The Emergence of Mpox: Epidemiology and Current Therapeutic Options
Tóm tắt
The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to controlling an epidemic include present knowledge of the disease, available treatment options, appropriate health infrastructures facilities, current scientific methods, operations concepts, availability of technical staff, financial funds, and lastly international policies to control an epidemic state. These insufficiencies often hinder the control of disease spread and jeopardize the health of countless people. Also, disease outbreaks often put a huge burden on the developing economies. These countries are the worst affected and are immensely dependent on assistance provided from the larger economies to control such outbreaks. The first case of mpox was reported in the 1970s and several outbreaks were detected thereafter in the endemic areas eventually leading to the recent outbreak. Approximately, more than 80,000 individuals were infected, and 110 countries were affected by this outbreak. Yet, no definite vaccines and drugs are available to date. The lack of human clinical trials affected thousands of individuals in availing definite disease management. This paper focuses on the epidemiology of mpox, scientific concepts, and treatment options including future treatment modalities for mpox.
Tài liệu tham khảo
Capobianchi MR, Di Caro A, Piubelli C, Mori A, Bisoffi Z, Castilletti C. Monkeypox 2022 outbreak in non-endemic countries: open questions relevant for public health, nonpharmacological intervention and literature review. Front Cell Infect Microbiol. 2022;12:1005955. https://doi.org/10.3389/fcimb.2022.1005955.
Forni D, Cagliani R, Molteni C, Clerici M, Sironi M. Monkeypox virus: the changing facets of a zoonotic pathogen. Infect Genet Evol. 2022;105:105372. https://doi.org/10.1016/j.meegid.2022.105372.
Mukherjee AG, Wanjari UR, Kannampuzha S, et al. The pathophysiological and immunological background of the monkeypox virus infection: an update. J Med Virol. 2023;95(1):e28206. https://doi.org/10.1002/jmv.28206.
Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox virus infection in humans across 16 countries - April-June 2022. N Engl J Med. 2022;387(8):679–91. https://doi.org/10.1056/NEJMoa2207323.
Risk assessment: Monkeypox multi-country Outbreak. European Centre for Disease Prevention and Control. 2022. https://www.ecdc.europa.eu/en/publications-data/risk-assessment-monkeypox-multi-country-outbreak. Accessed 11 Oct 2023.
Pan D, Nazareth J, Sze S, et al. Transmission of monkeypox/mpox virus: a narrative review of environmental, viral, host, and population factors in relation to the 2022 international outbreak. J Med Virol. 2023;95(2):e28534. https://doi.org/10.1002/jmv.28534.
Monkeypox: experts give virus variants new names. World Health Organization. 2022. https://www.who.int/news/item/12-08-2022-monkeypox--experts-give-virus-variants-new-names. Accessed 16 Mar 2023.
Factsheet for health professionals on mpox (monkeypox). European Centre for Disease Prevention and Control. 2022. https://www.ecdc.europa.eu/en/all-topics-z/monkeypox/factsheet-health-professionals. Accessed 16 Mar 2023.
Arita I, Gispen R, Kalter SS, et al. Outbreaks of monkeypox and serological surveys in nonhuman primates. Bull World Health Organ. 1972;46(5):625–31.
Sklenovská N, Van Ranst M. Emergence of monkeypox as the most important Orthopoxvirus infection in humans. Front Public Health. 2018;6:241.
Beer EM, Rao VB. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. Holbrook MR, ed. PLoS Negl Trop Dis. 2019;13(10):e0007791. https://doi.org/10.1371/journal.pntd.0007791.
Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox—a potential threat?. A systematic review Gromowski G, ed. PLoS Negl Trop Dis. 2022;16(2):e0010141. https://doi.org/10.1371/journal.pntd.0010141.
Di Giulio DB, Eckburg PB. Human monkeypox: an emerging zoonosis. Lancet Infect Dis. 2004;4(1):15–25. https://doi.org/10.1016/S1473-3099(03)00856-9.
Ligon BL. Monkeypox: a review of the history and emergence in the Western hemisphere. Semin Pediatr Infect Dis. 2004;15(4):280–7. https://doi.org/10.1053/j.spid.2004.09.001.
Centers for Disease Control and Prevention (CDC). Update: multistate outbreak of monkeypox--Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep. 2003;52(27):642–6.
Rapid risk assessment: Monkeypox cases in the UK imported by travellers returning from Nigeria, 2018. European Centre for Disease Prevention and Control. 2018. https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-monkeypox-cases-uk-imported-travellers-returning-nigeria. Accessed 11 Oct 2022.
Zumla A, Valdoleiros SR, Haider N, et al. Monkeypox outbreaks outside endemic regions: scientific and social priorities. Lancet Infect Dis. 2022;22(7):929–31. https://doi.org/10.1016/S1473-3099(22)00354-1.
Shafaati M, Zandi M. State-of-the-art on monkeypox virus: an emerging zoonotic disease. Infection. 2022. https://doi.org/10.1007/s15010-022-01935-3.
2022 Mpox Outbreak Global Map. Mpox. 2023. https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html. Accessed 16 Mar 2023.
2022-23 Mpox (Monkeypox) Outbreak: Global Trends. World Health Organization. 2023. https://worldhealthorg.shinyapps.io/mpx_global/. Accessed 16 Mar 2023.
Tiecco G, Degli Antoni M, Storti S, Tomasoni LR, Castelli F, Quiros-Roldan E. Monkeypox, a literature review: what is new and where does this concerning virus come from? Viruses. 2022;14(9):1894. https://doi.org/10.3390/v14091894.
Rimoin AW, Mulembakani PM, Johnston SC, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010;107(37):16262–7. https://doi.org/10.1073/pnas.1005769107.
Ramnarayan P, Mitting R, Whittaker E, et al. Neonatal Monkeypox Virus Infection. N Engl J Med. 2022;387(17):1618–20. https://doi.org/10.1056/NEJMc2210828.
Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D. Monkeypox: a comprehensive review of transmission, pathogenesis, and manifestation. Cureus. 2022;14(7):e26531. https://doi.org/10.7759/cureus.26531.
Wenham C, Eccleston-Turner M. Monkeypox as a PHEIC: implications for global health governance. Lancet. 2022;400(10369):2169–71. https://doi.org/10.1016/S0140-6736(22)01437-4.
Titanji BK, Tegomoh B, Nematollahi S, Konomos M, Kulkarni PA. Monkeypox: a contemporary review for healthcare professionals. Open Forum Infect Dis. 2022;9(7):ofac310. https://doi.org/10.1093/ofid/ofac310.
Harapan H, Ophinni Y, Megawati D, et al. Monkeypox: a comprehensive review. Viruses. 2022;14(10):2155. https://doi.org/10.3390/v14102155.
Patel M, Adnan M, Aldarhami A, et al. Current insights into diagnosis, prevention strategies, treatment, therapeutic targets, and challenges of monkeypox (mpox) infections in human populations. Life (Basel). 2023;13(1):249. https://doi.org/10.3390/life13010249.
Treatment information for healthcare professionals. Mpox Health Professionals Clinical Guidance. 2023. https://www.cdc.gov/poxvirus/mpox/clinicians/treatment.html. Accessed 18 Mar 2023.
Adler H, Gould S, Hine P, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 2022;22(8):1153–62. https://doi.org/10.1016/S1473-3099(22)00228-6.
Rallapalli S, Razai MS, Majeed A, Drysdale SB. Diagnosis and management of monkeypox in primary care. J R Soc Med. 2022;115(10):384–9. https://doi.org/10.1177/01410768221131914.
Shamim MA, Padhi BK, Satapathy P, et al. The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review. Int J Infect Dis. 2023;127:150–61. https://doi.org/10.1016/j.ijid.2022.11.040.
Johri N, Kumar D, Nagar P, Maurya A, Vengat M, Jain P. Clinical manifestations of human monkeypox infection and implications for outbreak strategy. Health Sci Rev (Oxf). 2022;5:100055. https://doi.org/10.1016/j.hsr.2022.100055.
Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y. Prevention and treatment of monkeypox. Drugs. 2022;82(9):957–63. https://doi.org/10.1007/s40265-022-01742-y.
Highlights of prescribing information dosage forms and strengths TPOXX. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208627s000lbl.pdf. Accessed 25 Mar 2023.
Desai AN, Thompson GR 3rd, Neumeister SM, Arutyunova AM, Trigg K, Cohen SH. Compassionate use of tecovirimat for the treatment of monkeypox infection. JAMA. 2022;328(13):1348–50. https://doi.org/10.1001/jama.2022.15336.
Lanier R, Trost L, Tippin T, et al. Development of CMX001 for the Treatment of Poxvirus Infections. Viruses. 2010;2(12):2740–62. https://doi.org/10.3390/v2122740.
Durski KN, McCollum AM, Nakazawa Y, et al. Emergence of monkeypox - West and Central Africa, 1970–2017. Centers for Disease Control and Prevention. 2018. https://www.cdc.gov/mmwr/volumes/67/wr/mm6710a5.htm. Accessed 30 Mar 2023.
Huang Y, Mu L, Wang W. Monkeypox: epidemiology, pathogenesis, treatment and prevention. Signal Transduct Target Ther. 2022;7(1):373. https://doi.org/10.1038/s41392-022-01215-4.
Jiang RM, Zheng YJ, Zhou L, et al. Diagnosis, treatment, and prevention of monkeypox in children: an experts' consensus statement. World J Pediatr. 2023;19(3):231–42. https://doi.org/10.1007/s12519-022-00624-3.
Petersen E, Kantele A, Koopmans M, et al. Human monkeypox. Infect Dis Clin North Am. 2019;33(4):1027–43. https://doi.org/10.1016/j.idc.2019.03.001.
Poland GA, Kennedy RB, Tosh PK. Prevention of monkeypox with vaccines: a rapid review. Lancet Infect Dis. 2022;22(12):e349–58. https://doi.org/10.1016/S1473-3099(22)00574-6.
Saied AA, Dhawan M, Metwally AA, Fahrni ML, Choudhary P, Choudhary OP. Disease history, pathogenesis, diagnostics, and therapeutics for human monkeypox disease: a comprehensive review. Vaccines. 2022;10(12):2091. https://doi.org/10.3390/vaccines10122091.
Hemati S, Farhadkhani M, Sanami S, Mohammadi-Moghadam F. A review on insights and lessons from COVID-19 to the prevent of monkeypox pandemic. Travel Med Infect Dis. 2022;50:102441. https://doi.org/10.1016/j.tmaid.2022.102441.
Nadar S, Khan T, Omri A. Reemergence of monkeypox: prevention and management. Expert Rev Anti Infect Ther. 2022;20(11):1425–33. https://doi.org/10.1080/14787210.2022.2128763.
Di Gennaro F, Veronese N, Marotta C, et al. Human monkeypox: a comprehensive narrative review and analysis of the public health implications. Microorganisms. 2022;10(8):1633. https://doi.org/10.3390/microorganisms10081633.
Shea J, Filardo TD, Morris SB, Weiser J, Petersen B, Brooks JT. Interim guidance for prevention and treatment of monkeypox in persons with HIV infection — United States, August 2022. MMWR Morb Mortal Wkly Rep. 2022;71(32):1023–8. https://doi.org/10.15585/mmwr.mm7132e4.
McCarthy MW. Therapeutic strategies to address monkeypox. Expert Rev Anti Infect Ther. 2022;20(10):1249–52. https://doi.org/10.1080/14787210.2022.2113058.
Islam MR, Hossain MJ, Roy A, et al. Repositioning potentials of smallpox vaccines and antiviral agents in monkeypox outbreak: A rapid review on comparative benefits and risks. Health Sci Rep. 2022;5(5):e798. https://doi.org/10.1002/hsr2.798.
Rajsri KS, Rao M. A review of monkeypox: the new global health emergency. Venereology. 2022;1(2):199–211. https://doi.org/10.3390/venereology1020014.
Mpox Vaccination Basics. 2023. https://www.cdc.gov/poxvirus/monkeypox/vaccines/index.html.
Lum FM, Torres-Ruesta A, Tay MZ, et al. Monkeypox: disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol. 2022;22(10):597–613. https://doi.org/10.1038/s41577-022-00775-4.
Sak K. Anticancer action of plant products: changing stereotyped attitudes. Explor Drug Sci. 2022;15:423–7. https://doi.org/10.37349/etat.2022.00092.
Behl T, Rocchetti G, Chadha S, et al. Phytochemicals from plant foods as potential source of antiviral agents: an overview. Pharmaceuticals. 2021;14(4):381. https://doi.org/10.3390/ph14040381.
Cao S, Realegeno S, Pant A, Satheshkumar PS, Yang Z. Suppression of poxvirus replication by resveratrol. Front Microbiol. 2017;8:2196. https://doi.org/10.3389/fmicb.2017.02196.
Fauci AS. Emerging and reemerging infectious diseases: the perpetual challenge. Acad Med. 2005;80(12):1079–85. https://doi.org/10.1097/00001888-200512000-00002.
Rothenburg S, Yang Z, Beard P, et al. Monkeypox emergency: urgent questions and perspectives. Cell. 2022;185(18):3279–81. https://doi.org/10.1016/j.cell.2022.08.002.