Efficacy and safety of moguisteine in comparison with levodropropizine in patients with cough associated with chronic obstructive pulmonary disease, lung cancer, or pulmonary fibrosis

Current Therapeutic Research - Tập 55 - Trang 251-261 - 1994
G. Fasciolo1, A. Nicolini2, N. Vacca3, P. Viglierchio3
1Pneumology Centre, USL XII, Genoa, Italy
2Department of Pneumology, Chiavari Hospital, Chiavari (GE), Italy
3Department of General Medicine, S. Paolo Hospital, Savona, Italy

Tài liệu tham khảo

Leith, 1977, 545 Pavia, 1987, Cough and mucociliary clearance, Clin Respir Physiol, 23, 41 Del Donno, 1991, Mucociliary clearance in humans as physiologic lung defense mechanism, 247 Irwin, 1991, The treatment of cough: A comprehensive review, Chest, 99, 1477, 10.1378/chest.99.6.1477 Hughes, 1978, Cough suppressants, expectorants, and mucolytic agents, BMJ, 1, 1202, 10.1136/bmj.1.6121.1202 Eddy, 1969, Codeine and its alternatives for pain and cough relief, Bull WHO, 40, 425 Banner, 1986, Cough: Physiology, evaluation and treatment, Lung, 164, 79, 10.1007/BF02713631 Gallico, 1988, BBR 2173, a new nonnarcotic antitussive agent, Pharmacol Res Commun, 20, 171, 10.1016/S0031-6989(88)80301-1 Gallico, 1990, Moguisteine: A new drug effective in experimental cough and hyperreactivity, Am Rev Respir Dis, 141, A654 Sestini, 1990, Protective effect of the new antitussive drug moguisteine on citric acid-induced cough, Eur Respir J, 3, 160s Moscato, 1990, Preliminary clinical experience with moguisteine in acetylcholine induced cough, Eur Respir J, 3, 93s Morrone, 1993, Pilot study on efficacy and safety of a new antitussive drug, moguisteine: A double-blind placebo-controlled trial, Adv Ther, 10, 67 Aversa C, Cazzola M, Clini V, et al. A double-blind, placebo-controlled, parallel group clinical trial on efficacy and safety of moguisteine in patients with cough associated to chronic respiratory diseases. Drugs Exp Clin Res (in press). Gallico, 1992, Effect of dexamethasone and moguisteine on allergen-induced early broncho-constriction and late phase airway leucocyte recruitment in sensitized guinea-pigs, Br J Pharmacol, 106, 75P Allegra, 1988, Clinical trials with the new antitussive levodropropizine in adult bronchitic patients, Arzneim-Forsch Drug Res, 38, 1163