 10.1038/43432

Taubenfeld, 2001, The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta, Nat. Neurosci., 4, 813, 10.1038/90520

Thomas, 2004, MAPK cascade signalling and synaptic plasticity, Nat. Rev. Neurosci., 5, 173, 10.1038/nrn1346

Tocco, 1992, Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus, Brain Res., 573, 228, 10.1016/0006-8993(92)90767-4

Trivedi, 2004, Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze, Neurobiol. Learn. Mem., 81, 172, 10.1016/j.nlm.2004.02.005

Tronel, 2005, Linking new information to a reactivated memory requires consolidation and not reconsolidation mechanisms, PLoS Biol., 3, e293, 10.1371/journal.pbio.0030293

Tronson, 2007, Molecular mechanisms of memory reconsolidation, Nat. Rev. Neurosci., 8, 262, 10.1038/nrn2090

Tronson, 2006, Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A, Nat. Neurosci., 9, 167, 10.1038/nn1628

Tsvetkov, 2002, Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala, Neuron, 34, 289, 10.1016/S0896-6273(02)00645-1

Turner, 1991, Thalamoamygdaloid projections in the rat: a test of the amygdala's role in sensory processing, J. Comp. Neurol., 313, 295, 10.1002/cne.903130208

Tye, 2011, Amygdala circuitry mediating reversible and bidirectional control of anxiety, Nature, 17, 358, 10.1038/nature09820

Tyler, 2003, Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones, J. Physiol., 553, 497, 10.1113/jphysiol.2003.052639

Van Eden, 1985, Cytoarchitectonic development of the prefrontal cortex in the rat, J. Comp. Neurol., 241, 253, 10.1002/cne.902410302

Van Eden, 1985, Postnatal volumetric development of the prefrontal cortex in the rat, J. Comp. Neurol., 241, 268, 10.1002/cne.902410303

Vertes, 2004, Differential projections of the infralimbic and prelimbic cortex in the rat, Synapse, 51, 32, 10.1002/syn.10279

Vianna, 2001, Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus, Proc. Natl. Acad. Sci. U.S.A., 98, 12251, 10.1073/pnas.211433298

Vidal-Gonzalez, 2006, Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear, Learn. Mem., 13, 728, 10.1101/lm.306106

Walker, 2002, The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction, Pharmacol. Biochem. Behav., 71, 379, 10.1016/S0091-3057(01)00698-0

Walker, 2008, Amygdala infusions of an NR2B-selective or an NR2A-prefering NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test, Learn Mem., 15, 67, 10.1101/lm.798908

Walker, 2002, Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D cycloserine as assessed with fear-potentiated startle in rats, J. Neurosci., 22, 2343, 10.1523/JNEUROSCI.22-06-02343.2002

Wallace, 2004, Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety, Biol. Psychiatry, 56, 151, 10.1016/j.biopsych.2004.04.010

Waltereit, 2008, Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response, Learn. Mem., 15, 348, 10.1101/lm.808608

Wang, 2008, Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions, Cell. Mol. Life Sci., 65, 237, 10.1007/s00018-007-7288-3

Weeber, 2000, A role for the beta isoform of protein kinase C in fear conditioning, J. Neurosci., 20, 5906, 10.1523/JNEUROSCI.20-16-05906.2000

Weiskrantz, 1956, Behavioral changes associated with ablation of the amygdaloid complex in monkeys, J. Comp. Physiol. Psychol., 49, 381, 10.1037/h0088009

Weisskopf, 1999, L-type voltage-gated calcium channels mediate NMDA-independent associative long-term potentiation at thalamic input synapses to the amygdala, J. Neurosci., 19, 10512, 10.1523/JNEUROSCI.19-23-10512.1999

Wilensky, 2006, Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning, J. Neurosci., 26, 12387, 10.1523/JNEUROSCI.4316-06.2006

Williams, 2001, Cellular and synaptic adaptations mediating opiod dependence, Physiol. Rev., 81, 299, 10.1152/physrev.2001.81.1.299

Willick, 1995, Cocaine enhances the expression of fear potentiated startle: evaluation of state-dependent extinction and the shock sensitization of acoustic startle, Behav. Neurosci., 109, 929, 10.1037/0735-7044.109.5.929

Wilson, 1995, The role of the rat hippocampal system in several effects of context in extinction, Behav. Neurosci., 109, 828, 10.1037/0735-7044.109.5.828

Wilson, 1984, A comparison of the postnatal development of post-activation potentiation in the neocortex and dentate gyrus of the rat, Brain Res., 318, 61, 10.1016/0165-3806(84)90063-4

Wilson, 2009, A discrete population of neurons in the lateral amygdala is specifically activated by contextual fear conditioning, Learn. Mem., 16, 357, 10.1101/lm.1361509

Wiltgen, 2006, Context fear learning in the absence of the hippocampus, J. Neurosci., 17, 5484, 10.1523/JNEUROSCI.2685-05.2006

Wiltgen, 2009, The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala, Front. Behav. Neurosci., 3, 1, 10.3389/neuro.08.037.2009

Woods, 2006, D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response, Behav. Neurosci., 120, 1159, 10.1037/0735-7044.120.5.1159

Wu, 2001, Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology, Nat. Neurosci., 4, 151, 10.1038/83976

Xu, 2004, Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects, Neuron, 43, 487, 10.1016/j.neuron.2004.08.005

Xu, 2007, Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain, J. Comp. Neurol., 500, 84, 10.1002/cne.21159

Yamada, 2009, Pharmacological discrimination of extinction and reconsolidation of contextual fear memory by a potentiator of AMPA receptors, Neuropsychopharmacology, 34, 2574, 10.1038/npp.2009.86

Yang, 2005, Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3 kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala, Neuroscience, 134, 247, 10.1016/j.neuroscience.2005.04.003

Zelikowsky, 2011, Temporal factors control hippocampal contributions to fear renewal after extinction, Hippocampus

Zhang, 2001, The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus, Behav. Brain Res., 126, 159, 10.1016/S0166-4328(01)00256-X

Zhou, 2009, CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala, Nat. Neurosci., 12, 1438, 10.1038/nn.2405

Zhu, 2002, Ras and Rap control AMPA receptor trafficking during synaptic plasticity, Cell, 110, 443, 10.1016/S0092-8674(02)00897-8

Zimmerman, 2007, The central nucleus of the amygdala is essential for acquiring and expressing conditioned fear after overtraining, Learn. Mem., 14, 634, 10.1101/lm.607207

Zimmerman, 2010, NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats, Eur. J. Neurosci., 31, 1664, 10.1111/j.1460-9568.2010.07223.x