Association between cognitive function and supplementation with omega-3 PUFAs and other nutrients in ≥ 75 years old patients: A randomized multicenter study

WHO | Dementia. WHO. World Health Organization; 2016

I Lourida, 2013, Mediterranean Diet Cognitive Function and Dementia, Epidemiology, 24, 479, 10.1097/EDE.0b013e3182944410

M Otsuka, 2000, Analysis of dietary factors in Alzheimer’s disease: clinical use of nutritional intervention for prevention and treatment of dementia, Nihon Ronen Igakkai Zasshi, 37, 970, 10.3143/geriatrics.37.970

MC Morris, 2017, Nutrition and risk of dementia:overview and methodological issues, Ann N Y Acad Sci, 1367, 31, 10.1111/nyas.13047

JE Morley, 2010, Nutrition and the brain, Clin Geriatr Med, 26, 89, 10.1016/j.cger.2009.11.005

S Larrieu, 2004, Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort, J Nutr Health Aging, 8, 150

BR Cardoso, 2013, Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease, Clin Interv Aging, 8, 531, 10.2147/CIA.S27983

A Oulhaj, 2016, Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment, J Alzheimers Dis, 50, 547, 10.3233/JAD-150777

V Vakhapova, 2010, Phosphatidylserine Containing ω–3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled Trial, Dement Geriatr Cogn Disord, 29, 467, 10.1159/000310330

MA Phillips, 2012, Lower omega-3 fatty acid intake and status are associated with poorer cognitive function in older age: A comparison of individuals with and without cognitive impairment and Alzheimer’s disease, Nutr Neurosci, 15, 271, 10.1179/1476830512Y.0000000026

M Weiser, 2016, Docosahexaenoic Acid and Cognition throughout the Lifespan, Nutrients, 8, 99, 10.3390/nu8020099

N Hu, 2013, Nutrition and the risk of Alzheimer’s disease, Biomed Res Int, 2013, 524820

M Hashiguchi, 2015, Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia, J Pharm Health Care Sci, 1, 14, 10.1186/s40780-015-0014-7

C Samieri, 2008, Dietary Patterns Derived by Hybrid Clustering Method in Older People: Association with Cognition Mood and Self-Rated Health, J Am Diet Assoc, 108, 1461, 10.1016/j.jada.2008.06.437

P Barberger-Gateau, 2014, Nutrition and brain aging: how can we move ahead?, Eur J Clin Nutr, 68, 1245, 10.1038/ejcn.2014.177

LM Donini, 2007, Nutritional status determinants and cognition in the elderly, Arch Gerontol Geriatr, 44, 143, 10.1016/j.archger.2007.01.022

V Vakhapova, 2014, Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study, Dement Geriatr Cogn Disord, 38, 39, 10.1159/000357793

S Bun, 2015, Combination of Supplements May Reduce the Risk of Alzheimer’s Disease in Elderly Japanese with Normal Cognition, J Alzheimers Dis, 45, 15, 10.3233/JAD-142232

SC Strike, 2016, A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized Double-blind Placebo-controlled Pilot Study, J Gerontol A Biol Sci Med Sci, 71, 236, 10.1093/gerona/glv109

M Rondanelli, 2012, Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment, Nutr Neurosci, 15, 46, 10.1179/1476830511Y.0000000032

DL Waitzberg, 2014, Contribución de los Ácidos Grasos Omega-3 para la Memoria y la Función Cognitiva, Nutr Hosp, 30, 467

H Yanai, 2017, Effects of N-3 Polyunsaturated Fatty Acids on Dementia, J Clin Med Res, 9, 1, 10.14740/jocmr2815w

XW Zhang, 2016, Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials, Aging Clin Exp Res, 28, 165, 10.1007/s40520-015-0381-9

Y Zhang, 2016, Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies, Am J Clin Nutr, 103, 330, 10.3945/ajcn.115.124081

AR Abubakari, 2014, Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial?, Int J Gen Med, 7, 463

K Yurko-Mauro, 2015, Docosahexaenoic acid and adult memory: a systematic review and meta-analysis, PLoS One, 10, e0120391, 10.1371/journal.pone.0120391

M Burckhardt, 2016, Omega-3 fatty acids for the treatment of dementia, Cochrane Database Syst Rev, 4, CD009002

E Sydenham, 2012, Omega 3 fatty acid for the prevention of cognitive decline and dementia, Cochrane Database Syst Rev, 6, CD005379

J Jiao, 2014, Effect of n-3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials, Am J Clin Nutr, 100, 1422, 10.3945/ajcn.114.095315

B Reisberg, 1982, The Global Deterioration Scale for assessment of primary degenerative dementia, Am J Psychiatry, 139, 1136, 10.1176/ajp.139.9.1136

B Reisberg, 1988, Global Deterioration Scale (GDS), Psychopharmacol Bull, 24, 661

MF Folstein, 1975, “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, 12, 189

J Olazarán-Rodríguez, 2015, No hay razones científicas para jubilar al MMSE, Neurología, 30, 589, 10.1016/j.nrl.2014.03.011

A Lobo, 1999, Revalidation and standardization of the cognition mini-exam (first Spanish version of the Mini-Mental Status Examination) in the general geriatric population, Med Clin, 112, 767

E Pfeiffer, 1975, A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients, J Am Geriatr Soc, 23, 433, 10.1111/j.1532-5415.1975.tb00927.x

W.G Rosen, 1980, Verbal fluency in aging and dementia, J Clin Neuropsychol, 2, 135, 10.1080/01688638008403788

KI Shulman, 2000, Clock-drawing: is it the ideal cognitive screening test?, Int J Geriatr Psychiatry, 15, 548, 10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U

Y Guigoz, 1994, Mini Nutritional Assessement: a practical tool for grading the nutritional state of elderly patients, Facts Res Gerontol, 2, 15

M Bes-Rastrollo, 2007, Cálculo del tamaño muestral, JANO, 1653, 51

D Moher, 2001, The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomised trials, Lancet, 357, 1191, 10.1016/S0140-6736(00)04337-3

A Cobos-Carbó, 2011, CONSORT 2010 Declaration: Updated guideline for reporting parallel group randomised trials, Med Clin, 137, 213

LM Jaremka, 2014, Omega-3 supplementation and loneliness-related memory problems: secondary analyses of a randomized controlled trial, Psychosom Med, 76, 650, 10.1097/PSY.0000000000000104

K Yurko-Mauro, 2010, Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline, Alzheimers Dement, 6, 456, 10.1016/j.jalz.2010.01.013

LK Lee, 2012, Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised double-blind placebo-controlled trial, Psychopharmacology, 225, 605, 10.1007/s00213-012-2848-0

EL Boespflug, 2016, Fish oil supplementation increases event-related posterior cingulate activation in older adults with subjective memory impairment, J Nutr Health Aging, 20, 161, 10.1007/s12603-015-0609-6

A Nilsson, 2012, Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study, Nutr J, 11, 99, 10.1186/1475-2891-11-99

S Kotani, 2006, Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction, Neurosci Res, 56, 159, 10.1016/j.neures.2006.06.010

AD Dangour, 2010, Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized double-blind controlled trial, Am J Clin Nutr, 91, 1725, 10.3945/ajcn.2009.29121

JM Geleijnse, 2012, Effects of n-3 fatty acids on cognitive decline: A randomized double-blind placebo-controlled trial in stable myocardial infarction patients, Alzheimer’s Dement, 8, 278, 10.1016/j.jalz.2011.06.002

MA Phillips, 2015, No Effect of Omega-3 Fatty Acid Supplementation on Cognition and Mood in Individuals with Cognitive Impairment and Probable Alzheimer’s Disease: A Randomised Controlled Trial, Int J Mol Sci, 16, 24600, 10.3390/ijms161024600

JF Quinn, 2010, Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease, JAMA, 304, 1903, 10.1001/jama.2010.1510

O van de Rest, 2008, Effect of fish oil on cognitive performance in older subjects: a randomized controlled trial, Neurology, 71, 430, 10.1212/01.wnl.0000324268.45138.86

PF Boston, 2004, Ethyl-EPA in Alzheimer’s disease—a pilot study, Prostaglandins Leukot Essent Fat Acids, 7, 341, 10.1016/j.plefa.2004.07.001

Y Freund-Levi, 2006, Omega-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: a randomized double-blind trial, Arch Neurol, 63, 1402, 10.1001/archneur.63.10.1402

CC Chiu, 2008, The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study, Prog Neuro-Psychopharmacology Biol Psychiatry, 32, 1538, 10.1016/j.pnpbp.2008.05.015

G Mazereeuw, 2012, Effects of omega-3 fatty acids on cognitive performance: a meta-analysis, Neurobiol Aging, 33, 1482.e17, 10.1016/j.neurobiolaging.2011.12.014

N Sinn, 2012, Effects of n-3 fatty acids EPA v. DHA on depressive symptoms quality of life memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial, Br J Nutr, 107, 1682, 10.1017/S0007114511004788

EJ Johnson, 2008, Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women, Nutr Neurosci, 11, 75, 10.1179/147683008X301450

AV Witte, 2014, Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults, Cereb Cortex, 24, 3059, 10.1093/cercor/bht163

OE Titova, 2013, Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly, Age, 35, 1495, 10.1007/s11357-012-9453-3

LB Lopez, 2011, High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the Rancho Bernardo study, J Nutr Health Aging, 15, 25, 10.1007/s12603-011-0009-5

OH del Brutto, 2016, Oily Fish Intake and Cognitive Performance in Community-Dwelling Older Adults: The Atahualpa Project, J Community Health, 41, 82, 10.1007/s10900-015-0070-9

MSL Restrepo, 2006, Los hábitos alimentarios en el adulto mayor y su relación con los procesos protectores y deteriorantes en salud, Rev Chil Nutr, 33, 500

B Shatenstein, 2007, Poor Nutrient Intakes during 1-Year Follow-Up with Community-Dwelling Older Adults with Early-Stage Alzheimer Dementia Compared to Cognitively Intact Matched Controls, J Am Diet Assoc, 107, 2091, 10.1016/j.jada.2007.09.008

Y Gu, 2010, Food Combination and Alzheimer Disease Risk, Arch Neurol, 67, 699, 10.1001/archneurol.2010.84

J Baleztena, 2017, Is the omega-3 supplementation useful for the cognitive function after 65 years old? Results from a systematic review, An Sis Sanit Navar, 40, 433, 10.23938/ASSN.0046